##### Computational cost for the whole process ##### Computational time (seconds) Direct 5 KMR 54 PKMR 55 em 87 KCCA 134 ##### 3-fold cross-validation ##### AUC AUPR Sens Spec PPV Direct 0.590 0.016 0.017 0.990 0.021 KMR 0.696 0.044 0.094 0.991 0.117 PKMR 0.707 0.052 0.112 0.991 0.138 em 0.688 0.039 0.082 0.990 0.101 KCCA 0.618 0.020 0.028 0.990 0.035 AUC: Area under the ROC curve AUPR: Area under the Precision-Recall curve Sens: Sensitivity Spec: Specificity: PPV: Positive predictive value Note that the upper one percentile in the prediction score is chosen as a threshold for Sens, Spec and PPV, because high-confidence prediction results are interesting in practical applications.