#### component 1: positive weight features and high scoring objects #### # positive weight on target proteins 1 0.593 26 SC6A4_HUMAN Sodium-dependent serotonin transporter; 1 0.493 28 SC6A2_HUMAN Sodium-dependent noradrenaline transporter; 1 0.304 35 DRD2_HUMAN D(2) dopamine receptor; 1 0.146 17 SCN7A_HUMAN Sodium channel protein type 7 subunit alpha; 1 0.146 17 SCN3B_HUMAN Sodium channel subunit beta-3; 1 0.146 17 SCN4A_HUMAN Sodium channel protein type 4 subunit alpha; 1 0.146 17 SCN4B_HUMAN Sodium channel subunit beta-4; 1 0.146 17 ACCN3_HUMAN Amiloride-sensitive cation channel 3; 1 0.146 17 EF1B_HUMAN Elongation factor 1-beta; 1 0.146 17 SCNAA_HUMAN Sodium channel protein type 10 subunit alpha; 1 0.146 17 SCN3A_HUMAN Sodium channel protein type 3 subunit alpha; 1 0.146 17 ACCN4_HUMAN Amiloride-sensitive cation channel 4; 1 0.146 17 DB124_HUMAN Beta-defensin 124; 1 0.146 17 SCN1B_HUMAN Sodium channel subunit beta-1; 1 0.136 28 DRD3_HUMAN D(3) dopamine receptor; 1 0.121 18 SCNNB_HUMAN Amiloride-sensitive sodium channel subunit beta; 1 0.121 18 SCNNG_HUMAN Amiloride-sensitive sodium channel subunit gamma; 1 0.121 18 SCNND_HUMAN Amiloride-sensitive sodium channel subunit delta; 1 0.106 42 ADA1A_HUMAN Alpha-1A adrenergic receptor; 1 0.064 18 SCN5A_HUMAN Sodium channel protein type 5 subunit alpha; 1 0.034 28 DRD1_HUMAN D(1A) dopamine receptor; # positive weight on side effects 1 0.573 247 tremor 1 0.399 152 urinary retention 1 0.369 185 impotence 1 0.258 149 ataxia 1 0.209 301 dry mouth 1 0.195 112 gynecomastia 1 0.19 105 psychosis 1 0.189 284 syncope 1 0.18 233 tinnitus 1 0.18 301 confusion 1 0.16 249 blurred vision 1 0.128 55 dyskinesia 1 0.117 368 somnolence 1 0.108 205 bradycardia 1 0.082 147 decreased libido 1 0.071 377 constipation 1 0.068 189 hallucinations 1 0.057 322 tachycardia 1 0.043 131 diplopia 1 0.04 254 nervousness 1 0.028 210 agitation 1 0.012 391 edema 1 0.003 123 urinary incontinence # high scoring drugs for both targets and side effects 1 2.164 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 1 2.153 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 1 2.066 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 1 2.05 135 5734 DB00909 Anticonvulsants.Antioxidants 1 1.992 91 3355 DB01195 Anti-Arrhythmia Agents.Antiarrhythmic Agents 1 1.986 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 1 1.844 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 1 1.769 75 4178 DB00379 Anti-Arrhythmia Agents 1 1.759 150 1775 DB00252 Anticonvulsants 1 1.707 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 1 1.615 95 16231 DB00594 Diuretics.Sodium channel blockers 1 1.61 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 1 1.601 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 1 1.599 87 5533 DB00656 Anti-anxiety Agents.Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 1 1.581 69 3696 DB00458 Adrenergic Uptake Inhibitors.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 1 1.568 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 1 1.541 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 1 1.527 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 1 1.52 84 2995 DB01151 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Enzyme Inhibitors.Norepinephrine-Reuptake Inhibitors 1 1.507 61 3114 DB00280 Anti-Arrhythmia Agents.Antiarrhythmic Agents 1 1.49 112 71273 DB00296 Anesthetics.Anesthetics, Local.Local Anesthetics 1 1.471 69 2170 DB00543 Adrenergic Uptake Inhibitors.Antidepressive Agents, Second-Generation.Dopamine Antagonists.Neurotransmitter Uptake Inhibitors.Serotonin Uptake Inhibitors 1 1.466 67 4976 DB00344 Adrenergic Uptake Inhibitors.Antidepressive Agents.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 1 1.466 64 5584 DB00726 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 1 1.465 72 2160 DB00321 Adrenergic Uptake Inhibitors.Analgesics, Non-Narcotic.Antidepressive Agents, Tricyclic 1 1.461 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 1 1.416 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 1 1.411 74 3676 DB00281 Anesthetics.Anesthetics, Local.Anti-Arrhythmia Agents.Antiarrhythmic Agents 1 1.395 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 1 1.382 51 48041 DB01228 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Sodium channel blockers 1 1.381 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 1 1.381 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 1 1.378 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 1 1.365 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 1 1.357 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 1 1.337 66 4011 DB00934 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Second-Generation 1 1.294 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 1 1.291 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 1 1.28 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 1 1.279 129 5210 DB01105 Anorexigenic Agents.Antidepressants.Antidepressive Agents.Appetite Depressants.Stimulants 1 1.276 151 60835 DB00476 Adrenergic Uptake Inhibitors.Antidepressive Agents.Dopamine Uptake Inhibitors.Serotonin Uptake Inhibitors 1 1.266 65 4543 DB00540 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 1 1.185 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 1 1.179 453 125889 DB00230 Analgesics.Anticonvulsants 1 1.175 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 1 1.151 50 3158 DB01142 Anti-anxiety Agents.Antidepressants.Antidepressive Agents, Tricyclic.Antipruritics.Histamine Antagonists.Norepinephrine-Reuptake Inhibitors 1 1.136 90 2477 DB00490 Anti-anxiety Agents.Anxiolytics sedatives and hypnotics.Serotonin Agonists 1 1.082 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 1 1.066 36 4914 DB00721 Anesthetics.Anesthetics, Local.Local Anesthetics 1 1.041 183 3648 DB00327 Analgesics, Opioid.Narcotics 1 1.039 154 3157 DB00590 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Anticholesteremic Agents.Antihypertensive Agents.Vasodilator Agents 1 1.024 128 4253 DB00295 Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 1 1.0 62 3007 DB00182 Adrenergic Agents.Adrenergic Uptake Inhibitors.Amphetamines.Central Nervous System Stimulants.Dopamine Agents.Dopamine Uptake Inhibitors.Sympathomimetics 1 0.99 73 34633 DB00680 Anti-Arrhythmia Agents 1 0.987 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 1 0.977 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 1 0.96 181 4932 DB01182 Anti-Arrhythmia Agents 1 0.952 157 4659569 DB00323 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Enzyme Inhibitors 1 0.93 143 4054 DB01043 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agents.Excitatory Amino Acid Antagonists 1 0.906 161 122316 DB01367 Monoamine Oxidase Inhibitors.Neuroprotective Agents 1 0.89 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 1 0.889 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 1 0.883 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 1 0.883 146 4158 DB00422 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Uptake Inhibitors.Sympathomimetics 1 0.868 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 1 0.864 49 4078 DB00933 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 1 0.862 120 2284 DB00181 GABA Agonists.Muscle Relaxants.Muscle Relaxants, Central.Skeletal Muscle Relaxants 1 0.856 196 1935 DB00382 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 1 0.848 133 2802 DB01068 Anticonvulsants.Benzodiazepines.GABA Modulators 1 0.835 196 3911 DB00007 Anti-Estrogen Agents.Antineoplastic Agents 1 0.826 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 1 0.825 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 1 0.819 118 4236 DB00745 Anorexigenic Agents.Central Nervous System Agents.Central Nervous System Stimulants.Neuroprotective Agents.Stimulants 1 0.805 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 1 0.796 41 5530 DB00752 Anti-anxiety Agents.Antidepressants.Antidepressive Agents.Monoamine Oxidase Inhibitors 1 0.788 167 5719 DB00962 Anticonvulsants.Anxiolytics sedatives and hypnotics.Hypnotics and Sedatives 1 0.77 62 5566 DB00831 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 1 0.744 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists 1 0.731 38 125017 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 1 0.729 47 4927 DB01069 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists.Phenothiazine Derivatives 1 0.727 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 1 0.71 136 56339 DB01320 Anticonvulsants 1 0.707 137 62959 DB00685 Anti-Infective Agents.Anti-Infectives.Fluoroquinolones 1 0.697 76 4748 DB00850 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 1 0.682 51 3964 DB00408 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists 1 0.682 64 2726 DB00477 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 1 0.673 157 3937 DB00722 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents.Cardiotonic Agents 1 0.661 55 2130 DB00915 Analgesics, Non-Narcotic.Antiparkinson Agents.Antiviral Agents.Dopamine Agents 1 0.657 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 1 0.649 185 4594 DB00338 Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 1 0.648 83 54841 DB00289 Adrenergic Uptake Inhibitors.Antidepressants.Central Nervous System Agents 1 0.647 104 3449 DB00674 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 1 0.647 142 3826 DB00465 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 1 0.646 142 2678 DB00341 Anti-Allergic Agents.Antihistamines.Histamine H1 Antagonists, Non-Sedating 1 0.636 131 4635 DB00497 Analgesics, Opioid.Antitussives.Narcotics.Opiate Agonists 1 0.634 76 2803 DB00575 Adrenergic alpha-Agonists.Analgesics.Antihypertensive Agents.Central Alpha-Agonists.Sympatholytics 1 0.632 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 1 0.63 51 3559 DB00502 Anti-Dyskinesia Agents.Antidyskinetics.Antiemetics.Antipsychotic Agents.Antipsychotics.Butyrophenones.Dopamine Antagonists 1 0.627 138 2369 DB00195 Adrenergic beta-Antagonists.Antihypertensive Agents.EENT Drugs.Sympatholytics 1 0.621 77 39860 DB00486 Anti-anxiety Agents.Antiemetics #### component 2: positive weight features and high scoring objects #### # positive weight on target proteins 2 0.525 29 GBRA1_HUMAN Gamma-aminobutyric acid receptor subunit alpha-1; 2 0.279 23 GBRA2_HUMAN Gamma-aminobutyric acid receptor subunit alpha-2; 2 0.231 21 GBRD_HUMAN Gamma-aminobutyric acid receptor subunit delta; 2 0.231 21 GBRB2_HUMAN Gamma-aminobutyric acid receptor subunit beta-2; 2 0.231 21 GBRR1_HUMAN Gamma-aminobutyric acid receptor subunit rho-1; 2 0.231 21 GBRG3_HUMAN Gamma-aminobutyric acid receptor subunit gamma-3; 2 0.231 21 GBRG2_HUMAN Gamma-aminobutyric acid receptor subunit gamma-2; 2 0.231 21 GBRE_HUMAN Gamma-aminobutyric acid receptor subunit epsilon; 2 0.231 21 GBRT_HUMAN Gamma-aminobutyric acid receptor subunit theta; 2 0.231 21 GBRB1_HUMAN Gamma-aminobutyric acid receptor subunit beta-1; 2 0.231 21 GBRB3_HUMAN Gamma-aminobutyric acid receptor subunit beta-3; 2 0.205 22 GBRA6_HUMAN Gamma-aminobutyric acid receptor subunit alpha-6; 2 0.205 22 GBRA3_HUMAN Gamma-aminobutyric acid receptor subunit alpha-3; 2 0.205 22 GBRA5_HUMAN Gamma-aminobutyric acid receptor subunit alpha-5; 2 0.205 22 GBRA4_HUMAN Gamma-aminobutyric acid receptor subunit alpha-4; # positive weight on side effects 2 0.497 89 increased salivation 2 0.365 189 hallucinations 2 0.331 74 apnea 2 0.302 149 ataxia 2 0.297 28 hypoventilation 2 0.272 322 hypotension 2 0.244 131 diplopia 2 0.202 210 agitation 2 0.197 85 hiccup 2 0.163 64 dysarthria 2 0.133 58 nystagmus 2 0.127 301 confusion 2 0.097 107 amnesia 2 0.064 123 urinary incontinence 2 0.039 254 nervousness 2 0.032 76 nightmares 2 0.019 205 bradycardia 2 0.007 180 seizures # high scoring drugs for both targets and side effects 2 3.133 61 4192 DB00683 Adjuvants, Anesthesia.Anesthetics, Intravenous.Anti-anxiety Agents.GABA Modulators.Hypnotics and Sedatives 2 3.059 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 2 3.036 167 5719 DB00962 Anticonvulsants.Anxiolytics sedatives and hypnotics.Hypnotics and Sedatives 2 3.009 120 2284 DB00181 GABA Agonists.Muscle Relaxants.Muscle Relaxants, Central.Skeletal Muscle Relaxants 2 2.984 73 3958 DB00186 Anti-anxiety Agents.Anticonvulsants.Antiemetics.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 2 2.857 84 3016 DB00829 Adjuvants, Anesthesia.Anesthetics, Intravenous.Anti-anxiety Agents.Anticonvulsants.Antiemetics.GABA Modulators.Hypnotics and Sedatives.Muscle Relaxants, Central 2 2.778 102 4943 DB00818 Anesthetics, Intravenous.Anticonvulsants.Antiemetics.Free Radical Scavengers.Hypnotics and Sedatives 2 2.623 86 2118 DB00404 Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 2 2.516 133 2802 DB01068 Anticonvulsants.Benzodiazepines.GABA Modulators 2 2.512 23 4737 DB00312 Adjuvants, Anesthesia.Barbiturates.GABA Modulators.Hypnotics and Sedatives 2 2.512 23 5193 DB00418 Adjuvants.Adjuvants, Anesthesia.Barbiturates.GABA Modulators.Hypnotics and Sedatives 2 2.468 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 2 2.465 58 5206 DB01236 Anesthetics, Inhalation.Platelet Aggregation Inhibitors 2 2.453 23 3821 DB01221 Analgesics.Anesthetics, Dissociative.Excitatory Amino Acid Antagonists.General Anesthetics 2 2.341 147 71158 DB00659 Alcohol Deterrents 2 2.335 38 3393 DB00690 Anti-anxiety Agents.GABA Modulators.Hypnotics and Sedatives 2 2.272 25 9034 DB00474 Anesthetics.Anesthetics, Intravenous.Barbiturates 2 2.185 16 3763 DB00753 Anesthetics.Anesthetics, Inhalation.General Anesthetics 2 2.081 13 36339 DB00292 Anesthetics, Intravenous.Hypnotics and Sedatives 2 1.733 10 2712 DB00475 Adjuvants, Anesthesia.Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 2 1.655 7 3562 DB01159 Anesthetics.Anesthetics, Inhalation.General Anesthetics 2 1.21 453 125889 DB00230 Analgesics.Anticonvulsants 2 1.131 183 3648 DB00327 Analgesics, Opioid.Narcotics 2 1.112 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 2 1.112 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 2 1.077 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 2 1.077 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 2 1.068 60 3373 DB01205 Antidotes.GABA Modulators 2 1.003 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 2 0.998 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 2 0.915 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 2 0.915 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 2 0.913 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 2 0.881 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 2 0.879 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 2 0.851 128 4253 DB00295 Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 2 0.845 71 2487 DB00611 Analgesics, Opioid.Antitussive Agents.Narcotic Antagonists.Narcotics 2 0.816 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 2 0.814 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 2 0.794 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 2 0.794 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 2 0.78 150 1775 DB00252 Anticonvulsants 2 0.763 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 2 0.762 157 4659569 DB00323 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Enzyme Inhibitors 2 0.734 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists 2 0.733 87 5533 DB00656 Anti-anxiety Agents.Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 2 0.731 196 1935 DB00382 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 2 0.726 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 2 0.692 136 56339 DB01320 Anticonvulsants 2 0.671 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 2 0.665 31 2441 DB01558 Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 2 0.654 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 2 0.649 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 2 0.648 199 5358 DB00669 Selective Serotonin Agonists.Serotonin Agonists.Vasoconstrictor Agents 2 0.647 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 2 0.636 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 2 0.63 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 2 0.614 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 2 0.593 104 3449 DB00674 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 2 0.592 47 4927 DB01069 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists.Phenothiazine Derivatives 2 0.587 73 34633 DB00680 Anti-Arrhythmia Agents 2 0.582 143 4054 DB01043 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agents.Excitatory Amino Acid Antagonists 2 0.581 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 2 0.58 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 2 0.577 77 28112 DB01356 Not Available 2 0.568 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 2 0.55 90 2477 DB00490 Anti-anxiety Agents.Anxiolytics sedatives and hypnotics.Serotonin Agonists 2 0.546 76 3661 DB00572 Adjuvants, Anesthesia.Anti-Arrhythmia Agents.Bronchodilator Agents.Muscarinic Antagonists.Mydriatics.Parasympatholytics 2 0.546 40 4064 DB00371 Anti-anxiety Agents.Anticonvulsants.Hypnotics and Sedatives.Muscle Relaxants, Central 2 0.538 66 4011 DB00934 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Second-Generation 2 0.536 142 2678 DB00341 Anti-Allergic Agents.Antihistamines.Histamine H1 Antagonists, Non-Sedating 2 0.536 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 2 0.534 161 122316 DB01367 Monoamine Oxidase Inhibitors.Neuroprotective Agents 2 0.532 59 2476 DB00921 Analgesics, Opioid.Narcotic Antagonists.Narcotics 2 0.529 105 4659568 DB00494 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Enzyme Inhibitors 2 0.516 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 2 0.515 137 62959 DB00685 Anti-Infective Agents.Anti-Infectives.Fluoroquinolones 2 0.515 26 4506 DB01595 Anti-anxiety Agents.Anticonvulsants.GABA Modulators.Hypnotics and Sedatives 2 0.501 132 3948 DB00978 Anti-Infective Agents.Anti-Infective Agents, Urinary.Antitubercular Agents.Photosensitizing Agents 2 0.491 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 2 0.485 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 2 0.483 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 2 0.483 135 5734 DB00909 Anticonvulsants.Antioxidants 2 0.468 20 4616 DB00842 Anti-anxiety Agents.GABA Modulators.Hypnotics and Sedatives 2 0.462 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 2 0.46 118 4236 DB00745 Anorexigenic Agents.Central Nervous System Agents.Central Nervous System Stimulants.Neuroprotective Agents.Stimulants 2 0.457 30 42113 DB01189 Anesthetics, Inhalation.Neuroprotective Agents 2 0.457 91 60815 DB00899 Analgesics, Opioid.Anesthetics, Intravenous.Hypnotics and Sedatives 2 0.456 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 2 0.447 84 2995 DB01151 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Enzyme Inhibitors.Norepinephrine-Reuptake Inhibitors 2 0.426 141 4819 DB01085 Cholinergic Agents.Miotics.Muscarinic Agonists 2 0.421 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 2 0.404 74 3676 DB00281 Anesthetics.Anesthetics, Local.Anti-Arrhythmia Agents.Antiarrhythmic Agents 2 0.401 131 4635 DB00497 Analgesics, Opioid.Antitussives.Narcotics.Opiate Agonists 2 0.395 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 2 0.394 138 2369 DB00195 Adrenergic beta-Antagonists.Antihypertensive Agents.EENT Drugs.Sympatholytics 2 0.393 61 60612 DB00633 Adrenergic alpha-Agonists.Analgesics.Analgesics, Non-Narcotic.Hypnotics and Sedatives 2 0.377 264 5372 DB00864 Immunosuppressive Agents 2 0.375 100 2578 DB00262 Antineoplastic Agents.Antineoplastic Agents, Alkylating 2 0.367 158 34312 DB00776 Anticonvulsants #### component 3: positive weight features and high scoring objects #### # positive weight on target proteins 3 0.588 38 ADRB1_HUMAN Beta-1 adrenergic receptor; 3 0.376 34 ADRB2_HUMAN Beta-2 adrenergic receptor; 3 0.301 38 ADA2A_HUMAN Alpha-2A adrenergic receptor; 3 0.297 34 ADA1B_HUMAN Alpha-1B adrenergic receptor; 3 0.281 33 ADA2B_HUMAN Alpha-2B adrenergic receptor; 3 0.264 24 ADRB3_HUMAN Beta-3 adrenergic receptor; 3 0.251 42 ADA1A_HUMAN Alpha-1A adrenergic receptor; 3 0.206 30 ADA1D_HUMAN Alpha-1D adrenergic receptor; 3 0.075 17 EF1B_HUMAN Elongation factor 1-beta; 3 0.075 17 DB124_HUMAN Beta-defensin 124; 3 0.075 17 SCNAA_HUMAN Sodium channel protein type 10 subunit alpha; 3 0.075 17 SCN1B_HUMAN Sodium channel subunit beta-1; 3 0.075 17 ACCN3_HUMAN Amiloride-sensitive cation channel 3; 3 0.075 17 SCN4B_HUMAN Sodium channel subunit beta-4; 3 0.075 17 SCN3A_HUMAN Sodium channel protein type 3 subunit alpha; 3 0.075 17 SCN7A_HUMAN Sodium channel protein type 7 subunit alpha; 3 0.075 17 SCN3B_HUMAN Sodium channel subunit beta-3; 3 0.075 17 ACCN4_HUMAN Amiloride-sensitive cation channel 4; 3 0.075 17 SCN4A_HUMAN Sodium channel protein type 4 subunit alpha; 3 0.068 18 SCNNG_HUMAN Amiloride-sensitive sodium channel subunit gamma; 3 0.068 18 SCNND_HUMAN Amiloride-sensitive sodium channel subunit delta; 3 0.068 18 SCNNB_HUMAN Amiloride-sensitive sodium channel subunit beta; 3 0.043 18 SCN5A_HUMAN Sodium channel protein type 5 subunit alpha; 3 0.007 12 ACE_HUMAN Angiotensin-converting enzyme; # positive weight on side effects 3 0.573 205 bradycardia 3 0.378 204 sweating 3 0.353 274 palpitations 3 0.301 64 AV block 3 0.231 152 postural hypotension 3 0.223 185 impotence 3 0.212 133 bronchospasm 3 0.212 187 weakness 3 0.202 284 syncope 3 0.142 326 paresthesia 3 0.11 35 mental depression 3 0.106 280 anxiety 3 0.078 346 dyspnea 3 0.074 322 hypotension 3 0.07 147 decreased libido 3 0.068 280 chest pain 3 0.057 368 somnolence 3 0.053 107 nasal congestion 3 0.053 254 nervousness 3 0.048 52 heart block 3 0.045 122 congestive heart failure 3 0.039 320 fatigue 3 0.033 474 dizziness # high scoring drugs for both targets and side effects 3 2.402 61 4828 DB00960 Adrenergic beta-Antagonists.Antihypertensive Agents.Serotonin Antagonists.Vasodilator Agents 3 2.309 135 2585 DB01136 Adrenergic Agents.Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 3 2.244 69 3869 DB00598 Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Sympatholytics 3 2.197 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 3 2.17 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 3 1.987 72 4893 DB00457 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Antihypertensive Agents 3 1.909 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 3 1.712 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 3 1.693 76 2803 DB00575 Adrenergic alpha-Agonists.Analgesics.Antihypertensive Agents.Central Alpha-Agonists.Sympatholytics 3 1.683 75 1978 DB01193 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents 3 1.679 99 5478 DB00373 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents 3 1.586 117 2405 DB00612 Adrenergic Agents.Adrenergic beta-Antagonists.Antihypertensive Agents.Sympatholytics 3 1.515 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 3 1.512 78 2249 DB00335 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Sympatholytics 3 1.461 84 2995 DB01151 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Enzyme Inhibitors.Norepinephrine-Reuptake Inhibitors 3 1.448 94 4171 DB00264 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Sympatholytics 3 1.422 87 5533 DB00656 Anti-anxiety Agents.Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 3 1.392 76 3661 DB00572 Adjuvants, Anesthesia.Anti-Arrhythmia Agents.Bronchodilator Agents.Muscarinic Antagonists.Mydriatics.Parasympatholytics 3 1.347 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 3 1.314 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 3 1.306 91 3355 DB01195 Anti-Arrhythmia Agents.Antiarrhythmic Agents 3 1.255 20 5775 DB00692 Adrenergic alpha-Antagonists.Antihypertensive Agents.Sympatholytics 3 1.21 60 3519 DB01018 Adrenergic alpha-Agonists.Antihypertensive Agents.Sympatholytics 3 1.176 138 2369 DB00195 Adrenergic beta-Antagonists.Antihypertensive Agents.EENT Drugs.Sympatholytics 3 1.161 14 951 DB00368 Adrenergic alpha-Agonists.Sympathomimetics.Vasoconstrictor Agents 3 1.147 75 4178 DB00379 Anti-Arrhythmia Agents 3 1.112 65 5253 DB00489 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Sympatholytics 3 1.092 42 4411 DB01203 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents.Sympatholytics 3 1.09 154 3157 DB00590 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Anticholesteremic Agents.Antihypertensive Agents.Vasodilator Agents 3 1.088 135 5734 DB00909 Anticonvulsants.Antioxidants 3 1.081 95 16231 DB00594 Diuretics.Sodium channel blockers 3 1.079 154 27661 DB01020 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 3 1.059 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 3 0.999 10 4436 Not Available Not Available 3 0.993 157 3937 DB00722 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents.Cardiotonic Agents 3 0.973 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 3 0.972 150 1775 DB00252 Anticonvulsants 3 0.966 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 3 0.962 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 3 0.955 61 4946 DB00571 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Anti-anxiety Agents.Antiarrhythmic Agents.Antihypertensive Agents.Vasodilator Agents 3 0.946 34 3518 DB01170 Adrenergic Agents.Antihypertensive Agents.Sympatholytics 3 0.928 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 3 0.917 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists 3 0.913 84 5401 DB01162 Adrenergic alpha-Antagonists.Antineoplastic Agents.Platelet Aggregation Inhibitors 3 0.908 112 71273 DB00296 Anesthetics.Anesthetics, Local.Local Anesthetics 3 0.904 118 4236 DB00745 Anorexigenic Agents.Central Nervous System Agents.Central Nervous System Stimulants.Neuroprotective Agents.Stimulants 3 0.902 128 4253 DB00295 Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 3 0.892 101 3154 DB00869 Antihypertensive Agents.Carbonic Anhydrase Inhibitors 3 0.89 183 3648 DB00327 Analgesics, Opioid.Narcotics 3 0.888 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 3 0.888 106 2083 DB01001 Adrenergic beta-Agonists.Bronchodilator Agents.Tocolytic Agents 3 0.887 453 125889 DB00230 Analgesics.Anticonvulsants 3 0.885 38 3914 DB01210 Adrenergic beta-Antagonists.EENT Drugs.Sympatholytics 3 0.882 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 3 0.867 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 3 0.863 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 3 0.854 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 3 0.854 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 3 0.829 61 3114 DB00280 Anti-Arrhythmia Agents.Antiarrhythmic Agents 3 0.818 34 71301 DB04861 Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 3 0.805 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 3 0.788 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 3 0.781 77 3066 DB00320 Analgesics.Analgesics, Non-Narcotic.Anti-migraine Agents.Dopamine Agonists.Sympatholytics.Vasoconstrictor Agents 3 0.78 74 3676 DB00281 Anesthetics.Anesthetics, Local.Anti-Arrhythmia Agents.Antiarrhythmic Agents 3 0.775 97 1065 DB00908 Adrenergic alpha-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antimalarials.Enzyme Inhibitors.Muscarinic Antagonists 3 0.772 127 2156 DB01118 Anti-Arrhythmia Agents.Enzyme Inhibitors.Vasodilator Agents 3 0.769 73 34633 DB00680 Anti-Arrhythmia Agents 3 0.766 62 59768 DB00187 Adrenergic beta-Antagonists 3 0.765 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 3 0.761 103 2751 DB01340 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 3 0.761 120 2284 DB00181 GABA Agonists.Muscle Relaxants.Muscle Relaxants, Central.Skeletal Muscle Relaxants 3 0.755 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 3 0.75 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 3 0.739 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 3 0.737 28 2583 DB00521 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents.Sympatholytics 3 0.73 161 5487 DB00697 Adrenergic alpha-Agonists.Analgesics.Anticonvulsants.Muscle Relaxants.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 3 0.701 118 65999 DB00966 Angiotensin II Type 1 Receptor Blockers.Angiotensin-converting Enzyme Inhibitors 3 0.7 25 4724 DB01359 Adrenergic beta-Antagonists.Antihypertensive Agents 3 0.686 131 3961 DB00678 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents 3 0.679 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 3 0.678 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 3 0.669 196 3911 DB00007 Anti-Estrogen Agents.Antineoplastic Agents 3 0.667 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 3 0.66 181 4932 DB01182 Anti-Arrhythmia Agents 3 0.653 152 60184 DB00790 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 3 0.643 44 191 DB00640 Analgesics.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Cardiac drugs.Vasodilator Agents 3 0.641 33 3340 DB00800 Antihypertensive Agents.Dopamine Agonists.Vasodilator Agents 3 0.638 199 5358 DB00669 Selective Serotonin Agonists.Serotonin Agonists.Vasoconstrictor Agents 3 0.634 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 3 0.634 62 3007 DB00182 Adrenergic Agents.Adrenergic Uptake Inhibitors.Amphetamines.Central Nervous System Stimulants.Dopamine Agents.Dopamine Uptake Inhibitors.Sympathomimetics 3 0.62 236 10631 DB00603 Contraceptives.Contraceptives, Oral, Synthetic.Progestins 3 0.615 131 4635 DB00497 Analgesics, Opioid.Antitussives.Narcotics.Opiate Agonists 3 0.608 89 3148 DB00757 Antiemetics.Serotonin Antagonists 3 0.602 36 4914 DB00721 Anesthetics.Anesthetics, Local.Local Anesthetics 3 0.599 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 3 0.599 17 5403 DB00871 Adrenergic beta-Agonists.Bronchodilator Agents.Sympathomimetic.Sympathomimetics.Tocolytic Agents 3 0.598 76 3108 DB00975 Phosphodiesterase Inhibitors.Platelet Aggregation Inhibitors.Vasodilator Agents 3 0.592 16 3168 DB00450 Adjuvants, Anesthesia.Antiemetics.Antipsychotic Agents.Dopamine Antagonists 3 0.591 30 31477 DB01214 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents.Sympatholytics 3 0.589 40 4845 DB01291 Adrenergic beta-Agonists.Bronchodilator Agents.Cardiotonic Agents #### component 4: positive weight features and high scoring objects #### # positive weight on target proteins 4 0.539 35 DRD2_HUMAN D(2) dopamine receptor; 4 0.471 28 DRD3_HUMAN D(3) dopamine receptor; 4 0.431 28 DRD1_HUMAN D(1A) dopamine receptor; 4 0.318 21 DRD5_HUMAN D(1B) dopamine receptor; 4 0.211 42 ADA1A_HUMAN Alpha-1A adrenergic receptor; 4 0.161 34 ADA1B_HUMAN Alpha-1B adrenergic receptor; 4 0.151 38 ADA2A_HUMAN Alpha-2A adrenergic receptor; 4 0.143 33 ADA2B_HUMAN Alpha-2B adrenergic receptor; 4 0.132 26 SC6A4_HUMAN Sodium-dependent serotonin transporter; 4 0.131 35 HRH1_HUMAN Histamine H1 receptor; 4 0.12 30 ADA1D_HUMAN Alpha-1D adrenergic receptor; 4 0.082 14 CALM_HUMAN Calmodulin; 4 0.081 28 SC6A2_HUMAN Sodium-dependent noradrenaline transporter; 4 0.081 6 DRD4_HUMAN D(4) dopamine receptor; 4 0.066 8 CALL3_HUMAN Calmodulin-like protein 3; 4 0.065 12 AOFB_HUMAN Amine oxidase [flavin-containing] B; 4 0.033 13 CAC1A_HUMAN Voltage-dependent P/Q-type calcium channel subunit alpha-1A; 4 0.024 36 ACM1_HUMAN Muscarinic acetylcholine receptor M1; 4 0.023 9 TRI32_HUMAN E3 ubiquitin-protein ligase TRIM32; 4 0.019 15 CAC1I_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1I; 4 0.019 15 CAC1H_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1H; 4 0.018 13 CAC1B_HUMAN Voltage-dependent N-type calcium channel subunit alpha-1B; 4 0.015 12 CCG4_HUMAN Voltage-dependent calcium channel gamma-4 subunit; 4 0.015 12 CACB3_HUMAN Voltage-dependent L-type calcium channel subunit beta-3; 4 0.015 12 ITPR1_HUMAN Inositol 1,4,5-trisphosphate receptor type 1; 4 0.015 12 ITPR3_HUMAN Inositol 1,4,5-trisphosphate receptor type 3; 4 0.015 12 CA2D1_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-1; 4 0.015 12 PKD1_HUMAN Polycystin-1; 4 0.015 12 CCG7_HUMAN Voltage-dependent calcium channel gamma-7 subunit; 4 0.015 12 TRPV6_HUMAN Transient receptor potential cation channel subfamily V member 6; 4 0.015 12 CAC1S_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1S; 4 0.015 12 CACB4_HUMAN Voltage-dependent L-type calcium channel subunit beta-4; 4 0.015 12 TRPA1_HUMAN Transient receptor potential cation channel subfamily A member 1; 4 0.015 12 CAC1E_HUMAN Voltage-dependent R-type calcium channel subunit alpha-1E; 4 0.015 16 CAC1G_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1G; 4 0.015 12 PKD2_HUMAN Polycystin-2; 4 0.015 12 CCG2_HUMAN Voltage-dependent calcium channel gamma-2 subunit; 4 0.014 13 CACB1_HUMAN Voltage-dependent L-type calcium channel subunit beta-1; 4 0.012 34 ACM2_HUMAN Muscarinic acetylcholine receptor M2; 4 0.01 16 CACB2_HUMAN Voltage-dependent L-type calcium channel subunit beta-2; 4 0.01 16 CAC1F_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1F; 4 0.01 16 CAC1D_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1D; 4 0.008 17 CCG1_HUMAN Voltage-dependent calcium channel gamma-1 subunit; 4 0.007 15 RYR3_HUMAN Ryanodine receptor 3; 4 0.007 15 RYR2_HUMAN Ryanodine receptor 2; 4 0.006 14 RYR1_HUMAN Ryanodine receptor 1; 4 0.006 18 CAC1C_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1C; # positive weight on side effects 4 0.429 30 tardive dyskinesia 4 0.408 34 Parkinson 4 0.371 40 priapism 4 0.359 107 nasal congestion 4 0.351 67 amenorrhea 4 0.245 112 gynecomastia 4 0.214 89 increased salivation 4 0.194 106 spasm 4 0.176 23 torticollis 4 0.131 152 postural hypotension 4 0.126 155 dysphagia 4 0.114 55 dyskinesia 4 0.107 46 galactorrhea 4 0.106 322 tachycardia 4 0.081 35 paralytic ileus 4 0.051 83 leukocytosis 4 0.051 123 urinary incontinence 4 0.039 368 somnolence 4 0.039 129 eosinophilia 4 0.038 377 constipation 4 0.028 187 photosensitivity 4 0.003 342 insomnia # high scoring drugs for both targets and side effects 4 2.622 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 4 2.617 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 4 2.447 52 5452 DB00679 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 4 2.382 64 2726 DB00477 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 4 2.203 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 4 2.197 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 4 2.174 76 4748 DB00850 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 4 2.128 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 4 2.009 62 5566 DB00831 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 4 1.985 51 3559 DB00502 Anti-Dyskinesia Agents.Antidyskinetics.Antiemetics.Antipsychotic Agents.Antipsychotics.Butyrophenones.Dopamine Antagonists 4 1.923 57 5454 DB01623 Antipsychotic Agents.Dopamine Antagonists 4 1.915 59 4917 DB00433 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 4 1.877 71 3372 DB00623 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 4 1.842 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 4 1.838 51 3964 DB00408 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists 4 1.74 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 4 1.575 86 115237 DB01267 Antipsychotic Agents 4 1.571 35 16362 DB01100 Anti-Dyskinesia Agents.Antipsychotic Agents.Dopamine Antagonists 4 1.552 90 2477 DB00490 Anti-anxiety Agents.Anxiolytics sedatives and hypnotics.Serotonin Agonists 4 1.506 49 4078 DB00933 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 4 1.337 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 4 1.336 20 5775 DB00692 Adrenergic alpha-Antagonists.Antihypertensive Agents.Sympatholytics 4 1.33 27 23897 DB01618 Antipsychotic Agents 4 1.308 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 4 1.163 87 5533 DB00656 Anti-anxiety Agents.Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 4 1.162 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 4 1.154 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 4 1.114 69 2512 DB00248 Antineoplastic Agents.Antiparkinson Agents.Dopamine Agonists 4 1.059 33 3340 DB00800 Antihypertensive Agents.Dopamine Agonists.Vasodilator Agents 4 1.054 11 3251 DB00696 Adrenergic alpha-Agonists.Analgesics, Non-Narcotic.Sympatholytics.Vasoconstrictor Agents 4 1.019 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 4 1.014 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 4 0.975 49 4168 DB01233 Antiemetics.Dopamine Antagonists.Prokinetic Agents 4 0.967 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 4 0.884 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 4 0.862 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 4 0.857 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 4 0.816 72 4893 DB00457 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Antihypertensive Agents 4 0.812 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 4 0.771 31 2215 DB00714 Antidyskinetics.Antiparkinson Agents.Dopamine Agonists 4 0.715 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 4 0.657 453 125889 DB00230 Analgesics.Anticonvulsants 4 0.636 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 4 0.633 47 4927 DB01069 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists.Phenothiazine Derivatives 4 0.616 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 4 0.611 66 4011 DB00934 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Second-Generation 4 0.609 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 4 0.594 84 5401 DB01162 Adrenergic alpha-Antagonists.Antineoplastic Agents.Platelet Aggregation Inhibitors 4 0.569 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 4 0.567 57 2443 DB01200 Antidyskinetics.Antiparkinson Agents.Dopamine Agonists.Hormone Antagonists 4 0.549 50 4138 DB00968 Adrenergic alpha-Agonists.Antihypertensive Agents.Sympatholytics 4 0.517 69 2170 DB00543 Adrenergic Uptake Inhibitors.Antidepressive Agents, Second-Generation.Dopamine Antagonists.Neurotransmitter Uptake Inhibitors.Serotonin Uptake Inhibitors 4 0.515 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 4 0.512 34 3518 DB01170 Adrenergic Agents.Antihypertensive Agents.Sympatholytics 4 0.506 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 4 0.497 72 2160 DB00321 Adrenergic Uptake Inhibitors.Analgesics, Non-Narcotic.Antidepressive Agents, Tricyclic 4 0.474 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 4 0.471 196 1935 DB00382 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 4 0.47 4 4768 DB00925 Adrenergic alpha-Antagonists.Antihypertensive Agents.Vasodilator Agents 4 0.468 161 122316 DB01367 Monoamine Oxidase Inhibitors.Neuroprotective Agents 4 0.468 95 16231 DB00594 Diuretics.Sodium channel blockers 4 0.461 84 2995 DB01151 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Enzyme Inhibitors.Norepinephrine-Reuptake Inhibitors 4 0.461 17 1206 DB01577 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Agents.Dopamine Uptake Inhibitors.Sympathomimetics 4 0.44 154 3157 DB00590 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Anticholesteremic Agents.Antihypertensive Agents.Vasodilator Agents 4 0.439 135 2585 DB01136 Adrenergic Agents.Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 4 0.433 76 3661 DB00572 Adjuvants, Anesthesia.Anti-Arrhythmia Agents.Bronchodilator Agents.Muscarinic Antagonists.Mydriatics.Parasympatholytics 4 0.423 16 3168 DB00450 Adjuvants, Anesthesia.Antiemetics.Antipsychotic Agents.Dopamine Antagonists 4 0.42 55 2130 DB00915 Analgesics, Non-Narcotic.Antiparkinson Agents.Antiviral Agents.Dopamine Agents 4 0.418 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists 4 0.411 143 4054 DB01043 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agents.Excitatory Amino Acid Antagonists 4 0.39 26 3151 DB01184 Antiemetics.Dopamine Antagonists 4 0.365 69 3869 DB00598 Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Sympatholytics 4 0.362 76 2803 DB00575 Adrenergic alpha-Agonists.Analgesics.Antihypertensive Agents.Central Alpha-Agonists.Sympatholytics 4 0.362 50 3158 DB01142 Anti-anxiety Agents.Antidepressants.Antidepressive Agents, Tricyclic.Antipruritics.Histamine Antagonists.Norepinephrine-Reuptake Inhibitors 4 0.355 150 1775 DB00252 Anticonvulsants 4 0.352 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 4 0.345 128 4253 DB00295 Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 4 0.329 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 4 0.325 77 3066 DB00320 Analgesics.Analgesics, Non-Narcotic.Anti-migraine Agents.Dopamine Agonists.Sympatholytics.Vasoconstrictor Agents 4 0.314 161 5212 DB00203 Phosphodiesterase Inhibitors.Vasodilator Agents 4 0.312 166 54374 DB00104 Anabolic Agents.Antineoplastic Agents, Hormonal.Gastrointestinal Agents.Hormone Replacement Agents 4 0.311 86 2118 DB00404 Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 4 0.307 146 3075 DB00343 Antihypertensive Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Cardiovascular Agents.Vasodilator Agents 4 0.292 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 4 0.289 157 3937 DB00722 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents.Cardiotonic Agents 4 0.289 236 10631 DB00603 Contraceptives.Contraceptives, Oral, Synthetic.Progestins 4 0.285 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 4 0.281 69 3696 DB00458 Adrenergic Uptake Inhibitors.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 4 0.276 183 3648 DB00327 Analgesics, Opioid.Narcotics 4 0.27 82 110634 DB00862 Anti-Impotence Agents.Phosphodiesterase Inhibitors.Vasoconstrictor Agents 4 0.262 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 4 0.259 191 450 DB00783 Anti-menopausal Agents.Anticholesteremic Agents.Estrogens 4 0.257 53 2092 DB00346 Adrenergic alpha-Antagonists.Antihypertensive Agents 4 0.256 68 110635 DB00820 Phosphodiesterase Inhibitors.Vasoconstrictor Agents 4 0.255 100 5038 DB00178 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 4 0.253 29 3125 DB00765 Enzyme Inhibitors 4 0.251 61 4828 DB00960 Adrenergic beta-Antagonists.Antihypertensive Agents.Serotonin Antagonists.Vasodilator Agents 4 0.251 135 5734 DB00909 Anticonvulsants.Antioxidants 4 0.251 73 3333 DB01023 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Calcium Channel Blockers.Dihydropyridines.Vasodilator Agents 4 0.244 62 3007 DB00182 Adrenergic Agents.Adrenergic Uptake Inhibitors.Amphetamines.Central Nervous System Stimulants.Dopamine Agents.Dopamine Uptake Inhibitors.Sympathomimetics #### component 5: positive weight features and high scoring objects #### # positive weight on target proteins 5 0.706 29 PGH2_HUMAN Prostaglandin G/H synthase 2; 5 0.547 23 PGH1_HUMAN Prostaglandin G/H synthase 1; 5 0.144 16 TOP2A_HUMAN DNA topoisomerase 2-alpha; 5 0.142 14 TTHY_HUMAN Transthyretin; 5 0.138 14 LOX5_HUMAN Arachidonate 5-lipoxygenase; 5 0.102 26 SC6A4_HUMAN Sodium-dependent serotonin transporter; 5 0.085 8 LX12B_HUMAN Arachidonate 12-lipoxygenase, 12R-type; 5 0.085 8 LOXE3_HUMAN Epidermis-type lipoxygenase 3; 5 0.085 8 LOX12_HUMAN Arachidonate 12-lipoxygenase, 12S-type; 5 0.07 10 LKHA4_HUMAN Leukotriene A-4 hydrolase; 5 0.068 18 SCN5A_HUMAN Sodium channel protein type 5 subunit alpha; 5 0.066 18 SCNNG_HUMAN Amiloride-sensitive sodium channel subunit gamma; 5 0.066 18 SCNNB_HUMAN Amiloride-sensitive sodium channel subunit beta; 5 0.066 18 SCNND_HUMAN Amiloride-sensitive sodium channel subunit delta; 5 0.064 17 ACCN3_HUMAN Amiloride-sensitive cation channel 3; 5 0.064 17 EF1B_HUMAN Elongation factor 1-beta; 5 0.064 17 SCNAA_HUMAN Sodium channel protein type 10 subunit alpha; 5 0.064 17 SCN4A_HUMAN Sodium channel protein type 4 subunit alpha; 5 0.064 17 SCN3A_HUMAN Sodium channel protein type 3 subunit alpha; 5 0.064 17 SCN7A_HUMAN Sodium channel protein type 7 subunit alpha; 5 0.064 17 ACCN4_HUMAN Amiloride-sensitive cation channel 4; 5 0.064 17 SCN4B_HUMAN Sodium channel subunit beta-4; 5 0.064 17 SCN3B_HUMAN Sodium channel subunit beta-3; 5 0.064 17 DB124_HUMAN Beta-defensin 124; 5 0.064 17 SCN1B_HUMAN Sodium channel subunit beta-1; 5 0.04 7 LX15B_HUMAN Arachidonate 15-lipoxygenase B; 5 0.025 8 LOX15_HUMAN Arachidonate 15-lipoxygenase; 5 0.015 13 CAC1A_HUMAN Voltage-dependent P/Q-type calcium channel subunit alpha-1A; 5 0.013 5 ATP4A_HUMAN Potassium-transporting ATPase alpha chain 1; 5 0.003 6 CRP_HUMAN C-reactive protein; 5 0.001 13 CAC1B_HUMAN Voltage-dependent N-type calcium channel subunit alpha-1B; # positive weight on side effects 5 0.416 143 Stevens Johnson syndrome 5 0.404 155 stomatitis 5 0.373 180 agranulocytosis 5 0.315 51 interstitial nephritis 5 0.285 233 tinnitus 5 0.262 209 jaundice 5 0.259 222 flatulence 5 0.207 179 hematuria 5 0.205 128 gastrointestinal hemorrhage 5 0.193 136 renal failure 5 0.191 122 erythema multiforme 5 0.147 108 toxic epidermal necrolysis 5 0.086 317 thrombocytopenia 5 0.083 144 gastritis 5 0.076 118 exfoliative dermatitis 5 0.056 191 hepatitis 5 0.053 162 dysuria 5 0.05 304 Dyspepsia # high scoring drugs for both targets and side effects 5 2.301 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 5 2.276 92 3825 DB01009 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 5 2.199 145 3672 DB01050 Analgesics.Analgesics, Non-Narcotic.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 5 2.162 120 3715 DB00328 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cardiovascular Agents.Cyclooxygenase Inhibitors.Gout Suppressants.Nonsteroidal Antiinflammatory Agents (NSAIDs).Tocolytic Agents 5 2.037 166 3394 DB00712 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Carbonic Anhydrase Inhibitors.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 5 2.037 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 5 2.037 60 3059 DB00861 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 5 1.966 142 3826 DB00465 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 5 1.966 119 3308 DB00749 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 5 1.966 103 5352 DB00605 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents.Cyclooxygenase Inhibitors 5 1.9 94 4409 DB00461 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents 5 1.893 89 4044 DB00784 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 5 1.669 71 3342 DB00573 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Propionic acid derivatives 5 1.655 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 5 1.596 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 5 1.596 104 4614 DB00991 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Nonsteroidal Antiinflammatory Agents (NSAIDs) 5 1.595 46 4036 DB00939 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 5 1.564 119 4052 DB00814 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Antiemetics.Antineoplastic Agents.Cyclooxygenase Inhibitors.Growth Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 5 1.539 108 4856 DB00554 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 5 1.526 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 5 1.504 43 5508 DB00500 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 5 1.45 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 5 1.431 154 5090 DB00533 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase 2 Inhibitors.Cyclooxygenase Inhibitors 5 1.411 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 5 1.411 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 5 1.397 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 5 1.267 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 5 1.245 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 5 1.241 106 4539 DB01059 Anti-Bacterial Agents.Anti-Infectives.Enzyme Inhibitors.Nucleic Acid Synthesis Inhibitors.Quinolones 5 1.239 95 16231 DB00594 Diuretics.Sodium channel blockers 5 1.233 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 5 1.211 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 5 1.211 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 5 1.206 81 5353980 DB00795 Anti-Infective Agents.Anti-Inflammatory Agents, Non-Steroidal.Antirheumatic Agents.Gastrointestinal Agents.Sulfonamides 5 1.183 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 5 1.178 150 1775 DB00252 Anticonvulsants 5 1.146 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 5 1.143 132 3948 DB00978 Anti-Infective Agents.Anti-Infective Agents, Urinary.Antitubercular Agents.Photosensitizing Agents 5 1.121 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 5 1.098 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 5 1.06 144 3702 DB00808 Antihypertensive Agents.Diuretics 5 1.052 102 83786 DB00437 Antimetabolites.Enzyme Inhibitors.Enzyme Inhibitors Antimetabolites.Free Radical Scavengers.Gout Suppressants 5 1.041 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 5 1.038 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 5 1.025 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 5 1.02 91 3355 DB01195 Anti-Arrhythmia Agents.Antiarrhythmic Agents 5 1.015 185 4594 DB00338 Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 5 1.005 97 4200 DB01017 Anti-Bacterial Agents.Tetracyclines 5 0.974 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 5 0.973 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 5 0.961 234 216326 DB00480 Antineoplastic Agents 5 0.938 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 5 0.905 131 3961 DB00678 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents 5 0.902 137 62959 DB00685 Anti-Infective Agents.Anti-Infectives.Fluoroquinolones 5 0.9 264 5372 DB00864 Immunosuppressive Agents 5 0.878 46 5362070 DB01014 Anti-Inflammatory Agents, Non-Steroidal.Anti-Ulcer Agents.Gastrointestinal Agents 5 0.871 144 3899 DB01097 Adjuvants.Anti-inflammatory Agents.Antineoplastic Agents.Antiparasitic Agents.Antirheumatic Agents.Antiviral Agents.Enzyme Inhibitors.Immunosuppressive Agents 5 0.867 128 3793 DB01167 Antifungal Agents.Antifungals.Antiprotozoal Agents.Antiprotozoals 5 0.837 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 5 0.826 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 5 0.82 158 34312 DB00776 Anticonvulsants 5 0.809 453 125889 DB00230 Analgesics.Anticonvulsants 5 0.806 135 5734 DB00909 Anticonvulsants.Antioxidants 5 0.772 72 6398970 DB00535 Anti-Bacterial Agents.Anti-Infectives 5 0.76 128 2250 DB01076 Anticholesteremic Agents.Hydroxymethylglutaryl-CoA Reductase Inhibitors 5 0.757 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 5 0.752 152 60184 DB00790 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 5 0.752 133 4112 DB00563 Abortifacient Agents.Abortifacient Agents, Nonsteroidal.Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Folic Acid Antagonists.Immunosuppressive Agents.Nucleic Acid Synthesis Inhibitors 5 0.747 123 2806 DB00758 Antiplatelet Agents.Fibrinolytic Agents.Platelet Aggregation Inhibitors 5 0.743 97 1065 DB00908 Adrenergic alpha-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antimalarials.Enzyme Inhibitors.Muscarinic Antagonists 5 0.722 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 5 0.701 140 3143 DB01248 Antimalarials.Antineoplastic Agents.Antineoplastic Agents, Phytogenic.Radiation-Sensitizing Agents 5 0.693 161 5291 DB00619 Antineoplastic Agents.Protein Kinase Inhibitors 5 0.685 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 5 0.674 201 5538 DB00755 Antineoplastic Agents.Cell Stimulants and Proliferants.Keratolytic Agents 5 0.671 151 60835 DB00476 Adrenergic Uptake Inhibitors.Antidepressive Agents.Dopamine Uptake Inhibitors.Serotonin Uptake Inhibitors 5 0.668 54 3639 DB00999 Antihypertensive Agents.Diuretics.Sodium Chloride Symporter Inhibitors 5 0.667 74 130881 DB00275 Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 5 0.667 75 4178 DB00379 Anti-Arrhythmia Agents 5 0.666 103 2751 DB01340 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 5 0.652 50 5472 DB00208 Fibrinolytic Agents.Platelet Aggregation Inhibitors 5 0.644 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 5 0.642 183 3648 DB00327 Analgesics, Opioid.Narcotics 5 0.633 114 5379 DB01044 Anti-Infective Agents.Antibiotics 5 0.63 161 5487 DB00697 Adrenergic alpha-Agonists.Analgesics.Anticonvulsants.Muscle Relaxants.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 5 0.618 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 5 0.612 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 5 0.6 43 2720 DB00880 Antihypertensive Agents.Diuretics.Diuretics, Thiazide.Sodium Chloride Symporter Inhibitors 5 0.592 98 3222 DB00584 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 5 0.585 106 216239 DB00398 Anticancer Agents.Antineoplastic Agents.Protein Kinase Inhibitors 5 0.58 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 5 0.58 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 5 0.552 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 5 0.547 135 2585 DB01136 Adrenergic Agents.Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 5 0.539 49 3365 DB00196 Antifungal Agents.Antifungals 5 0.539 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 5 0.538 126 104865 DB00559 Antihypertensive Agents 5 0.537 61 3114 DB00280 Anti-Arrhythmia Agents.Antiarrhythmic Agents 5 0.499 110 4212 DB01204 Analgesics.Antineoplastic Agents 5 0.496 181 4932 DB01182 Anti-Arrhythmia Agents #### component 6: positive weight features and high scoring objects #### # positive weight on target proteins 6 0.287 17 DB124_HUMAN Beta-defensin 124; 6 0.287 17 ACCN4_HUMAN Amiloride-sensitive cation channel 4; 6 0.287 17 SCN4A_HUMAN Sodium channel protein type 4 subunit alpha; 6 0.287 17 SCN4B_HUMAN Sodium channel subunit beta-4; 6 0.287 17 ACCN3_HUMAN Amiloride-sensitive cation channel 3; 6 0.287 17 EF1B_HUMAN Elongation factor 1-beta; 6 0.287 17 SCNAA_HUMAN Sodium channel protein type 10 subunit alpha; 6 0.287 17 SCN7A_HUMAN Sodium channel protein type 7 subunit alpha; 6 0.287 17 SCN3B_HUMAN Sodium channel subunit beta-3; 6 0.287 17 SCN3A_HUMAN Sodium channel protein type 3 subunit alpha; 6 0.287 17 SCN1B_HUMAN Sodium channel subunit beta-1; 6 0.26 18 SCN5A_HUMAN Sodium channel protein type 5 subunit alpha; 6 0.094 18 SCNNG_HUMAN Amiloride-sensitive sodium channel subunit gamma; 6 0.094 18 SCNNB_HUMAN Amiloride-sensitive sodium channel subunit beta; 6 0.094 18 SCNND_HUMAN Amiloride-sensitive sodium channel subunit delta; # positive weight on side effects 6 0.532 131 diplopia 6 0.445 58 nystagmus 6 0.365 68 paralysis 6 0.296 130 cardiac arrest 6 0.255 282 arthralgia 6 0.231 254 nervousness 6 0.218 252 malaise 6 0.168 74 apnea 6 0.143 118 shock 6 0.12 159 increased sweating 6 0.119 304 Dyspepsia 6 0.105 391 edema 6 0.101 123 urinary incontinence 6 0.082 346 dyspnea 6 0.081 99 photophobia 6 0.078 326 paresthesia 6 0.065 162 dysuria 6 0.054 64 dysarthria 6 0.05 317 thrombocytopenia 6 0.047 137 convulsions 6 0.045 280 chest pain 6 0.034 107 amnesia 6 0.028 377 urticaria # high scoring drugs for both targets and side effects 6 3.064 150 1775 DB00252 Anticonvulsants 6 2.891 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 6 2.853 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 6 2.754 91 3355 DB01195 Anti-Arrhythmia Agents.Antiarrhythmic Agents 6 2.709 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 6 2.638 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 6 2.566 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 6 2.538 135 5734 DB00909 Anticonvulsants.Antioxidants 6 2.514 74 3676 DB00281 Anesthetics.Anesthetics, Local.Anti-Arrhythmia Agents.Antiarrhythmic Agents 6 2.484 112 71273 DB00296 Anesthetics.Anesthetics, Local.Local Anesthetics 6 2.426 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 6 2.395 61 3114 DB00280 Anti-Arrhythmia Agents.Antiarrhythmic Agents 6 2.385 51 48041 DB01228 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Sodium channel blockers 6 2.308 75 4178 DB00379 Anti-Arrhythmia Agents 6 2.159 95 16231 DB00594 Diuretics.Sodium channel blockers 6 1.887 43 4913 DB01035 Anti-Arrhythmia Agents.Antiarrhythmic Agents 6 1.83 36 4914 DB00721 Anesthetics.Anesthetics, Local.Local Anesthetics 6 1.32 136 56339 DB01320 Anticonvulsants 6 1.293 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 6 1.259 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 6 1.237 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 6 1.178 453 125889 DB00230 Analgesics.Anticonvulsants 6 1.125 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 6 1.088 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 6 1.072 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 6 1.07 183 3648 DB00327 Analgesics, Opioid.Narcotics 6 1.054 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 6 1.03 158 34312 DB00776 Anticonvulsants 6 1.026 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 6 1.02 128 4253 DB00295 Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 6 1.01 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 6 1.004 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 6 1.001 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 6 0.987 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 6 0.974 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 6 0.965 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists 6 0.913 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 6 0.913 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 6 0.902 196 1935 DB00382 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 6 0.902 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 6 0.879 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 6 0.843 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 6 0.816 264 5372 DB00864 Immunosuppressive Agents 6 0.81 167 5719 DB00962 Anticonvulsants.Anxiolytics sedatives and hypnotics.Hypnotics and Sedatives 6 0.798 133 2802 DB01068 Anticonvulsants.Benzodiazepines.GABA Modulators 6 0.792 73 34633 DB00680 Anti-Arrhythmia Agents 6 0.786 199 5358 DB00669 Selective Serotonin Agonists.Serotonin Agonists.Vasoconstrictor Agents 6 0.784 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 6 0.778 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 6 0.767 137 62959 DB00685 Anti-Infective Agents.Anti-Infectives.Fluoroquinolones 6 0.753 157 4659569 DB00323 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Enzyme Inhibitors 6 0.741 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 6 0.74 132 3948 DB00978 Anti-Infective Agents.Anti-Infective Agents, Urinary.Antitubercular Agents.Photosensitizing Agents 6 0.739 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 6 0.738 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 6 0.714 157 3937 DB00722 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents.Cardiotonic Agents 6 0.703 211 93860 DB00188 Antineoplastic Agents.Protease Inhibitors 6 0.677 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 6 0.667 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 6 0.651 120 2284 DB00181 GABA Agonists.Muscle Relaxants.Muscle Relaxants, Central.Skeletal Muscle Relaxants 6 0.647 161 5212 DB00203 Phosphodiesterase Inhibitors.Vasodilator Agents 6 0.635 234 216326 DB00480 Antineoplastic Agents 6 0.624 65 2474 DB00297 Anesthetics, Local 6 0.62 84 5978 DB00541 Antineoplastic Agents.Antineoplastic Agents, Phytogenic.Tubulin Modulators 6 0.609 146 3075 DB00343 Antihypertensive Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Cardiovascular Agents.Vasodilator Agents 6 0.605 143 4054 DB01043 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agents.Excitatory Amino Acid Antagonists 6 0.595 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 6 0.589 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 6 0.585 154 3157 DB00590 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Anticholesteremic Agents.Antihypertensive Agents.Vasodilator Agents 6 0.584 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 6 0.582 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 6 0.569 154 27661 DB01020 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 6 0.556 181 4932 DB01182 Anti-Arrhythmia Agents 6 0.549 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 6 0.541 147 71158 DB00659 Alcohol Deterrents 6 0.534 102 4943 DB00818 Anesthetics, Intravenous.Anticonvulsants.Antiemetics.Free Radical Scavengers.Hypnotics and Sedatives 6 0.533 146 4158 DB00422 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Uptake Inhibitors.Sympathomimetics 6 0.526 106 4539 DB01059 Anti-Bacterial Agents.Anti-Infectives.Enzyme Inhibitors.Nucleic Acid Synthesis Inhibitors.Quinolones 6 0.523 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 6 0.523 84 3016 DB00829 Adjuvants, Anesthesia.Anesthetics, Intravenous.Anti-anxiety Agents.Anticonvulsants.Antiemetics.GABA Modulators.Hypnotics and Sedatives.Muscle Relaxants, Central 6 0.523 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 6 0.518 87 5533 DB00656 Anti-anxiety Agents.Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 6 0.511 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 6 0.499 201 5538 DB00755 Antineoplastic Agents.Cell Stimulants and Proliferants.Keratolytic Agents 6 0.482 73 3958 DB00186 Anti-anxiety Agents.Anticonvulsants.Antiemetics.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 6 0.475 161 5487 DB00697 Adrenergic alpha-Agonists.Analgesics.Anticonvulsants.Muscle Relaxants.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 6 0.472 161 122316 DB01367 Monoamine Oxidase Inhibitors.Neuroprotective Agents 6 0.471 90 2162 DB00381 Antianginals.Antihypertensive Agents.Calcium Channel Blockers.Vasodilator Agents 6 0.468 151 60835 DB00476 Adrenergic Uptake Inhibitors.Antidepressive Agents.Dopamine Uptake Inhibitors.Serotonin Uptake Inhibitors 6 0.466 185 4594 DB00338 Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 6 0.462 196 3911 DB00007 Anti-Estrogen Agents.Antineoplastic Agents 6 0.461 117 2182 DB00261 Antithrombotic Agents.Fibrinolytic Agents.Platelet Aggregation Inhibitors 6 0.461 147 5645 DB01586 Cholagogues and Choleretics 6 0.46 132 4739 DB00552 Antibiotics.Antineoplastic Agents.Enzyme Inhibitors.Immunosuppressive Agents 6 0.46 105 4659568 DB00494 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Enzyme Inhibitors 6 0.454 99 4889 DB00175 Anticholesteremic Agents.HMG-CoA Reductase Inhibitors.Hydroxymethylglutaryl-CoA Reductase Inhibitors 6 0.447 142 2678 DB00341 Anti-Allergic Agents.Antihistamines.Histamine H1 Antagonists, Non-Sedating 6 0.444 97 1065 DB00908 Adrenergic alpha-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antimalarials.Enzyme Inhibitors.Muscarinic Antagonists 6 0.429 86 2118 DB00404 Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 6 0.428 151 41317 DB00459 Keratolytic Agents #### component 7: positive weight features and high scoring objects #### # positive weight on target proteins 7 0.71 26 SC6A4_HUMAN Sodium-dependent serotonin transporter; 7 0.519 28 SC6A2_HUMAN Sodium-dependent noradrenaline transporter; 7 0.225 29 PGH2_HUMAN Prostaglandin G/H synthase 2; 7 0.149 23 PGH1_HUMAN Prostaglandin G/H synthase 1; 7 0.073 12 ACE_HUMAN Angiotensin-converting enzyme; 7 0.065 35 DRD2_HUMAN D(2) dopamine receptor; 7 0.039 18 ESR1_HUMAN Estrogen receptor; 7 0.021 14 LOX5_HUMAN Arachidonate 5-lipoxygenase; # positive weight on side effects 7 0.419 270 alopecia 7 0.25 179 myocardial infarction 7 0.235 166 purpura 7 0.216 459 diarrhea 7 0.145 274 palpitations 7 0.141 134 cerebrovascular accident 7 0.131 187 photosensitivity 7 0.127 252 malaise 7 0.125 46 breast enlargement 7 0.105 45 SIADH 7 0.099 129 eosinophilia 7 0.099 186 weight gain 7 0.088 330 anorexia 7 0.083 326 paresthesia 7 0.068 317 thrombocytopenia 7 0.068 191 hepatitis 7 0.066 273 leukopenia 7 0.058 391 edema 7 0.048 377 urticaria 7 0.041 373 fever 7 0.027 46 galactorrhea 7 0.02 244 arrhythmia 7 0.005 162 urinary frequency # high scoring drugs for both targets and side effects 7 1.039 65 4543 DB00540 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 7 1.024 67 4976 DB00344 Adrenergic Uptake Inhibitors.Antidepressive Agents.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 7 1.01 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 7 0.995 69 2170 DB00543 Adrenergic Uptake Inhibitors.Antidepressive Agents, Second-Generation.Dopamine Antagonists.Neurotransmitter Uptake Inhibitors.Serotonin Uptake Inhibitors 7 0.958 64 5584 DB00726 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 7 0.949 72 2160 DB00321 Adrenergic Uptake Inhibitors.Analgesics, Non-Narcotic.Antidepressive Agents, Tricyclic 7 0.933 146 4158 DB00422 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Uptake Inhibitors.Sympathomimetics 7 0.917 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 7 0.901 92 3825 DB01009 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 7 0.873 84 2995 DB01151 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Enzyme Inhibitors.Norepinephrine-Reuptake Inhibitors 7 0.871 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 7 0.864 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 7 0.829 69 3696 DB00458 Adrenergic Uptake Inhibitors.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 7 0.808 151 60835 DB00476 Adrenergic Uptake Inhibitors.Antidepressive Agents.Dopamine Uptake Inhibitors.Serotonin Uptake Inhibitors 7 0.801 87 5533 DB00656 Anti-anxiety Agents.Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 7 0.795 103 5352 DB00605 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents.Cyclooxygenase Inhibitors 7 0.779 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 7 0.769 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 7 0.751 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 7 0.738 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 7 0.738 119 3308 DB00749 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 7 0.736 166 3394 DB00712 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Carbonic Anhydrase Inhibitors.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 7 0.729 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 7 0.698 120 3715 DB00328 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cardiovascular Agents.Cyclooxygenase Inhibitors.Gout Suppressants.Nonsteroidal Antiinflammatory Agents (NSAIDs).Tocolytic Agents 7 0.693 87 5005 DB00881 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 7 0.691 134 3339 DB01039 Antilipemic Agents.Fribic Acid Derivatives 7 0.682 145 3672 DB01050 Analgesics.Analgesics, Non-Narcotic.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 7 0.678 147 5645 DB01586 Cholagogues and Choleretics 7 0.678 151 41317 DB00459 Keratolytic Agents 7 0.674 108 3015 DB04839 Androgen Antagonists 7 0.672 98 3222 DB00584 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 7 0.667 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 7 0.665 46 4036 DB00939 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 7 0.66 135 2585 DB01136 Adrenergic Agents.Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 7 0.652 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 7 0.645 117 2182 DB00261 Antithrombotic Agents.Fibrinolytic Agents.Platelet Aggregation Inhibitors 7 0.64 104 4614 DB00991 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Nonsteroidal Antiinflammatory Agents (NSAIDs) 7 0.621 89 4044 DB00784 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 7 0.617 79 2311 DB00542 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 7 0.601 129 5210 DB01105 Anorexigenic Agents.Antidepressants.Antidepressive Agents.Appetite Depressants.Stimulants 7 0.601 116 5376 DB00675 Antineoplastic Agents, Hormonal.Bone Density Conservation Agents.Estrogen Antagonists.Selective Estrogen Receptor Modulators 7 0.597 116 5525 DB00519 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 7 0.589 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 7 0.588 91 3902 DB01006 Antineoplastic Agents.Aromatase Inhibitors 7 0.582 112 3367 DB01073 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Immunosuppressive Agents 7 0.581 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 7 0.576 161 5291 DB00619 Antineoplastic Agents.Protein Kinase Inhibitors 7 0.552 108 4856 DB00554 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 7 0.552 62 3007 DB00182 Adrenergic Agents.Adrenergic Uptake Inhibitors.Amphetamines.Central Nervous System Stimulants.Dopamine Agents.Dopamine Uptake Inhibitors.Sympathomimetics 7 0.551 50 3158 DB01142 Anti-anxiety Agents.Antidepressants.Antidepressive Agents, Tricyclic.Antipruritics.Histamine Antagonists.Norepinephrine-Reuptake Inhibitors 7 0.551 75 2550 DB01197 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 7 0.548 101 3154 DB00869 Antihypertensive Agents.Carbonic Anhydrase Inhibitors 7 0.543 191 450 DB00783 Anti-menopausal Agents.Anticholesteremic Agents.Estrogens 7 0.54 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 7 0.533 102 83786 DB00437 Antimetabolites.Enzyme Inhibitors.Enzyme Inhibitors Antimetabolites.Free Radical Scavengers.Gout Suppressants 7 0.53 110 4666 DB01229 Antineoplastic Agents.Antineoplastic Agents, Phytogenic.Tubulin Modulators 7 0.53 154 5090 DB00533 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase 2 Inhibitors.Cyclooxygenase Inhibitors 7 0.526 65 5253 DB00489 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Sympatholytics 7 0.525 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 7 0.524 94 4171 DB00264 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Sympatholytics 7 0.517 103 2751 DB01340 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 7 0.514 94 4409 DB00461 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents 7 0.512 72 5672 DB00361 Antineoplastic Agents.Antineoplastic Agents, Phytogenic.Radiation-Sensitizing Agents 7 0.509 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 7 0.504 84 57469 DB00724 Adjuvants, Immunologic.Antineoplastic Agents.Antiviral Agents.Interferon Inducers 7 0.501 110 4212 DB01204 Analgesics.Antineoplastic Agents 7 0.497 142 3826 DB00465 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 7 0.487 55 91270 DB00691 Angiotensin-converting Enzyme Inhibitors 7 0.485 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 7 0.475 73 4493 DB00665 Androgen Antagonists.Antineoplastic Agents 7 0.465 81 3461 DB00441 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Antiviral Agents.Enzyme Inhibitors.Immunosuppressive Agents.Radiation-Sensitizing Agents 7 0.461 125 3285 DB00977 Estrogens 7 0.458 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 7 0.457 40 13342 DB00570 Antineoplastic Agents, Phytogenic.Tubulin Modulators 7 0.456 111 5281104 DB00910 Not Available 7 0.455 75 1978 DB01193 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents 7 0.446 83 5487301 DB01079 Gastrointestinal Agents.Serotonin Agonists 7 0.446 146 3475 DB01120 Hypoglycemic Agents.Sulfonylureas 7 0.444 157 3937 DB00722 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents.Cardiotonic Agents 7 0.444 234 216326 DB00480 Antineoplastic Agents 7 0.443 453 125889 DB00230 Analgesics.Anticonvulsants 7 0.438 100 5038 DB00178 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 7 0.438 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 7 0.436 146 3075 DB00343 Antihypertensive Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Cardiovascular Agents.Vasodilator Agents 7 0.431 133 4112 DB00563 Abortifacient Agents.Abortifacient Agents, Nonsteroidal.Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Folic Acid Antagonists.Immunosuppressive Agents.Nucleic Acid Synthesis Inhibitors 7 0.426 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 7 0.423 99 5478 DB00373 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents 7 0.422 54 3639 DB00999 Antihypertensive Agents.Diuretics.Sodium Chloride Symporter Inhibitors 7 0.422 144 3899 DB01097 Adjuvants.Anti-inflammatory Agents.Antineoplastic Agents.Antiparasitic Agents.Antirheumatic Agents.Antiviral Agents.Enzyme Inhibitors.Immunosuppressive Agents 7 0.417 118 65999 DB00966 Angiotensin II Type 1 Receptor Blockers.Angiotensin-converting Enzyme Inhibitors 7 0.416 144 3702 DB00808 Antihypertensive Agents.Diuretics 7 0.414 140 3143 DB01248 Antimalarials.Antineoplastic Agents.Antineoplastic Agents, Phytogenic.Radiation-Sensitizing Agents 7 0.412 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 7 0.407 85 3385 DB00544 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Immunosuppressive Agents 7 0.404 131 3961 DB00678 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents 7 0.401 70 2179 DB00276 Antineoplastic Agents.Intercalating Agents 7 0.401 201 5538 DB00755 Antineoplastic Agents.Cell Stimulants and Proliferants.Keratolytic Agents 7 0.4 72 4183806 DB00929 Abortifacient Agents.Abortifacient Agents, Nonsteroidal.Anti-Ulcer Agents.Oxytocics.Prostaglandins 7 0.395 132 4542 DB00367 Contraceptive Agents, Female.Contraceptives.Contraceptives, Oral, Synthetic 7 0.394 90 2162 DB00381 Antianginals.Antihypertensive Agents.Calcium Channel Blockers.Vasodilator Agents #### component 8: positive weight features and high scoring objects #### # positive weight on target proteins 8 0.476 29 PGH2_HUMAN Prostaglandin G/H synthase 2; 8 0.455 35 DRD2_HUMAN D(2) dopamine receptor; 8 0.433 28 DRD3_HUMAN D(3) dopamine receptor; 8 0.332 28 DRD1_HUMAN D(1A) dopamine receptor; 8 0.307 23 PGH1_HUMAN Prostaglandin G/H synthase 1; 8 0.233 21 DRD5_HUMAN D(1B) dopamine receptor; 8 0.079 17 ACCN3_HUMAN Amiloride-sensitive cation channel 3; 8 0.079 17 SCN4B_HUMAN Sodium channel subunit beta-4; 8 0.079 17 SCN4A_HUMAN Sodium channel protein type 4 subunit alpha; 8 0.079 17 DB124_HUMAN Beta-defensin 124; 8 0.079 17 EF1B_HUMAN Elongation factor 1-beta; 8 0.079 17 SCNAA_HUMAN Sodium channel protein type 10 subunit alpha; 8 0.079 17 SCN7A_HUMAN Sodium channel protein type 7 subunit alpha; 8 0.079 17 ACCN4_HUMAN Amiloride-sensitive cation channel 4; 8 0.079 17 SCN3B_HUMAN Sodium channel subunit beta-3; 8 0.079 17 SCN3A_HUMAN Sodium channel protein type 3 subunit alpha; 8 0.079 17 SCN1B_HUMAN Sodium channel subunit beta-1; 8 0.061 18 SCNNG_HUMAN Amiloride-sensitive sodium channel subunit gamma; 8 0.061 18 SCNNB_HUMAN Amiloride-sensitive sodium channel subunit beta; 8 0.061 18 SCNND_HUMAN Amiloride-sensitive sodium channel subunit delta; 8 0.054 18 SCN5A_HUMAN Sodium channel protein type 5 subunit alpha; 8 0.017 16 CAC1G_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1G; 8 0.017 13 CAC1A_HUMAN Voltage-dependent P/Q-type calcium channel subunit alpha-1A; 8 0.01 26 SC6A4_HUMAN Sodium-dependent serotonin transporter; # positive weight on side effects 8 0.564 273 leukopenia 8 0.407 342 insomnia 8 0.308 377 constipation 8 0.304 205 angioedema 8 0.237 151 asthma 8 0.224 173 hyperglycemia 8 0.214 129 eosinophilia 8 0.203 322 hypotension 8 0.18 368 somnolence 8 0.164 391 edema 8 0.11 187 photosensitivity 8 0.109 346 dyspnea 8 0.101 118 exfoliative dermatitis 8 0.096 101 coma 8 0.089 63 lupus 8 0.086 191 peripheral edema 8 0.084 82 rectal hemorrhage 8 0.072 116 pancytopenia 8 0.069 62 hematemesis 8 0.021 301 confusion 8 0.018 280 hypertension # high scoring drugs for both targets and side effects 8 1.681 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 8 1.668 64 2726 DB00477 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 8 1.668 59 4917 DB00433 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 8 1.615 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 8 1.608 62 5566 DB00831 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 8 1.574 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 8 1.54 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 8 1.516 76 4748 DB00850 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 8 1.477 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 8 1.477 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 8 1.463 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 8 1.441 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 8 1.434 145 3672 DB01050 Analgesics.Analgesics, Non-Narcotic.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 8 1.432 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 8 1.413 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 8 1.409 71 3372 DB00623 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 8 1.401 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 8 1.397 57 5454 DB01623 Antipsychotic Agents.Dopamine Antagonists 8 1.389 89 4044 DB00784 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 8 1.389 166 3394 DB00712 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Carbonic Anhydrase Inhibitors.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 8 1.389 142 3826 DB00465 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 8 1.389 119 3308 DB00749 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 8 1.331 150 1775 DB00252 Anticonvulsants 8 1.33 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 8 1.308 52 5452 DB00679 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 8 1.286 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 8 1.285 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 8 1.28 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 8 1.236 104 4614 DB00991 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Nonsteroidal Antiinflammatory Agents (NSAIDs) 8 1.21 49 4078 DB00933 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 8 1.192 103 5352 DB00605 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents.Cyclooxygenase Inhibitors 8 1.157 120 3715 DB00328 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cardiovascular Agents.Cyclooxygenase Inhibitors.Gout Suppressants.Nonsteroidal Antiinflammatory Agents (NSAIDs).Tocolytic Agents 8 1.151 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 8 1.151 108 4856 DB00554 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 8 1.139 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 8 1.094 453 125889 DB00230 Analgesics.Anticonvulsants 8 1.07 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 8 1.059 91 3355 DB01195 Anti-Arrhythmia Agents.Antiarrhythmic Agents 8 1.012 94 4409 DB00461 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents 8 1.012 90 2477 DB00490 Anti-anxiety Agents.Anxiolytics sedatives and hypnotics.Serotonin Agonists 8 0.993 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 8 0.982 119 4052 DB00814 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Antiemetics.Antineoplastic Agents.Cyclooxygenase Inhibitors.Growth Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 8 0.971 158 34312 DB00776 Anticonvulsants 8 0.945 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 8 0.939 135 5734 DB00909 Anticonvulsants.Antioxidants 8 0.937 51 3559 DB00502 Anti-Dyskinesia Agents.Antidyskinetics.Antiemetics.Antipsychotic Agents.Antipsychotics.Butyrophenones.Dopamine Antagonists 8 0.917 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 8 0.914 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 8 0.907 51 3964 DB00408 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists 8 0.903 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 8 0.871 35 16362 DB01100 Anti-Dyskinesia Agents.Antipsychotic Agents.Dopamine Antagonists 8 0.866 137 62959 DB00685 Anti-Infective Agents.Anti-Infectives.Fluoroquinolones 8 0.857 264 5372 DB00864 Immunosuppressive Agents 8 0.855 154 5090 DB00533 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase 2 Inhibitors.Cyclooxygenase Inhibitors 8 0.849 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 8 0.842 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 8 0.839 112 71273 DB00296 Anesthetics.Anesthetics, Local.Local Anesthetics 8 0.838 51 48041 DB01228 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Sodium channel blockers 8 0.827 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 8 0.82 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 8 0.805 147 71158 DB00659 Alcohol Deterrents 8 0.801 95 16231 DB00594 Diuretics.Sodium channel blockers 8 0.784 49 4168 DB01233 Antiemetics.Dopamine Antagonists.Prokinetic Agents 8 0.78 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 8 0.78 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 8 0.767 132 3948 DB00978 Anti-Infective Agents.Anti-Infective Agents, Urinary.Antitubercular Agents.Photosensitizing Agents 8 0.758 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 8 0.755 188 5040 DB00877 Anti-Bacterial Agents.Antibiotics, Antineoplastic.Antifungal Agents.Antifungals.Immunosuppressive Agents 8 0.736 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 8 0.727 55 2130 DB00915 Analgesics, Non-Narcotic.Antiparkinson Agents.Antiviral Agents.Dopamine Agents 8 0.721 69 2512 DB00248 Antineoplastic Agents.Antiparkinson Agents.Dopamine Agonists 8 0.72 234 216326 DB00480 Antineoplastic Agents 8 0.716 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 8 0.712 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 8 0.71 131 3961 DB00678 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents 8 0.699 61 3114 DB00280 Anti-Arrhythmia Agents.Antiarrhythmic Agents 8 0.697 183 3648 DB00327 Analgesics, Opioid.Narcotics 8 0.693 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 8 0.686 161 5291 DB00619 Antineoplastic Agents.Protein Kinase Inhibitors 8 0.678 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 8 0.654 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 8 0.649 109 60879 DB00876 Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 8 0.646 135 2585 DB01136 Adrenergic Agents.Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 8 0.645 128 3793 DB01167 Antifungal Agents.Antifungals.Antiprotozoal Agents.Antiprotozoals 8 0.644 161 5212 DB00203 Phosphodiesterase Inhibitors.Vasodilator Agents 8 0.641 211 60953 DB01101 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Prodrugs 8 0.64 75 4178 DB00379 Anti-Arrhythmia Agents 8 0.613 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 8 0.61 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 8 0.606 215 60787 DB01232 Anti-HIV Agents.HIV Protease Inhibitors 8 0.606 146 4158 DB00422 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Uptake Inhibitors.Sympathomimetics 8 0.6 111 3419 DB00492 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 8 0.599 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 8 0.598 134 3339 DB01039 Antilipemic Agents.Fribic Acid Derivatives 8 0.592 118 68740 DB00399 Antihypocalcemic Agents.Antiresorptives.Bisphosphonates.Bone Density Conservation Agents 8 0.576 31 2215 DB00714 Antidyskinetics.Antiparkinson Agents.Dopamine Agonists 8 0.574 116 5525 DB00519 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 8 0.57 46 4036 DB00939 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 8 0.566 114 5379 DB01044 Anti-Infective Agents.Antibiotics 8 0.565 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents #### component 9: positive weight features and high scoring objects #### # positive weight on target proteins 9 0.625 26 SC6A4_HUMAN Sodium-dependent serotonin transporter; 9 0.511 28 SC6A2_HUMAN Sodium-dependent noradrenaline transporter; 9 0.209 35 HRH1_HUMAN Histamine H1 receptor; 9 0.189 38 ADA2A_HUMAN Alpha-2A adrenergic receptor; 9 0.162 35 DRD2_HUMAN D(2) dopamine receptor; 9 0.157 33 ADA2B_HUMAN Alpha-2B adrenergic receptor; 9 0.156 19 OPRM_HUMAN Mu-type opioid receptor; 9 0.156 34 ADA1B_HUMAN Alpha-1B adrenergic receptor; 9 0.155 28 DRD1_HUMAN D(1A) dopamine receptor; 9 0.15 36 ACM1_HUMAN Muscarinic acetylcholine receptor M1; 9 0.147 42 ADA1A_HUMAN Alpha-1A adrenergic receptor; 9 0.134 28 DRD3_HUMAN D(3) dopamine receptor; 9 0.12 16 OPRK_HUMAN Kappa-type opioid receptor; 9 0.099 17 OPRD_HUMAN Delta-type opioid receptor; 9 0.081 34 ACM2_HUMAN Muscarinic acetylcholine receptor M2; 9 0.076 12 AOFB_HUMAN Amine oxidase [flavin-containing] B; 9 0.069 30 ADA1D_HUMAN Alpha-1D adrenergic receptor; 9 0.059 9 GABR2_HUMAN Gamma-aminobutyric acid type B receptor subunit 2; 9 0.047 21 DRD5_HUMAN D(1B) dopamine receptor; 9 0.022 8 TSPOA_HUMAN Translocator protein; 9 0.022 8 GBRR2_HUMAN Gamma-aminobutyric acid receptor subunit rho-2; 9 0.02 12 SC6A3_HUMAN Sodium-dependent dopamine transporter; 9 0.003 6 DRD4_HUMAN D(4) dopamine receptor; # positive weight on side effects 9 0.412 162 urinary frequency 9 0.391 152 urinary retention 9 0.384 189 hallucinations 9 0.381 322 tachycardia 9 0.36 180 seizures 9 0.323 76 nightmares 9 0.181 210 agitation 9 0.181 204 sweating 9 0.115 46 galactorrhea 9 0.112 35 paralytic ileus 9 0.103 147 decreased libido 9 0.103 70 delirium 9 0.088 244 arrhythmia 9 0.085 85 dysmenorrhea 9 0.061 152 weight loss 9 0.06 46 breast enlargement 9 0.059 247 tremor 9 0.052 73 ventricular tachycardia 9 0.051 322 hypotension 9 0.048 123 urinary incontinence 9 0.043 45 SIADH 9 0.018 280 hypertension # high scoring drugs for both targets and side effects 9 2.094 84 2995 DB01151 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Enzyme Inhibitors.Norepinephrine-Reuptake Inhibitors 9 2.015 87 5533 DB00656 Anti-anxiety Agents.Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 9 1.908 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 9 1.885 72 2160 DB00321 Adrenergic Uptake Inhibitors.Analgesics, Non-Narcotic.Antidepressive Agents, Tricyclic 9 1.744 69 3696 DB00458 Adrenergic Uptake Inhibitors.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 9 1.679 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 9 1.675 64 5584 DB00726 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 9 1.675 67 4976 DB00344 Adrenergic Uptake Inhibitors.Antidepressive Agents.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 9 1.655 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 9 1.588 66 4011 DB00934 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Second-Generation 9 1.588 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 9 1.585 69 2170 DB00543 Adrenergic Uptake Inhibitors.Antidepressive Agents, Second-Generation.Dopamine Antagonists.Neurotransmitter Uptake Inhibitors.Serotonin Uptake Inhibitors 9 1.583 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 9 1.55 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 9 1.523 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 9 1.477 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 9 1.448 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 9 1.366 62 3007 DB00182 Adrenergic Agents.Adrenergic Uptake Inhibitors.Amphetamines.Central Nervous System Stimulants.Dopamine Agents.Dopamine Uptake Inhibitors.Sympathomimetics 9 1.347 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 9 1.308 129 5210 DB01105 Anorexigenic Agents.Antidepressants.Antidepressive Agents.Appetite Depressants.Stimulants 9 1.271 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 9 1.256 65 4543 DB00540 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 9 1.239 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 9 1.209 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 9 1.206 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists 9 1.202 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 9 1.188 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 9 1.14 50 3158 DB01142 Anti-anxiety Agents.Antidepressants.Antidepressive Agents, Tricyclic.Antipruritics.Histamine Antagonists.Norepinephrine-Reuptake Inhibitors 9 1.138 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 9 1.122 183 3648 DB00327 Analgesics, Opioid.Narcotics 9 1.107 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 9 1.023 142 2678 DB00341 Anti-Allergic Agents.Antihistamines.Histamine H1 Antagonists, Non-Sedating 9 1.016 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 9 1.011 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 9 1.009 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 9 1.005 146 4158 DB00422 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Uptake Inhibitors.Sympathomimetics 9 1.004 90 2477 DB00490 Anti-anxiety Agents.Anxiolytics sedatives and hypnotics.Serotonin Agonists 9 0.995 151 60835 DB00476 Adrenergic Uptake Inhibitors.Antidepressive Agents.Dopamine Uptake Inhibitors.Serotonin Uptake Inhibitors 9 0.994 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 9 0.99 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 9 0.989 51 3559 DB00502 Anti-Dyskinesia Agents.Antidyskinetics.Antiemetics.Antipsychotic Agents.Antipsychotics.Butyrophenones.Dopamine Antagonists 9 0.973 120 2284 DB00181 GABA Agonists.Muscle Relaxants.Muscle Relaxants, Central.Skeletal Muscle Relaxants 9 0.959 76 2803 DB00575 Adrenergic alpha-Agonists.Analgesics.Antihypertensive Agents.Central Alpha-Agonists.Sympatholytics 9 0.872 91 60815 DB00899 Analgesics, Opioid.Anesthetics, Intravenous.Hypnotics and Sedatives 9 0.87 118 4236 DB00745 Anorexigenic Agents.Central Nervous System Agents.Central Nervous System Stimulants.Neuroprotective Agents.Stimulants 9 0.854 264 5372 DB00864 Immunosuppressive Agents 9 0.854 128 4253 DB00295 Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 9 0.853 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 9 0.837 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 9 0.813 131 4635 DB00497 Analgesics, Opioid.Antitussives.Narcotics.Opiate Agonists 9 0.781 453 125889 DB00230 Analgesics.Anticonvulsants 9 0.779 76 3661 DB00572 Adjuvants, Anesthesia.Anti-Arrhythmia Agents.Bronchodilator Agents.Muscarinic Antagonists.Mydriatics.Parasympatholytics 9 0.773 47 4927 DB01069 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists.Phenothiazine Derivatives 9 0.756 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 9 0.754 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 9 0.75 59 4095 DB00333 Analgesics.Analgesics, Opioid.Antitussive Agents.Antitussives.Narcotics.Opiate Agonists 9 0.75 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 9 0.746 76 4748 DB00850 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 9 0.746 61 4828 DB00960 Adrenergic beta-Antagonists.Antihypertensive Agents.Serotonin Antagonists.Vasodilator Agents 9 0.734 161 5487 DB00697 Adrenergic alpha-Agonists.Analgesics.Anticonvulsants.Muscle Relaxants.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 9 0.732 167 5719 DB00962 Anticonvulsants.Anxiolytics sedatives and hypnotics.Hypnotics and Sedatives 9 0.716 196 3911 DB00007 Anti-Estrogen Agents.Antineoplastic Agents 9 0.713 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 9 0.695 55 2130 DB00915 Analgesics, Non-Narcotic.Antiparkinson Agents.Antiviral Agents.Dopamine Agents 9 0.681 154 3157 DB00590 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Anticholesteremic Agents.Antihypertensive Agents.Vasodilator Agents 9 0.672 86 2118 DB00404 Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 9 0.666 199 5358 DB00669 Selective Serotonin Agonists.Serotonin Agonists.Vasoconstrictor Agents 9 0.664 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 9 0.659 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 9 0.656 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 9 0.655 17 1206 DB01577 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Agents.Dopamine Uptake Inhibitors.Sympathomimetics 9 0.648 147 71158 DB00659 Alcohol Deterrents 9 0.646 167 170361 DB01273 Nicotinic Agonists 9 0.645 112 71273 DB00296 Anesthetics.Anesthetics, Local.Local Anesthetics 9 0.643 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 9 0.628 52 5452 DB00679 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 9 0.626 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 9 0.618 135 2585 DB01136 Adrenergic Agents.Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 9 0.617 157 4659569 DB00323 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Enzyme Inhibitors 9 0.614 64 2726 DB00477 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 9 0.613 196 1935 DB00382 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 9 0.601 44 2913 DB00434 Anti-Allergic Agents.Antihistamine derivatives.Antipruritics.Gastrointestinal Agents.Histamine H1 Antagonists.Serotonin Antagonists 9 0.598 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 9 0.571 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 9 0.568 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 9 0.567 51 3964 DB00408 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists 9 0.562 161 122316 DB01367 Monoamine Oxidase Inhibitors.Neuroprotective Agents 9 0.56 188 5040 DB00877 Anti-Bacterial Agents.Antibiotics, Antineoplastic.Antifungal Agents.Antifungals.Immunosuppressive Agents 9 0.552 38 125017 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 9 0.552 133 2802 DB01068 Anticonvulsants.Benzodiazepines.GABA Modulators 9 0.549 77 39860 DB00486 Anti-anxiety Agents.Antiemetics 9 0.548 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 9 0.547 181 4932 DB01182 Anti-Arrhythmia Agents 9 0.545 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 9 0.541 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 9 0.54 201 5538 DB00755 Antineoplastic Agents.Cell Stimulants and Proliferants.Keratolytic Agents 9 0.538 104 3449 DB00674 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 9 0.538 102 4943 DB00818 Anesthetics, Intravenous.Anticonvulsants.Antiemetics.Free Radical Scavengers.Hypnotics and Sedatives 9 0.535 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 9 0.531 11 3251 DB00696 Adrenergic alpha-Agonists.Analgesics, Non-Narcotic.Sympatholytics.Vasoconstrictor Agents #### component 10: positive weight features and high scoring objects #### # positive weight on target proteins 10 0.639 29 PGH2_HUMAN Prostaglandin G/H synthase 2; 10 0.439 23 PGH1_HUMAN Prostaglandin G/H synthase 1; 10 0.158 12 ACE_HUMAN Angiotensin-converting enzyme; 10 0.089 16 TOP2A_HUMAN DNA topoisomerase 2-alpha; 10 0.068 14 LOX5_HUMAN Arachidonate 5-lipoxygenase; 10 0.033 8 HMDH_HUMAN 3-hydroxy-3-methylglutaryl-coenzyme A reductase; 10 0.024 14 TTHY_HUMAN Transthyretin; 10 0.022 17 SCN1B_HUMAN Sodium channel subunit beta-1; 10 0.022 17 EF1B_HUMAN Elongation factor 1-beta; 10 0.022 17 SCNAA_HUMAN Sodium channel protein type 10 subunit alpha; 10 0.022 17 ACCN3_HUMAN Amiloride-sensitive cation channel 3; 10 0.022 17 DB124_HUMAN Beta-defensin 124; 10 0.022 17 SCN4B_HUMAN Sodium channel subunit beta-4; 10 0.022 17 SCN3A_HUMAN Sodium channel protein type 3 subunit alpha; 10 0.022 17 SCN4A_HUMAN Sodium channel protein type 4 subunit alpha; 10 0.022 17 ACCN4_HUMAN Amiloride-sensitive cation channel 4; 10 0.022 17 SCN3B_HUMAN Sodium channel subunit beta-3; 10 0.022 17 SCN7A_HUMAN Sodium channel protein type 7 subunit alpha; 10 0.018 26 SC6A4_HUMAN Sodium-dependent serotonin transporter; 10 0.012 18 SCNND_HUMAN Amiloride-sensitive sodium channel subunit delta; 10 0.012 18 SCNNG_HUMAN Amiloride-sensitive sodium channel subunit gamma; 10 0.012 18 SCNNB_HUMAN Amiloride-sensitive sodium channel subunit beta; 10 0.01 13 CAC1A_HUMAN Voltage-dependent P/Q-type calcium channel subunit alpha-1A; 10 0.002 6 ANGT_HUMAN Angiotensinogen; # positive weight on side effects 10 0.528 262 anemia 10 0.414 163 pancreatitis 10 0.339 100 hepatic failure 10 0.255 97 aplastic anemia 10 0.249 298 asthenia 10 0.228 60 peptic ulcer 10 0.221 439 pruritus 10 0.207 112 hemolytic anemia 10 0.206 355 abdominal pain 10 0.187 247 tremor 10 0.179 53 proteinuria 10 0.133 104 vasculitis 10 0.105 184 pneumonia 10 0.092 68 hearing loss 10 0.088 282 vertigo 10 0.083 304 Dyspepsia 10 0.04 107 melena 10 0.03 317 thrombocytopenia 10 0.022 116 pancytopenia 10 0.02 346 dyspnea 10 0.017 377 urticaria 10 0.017 108 ecchymosis # high scoring drugs for both targets and side effects 10 1.874 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 10 1.84 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 10 1.84 166 3394 DB00712 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Carbonic Anhydrase Inhibitors.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 10 1.828 119 3308 DB00749 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 10 1.828 89 4044 DB00784 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 10 1.748 145 3672 DB01050 Analgesics.Analgesics, Non-Narcotic.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 10 1.718 142 3826 DB00465 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 10 1.609 104 4614 DB00991 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Nonsteroidal Antiinflammatory Agents (NSAIDs) 10 1.533 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 10 1.517 94 4409 DB00461 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents 10 1.401 103 5352 DB00605 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents.Cyclooxygenase Inhibitors 10 1.395 108 4856 DB00554 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 10 1.378 71 3342 DB00573 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Propionic acid derivatives 10 1.298 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 10 1.195 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 10 1.167 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 10 1.097 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 10 1.097 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 10 1.09 154 5090 DB00533 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase 2 Inhibitors.Cyclooxygenase Inhibitors 10 1.082 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 10 1.08 157 3937 DB00722 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents.Cardiotonic Agents 10 1.074 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 10 1.061 152 60184 DB00790 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 10 1.046 119 4052 DB00814 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Antiemetics.Antineoplastic Agents.Cyclooxygenase Inhibitors.Growth Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 10 1.034 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 10 1.033 120 3715 DB00328 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cardiovascular Agents.Cyclooxygenase Inhibitors.Gout Suppressants.Nonsteroidal Antiinflammatory Agents (NSAIDs).Tocolytic Agents 10 1.028 92 3825 DB01009 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 10 1.012 46 5362070 DB01014 Anti-Inflammatory Agents, Non-Steroidal.Anti-Ulcer Agents.Gastrointestinal Agents 10 0.999 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 10 0.992 119 5064 DB00811 Antimetabolites.Antiviral Agents 10 0.968 98 3222 DB00584 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 10 0.963 81 5353980 DB00795 Anti-Infective Agents.Anti-Inflammatory Agents, Non-Steroidal.Antirheumatic Agents.Gastrointestinal Agents.Sulfonamides 10 0.954 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 10 0.942 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 10 0.937 123 2806 DB00758 Antiplatelet Agents.Fibrinolytic Agents.Platelet Aggregation Inhibitors 10 0.925 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 10 0.918 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 10 0.902 234 216326 DB00480 Antineoplastic Agents 10 0.893 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 10 0.854 137 62959 DB00685 Anti-Infective Agents.Anti-Infectives.Fluoroquinolones 10 0.839 131 3961 DB00678 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents 10 0.838 80 54454 DB00641 Anticholesteremic Agents.Antilipemic Agents.Hydroxymethylglutaryl-CoA Reductase Inhibitors 10 0.838 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 10 0.835 100 5038 DB00178 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 10 0.835 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 10 0.833 185 4594 DB00338 Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 10 0.822 127 2156 DB01118 Anti-Arrhythmia Agents.Enzyme Inhibitors.Vasodilator Agents 10 0.803 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 10 0.802 236 10631 DB00603 Contraceptives.Contraceptives, Oral, Synthetic.Progestins 10 0.797 171 2909 DB00091 Antifungal Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Immunomodulatory Agents.Immunosuppressive Agents 10 0.797 111 3419 DB00492 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 10 0.796 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 10 0.792 87 5005 DB00881 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 10 0.783 97 159 DB01240 Antihypertensive Agents.Platelet Aggregation Inhibitors 10 0.768 161 5291 DB00619 Antineoplastic Agents.Protein Kinase Inhibitors 10 0.756 146 4158 DB00422 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Uptake Inhibitors.Sympathomimetics 10 0.756 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 10 0.755 103 2751 DB01340 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 10 0.749 144 3899 DB01097 Adjuvants.Anti-inflammatory Agents.Antineoplastic Agents.Antiparasitic Agents.Antirheumatic Agents.Antiviral Agents.Enzyme Inhibitors.Immunosuppressive Agents 10 0.742 211 93860 DB00188 Antineoplastic Agents.Protease Inhibitors 10 0.737 106 4539 DB01059 Anti-Bacterial Agents.Anti-Infectives.Enzyme Inhibitors.Nucleic Acid Synthesis Inhibitors.Quinolones 10 0.734 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 10 0.728 74 130881 DB00275 Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 10 0.726 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 10 0.725 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 10 0.718 60 3059 DB00861 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 10 0.717 453 125889 DB00230 Analgesics.Anticonvulsants 10 0.714 215 60787 DB01232 Anti-HIV Agents.HIV Protease Inhibitors 10 0.713 99 4889 DB00175 Anticholesteremic Agents.HMG-CoA Reductase Inhibitors.Hydroxymethylglutaryl-CoA Reductase Inhibitors 10 0.71 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 10 0.708 47 3476 DB00222 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Hypoglycemic Agents.Immunosuppressive Agents.Sulfonylureas 10 0.701 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 10 0.699 95 16231 DB00594 Diuretics.Sodium channel blockers 10 0.692 201 5538 DB00755 Antineoplastic Agents.Cell Stimulants and Proliferants.Keratolytic Agents 10 0.686 147 5645 DB01586 Cholagogues and Choleretics 10 0.679 166 54374 DB00104 Anabolic Agents.Antineoplastic Agents, Hormonal.Gastrointestinal Agents.Hormone Replacement Agents 10 0.678 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 10 0.677 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 10 0.676 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 10 0.674 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 10 0.667 75 2550 DB01197 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 10 0.667 87 2676 DB00439 Anticholesteremic Agents.Antilipemic Agents.Hydroxymethylglutaryl-CoA Reductase Inhibitors 10 0.664 72 6398970 DB00535 Anti-Bacterial Agents.Anti-Infectives 10 0.642 144 3702 DB00808 Antihypertensive Agents.Diuretics 10 0.639 63 5039 DB00863 Anti-Ulcer Agents.Histamine H2 Antagonists 10 0.635 181 4932 DB01182 Anti-Arrhythmia Agents 10 0.635 137 3062316 DB01254 Protein Kinase Inhibitors 10 0.619 133 4112 DB00563 Abortifacient Agents.Abortifacient Agents, Nonsteroidal.Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Folic Acid Antagonists.Immunosuppressive Agents.Nucleic Acid Synthesis Inhibitors 10 0.617 108 3015 DB04839 Androgen Antagonists 10 0.612 102 83786 DB00437 Antimetabolites.Enzyme Inhibitors.Enzyme Inhibitors Antimetabolites.Free Radical Scavengers.Gout Suppressants 10 0.611 43 5508 DB00500 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 10 0.599 264 5372 DB00864 Immunosuppressive Agents 10 0.597 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists 10 0.59 188 5040 DB00877 Anti-Bacterial Agents.Antibiotics, Antineoplastic.Antifungal Agents.Antifungals.Immunosuppressive Agents 10 0.577 120 82146 DB00307 Anticarcinogenic Agents 10 0.577 116 5525 DB00519 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 10 0.573 38 3488 DB01016 Antiarrhythmic Agents.Hypoglycemic Agents.Sulfonylureas 10 0.573 199 5358 DB00669 Selective Serotonin Agonists.Serotonin Agonists.Vasoconstrictor Agents 10 0.567 72 3440 DB00695 Diuretics.Sodium Potassium Chloride Symporter Inhibitors 10 0.565 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors #### component 11: positive weight features and high scoring objects #### # positive weight on target proteins 11 0.625 29 PGH2_HUMAN Prostaglandin G/H synthase 2; 11 0.416 23 PGH1_HUMAN Prostaglandin G/H synthase 1; 11 0.174 18 SCN5A_HUMAN Sodium channel protein type 5 subunit alpha; 11 0.168 18 SCNNB_HUMAN Amiloride-sensitive sodium channel subunit beta; 11 0.168 18 SCNNG_HUMAN Amiloride-sensitive sodium channel subunit gamma; 11 0.168 18 SCNND_HUMAN Amiloride-sensitive sodium channel subunit delta; 11 0.166 17 SCN1B_HUMAN Sodium channel subunit beta-1; 11 0.166 17 ACCN3_HUMAN Amiloride-sensitive cation channel 3; 11 0.166 17 EF1B_HUMAN Elongation factor 1-beta; 11 0.166 17 SCNAA_HUMAN Sodium channel protein type 10 subunit alpha; 11 0.166 17 DB124_HUMAN Beta-defensin 124; 11 0.166 17 SCN4B_HUMAN Sodium channel subunit beta-4; 11 0.166 17 SCN4A_HUMAN Sodium channel protein type 4 subunit alpha; 11 0.166 17 SCN3B_HUMAN Sodium channel subunit beta-3; 11 0.166 17 SCN7A_HUMAN Sodium channel protein type 7 subunit alpha; 11 0.166 17 ACCN4_HUMAN Amiloride-sensitive cation channel 4; 11 0.166 17 SCN3A_HUMAN Sodium channel protein type 3 subunit alpha; 11 0.139 26 SC6A4_HUMAN Sodium-dependent serotonin transporter; 11 0.012 14 TTHY_HUMAN Transthyretin; 11 0.006 16 TOP2A_HUMAN DNA topoisomerase 2-alpha; # positive weight on side effects 11 0.533 122 congestive heart failure 11 0.337 162 dysuria 11 0.308 87 glossitis 11 0.295 301 confusion 11 0.275 114 lymphadenopathy 11 0.272 377 urticaria 11 0.27 280 hypertension 11 0.24 137 convulsions 11 0.2 108 ecchymosis 11 0.15 249 blurred vision 11 0.125 282 vertigo 11 0.112 99 polyuria 11 0.112 75 amblyopia 11 0.103 284 syncope 11 0.098 101 coma 11 0.097 191 hepatitis 11 0.078 172 chills 11 0.028 28 meningitis 11 0.026 326 paresthesia # high scoring drugs for both targets and side effects 11 2.363 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 11 2.248 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 11 2.188 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 11 2.046 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 11 2.007 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 11 1.964 91 3355 DB01195 Anti-Arrhythmia Agents.Antiarrhythmic Agents 11 1.903 150 1775 DB00252 Anticonvulsants 11 1.814 135 5734 DB00909 Anticonvulsants.Antioxidants 11 1.788 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 11 1.788 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 11 1.769 145 3672 DB01050 Analgesics.Analgesics, Non-Narcotic.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 11 1.727 142 3826 DB00465 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 11 1.727 119 3308 DB00749 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 11 1.713 166 3394 DB00712 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Carbonic Anhydrase Inhibitors.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 11 1.688 89 4044 DB00784 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 11 1.607 112 71273 DB00296 Anesthetics.Anesthetics, Local.Local Anesthetics 11 1.604 61 3114 DB00280 Anti-Arrhythmia Agents.Antiarrhythmic Agents 11 1.54 75 4178 DB00379 Anti-Arrhythmia Agents 11 1.48 104 4614 DB00991 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Nonsteroidal Antiinflammatory Agents (NSAIDs) 11 1.414 74 3676 DB00281 Anesthetics.Anesthetics, Local.Anti-Arrhythmia Agents.Antiarrhythmic Agents 11 1.375 108 4856 DB00554 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 11 1.355 95 16231 DB00594 Diuretics.Sodium channel blockers 11 1.317 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 11 1.286 51 48041 DB01228 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Sodium channel blockers 11 1.248 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 11 1.246 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 11 1.236 103 5352 DB00605 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents.Cyclooxygenase Inhibitors 11 1.213 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 11 1.2 183 3648 DB00327 Analgesics, Opioid.Narcotics 11 1.191 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 11 1.175 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 11 1.161 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 11 1.16 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 11 1.142 453 125889 DB00230 Analgesics.Anticonvulsants 11 1.121 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 11 1.115 120 3715 DB00328 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cardiovascular Agents.Cyclooxygenase Inhibitors.Gout Suppressants.Nonsteroidal Antiinflammatory Agents (NSAIDs).Tocolytic Agents 11 1.114 36 4914 DB00721 Anesthetics.Anesthetics, Local.Local Anesthetics 11 1.097 154 5090 DB00533 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase 2 Inhibitors.Cyclooxygenase Inhibitors 11 1.064 181 4932 DB01182 Anti-Arrhythmia Agents 11 1.053 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 11 1.038 234 216326 DB00480 Antineoplastic Agents 11 0.996 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 11 0.975 196 3911 DB00007 Anti-Estrogen Agents.Antineoplastic Agents 11 0.951 136 56339 DB01320 Anticonvulsants 11 0.95 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 11 0.944 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 11 0.939 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 11 0.933 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 11 0.929 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 11 0.886 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 11 0.881 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 11 0.87 43 5508 DB00500 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 11 0.862 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 11 0.862 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 11 0.86 94 4409 DB00461 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents 11 0.858 43 4913 DB01035 Anti-Arrhythmia Agents.Antiarrhythmic Agents 11 0.843 264 5372 DB00864 Immunosuppressive Agents 11 0.814 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 11 0.807 92 3825 DB01009 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 11 0.804 151 60835 DB00476 Adrenergic Uptake Inhibitors.Antidepressive Agents.Dopamine Uptake Inhibitors.Serotonin Uptake Inhibitors 11 0.798 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 11 0.796 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 11 0.796 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 11 0.787 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 11 0.781 201 5538 DB00755 Antineoplastic Agents.Cell Stimulants and Proliferants.Keratolytic Agents 11 0.78 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 11 0.769 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 11 0.763 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 11 0.758 196 1935 DB00382 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 11 0.758 117 2182 DB00261 Antithrombotic Agents.Fibrinolytic Agents.Platelet Aggregation Inhibitors 11 0.753 114 5379 DB01044 Anti-Infective Agents.Antibiotics 11 0.746 147 5645 DB01586 Cholagogues and Choleretics 11 0.74 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 11 0.738 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 11 0.738 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 11 0.719 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 11 0.704 106 2958 DB00694 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 11 0.686 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 11 0.673 73 34633 DB00680 Anti-Arrhythmia Agents 11 0.667 71 3342 DB00573 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Propionic acid derivatives 11 0.665 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 11 0.662 60 3059 DB00861 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 11 0.654 146 3075 DB00343 Antihypertensive Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Cardiovascular Agents.Vasodilator Agents 11 0.618 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 11 0.614 90 2477 DB00490 Anti-anxiety Agents.Anxiolytics sedatives and hypnotics.Serotonin Agonists 11 0.613 137 2462 DB01222 Anti-inflammatory Agents.Bronchodilator Agents.Corticosteroids.Glucocorticoids 11 0.612 171 2909 DB00091 Antifungal Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Immunomodulatory Agents.Immunosuppressive Agents 11 0.61 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 11 0.608 133 4112 DB00563 Abortifacient Agents.Abortifacient Agents, Nonsteroidal.Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Folic Acid Antagonists.Immunosuppressive Agents.Nucleic Acid Synthesis Inhibitors 11 0.6 132 3948 DB00978 Anti-Infective Agents.Anti-Infective Agents, Urinary.Antitubercular Agents.Photosensitizing Agents 11 0.584 119 4052 DB00814 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Antiemetics.Antineoplastic Agents.Cyclooxygenase Inhibitors.Growth Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 11 0.577 111 5281104 DB00910 Not Available 11 0.577 167 5719 DB00962 Anticonvulsants.Anxiolytics sedatives and hypnotics.Hypnotics and Sedatives 11 0.569 146 4158 DB00422 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Uptake Inhibitors.Sympathomimetics 11 0.558 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 11 0.547 188 5040 DB00877 Anti-Bacterial Agents.Antibiotics, Antineoplastic.Antifungal Agents.Antifungals.Immunosuppressive Agents 11 0.534 158 34312 DB00776 Anticonvulsants 11 0.491 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists 11 0.49 136 2375 DB01128 Androgen Antagonists.Antineoplastic Agents 11 0.487 97 1065 DB00908 Adrenergic alpha-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antimalarials.Enzyme Inhibitors.Muscarinic Antagonists #### component 12: positive weight features and high scoring objects #### # positive weight on target proteins 12 0.587 17 ANXA1_HUMAN Annexin A1; 12 0.374 17 CBG_HUMAN Corticosteroid-binding globulin; 12 0.372 20 ACHA2_HUMAN Neuronal acetylcholine receptor subunit alpha-2; 12 0.356 34 ACM2_HUMAN Muscarinic acetylcholine receptor M2; 12 0.302 36 ACM1_HUMAN Muscarinic acetylcholine receptor M1; 12 0.052 14 CALM_HUMAN Calmodulin; 12 0.049 17 ACH10_HUMAN Neuronal acetylcholine receptor subunit alpha-10; 12 0.011 14 ACHA9_HUMAN Neuronal acetylcholine receptor subunit alpha-9; 12 0.011 14 ACHB2_HUMAN Neuronal acetylcholine receptor subunit beta-2; 12 0.011 14 ACHE_HUMAN Acetylcholine receptor subunit epsilon; 12 0.011 14 ACHA3_HUMAN Neuronal acetylcholine receptor subunit alpha-3; 12 0.011 14 ACHA6_HUMAN Neuronal acetylcholine receptor subunit alpha-6; 12 0.009 16 G109B_HUMAN G-protein coupled receptor 109B; # positive weight on side effects # high scoring drugs for both targets and side effects 12 1.602 7 2551 DB00411 Analgesics, Non-Narcotic.Cardiotonic Agents.Cholinergic Agonists.Miotics 12 1.546 8 2381 DB00810 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists.Parasympatholytics 12 1.512 10 4630253 DB00240 Anti-inflammatory Agents.Antipruritic Agents.Corticosteroids.Glucocorticoids 12 1.512 31 4900 DB00635 Adrenergic Agents.Anti-inflammatory Agents.Antineoplastic Agents.Antineoplastic Agents, Hormonal.Glucocorticoids 12 1.512 15 39507 DB00896 Anti-inflammatory Agents.Corticosteroids 12 1.491 16 5314 DB00202 Neuromuscular Depolarizing Agents.Skeletal Muscle Relaxants 12 1.479 17 48175 DB00596 Anti-inflammatory Agents.Vasoconstrictor Agents 12 1.386 4 4768 DB00925 Adrenergic alpha-Antagonists.Antihypertensive Agents.Vasodilator Agents 12 1.325 11 3375 DB00223 Anti-inflammatory Agents.Glucocorticoids 12 1.325 17 3000 DB00547 Anti-inflammatory Agents.Glucocorticoids 12 1.325 14 2133 DB00288 Corticosteroids, topical 12 1.308 29 2308 DB00394 Anti-Asthmatic Agents.Anti-inflammatory Agents.Antiarrhythmic Agents.Corticosteroids.Glucocorticoids 12 1.302 11 4919 DB00387 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists 12 1.292 86 3003 DB01234 Adrenergic Agents.Anti-inflammatory Agents.Antiemetics.Antineoplastic Agents, Hormonal.Glucocorticoids 12 1.273 5 10548 DB01057 Cholinesterase Inhibitors.Miotics.Parasympathomimetics 12 1.25 26 12536 DB01260 Anti-inflammatory Agents 12 1.246 12 60169 DB01334 Neuromuscular Nondepolarizing Agents 12 1.243 41 32797 DB01013 Anti-inflammatory Agents.Corticosteroids, topical.Glucocorticoids 12 1.239 14 104803 DB01226 Neuromuscular Nondepolarizing Agents 12 1.227 17 52421 DB01130 Anti Inflammatory.Anti-inflammatory Agents.Corticosteroid.Glucocorticoids.Steroidal 12 1.218 11 4043 DB00253 Topical anti-inflammatory Agent 12 1.218 12 3384 DB00324 Anti-Allergic Agents.Anti-inflammatory Agents.Glucocorticoids 12 1.218 16 3382 DB01047 Anti-Allergic Agents.Anti-inflammatory Agents.Glucocorticoids 12 1.218 10 3392 DB00846 Anti-inflammatory Agents.Glucocorticoids 12 1.217 10 4675 DB01337 Neuromuscular Nondepolarizing Agents.Nicotinic Antagonists 12 1.217 10 47320 DB00565 Neuromuscular Blocking Agents 12 1.182 16 2905 DB00979 Antimuscarinic eye preparations.Muscarinic Antagonists.Mydriatics.Parasympatholytics 12 1.126 14 47319 DB00732 Neuromuscular Nondepolarizing Agents.Nicotinic Antagonists 12 1.099 83 3640 DB00741 Anti-inflammatory Agents 12 1.096 21 60696 DB00728 Neuromuscular Nondepolarizing Agents.Skeletal Muscle Relaxants 12 1.06 9 5593 DB00809 Diagnostic aid, cycloplegic.Diagnostic aid, mydriatic.Muscarinic Antagonists.Mydriatics 12 1.06 14 3354 DB01148 Parasympatholytics 12 1.057 74 4894 DB00860 Adrenergic Agents.Anti-inflammatory Agents.Antineoplastic Agents.Antineoplastic Agents, Hormonal.Glucocorticoids 12 1.031 4 6503 DB03754 Buffers.Excipients 12 1.031 3 4034 DB00737 Anti-Allergic Agents.Antiemetics.Antihistamines.Histamine H1 Antagonists 12 1.031 11 3117 DB00822 Alcohol Deterrents.Enzyme Inhibitors 12 1.031 2 1071 DB00162 Anti-acne Agents.Essential Vitamin.Vitamins.Vitamins (Vitamin A) 12 1.031 3 6256 DB00432 Antimetabolites.Antiviral Agents 12 1.031 11 2522 DB02300 Antipsoriatic Agents.Dermatologic Agents.Vitamin D3 Receptor inhibitor 12 1.031 6 3780 DB00883 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 12 1.031 3 2484 DB01091 Antifungal Agents 12 1.031 4 5878 DB00621 Anabolic Agents.Androgens 12 1.031 6 888 DB01378 Not Available 12 1.031 3 47641 DB00735 Anti-Inflammatory Agents, Non-Steroidal.Antifungal Agents 12 1.031 18 2266 DB00548 Antineoplastic Agents.Dermatologic Agents 12 1.031 11 5381 DB00799 Dermatologic Agents.Keratolytic Agents.Prodrugs.Teratogens 12 1.031 43 31378 DB00687 Adrenergic Agents.Anti-inflammatory Agents 12 1.031 8 3105 DB00449 Adrenergic Agonists.Ophthalmologicals.Sympathomimetics 12 1.021 8 3241 DB00751 Antihistamines.Histamine H1 Antagonists.Ophthalmics 12 1.017 68 5596 DB00209 Analgesics.Parasympatholytics 12 1.009 15 2370 DB01019 Muscarinic Agonists.Parasympathomimetics 12 0.996 47 4927 DB01069 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists.Phenothiazine Derivatives 12 0.993 54 4159 DB00959 Adrenergic Agents.Anti-inflammatory Agents.Antiemetics.Glucocorticoids.Neuroprotective Agents 12 0.97 76 3661 DB00572 Adjuvants, Anesthesia.Anti-Arrhythmia Agents.Bronchodilator Agents.Muscarinic Antagonists.Mydriatics.Parasympatholytics 12 0.967 22 60164 DB00210 Anti-Inflammatory Agents, Non-Steroidal.Dermatologic Agents 12 0.967 11 157922 DB00992 Antineoplastic Agents 12 0.967 4 119 DB02530 GABA Agents 12 0.967 9 3219 DB01084 Anti-Allergic Agents.Histamine H1 Antagonists 12 0.967 7 5359 DB00870 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 12 0.967 3 175 DB04184 Indicators and Reagents 12 0.967 13 137 DB00855 Photosensitizing Agents 12 0.967 9 3658 DB00557 Antipruritics.Anxiolytics sedatives and hypnotics.Histamine H1 Antagonists 12 0.949 14 2749 DB01188 Antifungal Agents 12 0.91 15 4189 DB01110 Antifungal Agents 12 0.904 25 5572 DB00376 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists 12 0.904 19 4934 DB00782 Anti-Ulcer Agents.Antimuscarinics.Antispasmodics.Muscarinic Antagonists 12 0.903 10 2712 DB00475 Adjuvants, Anesthesia.Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 12 0.903 9 2366 Not Available Not Available 12 0.9 35 16362 DB01100 Anti-Dyskinesia Agents.Antipsychotic Agents.Dopamine Antagonists 12 0.885 11 2519 DB00201 Anorexigenic Agents.Central Nervous System Stimulants.Phosphodiesterase Inhibitors 12 0.882 24 145068 DB00435 Bronchodilator Agents.Endothelium-Dependent Relaxing Factors.Free Radical Scavengers 12 0.874 9 2733 DB00356 Muscle Relaxants, Central 12 0.874 17 152945 DB01126 Anti-baldness Agents.Antihyperplasia Agents.Enzyme Inhibitors 12 0.866 9 861 DB00279 Hormone Replacement Agents 12 0.862 9 5342 DB01138 Uricosuric Agents 12 0.862 21 5311082 DB00063 Anticoagulants.Antiplatelet Agents.Platelet Aggregation Inhibitors 12 0.859 39 5282226 DB00287 Antiglaucoma preparations and miotics.Antihypertensive Agents.Ophthalmologicals.Prostaglandin analogues 12 0.852 19 3387 DB01185 Anabolic Agents.Antineoplastic Agents, Hormonal 12 0.852 16 4160 DB00624 Androgens 12 0.851 16 3168 DB00450 Adjuvants, Anesthesia.Antiemetics.Antipsychotic Agents.Dopamine Antagonists 12 0.838 11 2131 DB01122 Antiarrhythmic Agents.Antimyasthenics 12 0.824 23 3821 DB01221 Analgesics.Anesthetics, Dissociative.Excitatory Amino Acid Antagonists.General Anesthetics 12 0.799 36 5636 Not Available Not Available 12 0.796 14 951 DB00368 Adrenergic alpha-Agonists.Sympathomimetics.Vasoconstrictor Agents 12 0.79 5 51577 DB00491 Anti-Bacterial Agents.Enzyme Inhibitors.Hypoglycemic Agents 12 0.775 7 5404 DB00251 Antifungal Agents.Antifungals 12 0.774 37 5512 DB01036 Anti-Incontinence Agents.Antispasmodics.Genitourinary Smooth Muscle Relaxants.Muscarinic Antagonists 12 0.762 19 2344 DB00245 Antidyskinetics.Antiparkinson Agents.Dopamine Uptake Inhibitors.Muscarinic Antagonists.Parasympatholytics 12 0.756 27 23897 DB01618 Antipsychotic Agents 12 0.754 14 4197 DB00235 Cardiotonic Agents.Phosphodiesterase Inhibitors.Platelet Aggregation Inhibitors.Vasodilator Agents 12 0.753 16 3405 DB00158 Dietary supplement.Hematinics.Micronutrient.Vitamin B Complex 12 0.753 19 3249 DB00153 Antihypocalcemic Agents.Antihypoparathyroid Agents.Bone Density Conservation Agents.Essential Vitamin.Vitamins.Vitamins (Vitamin D) 12 0.747 16 3763 DB00753 Anesthetics.Anesthetics, Inhalation.General Anesthetics 12 0.746 10 4436 Not Available Not Available 12 0.745 12 3915 DB01106 Histamine H1 Antagonists.Histamine H1 Antagonists, Non-Sedating 12 0.74 21 4114 DB00553 Antineoplastic Agents.Cross-Linking Reagents.Photosensitizing Agents.Pigmenting Agents 12 0.738 90 4634 DB01062 Anticholinergic Agents.Antispasmodics.Genitourinary Smooth Muscle Relaxants.Muscarinic Antagonists.Parasympatholytics 12 0.733 19 5505 DB01124 Hypoglycemic Agents.Sulfonylureas 12 0.731 16 5771 DB00107 Anti-tocolytic Agents.Labor Induction Agents.Oxytocics 12 0.731 16 2812 DB00257 Anti-Infective Agents, Local.Antifungal Agents.Growth Inhibitors #### component 13: positive weight features and high scoring objects #### # positive weight on target proteins 13 0.534 19 OPRM_HUMAN Mu-type opioid receptor; 13 0.418 17 OPRD_HUMAN Delta-type opioid receptor; 13 0.374 16 OPRK_HUMAN Kappa-type opioid receptor; 13 0.233 18 SCNNB_HUMAN Amiloride-sensitive sodium channel subunit beta; 13 0.233 18 SCNNG_HUMAN Amiloride-sensitive sodium channel subunit gamma; 13 0.233 18 SCNND_HUMAN Amiloride-sensitive sodium channel subunit delta; 13 0.146 17 SCNAA_HUMAN Sodium channel protein type 10 subunit alpha; 13 0.146 17 DB124_HUMAN Beta-defensin 124; 13 0.146 17 EF1B_HUMAN Elongation factor 1-beta; 13 0.146 17 ACCN3_HUMAN Amiloride-sensitive cation channel 3; 13 0.146 17 SCN1B_HUMAN Sodium channel subunit beta-1; 13 0.146 17 SCN4A_HUMAN Sodium channel protein type 4 subunit alpha; 13 0.146 17 SCN4B_HUMAN Sodium channel subunit beta-4; 13 0.146 17 SCN3B_HUMAN Sodium channel subunit beta-3; 13 0.146 17 SCN7A_HUMAN Sodium channel protein type 7 subunit alpha; 13 0.146 17 ACCN4_HUMAN Amiloride-sensitive cation channel 4; 13 0.146 17 SCN3A_HUMAN Sodium channel protein type 3 subunit alpha; 13 0.041 9 NMD3A_HUMAN Glutamate [NMDA] receptor subunit 3A; 13 0.024 9 GABR2_HUMAN Gamma-aminobutyric acid type B receptor subunit 2; # positive weight on side effects 13 0.578 210 agitation 13 0.382 74 apnea 13 0.322 189 hallucinations 13 0.291 118 shock 13 0.264 205 bradycardia 13 0.226 70 abnormal gait 13 0.221 107 amnesia 13 0.186 75 amblyopia 13 0.157 222 flushing 13 0.151 85 hiccup 13 0.136 322 hypotension 13 0.125 28 respiratory arrest 13 0.099 52 ventricular fibrillation 13 0.09 284 syncope 13 0.084 172 chills 13 0.083 301 dry mouth 13 0.066 104 pulmonary edema 13 0.062 44 acidosis 13 0.048 29 hyperacusis 13 0.048 35 sneezing 13 0.036 137 convulsions 13 0.004 51 hyperesthesia # high scoring drugs for both targets and side effects 13 2.442 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 13 2.125 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 13 2.068 112 71273 DB00296 Anesthetics.Anesthetics, Local.Local Anesthetics 13 1.986 183 3648 DB00327 Analgesics, Opioid.Narcotics 13 1.981 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 13 1.98 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 13 1.962 150 1775 DB00252 Anticonvulsants 13 1.958 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 13 1.931 128 4253 DB00295 Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 13 1.901 74 3676 DB00281 Anesthetics.Anesthetics, Local.Anti-Arrhythmia Agents.Antiarrhythmic Agents 13 1.718 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 13 1.673 135 5734 DB00909 Anticonvulsants.Antioxidants 13 1.67 91 60815 DB00899 Analgesics, Opioid.Anesthetics, Intravenous.Hypnotics and Sedatives 13 1.669 131 4635 DB00497 Analgesics, Opioid.Antitussives.Narcotics.Opiate Agonists 13 1.58 36 4914 DB00721 Anesthetics.Anesthetics, Local.Local Anesthetics 13 1.538 95 16231 DB00594 Diuretics.Sodium channel blockers 13 1.436 91 3355 DB01195 Anti-Arrhythmia Agents.Antiarrhythmic Agents 13 1.385 75 4178 DB00379 Anti-Arrhythmia Agents 13 1.326 43 4913 DB01035 Anti-Arrhythmia Agents.Antiarrhythmic Agents 13 1.325 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 13 1.322 59 2476 DB00921 Analgesics, Opioid.Narcotic Antagonists.Narcotics 13 1.27 28 4058 DB00454 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 13 1.264 47 4419 DB00844 Analgesics, Opioid.Narcotic Antagonists.Narcotics 13 1.202 71 2487 DB00611 Analgesics, Opioid.Antitussive Agents.Narcotic Antagonists.Narcotics 13 1.191 453 125889 DB00230 Analgesics.Anticonvulsants 13 1.171 59 4095 DB00333 Analgesics.Analgesics, Opioid.Antitussive Agents.Antitussives.Narcotics.Opiate Agonists 13 1.166 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 13 1.137 102 4943 DB00818 Anesthetics, Intravenous.Anticonvulsants.Antiemetics.Free Radical Scavengers.Hypnotics and Sedatives 13 1.131 61 3114 DB00280 Anti-Arrhythmia Agents.Antiarrhythmic Agents 13 1.077 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 13 1.03 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 13 1.023 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 13 0.947 51 48041 DB01228 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Sodium channel blockers 13 0.937 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 13 0.932 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 13 0.926 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 13 0.926 23 3821 DB01221 Analgesics.Anesthetics, Dissociative.Excitatory Amino Acid Antagonists.General Anesthetics 13 0.907 131 4428 DB00704 Alcohol Antagonists.Anti-craving Agents.Depressants.Narcotic Antagonists.Opiate Antagonists 13 0.906 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 13 0.901 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 13 0.896 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 13 0.888 23 51263 DB00802 Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 13 0.85 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 13 0.847 120 2284 DB00181 GABA Agonists.Muscle Relaxants.Muscle Relaxants, Central.Skeletal Muscle Relaxants 13 0.846 157 4659569 DB00323 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Enzyme Inhibitors 13 0.796 264 5372 DB00864 Immunosuppressive Agents 13 0.79 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 13 0.783 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 13 0.748 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 13 0.747 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 13 0.743 137 62959 DB00685 Anti-Infective Agents.Anti-Infectives.Fluoroquinolones 13 0.742 118 4236 DB00745 Anorexigenic Agents.Central Nervous System Agents.Central Nervous System Stimulants.Neuroprotective Agents.Stimulants 13 0.742 33 4425 DB01183 Antinarcotic Agents.Depressants.Narcotic Antagonists.Opiate Antagonists 13 0.726 143 4054 DB01043 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agents.Excitatory Amino Acid Antagonists 13 0.719 167 5719 DB00962 Anticonvulsants.Anxiolytics sedatives and hypnotics.Hypnotics and Sedatives 13 0.717 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 13 0.715 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 13 0.703 37 4736 DB00652 Adjuvants, Anesthesia.Analgesics, Opioid.Narcotic Antagonists.Narcotics 13 0.693 199 5358 DB00669 Selective Serotonin Agonists.Serotonin Agonists.Vasoconstrictor Agents 13 0.691 136 56339 DB01320 Anticonvulsants 13 0.687 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 13 0.683 73 3958 DB00186 Anti-anxiety Agents.Anticonvulsants.Antiemetics.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 13 0.681 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 13 0.675 141 4819 DB01085 Cholinergic Agents.Miotics.Muscarinic Agonists 13 0.672 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 13 0.67 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists 13 0.67 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 13 0.665 196 3911 DB00007 Anti-Estrogen Agents.Antineoplastic Agents 13 0.643 65 2474 DB00297 Anesthetics, Local 13 0.636 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 13 0.632 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 13 0.616 196 1935 DB00382 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 13 0.608 61 4192 DB00683 Adjuvants, Anesthesia.Anesthetics, Intravenous.Anti-anxiety Agents.GABA Modulators.Hypnotics and Sedatives 13 0.6 47 4927 DB01069 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists.Phenothiazine Derivatives 13 0.59 117 2405 DB00612 Adrenergic Agents.Adrenergic beta-Antagonists.Antihypertensive Agents.Sympatholytics 13 0.588 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 13 0.587 161 122316 DB01367 Monoamine Oxidase Inhibitors.Neuroprotective Agents 13 0.585 73 34633 DB00680 Anti-Arrhythmia Agents 13 0.578 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 13 0.577 146 3075 DB00343 Antihypertensive Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Cardiovascular Agents.Vasodilator Agents 13 0.573 147 71158 DB00659 Alcohol Deterrents 13 0.569 201 5538 DB00755 Antineoplastic Agents.Cell Stimulants and Proliferants.Keratolytic Agents 13 0.567 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 13 0.56 132 3948 DB00978 Anti-Infective Agents.Anti-Infective Agents, Urinary.Antitubercular Agents.Photosensitizing Agents 13 0.553 234 216326 DB00480 Antineoplastic Agents 13 0.55 118 68740 DB00399 Antihypocalcemic Agents.Antiresorptives.Bisphosphonates.Bone Density Conservation Agents 13 0.548 154 27661 DB01020 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 13 0.539 119 5064 DB00811 Antimetabolites.Antiviral Agents 13 0.535 89 3148 DB00757 Antiemetics.Serotonin Antagonists 13 0.535 161 5487 DB00697 Adrenergic alpha-Agonists.Analgesics.Anticonvulsants.Muscle Relaxants.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 13 0.534 84 2995 DB01151 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Enzyme Inhibitors.Norepinephrine-Reuptake Inhibitors 13 0.533 61 60612 DB00633 Adrenergic alpha-Agonists.Analgesics.Analgesics, Non-Narcotic.Hypnotics and Sedatives 13 0.531 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 13 0.516 158 34312 DB00776 Anticonvulsants 13 0.515 185 4594 DB00338 Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 13 0.514 97 159 DB01240 Antihypertensive Agents.Platelet Aggregation Inhibitors 13 0.51 58 5206 DB01236 Anesthetics, Inhalation.Platelet Aggregation Inhibitors 13 0.506 116 5525 DB00519 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 13 0.502 84 3016 DB00829 Adjuvants, Anesthesia.Anesthetics, Intravenous.Anti-anxiety Agents.Anticonvulsants.Antiemetics.GABA Modulators.Hypnotics and Sedatives.Muscle Relaxants, Central 13 0.493 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents #### component 14: positive weight features and high scoring objects #### # positive weight on target proteins 14 0.8 29 PGH2_HUMAN Prostaglandin G/H synthase 2; 14 0.254 23 PGH1_HUMAN Prostaglandin G/H synthase 1; # positive weight on side effects 14 0.111 101 ulcer 14 0.023 244 arrhythmia 14 0.004 23 nephrotic syndrome # high scoring drugs for both targets and side effects 14 1.063 14 2749 DB01188 Antifungal Agents 14 1.063 7 5359 DB00870 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 14 0.731 43 5508 DB00500 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 14 0.65 46 5362070 DB01014 Anti-Inflammatory Agents, Non-Steroidal.Anti-Ulcer Agents.Gastrointestinal Agents 14 0.619 33 60865 DB00768 Anti-Allergic Agents.Anti-Inflammatory Agents, Non-Steroidal.Antihistamines.Histamine H1 Antagonists.Histamine H1 Antagonists, Non-Sedating 14 0.619 11 4043 DB00253 Topical anti-inflammatory Agent 14 0.619 12 3384 DB00324 Anti-Allergic Agents.Anti-inflammatory Agents.Glucocorticoids 14 0.591 13 137 DB00855 Photosensitizing Agents 14 0.58 54 4159 DB00959 Adrenergic Agents.Anti-inflammatory Agents.Antiemetics.Glucocorticoids.Neuroprotective Agents 14 0.579 9 5342 DB01138 Uricosuric Agents 14 0.575 16 5314 DB00202 Neuromuscular Depolarizing Agents.Skeletal Muscle Relaxants 14 0.575 13 36339 DB00292 Anesthetics, Intravenous.Hypnotics and Sedatives 14 0.575 20 838 DB00668 Adrenergic Agonists.Adrenergic alpha-Agonists.Adrenergic beta-Agonists.Bronchodilator Agents.Mydriatics.Sympathomimetics.Vasoconstrictor Agents 14 0.575 16 3763 DB00753 Anesthetics.Anesthetics, Inhalation.General Anesthetics 14 0.575 16 5771 DB00107 Anti-tocolytic Agents.Labor Induction Agents.Oxytocics 14 0.575 18 3698 DB01427 Calcium Channel Blockers.Cardiotonic Agents.Phosphodiesterase Inhibitors.Vasodilator Agents 14 0.575 10 3226 DB00228 Anesthetics, Inhalation.General Anesthetics 14 0.575 14 951 DB00368 Adrenergic alpha-Agonists.Sympathomimetics.Vasoconstrictor Agents 14 0.575 15 681 DB00988 Cardiotonic Agents.Dopamine Agents.Sympathomimetic.Sympathomimetics 14 0.575 44 191 DB00640 Analgesics.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Cardiac drugs.Vasodilator Agents 14 0.57 50 158 DB00917 Oxytocics.Prostaglandins 14 0.564 5 10548 DB01057 Cholinesterase Inhibitors.Miotics.Parasympathomimetics 14 0.564 11 5381 DB00799 Dermatologic Agents.Keratolytic Agents.Prodrugs.Teratogens 14 0.564 18 3957 DB00455 Anti-Allergic Agents.Antihistamines.Antipruritics.Histamine H1 Antagonists, Non-Sedating 14 0.564 6 3780 DB00883 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 14 0.564 21 5473385 DB00352 Antimetabolites, Antineoplastic 14 0.564 14 4197 DB00235 Cardiotonic Agents.Phosphodiesterase Inhibitors.Platelet Aggregation Inhibitors.Vasodilator Agents 14 0.564 16 2905 DB00979 Antimuscarinic eye preparations.Muscarinic Antagonists.Mydriatics.Parasympatholytics 14 0.564 12 4812 DB01022 Antifibrinolytic Agents.Vitamins.Vitamins (Vitamin K) 14 0.564 8 3241 DB00751 Antihistamines.Histamine H1 Antagonists.Ophthalmics 14 0.564 30 31477 DB01214 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents.Sympatholytics 14 0.564 38 2232 DB00278 Anticoagulants.Platelet Aggregation Inhibitors 14 0.564 6 12555 Not Available Not Available 14 0.564 11 2131 DB01122 Antiarrhythmic Agents.Antimyasthenics 14 0.564 5 2283 DB00626 Anti-Bacterial Agents.Anti-Infective Agents, Local 14 0.564 4 5878 DB00621 Anabolic Agents.Androgens 14 0.564 16 3168 DB00450 Adjuvants, Anesthesia.Antiemetics.Antipsychotic Agents.Dopamine Antagonists 14 0.564 15 3739 DB04711 Contrast Media 14 0.564 3 6256 DB00432 Antimetabolites.Antiviral Agents 14 0.564 2 1071 DB00162 Anti-acne Agents.Essential Vitamin.Vitamins.Vitamins (Vitamin A) 14 0.564 9 232 DB00125 Conditionally Essential Amino Acids.Dietary supplement.Micronutrient 14 0.564 3 4034 DB00737 Anti-Allergic Agents.Antiemetics.Antihistamines.Histamine H1 Antagonists 14 0.564 7 2551 DB00411 Analgesics, Non-Narcotic.Cardiotonic Agents.Cholinergic Agonists.Miotics 14 0.564 33 4425 DB01183 Antinarcotic Agents.Depressants.Narcotic Antagonists.Opiate Antagonists 14 0.564 10 4675 DB01337 Neuromuscular Nondepolarizing Agents.Nicotinic Antagonists 14 0.564 24 145068 DB00435 Bronchodilator Agents.Endothelium-Dependent Relaxing Factors.Free Radical Scavengers 14 0.564 12 3915 DB01106 Histamine H1 Antagonists.Histamine H1 Antagonists, Non-Sedating 14 0.564 21 5546 DB00384 Diuretics.Potassium-sparing Diuretics 14 0.564 17 5403 DB00871 Adrenergic beta-Agonists.Bronchodilator Agents.Sympathomimetic.Sympathomimetics.Tocolytic Agents 14 0.564 9 1148 DB00150 Antidepressive Agents, Second-Generation.Dietary supplement.Essential Amino Acids.Micronutrient 14 0.564 15 2370 DB01019 Muscarinic Agonists.Parasympathomimetics 14 0.564 4 6503 DB03754 Buffers.Excipients 14 0.564 3 247 DB04455 Gastrointestinal Agents.Lipotropic Agents 14 0.564 3 175 DB04184 Indicators and Reagents 14 0.564 10 5526 DB00302 Antifibrinolytic Agents 14 0.564 9 3658 DB00557 Antipruritics.Anxiolytics sedatives and hypnotics.Histamine H1 Antagonists 14 0.564 6 4174 DB01011 Antimetabolites.Enzyme Inhibitors 14 0.564 9 5593 DB00809 Diagnostic aid, cycloplegic.Diagnostic aid, mydriatic.Muscarinic Antagonists.Mydriatics 14 0.564 6 888 DB01378 Not Available 14 0.564 9 2733 DB00356 Muscle Relaxants, Central 14 0.564 10 4436 Not Available Not Available 14 0.547 21 60696 DB00728 Neuromuscular Nondepolarizing Agents.Skeletal Muscle Relaxants 14 0.547 8 3105 DB00449 Adrenergic Agonists.Ophthalmologicals.Sympathomimetics 14 0.547 30 42113 DB01189 Anesthetics, Inhalation.Neuroprotective Agents 14 0.536 17 3000 DB00547 Anti-inflammatory Agents.Glucocorticoids 14 0.536 14 2955 DB00250 Anti-Infective Agents.Anti-Infectives.Anti-inflammatory Agents.Antimalarials.Antimycobacterials.Folic Acid Antagonists.Leprostatic Agents 14 0.536 11 2522 DB02300 Antipsoriatic Agents.Dermatologic Agents.Vitamin D3 Receptor inhibitor 14 0.536 10 3392 DB00846 Anti-inflammatory Agents.Glucocorticoids 14 0.536 11 3251 DB00696 Adrenergic alpha-Agonists.Analgesics, Non-Narcotic.Sympatholytics.Vasoconstrictor Agents 14 0.536 3 2484 DB01091 Antifungal Agents 14 0.536 3 47641 DB00735 Anti-Inflammatory Agents, Non-Steroidal.Antifungal Agents 14 0.536 9 3219 DB01084 Anti-Allergic Agents.Histamine H1 Antagonists 14 0.536 7 5404 DB00251 Antifungal Agents.Antifungals 14 0.536 10 47320 DB00565 Neuromuscular Blocking Agents 14 0.536 10 4630253 DB00240 Anti-inflammatory Agents.Antipruritic Agents.Corticosteroids.Glucocorticoids 14 0.536 16 3382 DB01047 Anti-Allergic Agents.Anti-inflammatory Agents.Glucocorticoids 14 0.536 14 36811 DB00841 Adrenergic beta-Agonists.Cardiotonic Agents.Sympathomimetic.Sympathomimetics 14 0.536 18 2266 DB00548 Antineoplastic Agents.Dermatologic Agents 14 0.536 11 3375 DB00223 Anti-inflammatory Agents.Glucocorticoids 14 0.536 14 2133 DB00288 Corticosteroids, topical 14 0.536 26 12536 DB01260 Anti-inflammatory Agents 14 0.536 15 39507 DB00896 Anti-inflammatory Agents.Corticosteroids 14 0.536 11 157922 DB00992 Antineoplastic Agents 14 0.535 29 3890 DB00654 Antihypertensive Agents.Neuroprotective Agents 14 0.532 24 2244 DB00945 Anti-Inflammatory Agents, Non-Steroidal.Anticoagulants.Cyclooxygenase Inhibitors.Fibrinolytic Agents.Platelet Aggregation Inhibitors.Salicylates 14 0.53 30 156419 DB01012 Calcimimetics 14 0.53 63 3381 DB00591 Anti-inflammatory Agents.Antipruritics.Glucocorticoids 14 0.529 9 861 DB00279 Hormone Replacement Agents 14 0.523 56 5229711 DB00429 Abortifacient Agents, Nonsteroidal.Oxytocics 14 0.523 24 4140 DB00353 Oxytocics 14 0.523 14 11947681 DB00325 Antihypertensive Agents.Indicators and Reagents.Nitric Oxide Donors.Vasodilator Agents 14 0.521 5 51577 DB00491 Anti-Bacterial Agents.Enzyme Inhibitors.Hypoglycemic Agents 14 0.515 39 5282226 DB00287 Antiglaucoma preparations and miotics.Antihypertensive Agents.Ophthalmologicals.Prostaglandin analogues 14 0.513 11 2519 DB00201 Anorexigenic Agents.Central Nervous System Stimulants.Phosphodiesterase Inhibitors 14 0.512 11 3117 DB00822 Alcohol Deterrents.Enzyme Inhibitors 14 0.51 25 150310 DB00700 Aldosterone Antagonists.Antihypertensive Agents 14 0.51 25 3767 DB00951 Antitubercular Agents.Fatty Acid Synthesis Inhibitors 14 0.507 29 2308 DB00394 Anti-Asthmatic Agents.Anti-inflammatory Agents.Antiarrhythmic Agents.Corticosteroids.Glucocorticoids 14 0.502 54 444033 DB01410 Anti-Allergic Agents.Glucocorticoids 14 0.5 15 4865 DB01179 Antimitotic agent.Antineoplastic Agents, Phytogenic.Keratolytic Agents.Tubulin Modulators #### component 15: positive weight features and high scoring objects #### # positive weight on target proteins 15 0.678 17 ANXA1_HUMAN Annexin A1; 15 0.453 18 GCR_HUMAN Glucocorticoid receptor; 15 0.444 17 CBG_HUMAN Corticosteroid-binding globulin; 15 0.137 8 PA24A_HUMAN Cytosolic phospholipase A2; # positive weight on side effects 15 0.358 24 striae 15 0.287 23 skin atrophy 15 0.277 103 cataract 15 0.238 36 folliculitis 15 0.224 20 miliaria 15 0.204 31 hypopigmentation 15 0.108 31 hypertrichosis 15 0.001 71 glaucoma # high scoring drugs for both targets and side effects 15 1.907 135 5544 DB00620 Adrenergic Agents.Anti-inflammatory Agents.Glucocorticoids 15 1.824 86 3003 DB01234 Adrenergic Agents.Anti-inflammatory Agents.Antiemetics.Antineoplastic Agents, Hormonal.Glucocorticoids 15 1.824 83 3640 DB00741 Anti-inflammatory Agents 15 1.824 14 2133 DB00288 Corticosteroids, topical 15 1.722 63 3381 DB00591 Anti-inflammatory Agents.Antipruritics.Glucocorticoids 15 1.685 66 123620 DB00764 Anti-Allergic Agents.Anti-inflammatory Agents 15 1.681 17 48175 DB00596 Anti-inflammatory Agents.Vasoconstrictor Agents 15 1.626 10 4630253 DB00240 Anti-inflammatory Agents.Antipruritic Agents.Corticosteroids.Glucocorticoids 15 1.597 17 3000 DB00547 Anti-inflammatory Agents.Glucocorticoids 15 1.488 124 62924 DB00588 Adrenergic Agents.Anti-Allergic Agents.Anti-inflammatory Agents.Bronchodilator Agents.Dermatologic Agents 15 1.487 29 2308 DB00394 Anti-Asthmatic Agents.Anti-inflammatory Agents.Antiarrhythmic Agents.Corticosteroids.Glucocorticoids 15 1.459 41 32797 DB01013 Anti-inflammatory Agents.Corticosteroids, topical.Glucocorticoids 15 1.459 26 12536 DB01260 Anti-inflammatory Agents 15 1.459 11 3375 DB00223 Anti-inflammatory Agents.Glucocorticoids 15 1.459 17 52421 DB01130 Anti Inflammatory.Anti-inflammatory Agents.Corticosteroid.Glucocorticoids.Steroidal 15 1.41 16 3382 DB01047 Anti-Allergic Agents.Anti-inflammatory Agents.Glucocorticoids 15 1.41 10 3392 DB00846 Anti-inflammatory Agents.Glucocorticoids 15 1.336 31 4900 DB00635 Adrenergic Agents.Anti-inflammatory Agents.Antineoplastic Agents.Antineoplastic Agents, Hormonal.Glucocorticoids 15 1.217 54 4159 DB00959 Adrenergic Agents.Anti-inflammatory Agents.Antiemetics.Glucocorticoids.Neuroprotective Agents 15 1.177 74 4894 DB00860 Adrenergic Agents.Anti-inflammatory Agents.Antineoplastic Agents.Antineoplastic Agents, Hormonal.Glucocorticoids 15 1.109 15 39507 DB00896 Anti-inflammatory Agents.Corticosteroids 15 0.839 12 3384 DB00324 Anti-Allergic Agents.Anti-inflammatory Agents.Glucocorticoids 15 0.839 11 4043 DB00253 Topical anti-inflammatory Agent 15 0.789 54 444033 DB01410 Anti-Allergic Agents.Glucocorticoids 15 0.728 43 31378 DB00687 Adrenergic Agents.Anti-inflammatory Agents 15 0.672 11 2522 DB02300 Antipsoriatic Agents.Dermatologic Agents.Vitamin D3 Receptor inhibitor 15 0.653 78 6447131 DB00337 Anti-Inflammatory Agents, Non-Steroidal.Dermatologic Agents.Enzyme Inhibitors.Immunosuppressive Agents 15 0.636 53 5035 DB00481 Antihypocalcemic Agents.Bone Density Conservation Agents.Estrogen Antagonists.Osteoporosis Prophylactic.Selective Estrogen Receptor Modulators 15 0.615 21 4114 DB00553 Antineoplastic Agents.Cross-Linking Reagents.Photosensitizing Agents.Pigmenting Agents 15 0.608 77 3379 DB00180 Anti-Asthmatic Agents.Anti-inflammatory Agents 15 0.583 46 4201 DB00350 Antihypertensive Agents.Vasodilator Agents 15 0.567 42 4196 DB00834 Abortifacient Agents, Steroidal.Contraceptives, Oral, Synthetic.Contraceptives, Postcoital, Synthetic.Hormone Antagonists.Luteolytic Agents.Menstruation-Inducing Agents 15 0.566 18 2266 DB00548 Antineoplastic Agents.Dermatologic Agents 15 0.548 50 2973 DB00746 Chelating agent.Iron Chelating Agents.Siderophores 15 0.548 39 5282226 DB00287 Antiglaucoma preparations and miotics.Antihypertensive Agents.Ophthalmologicals.Prostaglandin analogues 15 0.511 36 5636 Not Available Not Available 15 0.491 116 5376 DB00675 Antineoplastic Agents, Hormonal.Bone Density Conservation Agents.Estrogen Antagonists.Selective Estrogen Receptor Modulators 15 0.442 84 57469 DB00724 Adjuvants, Immunologic.Antineoplastic Agents.Antiviral Agents.Interferon Inducers 15 0.441 57 2949 DB01406 Estrogen Antagonists 15 0.41 12 4812 DB01022 Antifibrinolytic Agents.Vitamins.Vitamins (Vitamin K) 15 0.41 6 4174 DB01011 Antimetabolites.Enzyme Inhibitors 15 0.41 39 5412 DB00759 Anti-Bacterial Agents.Antiprotozoals.Protein Synthesis Inhibitors.Tetracyclines 15 0.41 21 5473385 DB00352 Antimetabolites, Antineoplastic 15 0.41 6 3780 DB00883 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 15 0.41 10 5526 DB00302 Antifibrinolytic Agents 15 0.41 27 1003 DB02831 Not Available 15 0.41 3 47641 DB00735 Anti-Inflammatory Agents, Non-Steroidal.Antifungal Agents 15 0.41 11 157922 DB00992 Antineoplastic Agents 15 0.41 4 119 DB02530 GABA Agents 15 0.41 4 5878 DB00621 Anabolic Agents.Androgens 15 0.41 24 2727 DB00672 Hypoglycemic Agents.Sulfonylureas 15 0.41 18 3698 DB01427 Calcium Channel Blockers.Cardiotonic Agents.Phosphodiesterase Inhibitors.Vasodilator Agents 15 0.41 7 5404 DB00251 Antifungal Agents.Antifungals 15 0.41 24 5503 DB00839 Hypoglycemic Agents 15 0.41 5 10548 DB01057 Cholinesterase Inhibitors.Miotics.Parasympathomimetics 15 0.41 13 36339 DB00292 Anesthetics, Intravenous.Hypnotics and Sedatives 15 0.41 25 150310 DB00700 Aldosterone Antagonists.Antihypertensive Agents 15 0.41 46 3685 DB01177 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 15 0.41 10 47320 DB00565 Neuromuscular Blocking Agents 15 0.41 25 9034 DB00474 Anesthetics.Anesthetics, Intravenous.Barbiturates 15 0.41 5 51577 DB00491 Anti-Bacterial Agents.Enzyme Inhibitors.Hypoglycemic Agents 15 0.41 3 2484 DB01091 Antifungal Agents 15 0.41 5 2283 DB00626 Anti-Bacterial Agents.Anti-Infective Agents, Local 15 0.41 3 247 DB04455 Gastrointestinal Agents.Lipotropic Agents 15 0.41 16 5771 DB00107 Anti-tocolytic Agents.Labor Induction Agents.Oxytocics 15 0.41 2 1071 DB00162 Anti-acne Agents.Essential Vitamin.Vitamins.Vitamins (Vitamin A) 15 0.41 16 2812 DB00257 Anti-Infective Agents, Local.Antifungal Agents.Growth Inhibitors 15 0.41 19 5505 DB01124 Hypoglycemic Agents.Sulfonylureas 15 0.41 41 2088 DB00630 Antihypocalcemic Agents.Antiresorptives.Bisphosphonates.Bone Density Conservation Agents 15 0.41 9 861 DB00279 Hormone Replacement Agents 15 0.41 25 3767 DB00951 Antitubercular Agents.Fatty Acid Synthesis Inhibitors 15 0.41 24 4911 DB01032 Adjuvants, Pharmaceutic.Uricosuric Agents 15 0.41 19 3387 DB01185 Anabolic Agents.Antineoplastic Agents, Hormonal 15 0.41 43 4913 DB01035 Anti-Arrhythmia Agents.Antiarrhythmic Agents 15 0.41 6 4908 DB01087 Antimalarial Agents.Antimalarials.Antiprotozoal Agents 15 0.41 30 156419 DB01012 Calcimimetics 15 0.41 20 667490 DB01033 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Immunosuppressive Agents.Nucleic Acid Synthesis Inhibitors.Purine analogues 15 0.41 14 4993 DB00205 Antimalarials.Antiprotozoal Agents.Antiprotozoals.Folic Acid Antagonists 15 0.41 74 130881 DB00275 Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 15 0.41 24 145068 DB00435 Bronchodilator Agents.Endothelium-Dependent Relaxing Factors.Free Radical Scavengers 15 0.41 32 2265 DB00993 Antimetabolites.Antimetabolites, Antineoplastic.Antirheumatic Agents.Immunosuppressive Agents 15 0.41 14 2955 DB00250 Anti-Infective Agents.Anti-Infectives.Anti-inflammatory Agents.Antimalarials.Antimycobacterials.Folic Acid Antagonists.Leprostatic Agents 15 0.41 25 5486 DB00775 Fibrinolytic Agents.Platelet Aggregation Inhibitors 15 0.41 10 3226 DB00228 Anesthetics, Inhalation.General Anesthetics 15 0.41 28 2719 DB00608 Amebicides.Antimalarials.Antirheumatic Agents 15 0.41 34 4536 DB00717 Contraceptives, Oral, Synthetic.Progestins 15 0.41 65 4727 DB00859 Antidotes.Antirheumatic Agents.Chelating Agents 15 0.41 11 5381 DB00799 Dermatologic Agents.Keratolytic Agents.Prodrugs.Teratogens 15 0.41 9 232 DB00125 Conditionally Essential Amino Acids.Dietary supplement.Micronutrient 15 0.41 16 4160 DB00624 Androgens 15 0.41 13 137 DB00855 Photosensitizing Agents 15 0.41 3 6256 DB00432 Antimetabolites.Antiviral Agents 15 0.41 21 5311082 DB00063 Anticoagulants.Antiplatelet Agents.Platelet Aggregation Inhibitors 15 0.41 18 1046 DB00339 Antitubercular Agents 15 0.41 15 4189 DB01110 Antifungal Agents 15 0.41 23 5578 DB00440 Anti-Infective Agents, Urinary.Anti-Infectives.Antimalarials.Folic Acid Antagonists 15 0.41 10 4675 DB01337 Neuromuscular Nondepolarizing Agents.Nicotinic Antagonists 15 0.41 30 41744 DB00385 Antineoplastic Agents 15 0.41 38 2232 DB00278 Anticoagulants.Platelet Aggregation Inhibitors 15 0.41 4 6503 DB03754 Buffers.Excipients #### component 16: positive weight features and high scoring objects #### # positive weight on target proteins 16 0.814 29 PGH2_HUMAN Prostaglandin G/H synthase 2; 16 0.186 14 RYR1_HUMAN Ryanodine receptor 1; 16 0.17 15 RYR2_HUMAN Ryanodine receptor 2; 16 0.17 15 RYR3_HUMAN Ryanodine receptor 3; 16 0.122 18 CAC1C_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1C; 16 0.111 13 CACB1_HUMAN Voltage-dependent L-type calcium channel subunit beta-1; 16 0.108 12 CCG2_HUMAN Voltage-dependent calcium channel gamma-2 subunit; 16 0.108 12 CACB3_HUMAN Voltage-dependent L-type calcium channel subunit beta-3; 16 0.108 12 CCG4_HUMAN Voltage-dependent calcium channel gamma-4 subunit; 16 0.108 12 CAC1E_HUMAN Voltage-dependent R-type calcium channel subunit alpha-1E; 16 0.108 12 CACB4_HUMAN Voltage-dependent L-type calcium channel subunit beta-4; 16 0.108 12 ITPR1_HUMAN Inositol 1,4,5-trisphosphate receptor type 1; 16 0.108 12 ITPR3_HUMAN Inositol 1,4,5-trisphosphate receptor type 3; 16 0.108 12 CA2D1_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-1; 16 0.108 12 PKD1_HUMAN Polycystin-1; 16 0.108 12 CAC1S_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1S; 16 0.108 12 PKD2_HUMAN Polycystin-2; 16 0.108 12 TRPA1_HUMAN Transient receptor potential cation channel subfamily A member 1; 16 0.108 12 TRPV6_HUMAN Transient receptor potential cation channel subfamily V member 6; 16 0.108 12 CCG7_HUMAN Voltage-dependent calcium channel gamma-7 subunit; 16 0.104 17 CCG1_HUMAN Voltage-dependent calcium channel gamma-1 subunit; 16 0.1 16 CAC1D_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1D; 16 0.1 16 CACB2_HUMAN Voltage-dependent L-type calcium channel subunit beta-2; 16 0.1 16 CAC1F_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1F; 16 0.093 13 CAC1A_HUMAN Voltage-dependent P/Q-type calcium channel subunit alpha-1A; 16 0.063 13 CAC1B_HUMAN Voltage-dependent N-type calcium channel subunit alpha-1B; 16 0.031 23 PGH1_HUMAN Prostaglandin G/H synthase 1; 16 0.027 16 CAC1G_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1G; # positive weight on side effects 16 0.517 143 Stevens Johnson syndrome 16 0.429 99 polyuria 16 0.37 162 urinary frequency 16 0.285 89 nocturia 16 0.233 93 eructation 16 0.227 112 gynecomastia 16 0.209 122 erythema multiforme 16 0.189 104 pulmonary edema 16 0.189 247 tremor 16 0.144 131 diplopia 16 0.142 274 palpitations 16 0.132 108 toxic epidermal necrolysis 16 0.121 301 dry mouth 16 0.12 254 nervousness 16 0.089 190 epistaxis 16 0.087 152 postural hypotension 16 0.054 166 purpura 16 0.043 204 sweating 16 0.032 377 urticaria 16 0.032 128 gastrointestinal hemorrhage 16 0.017 304 Dyspepsia # high scoring drugs for both targets and side effects 16 2.792 146 3075 DB00343 Antihypertensive Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Cardiovascular Agents.Vasodilator Agents 16 2.792 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 16 2.666 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 16 2.537 95 16231 DB00594 Diuretics.Sodium channel blockers 16 2.452 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 16 2.132 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 16 2.009 150 1775 DB00252 Anticonvulsants 16 1.978 73 3333 DB01023 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Calcium Channel Blockers.Dihydropyridines.Vasodilator Agents 16 1.631 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 16 1.569 57 2951 DB01219 Muscle Relaxants, Central 16 1.536 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 16 1.488 142 3826 DB00465 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 16 1.476 29 3954 DB00836 Antidiarrheals 16 1.372 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 16 1.346 90 2162 DB00381 Antianginals.Antihypertensive Agents.Calcium Channel Blockers.Vasodilator Agents 16 1.301 145 3672 DB01050 Analgesics.Analgesics, Non-Narcotic.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 16 1.278 119 3308 DB00749 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 16 1.274 35 16362 DB01100 Anti-Dyskinesia Agents.Antipsychotic Agents.Dopamine Antagonists 16 1.233 453 125889 DB00230 Analgesics.Anticonvulsants 16 1.209 166 3394 DB00712 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Carbonic Anhydrase Inhibitors.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 16 1.207 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 16 1.189 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 16 1.178 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 16 1.178 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 16 1.157 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 16 1.141 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 16 1.138 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 16 1.128 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 16 1.116 120 3715 DB00328 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cardiovascular Agents.Cyclooxygenase Inhibitors.Gout Suppressants.Nonsteroidal Antiinflammatory Agents (NSAIDs).Tocolytic Agents 16 1.113 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 16 1.106 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 16 1.06 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 16 1.058 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 16 1.058 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 16 1.056 104 4614 DB00991 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Nonsteroidal Antiinflammatory Agents (NSAIDs) 16 1.037 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 16 1.013 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 16 1.011 119 4052 DB00814 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Antiemetics.Antineoplastic Agents.Cyclooxygenase Inhibitors.Growth Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 16 1.006 89 4044 DB00784 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 16 0.992 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 16 0.978 158 34312 DB00776 Anticonvulsants 16 0.962 7 3562 DB01159 Anesthetics.Anesthetics, Inhalation.General Anesthetics 16 0.949 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 16 0.942 92 3825 DB01009 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 16 0.939 185 4594 DB00338 Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 16 0.936 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 16 0.909 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 16 0.888 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 16 0.887 152 60184 DB00790 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 16 0.885 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 16 0.883 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 16 0.864 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 16 0.853 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 16 0.849 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 16 0.833 131 3961 DB00678 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents 16 0.83 94 4409 DB00461 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents 16 0.829 188 5040 DB00877 Anti-Bacterial Agents.Antibiotics, Antineoplastic.Antifungal Agents.Antifungals.Immunosuppressive Agents 16 0.826 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 16 0.805 103 2751 DB01340 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 16 0.803 71 3342 DB00573 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Propionic acid derivatives 16 0.798 151 60835 DB00476 Adrenergic Uptake Inhibitors.Antidepressive Agents.Dopamine Uptake Inhibitors.Serotonin Uptake Inhibitors 16 0.786 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 16 0.757 154 5090 DB00533 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase 2 Inhibitors.Cyclooxygenase Inhibitors 16 0.751 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 16 0.744 264 5372 DB00864 Immunosuppressive Agents 16 0.742 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 16 0.727 103 5352 DB00605 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents.Cyclooxygenase Inhibitors 16 0.727 144 3702 DB00808 Antihypertensive Agents.Diuretics 16 0.722 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 16 0.719 157 4659569 DB00323 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Enzyme Inhibitors 16 0.701 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 16 0.701 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 16 0.701 147 71158 DB00659 Alcohol Deterrents 16 0.696 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 16 0.696 60 3059 DB00861 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 16 0.695 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 16 0.673 128 2250 DB01076 Anticholesteremic Agents.Hydroxymethylglutaryl-CoA Reductase Inhibitors 16 0.671 75 2550 DB01197 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 16 0.653 183 3648 DB00327 Analgesics, Opioid.Narcotics 16 0.643 108 4856 DB00554 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 16 0.634 171 2909 DB00091 Antifungal Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Immunomodulatory Agents.Immunosuppressive Agents 16 0.608 135 5734 DB00909 Anticonvulsants.Antioxidants 16 0.59 133 2802 DB01068 Anticonvulsants.Benzodiazepines.GABA Modulators 16 0.589 196 3911 DB00007 Anti-Estrogen Agents.Antineoplastic Agents 16 0.581 196 1935 DB00382 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 16 0.578 46 4036 DB00939 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 16 0.567 135 2585 DB01136 Adrenergic Agents.Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 16 0.567 132 3948 DB00978 Anti-Infective Agents.Anti-Infective Agents, Urinary.Antitubercular Agents.Photosensitizing Agents 16 0.562 154 3157 DB00590 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Anticholesteremic Agents.Antihypertensive Agents.Vasodilator Agents 16 0.554 154 27661 DB01020 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 16 0.55 157 3937 DB00722 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents.Cardiotonic Agents 16 0.543 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists 16 0.536 166 54374 DB00104 Anabolic Agents.Antineoplastic Agents, Hormonal.Gastrointestinal Agents.Hormone Replacement Agents 16 0.523 137 62959 DB00685 Anti-Infective Agents.Anti-Infectives.Fluoroquinolones 16 0.516 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 16 0.516 126 104865 DB00559 Antihypertensive Agents 16 0.498 99 4889 DB00175 Anticholesteremic Agents.HMG-CoA Reductase Inhibitors.Hydroxymethylglutaryl-CoA Reductase Inhibitors 16 0.493 66 4011 DB00934 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Second-Generation 16 0.493 172 4920 DB00396 Contraceptives.Progestins 16 0.483 149 5394 DB00853 Antineoplastic Agents.Antineoplastic Agents, Alkylating #### component 17: positive weight features and high scoring objects #### # positive weight on target proteins 17 0.568 38 ADRB1_HUMAN Beta-1 adrenergic receptor; 17 0.526 34 ADRB2_HUMAN Beta-2 adrenergic receptor; 17 0.349 24 ADRB3_HUMAN Beta-3 adrenergic receptor; 17 0.193 42 ADA1A_HUMAN Alpha-1A adrenergic receptor; 17 0.18 38 ADA2A_HUMAN Alpha-2A adrenergic receptor; 17 0.178 34 ADA1B_HUMAN Alpha-1B adrenergic receptor; 17 0.147 33 ADA2B_HUMAN Alpha-2B adrenergic receptor; 17 0.145 30 ADA1D_HUMAN Alpha-1D adrenergic receptor; 17 0.057 36 ACM1_HUMAN Muscarinic acetylcholine receptor M1; 17 0.046 34 ACM2_HUMAN Muscarinic acetylcholine receptor M2; 17 0.045 18 GCR_HUMAN Glucocorticoid receptor; 17 0.029 16 G109B_HUMAN G-protein coupled receptor 109B; 17 0.015 14 ACHB2_HUMAN Neuronal acetylcholine receptor subunit beta-2; 17 0.015 14 ACHA3_HUMAN Neuronal acetylcholine receptor subunit alpha-3; 17 0.015 14 ACHA6_HUMAN Neuronal acetylcholine receptor subunit alpha-6; 17 0.015 14 ACHE_HUMAN Acetylcholine receptor subunit epsilon; 17 0.015 14 ACHA9_HUMAN Neuronal acetylcholine receptor subunit alpha-9; 17 0.012 7 AT2C1_HUMAN Calcium-transporting ATPase type 2C member 1; 17 0.009 17 ACH10_HUMAN Neuronal acetylcholine receptor subunit alpha-10; 17 0.009 16 ANDR_HUMAN Androgen receptor; 17 0.007 6 ADCY1_HUMAN Adenylate cyclase type 1; 17 0.006 19 CP27B_HUMAN 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; 17 0.003 8 SHBG_HUMAN Sex hormone-binding globulin; 17 0.002 6 ADCY7_HUMAN Adenylate cyclase type 7; 17 0.002 8 PA24A_HUMAN Cytosolic phospholipase A2; 17 0.001 8 PDE4A_HUMAN cAMP-specific 3',5'-cyclic phosphodiesterase 4A; # positive weight on side effects 17 0.238 67 sore throat 17 0.193 20 ischemic colitis 17 0.16 29 memory loss 17 0.017 52 heart block # high scoring drugs for both targets and side effects 17 1.652 76 3661 DB00572 Adjuvants, Anesthesia.Anti-Arrhythmia Agents.Bronchodilator Agents.Muscarinic Antagonists.Mydriatics.Parasympatholytics 17 1.64 61 4828 DB00960 Adrenergic beta-Antagonists.Antihypertensive Agents.Serotonin Antagonists.Vasodilator Agents 17 1.636 69 3869 DB00598 Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Sympatholytics 17 1.582 10 4436 Not Available Not Available 17 1.337 20 5775 DB00692 Adrenergic alpha-Antagonists.Antihypertensive Agents.Sympatholytics 17 1.336 14 951 DB00368 Adrenergic alpha-Agonists.Sympathomimetics.Vasoconstrictor Agents 17 1.334 61 4946 DB00571 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Anti-anxiety Agents.Antiarrhythmic Agents.Antihypertensive Agents.Vasodilator Agents 17 1.293 72 4893 DB00457 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Antihypertensive Agents 17 1.17 40 4845 DB01291 Adrenergic beta-Agonists.Bronchodilator Agents.Cardiotonic Agents 17 1.16 17 5403 DB00871 Adrenergic beta-Agonists.Bronchodilator Agents.Sympathomimetic.Sympathomimetics.Tocolytic Agents 17 1.11 42 4411 DB01203 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents.Sympatholytics 17 1.101 19 3779 DB01064 Adrenergic beta-Agonists.Bronchodilator Agents.Cardiotonic Agents.Sympathomimetic.Sympathomimetics 17 1.099 75 1978 DB01193 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents 17 1.061 14 36811 DB00841 Adrenergic beta-Agonists.Cardiotonic Agents.Sympathomimetic.Sympathomimetics 17 1.041 20 838 DB00668 Adrenergic Agonists.Adrenergic alpha-Agonists.Adrenergic beta-Agonists.Bronchodilator Agents.Mydriatics.Sympathomimetics.Vasoconstrictor Agents 17 1.036 25 4724 DB01359 Adrenergic beta-Antagonists.Antihypertensive Agents 17 1.008 78 2249 DB00335 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Sympatholytics 17 0.926 28 2583 DB00521 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents.Sympatholytics 17 0.917 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 17 0.915 30 31477 DB01214 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents.Sympatholytics 17 0.911 4 4768 DB00925 Adrenergic alpha-Antagonists.Antihypertensive Agents.Vasodilator Agents 17 0.911 99 5478 DB00373 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents 17 0.885 52 32170 DB00668 Adrenergic Agonists.Adrenergic alpha-Agonists.Adrenergic beta-Agonists.Bronchodilator Agents.Mydriatics.Sympathomimetics.Vasoconstrictor Agents 17 0.842 34 4195 DB00211 Adrenergic alpha-Agonists.Sympathomimetics.Vasoconstrictor Agents 17 0.816 106 2083 DB01001 Adrenergic beta-Agonists.Bronchodilator Agents.Tocolytic Agents 17 0.814 34 71301 DB04861 Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 17 0.801 16 3168 DB00450 Adjuvants, Anesthesia.Antiemetics.Antipsychotic Agents.Dopamine Antagonists 17 0.748 77 3066 DB00320 Analgesics.Analgesics, Non-Narcotic.Anti-migraine Agents.Dopamine Agonists.Sympatholytics.Vasoconstrictor Agents 17 0.747 38 3914 DB01210 Adrenergic beta-Antagonists.EENT Drugs.Sympatholytics 17 0.74 24 2431 DB01158 Adrenergic Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents 17 0.704 8 3241 DB00751 Antihistamines.Histamine H1 Antagonists.Ophthalmics 17 0.694 84 2995 DB01151 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Enzyme Inhibitors.Norepinephrine-Reuptake Inhibitors 17 0.682 27 4086 DB00816 Adrenergic beta-Agonists.Bronchodilator Agents.Sympathomimetics.Tocolytic Agents 17 0.663 65 5253 DB00489 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Sympatholytics 17 0.622 17 1206 DB01577 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Agents.Dopamine Uptake Inhibitors.Sympathomimetics 17 0.621 90 5152 DB00938 Adrenergic beta-Agonists.Bronchodilator Agents.Sympathomimetic 17 0.615 11 3251 DB00696 Adrenergic alpha-Agonists.Analgesics, Non-Narcotic.Sympatholytics.Vasoconstrictor Agents 17 0.584 117 2405 DB00612 Adrenergic Agents.Adrenergic beta-Antagonists.Antihypertensive Agents.Sympatholytics 17 0.549 7 2551 DB00411 Analgesics, Non-Narcotic.Cardiotonic Agents.Cholinergic Agonists.Miotics 17 0.545 11 4919 DB00387 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists 17 0.542 77 3379 DB00180 Anti-Asthmatic Agents.Anti-inflammatory Agents 17 0.538 53 2092 DB00346 Adrenergic alpha-Antagonists.Antihypertensive Agents 17 0.528 8 3105 DB00449 Adrenergic Agonists.Ophthalmologicals.Sympathomimetics 17 0.528 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 17 0.521 58 60147 DB00706 Adrenergic alpha-Antagonists.Antineoplastic Agents 17 0.516 36 41781 DB00214 Antihypertensive Agents.Diuretics 17 0.495 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 17 0.494 5 10548 DB01057 Cholinesterase Inhibitors.Miotics.Parasympathomimetics 17 0.49 9 5593 DB00809 Diagnostic aid, cycloplegic.Diagnostic aid, mydriatic.Muscarinic Antagonists.Mydriatics 17 0.49 11 2131 DB01122 Antiarrhythmic Agents.Antimyasthenics 17 0.49 25 5572 DB00376 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists 17 0.478 135 2585 DB01136 Adrenergic Agents.Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 17 0.477 15 681 DB00988 Cardiotonic Agents.Dopamine Agents.Sympathomimetic.Sympathomimetics 17 0.475 68 942 DB00184 Anti-craving Agents.Autonomic drugs.Central Nervous System Agents.Ganglionic Stimulants.Nicotinic Agonists 17 0.468 16 5504 DB00797 Adrenergic alpha-Antagonists.Antihypertensive Agents.Vasodilator Agents 17 0.459 12 60169 DB01334 Neuromuscular Nondepolarizing Agents 17 0.454 60 3519 DB01018 Adrenergic alpha-Agonists.Antihypertensive Agents.Sympatholytics 17 0.447 19 4934 DB00782 Anti-Ulcer Agents.Antimuscarinics.Antispasmodics.Muscarinic Antagonists 17 0.447 7 3562 DB01159 Anesthetics.Anesthetics, Inhalation.General Anesthetics 17 0.444 16 3763 DB00753 Anesthetics.Anesthetics, Inhalation.General Anesthetics 17 0.443 4 5878 DB00621 Anabolic Agents.Androgens 17 0.442 15 4189 DB01110 Antifungal Agents 17 0.441 14 10100 DB00647 Analgesics.Analgesics, Opioid.Antitussives.Narcotics 17 0.441 28 5311181 DB01088 Antihypertensive Agents 17 0.441 6 4174 DB01011 Antimetabolites.Enzyme Inhibitors 17 0.438 12 3915 DB01106 Histamine H1 Antagonists.Histamine H1 Antagonists, Non-Sedating 17 0.438 14 27400 Not Available Not Available 17 0.438 3 4034 DB00737 Anti-Allergic Agents.Antiemetics.Antihistamines.Histamine H1 Antagonists 17 0.438 47 72054 DB00496 Muscarinic Antagonists.Urinary antispasmodics 17 0.438 3 2484 DB01091 Antifungal Agents 17 0.438 9 3219 DB01084 Anti-Allergic Agents.Histamine H1 Antagonists 17 0.438 6 3780 DB00883 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 17 0.438 5 51577 DB00491 Anti-Bacterial Agents.Enzyme Inhibitors.Hypoglycemic Agents 17 0.438 10 5526 DB00302 Antifibrinolytic Agents 17 0.438 14 2955 DB00250 Anti-Infective Agents.Anti-Infectives.Anti-inflammatory Agents.Antimalarials.Antimycobacterials.Folic Acid Antagonists.Leprostatic Agents 17 0.438 6 888 DB01378 Not Available 17 0.438 18 2266 DB00548 Antineoplastic Agents.Dermatologic Agents 17 0.438 3 247 DB04455 Gastrointestinal Agents.Lipotropic Agents 17 0.438 11 3117 DB00822 Alcohol Deterrents.Enzyme Inhibitors 17 0.438 9 232 DB00125 Conditionally Essential Amino Acids.Dietary supplement.Micronutrient 17 0.438 6 12555 Not Available Not Available 17 0.438 11 2522 DB02300 Antipsoriatic Agents.Dermatologic Agents.Vitamin D3 Receptor inhibitor 17 0.438 10 4675 DB01337 Neuromuscular Nondepolarizing Agents.Nicotinic Antagonists 17 0.438 12 4812 DB01022 Antifibrinolytic Agents.Vitamins.Vitamins (Vitamin K) 17 0.438 59 5665 DB01080 Anticonvulsants.Enzyme Inhibitors.GABA Agents 17 0.438 15 39507 DB00896 Anti-inflammatory Agents.Corticosteroids 17 0.438 9 3658 DB00557 Antipruritics.Anxiolytics sedatives and hypnotics.Histamine H1 Antagonists 17 0.438 3 47641 DB00735 Anti-Inflammatory Agents, Non-Steroidal.Antifungal Agents 17 0.438 5 2283 DB00626 Anti-Bacterial Agents.Anti-Infective Agents, Local 17 0.437 10 2712 DB00475 Adjuvants, Anesthesia.Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 17 0.437 9 861 DB00279 Hormone Replacement Agents 17 0.436 25 68844 DB01194 Antiglaucomic Agents.Carbonic Anhydrase Inhibitors.Ophthalmics 17 0.436 12 4771 DB00191 Adrenergic Agents.Anorexigenic Agents.Appetite Depressants.Central Nervous System Agents.Central Nervous System Stimulants.Stimulants.Sympathomimetics 17 0.436 28 443871 DB00731 Hypoglycemic Agents.Meglitinides 17 0.436 26 3151 DB01184 Antiemetics.Dopamine Antagonists 17 0.436 22 60164 DB00210 Anti-Inflammatory Agents, Non-Steroidal.Dermatologic Agents 17 0.436 21 6398525 DB00364 Anti-Ulcer Agents 17 0.43 15 2370 DB01019 Muscarinic Agonists.Parasympathomimetics 17 0.429 3 175 DB04184 Indicators and Reagents 17 0.424 18 3636 DB00747 Adjuvants.Adjuvants, Anesthesia.Antimuscarinics.Antispasmodics.Cholinergic Antagonists.Muscarinic Antagonists.Mydriatics #### component 18: positive weight features and high scoring objects #### # positive weight on target proteins 18 0.527 28 DRD3_HUMAN D(3) dopamine receptor; 18 0.521 35 DRD2_HUMAN D(2) dopamine receptor; 18 0.425 28 DRD1_HUMAN D(1A) dopamine receptor; 18 0.321 21 DRD5_HUMAN D(1B) dopamine receptor; 18 0.255 26 SC6A4_HUMAN Sodium-dependent serotonin transporter; 18 0.122 28 SC6A2_HUMAN Sodium-dependent noradrenaline transporter; 18 0.112 6 DRD4_HUMAN D(4) dopamine receptor; 18 0.068 18 SCNNB_HUMAN Amiloride-sensitive sodium channel subunit beta; 18 0.068 18 SCNNG_HUMAN Amiloride-sensitive sodium channel subunit gamma; 18 0.068 18 SCNND_HUMAN Amiloride-sensitive sodium channel subunit delta; 18 0.062 17 ACCN3_HUMAN Amiloride-sensitive cation channel 3; 18 0.062 17 DB124_HUMAN Beta-defensin 124; 18 0.062 17 EF1B_HUMAN Elongation factor 1-beta; 18 0.062 17 SCNAA_HUMAN Sodium channel protein type 10 subunit alpha; 18 0.062 17 SCN1B_HUMAN Sodium channel subunit beta-1; 18 0.062 17 SCN4B_HUMAN Sodium channel subunit beta-4; 18 0.062 17 ACCN4_HUMAN Amiloride-sensitive cation channel 4; 18 0.062 5 ATP4A_HUMAN Potassium-transporting ATPase alpha chain 1; 18 0.062 17 SCN4A_HUMAN Sodium channel protein type 4 subunit alpha; 18 0.062 17 SCN3A_HUMAN Sodium channel protein type 3 subunit alpha; 18 0.062 17 SCN3B_HUMAN Sodium channel subunit beta-3; 18 0.062 17 SCN7A_HUMAN Sodium channel protein type 7 subunit alpha; 18 0.05 35 HRH1_HUMAN Histamine H1 receptor; 18 0.043 11 CAH4_HUMAN Carbonic anhydrase 4; 18 0.04 13 CAH2_HUMAN Carbonic anhydrase 2; 18 0.033 42 ADA1A_HUMAN Alpha-1A adrenergic receptor; 18 0.027 18 SCN5A_HUMAN Sodium channel protein type 5 subunit alpha; 18 0.015 12 IRK1_HUMAN ATP-sensitive inward rectifier potassium channel 1; 18 0.012 5 SCN1A_HUMAN Sodium channel protein type 1 subunit alpha; 18 0.009 13 CAH1_HUMAN Carbonic anhydrase 1; # positive weight on side effects 18 0.44 209 jaundice 18 0.407 111 hypoglycemia 18 0.397 113 eczema 18 0.34 68 glycosuria 18 0.321 180 agranulocytosis 18 0.26 83 leukocytosis 18 0.209 87 contact dermatitis 18 0.18 16 choreoathetosis 18 0.174 40 fecal incontinence 18 0.154 35 grand mal 18 0.129 186 weight gain 18 0.123 55 seborrhea 18 0.114 130 cardiac arrest 18 0.079 34 Endocrine Disorders 18 0.074 70 abnormal gait 18 0.062 191 peripheral edema 18 0.059 102 hyponatremia 18 0.039 99 photophobia 18 0.038 52 menorrhagia 18 0.031 155 dysphagia 18 0.021 123 urinary incontinence 18 0.006 85 dysmenorrhea 18 0.005 64 dysarthria # high scoring drugs for both targets and side effects 18 2.194 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 18 2.164 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 18 2.162 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 18 1.976 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 18 1.817 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 18 1.793 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 18 1.792 59 4917 DB00433 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 18 1.711 62 5566 DB00831 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 18 1.683 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 18 1.662 57 5454 DB01623 Antipsychotic Agents.Dopamine Antagonists 18 1.609 64 2726 DB00477 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 18 1.577 76 4748 DB00850 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 18 1.573 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 18 1.434 71 3372 DB00623 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 18 1.402 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 18 1.356 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 18 1.337 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 18 1.321 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 18 1.262 51 3559 DB00502 Anti-Dyskinesia Agents.Antidyskinetics.Antiemetics.Antipsychotic Agents.Antipsychotics.Butyrophenones.Dopamine Antagonists 18 1.237 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 18 1.195 52 5452 DB00679 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 18 1.179 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 18 1.168 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 18 1.166 49 4078 DB00933 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 18 1.118 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 18 1.069 453 125889 DB00230 Analgesics.Anticonvulsants 18 1.065 135 5734 DB00909 Anticonvulsants.Antioxidants 18 1.054 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 18 1.043 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 18 1.039 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 18 1.0 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 18 0.999 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 18 0.968 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 18 0.961 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 18 0.954 264 5372 DB00864 Immunosuppressive Agents 18 0.909 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 18 0.894 35 16362 DB01100 Anti-Dyskinesia Agents.Antipsychotic Agents.Dopamine Antagonists 18 0.892 51 3964 DB00408 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists 18 0.794 61 3114 DB00280 Anti-Arrhythmia Agents.Antiarrhythmic Agents 18 0.778 151 60835 DB00476 Adrenergic Uptake Inhibitors.Antidepressive Agents.Dopamine Uptake Inhibitors.Serotonin Uptake Inhibitors 18 0.766 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 18 0.763 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 18 0.745 146 3475 DB01120 Hypoglycemic Agents.Sulfonylureas 18 0.692 185 4594 DB00338 Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 18 0.676 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 18 0.666 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 18 0.66 33 3340 DB00800 Antihypertensive Agents.Dopamine Agonists.Vasodilator Agents 18 0.65 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 18 0.629 69 2512 DB00248 Antineoplastic Agents.Antiparkinson Agents.Dopamine Agonists 18 0.623 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 18 0.615 90 2477 DB00490 Anti-anxiety Agents.Anxiolytics sedatives and hypnotics.Serotonin Agonists 18 0.61 112 71273 DB00296 Anesthetics.Anesthetics, Local.Local Anesthetics 18 0.608 11 3251 DB00696 Adrenergic alpha-Agonists.Analgesics, Non-Narcotic.Sympatholytics.Vasoconstrictor Agents 18 0.598 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 18 0.598 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 18 0.595 50 3158 DB01142 Anti-anxiety Agents.Antidepressants.Antidepressive Agents, Tricyclic.Antipruritics.Histamine Antagonists.Norepinephrine-Reuptake Inhibitors 18 0.594 150 1775 DB00252 Anticonvulsants 18 0.587 31 2215 DB00714 Antidyskinetics.Antiparkinson Agents.Dopamine Agonists 18 0.571 20 5775 DB00692 Adrenergic alpha-Antagonists.Antihypertensive Agents.Sympatholytics 18 0.562 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 18 0.556 215 60787 DB01232 Anti-HIV Agents.HIV Protease Inhibitors 18 0.55 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 18 0.549 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 18 0.549 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 18 0.545 91 3355 DB01195 Anti-Arrhythmia Agents.Antiarrhythmic Agents 18 0.543 128 2250 DB01076 Anticholesteremic Agents.Hydroxymethylglutaryl-CoA Reductase Inhibitors 18 0.52 61 5402 DB00857 Allylamines.Antifungal Agents.Antifungals.Enzyme Inhibitors.Trypanocidal Agents 18 0.517 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 18 0.514 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 18 0.505 95 16231 DB00594 Diuretics.Sodium channel blockers 18 0.502 158 34312 DB00776 Anticonvulsants 18 0.501 55 2130 DB00915 Analgesics, Non-Narcotic.Antiparkinson Agents.Antiviral Agents.Dopamine Agents 18 0.496 167 170361 DB01273 Nicotinic Agonists 18 0.49 62 3478 DB01067 Hypoglycemic Agents 18 0.484 120 3715 DB00328 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cardiovascular Agents.Cyclooxygenase Inhibitors.Gout Suppressants.Nonsteroidal Antiinflammatory Agents (NSAIDs).Tocolytic Agents 18 0.481 131 3961 DB00678 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents 18 0.473 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 18 0.472 167 5719 DB00962 Anticonvulsants.Anxiolytics sedatives and hypnotics.Hypnotics and Sedatives 18 0.464 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 18 0.463 43 1986 DB00819 Anticonvulsants.Carbonic Anhydrase Inhibitors.Diuretics 18 0.457 126 104865 DB00559 Antihypertensive Agents 18 0.455 134 3339 DB01039 Antilipemic Agents.Fribic Acid Derivatives 18 0.453 146 4158 DB00422 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Uptake Inhibitors.Sympathomimetics 18 0.453 51 48041 DB01228 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Sodium channel blockers 18 0.448 49 4168 DB01233 Antiemetics.Dopamine Antagonists.Prokinetic Agents 18 0.435 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 18 0.435 161 5487 DB00697 Adrenergic alpha-Agonists.Analgesics.Anticonvulsants.Muscle Relaxants.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 18 0.434 166 3394 DB00712 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Carbonic Anhydrase Inhibitors.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 18 0.426 138 2369 DB00195 Adrenergic beta-Antagonists.Antihypertensive Agents.EENT Drugs.Sympatholytics 18 0.426 84 2995 DB01151 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Enzyme Inhibitors.Norepinephrine-Reuptake Inhibitors 18 0.422 87 5533 DB00656 Anti-anxiety Agents.Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 18 0.412 97 1065 DB00908 Adrenergic alpha-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antimalarials.Enzyme Inhibitors.Muscarinic Antagonists 18 0.411 201 5538 DB00755 Antineoplastic Agents.Cell Stimulants and Proliferants.Keratolytic Agents 18 0.409 106 4539 DB01059 Anti-Bacterial Agents.Anti-Infectives.Enzyme Inhibitors.Nucleic Acid Synthesis Inhibitors.Quinolones 18 0.404 151 41317 DB00459 Keratolytic Agents 18 0.395 183 3648 DB00327 Analgesics, Opioid.Narcotics 18 0.389 157 3937 DB00722 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents.Cardiotonic Agents 18 0.388 144 3899 DB01097 Adjuvants.Anti-inflammatory Agents.Antineoplastic Agents.Antiparasitic Agents.Antirheumatic Agents.Antiviral Agents.Enzyme Inhibitors.Immunosuppressive Agents 18 0.375 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 18 0.37 94 4171 DB00264 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Sympatholytics #### component 19: positive weight features and high scoring objects #### # positive weight on target proteins 19 0.602 26 SC6A4_HUMAN Sodium-dependent serotonin transporter; 19 0.272 28 SC6A2_HUMAN Sodium-dependent noradrenaline transporter; 19 0.202 17 DB124_HUMAN Beta-defensin 124; 19 0.202 17 SCN3B_HUMAN Sodium channel subunit beta-3; 19 0.202 17 ACCN3_HUMAN Amiloride-sensitive cation channel 3; 19 0.202 17 EF1B_HUMAN Elongation factor 1-beta; 19 0.202 17 SCNAA_HUMAN Sodium channel protein type 10 subunit alpha; 19 0.202 17 SCN1B_HUMAN Sodium channel subunit beta-1; 19 0.202 17 SCN4A_HUMAN Sodium channel protein type 4 subunit alpha; 19 0.202 17 SCN7A_HUMAN Sodium channel protein type 7 subunit alpha; 19 0.202 17 SCN4B_HUMAN Sodium channel subunit beta-4; 19 0.202 17 SCN3A_HUMAN Sodium channel protein type 3 subunit alpha; 19 0.202 17 ACCN4_HUMAN Amiloride-sensitive cation channel 4; 19 0.195 18 SCNNG_HUMAN Amiloride-sensitive sodium channel subunit gamma; 19 0.195 18 SCNND_HUMAN Amiloride-sensitive sodium channel subunit delta; 19 0.195 18 SCNNB_HUMAN Amiloride-sensitive sodium channel subunit beta; 19 0.016 18 SCN5A_HUMAN Sodium channel protein type 5 subunit alpha; # positive weight on side effects 19 0.464 89 nocturia 19 0.441 51 hyperesthesia 19 0.35 29 hyperacusis 19 0.333 64 dysarthria 19 0.261 70 petechiae 19 0.252 62 ventricular extrasystoles 19 0.2 75 deafness 19 0.192 71 numbness 19 0.165 105 leg cramps 19 0.159 37 gum hemorrhage 19 0.15 67 gingivitis 19 0.135 38 kidney pain 19 0.126 32 suicide attempt 19 0.117 99 polyuria 19 0.094 52 heart block 19 0.086 113 ear pain 19 0.071 49 urinary urgency 19 0.055 58 visual field defect 19 0.006 101 coma # high scoring drugs for both targets and side effects 19 2.597 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 19 2.562 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 19 2.507 135 5734 DB00909 Anticonvulsants.Antioxidants 19 2.484 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 19 2.314 150 1775 DB00252 Anticonvulsants 19 2.3 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 19 2.092 74 3676 DB00281 Anesthetics.Anesthetics, Local.Anti-Arrhythmia Agents.Antiarrhythmic Agents 19 1.739 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 19 1.714 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 19 1.615 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 19 1.609 95 16231 DB00594 Diuretics.Sodium channel blockers 19 1.479 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 19 1.473 453 125889 DB00230 Analgesics.Anticonvulsants 19 1.468 91 3355 DB01195 Anti-Arrhythmia Agents.Antiarrhythmic Agents 19 1.465 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 19 1.441 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 19 1.419 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 19 1.306 51 48041 DB01228 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Sodium channel blockers 19 1.276 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 19 1.276 75 4178 DB00379 Anti-Arrhythmia Agents 19 1.276 61 3114 DB00280 Anti-Arrhythmia Agents.Antiarrhythmic Agents 19 1.222 112 71273 DB00296 Anesthetics.Anesthetics, Local.Local Anesthetics 19 1.18 43 4913 DB01035 Anti-Arrhythmia Agents.Antiarrhythmic Agents 19 1.172 36 4914 DB00721 Anesthetics.Anesthetics, Local.Local Anesthetics 19 1.148 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 19 1.131 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 19 1.022 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 19 1.015 84 2995 DB01151 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Enzyme Inhibitors.Norepinephrine-Reuptake Inhibitors 19 0.995 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 19 0.979 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 19 0.975 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 19 0.961 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 19 0.91 136 56339 DB01320 Anticonvulsants 19 0.907 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 19 0.9 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 19 0.884 167 5719 DB00962 Anticonvulsants.Anxiolytics sedatives and hypnotics.Hypnotics and Sedatives 19 0.873 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 19 0.816 151 60835 DB00476 Adrenergic Uptake Inhibitors.Antidepressive Agents.Dopamine Uptake Inhibitors.Serotonin Uptake Inhibitors 19 0.786 65 4543 DB00540 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 19 0.747 215 60787 DB01232 Anti-HIV Agents.HIV Protease Inhibitors 19 0.742 264 5372 DB00864 Immunosuppressive Agents 19 0.728 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 19 0.711 67 4976 DB00344 Adrenergic Uptake Inhibitors.Antidepressive Agents.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 19 0.685 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists 19 0.672 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 19 0.671 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 19 0.654 171 2909 DB00091 Antifungal Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Immunomodulatory Agents.Immunosuppressive Agents 19 0.64 196 1935 DB00382 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 19 0.636 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 19 0.627 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 19 0.614 144 3702 DB00808 Antihypertensive Agents.Diuretics 19 0.595 199 5358 DB00669 Selective Serotonin Agonists.Serotonin Agonists.Vasoconstrictor Agents 19 0.587 129 5210 DB01105 Anorexigenic Agents.Antidepressants.Antidepressive Agents.Appetite Depressants.Stimulants 19 0.568 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 19 0.562 146 4158 DB00422 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Uptake Inhibitors.Sympathomimetics 19 0.557 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 19 0.554 167 170361 DB01273 Nicotinic Agonists 19 0.544 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 19 0.535 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 19 0.517 72 2160 DB00321 Adrenergic Uptake Inhibitors.Analgesics, Non-Narcotic.Antidepressive Agents, Tricyclic 19 0.511 161 122316 DB01367 Monoamine Oxidase Inhibitors.Neuroprotective Agents 19 0.504 71 2487 DB00611 Analgesics, Opioid.Antitussive Agents.Narcotic Antagonists.Narcotics 19 0.499 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 19 0.497 211 60953 DB01101 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Prodrugs 19 0.479 69 2170 DB00543 Adrenergic Uptake Inhibitors.Antidepressive Agents, Second-Generation.Dopamine Antagonists.Neurotransmitter Uptake Inhibitors.Serotonin Uptake Inhibitors 19 0.479 69 3696 DB00458 Adrenergic Uptake Inhibitors.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 19 0.479 64 5584 DB00726 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 19 0.465 149 5394 DB00853 Antineoplastic Agents.Antineoplastic Agents, Alkylating 19 0.444 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 19 0.443 181 4932 DB01182 Anti-Arrhythmia Agents 19 0.439 161 5212 DB00203 Phosphodiesterase Inhibitors.Vasodilator Agents 19 0.438 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 19 0.428 128 2250 DB01076 Anticholesteremic Agents.Hydroxymethylglutaryl-CoA Reductase Inhibitors 19 0.427 188 5040 DB00877 Anti-Bacterial Agents.Antibiotics, Antineoplastic.Antifungal Agents.Antifungals.Immunosuppressive Agents 19 0.42 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 19 0.412 196 3911 DB00007 Anti-Estrogen Agents.Antineoplastic Agents 19 0.409 132 4739 DB00552 Antibiotics.Antineoplastic Agents.Enzyme Inhibitors.Immunosuppressive Agents 19 0.407 106 2958 DB00694 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 19 0.405 146 3075 DB00343 Antihypertensive Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Cardiovascular Agents.Vasodilator Agents 19 0.399 76 2803 DB00575 Adrenergic alpha-Agonists.Analgesics.Antihypertensive Agents.Central Alpha-Agonists.Sympatholytics 19 0.396 120 2284 DB00181 GABA Agonists.Muscle Relaxants.Muscle Relaxants, Central.Skeletal Muscle Relaxants 19 0.396 151 41317 DB00459 Keratolytic Agents 19 0.382 133 2802 DB01068 Anticonvulsants.Benzodiazepines.GABA Modulators 19 0.365 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 19 0.356 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 19 0.354 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 19 0.344 66 4011 DB00934 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Second-Generation 19 0.339 147 71158 DB00659 Alcohol Deterrents 19 0.332 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 19 0.328 118 4236 DB00745 Anorexigenic Agents.Central Nervous System Agents.Central Nervous System Stimulants.Neuroprotective Agents.Stimulants 19 0.325 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 19 0.32 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 19 0.319 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 19 0.303 166 54374 DB00104 Anabolic Agents.Antineoplastic Agents, Hormonal.Gastrointestinal Agents.Hormone Replacement Agents 19 0.301 87 5533 DB00656 Anti-anxiety Agents.Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 19 0.301 50 3158 DB01142 Anti-anxiety Agents.Antidepressants.Antidepressive Agents, Tricyclic.Antipruritics.Histamine Antagonists.Norepinephrine-Reuptake Inhibitors 19 0.3 142 2678 DB00341 Anti-Allergic Agents.Antihistamines.Histamine H1 Antagonists, Non-Sedating 19 0.296 183 3648 DB00327 Analgesics, Opioid.Narcotics 19 0.293 161 5487 DB00697 Adrenergic alpha-Agonists.Analgesics.Anticonvulsants.Muscle Relaxants.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 19 0.292 172 4920 DB00396 Contraceptives.Progestins #### component 20: positive weight features and high scoring objects #### # positive weight on target proteins 20 0.777 26 SC6A4_HUMAN Sodium-dependent serotonin transporter; 20 0.447 28 SC6A2_HUMAN Sodium-dependent noradrenaline transporter; 20 0.006 20 ACHA2_HUMAN Neuronal acetylcholine receptor subunit alpha-2; # positive weight on side effects 20 0.137 155 stomatitis 20 0.136 10 testicular swelling 20 0.117 280 hypertension 20 0.065 68 laryngitis 20 0.054 12 serotonin syndrome 20 0.043 85 peripheral neuropathy 20 0.029 66 sleep disorder 20 0.022 45 SIADH # high scoring drugs for both targets and side effects 20 0.712 38 125017 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 20 0.631 146 4158 DB00422 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Uptake Inhibitors.Sympathomimetics 20 0.572 12 4771 DB00191 Adrenergic Agents.Anorexigenic Agents.Appetite Depressants.Central Nervous System Agents.Central Nervous System Stimulants.Stimulants.Sympathomimetics 20 0.562 14 951 DB00368 Adrenergic alpha-Agonists.Sympathomimetics.Vasoconstrictor Agents 20 0.5 17 1206 DB01577 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Agents.Dopamine Uptake Inhibitors.Sympathomimetics 20 0.493 39 5412 DB00759 Anti-Bacterial Agents.Antiprotozoals.Protein Synthesis Inhibitors.Tetracyclines 20 0.493 21 5473385 DB00352 Antimetabolites, Antineoplastic 20 0.485 50 3158 DB01142 Anti-anxiety Agents.Antidepressants.Antidepressive Agents, Tricyclic.Antipruritics.Histamine Antagonists.Norepinephrine-Reuptake Inhibitors 20 0.472 83 5487301 DB01079 Gastrointestinal Agents.Serotonin Agonists 20 0.434 43 5508 DB00500 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 20 0.432 72 6398970 DB00535 Anti-Bacterial Agents.Anti-Infectives 20 0.425 30 156419 DB01012 Calcimimetics 20 0.425 39 5282226 DB00287 Antiglaucoma preparations and miotics.Antihypertensive Agents.Ophthalmologicals.Prostaglandin analogues 20 0.425 51 60852 DB00710 Antihypocalcemic Agents.Antiresorptives.Bisphosphonates.Bone Density Conservation Agents 20 0.425 20 838 DB00668 Adrenergic Agonists.Adrenergic alpha-Agonists.Adrenergic beta-Agonists.Bronchodilator Agents.Mydriatics.Sympathomimetics.Vasoconstrictor Agents 20 0.425 36 5636 Not Available Not Available 20 0.425 30 31477 DB01214 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents.Sympatholytics 20 0.425 43 31378 DB00687 Adrenergic Agents.Anti-inflammatory Agents 20 0.425 16 4211 DB00648 Antineoplastic Agents.Antineoplastic Agents, Hormonal 20 0.425 54 4159 DB00959 Adrenergic Agents.Anti-inflammatory Agents.Antiemetics.Glucocorticoids.Neuroprotective Agents 20 0.425 29 4829 DB01132 Hypoglycemic Agents.Thazolidinediones 20 0.425 31 4900 DB00635 Adrenergic Agents.Anti-inflammatory Agents.Antineoplastic Agents.Antineoplastic Agents, Hormonal.Glucocorticoids 20 0.425 25 5486 DB00775 Fibrinolytic Agents.Platelet Aggregation Inhibitors 20 0.42 38 77999 DB00412 Fibrinolytic Agents.Hypoglycemic Agents.Thazolidinediones.Vasodilator Agents 20 0.417 68 942 DB00184 Anti-craving Agents.Autonomic drugs.Central Nervous System Agents.Ganglionic Stimulants.Nicotinic Agonists 20 0.416 11 3251 DB00696 Adrenergic alpha-Agonists.Analgesics, Non-Narcotic.Sympatholytics.Vasoconstrictor Agents 20 0.41 124 62924 DB00588 Adrenergic Agents.Anti-Allergic Agents.Anti-inflammatory Agents.Bronchodilator Agents.Dermatologic Agents 20 0.403 27 298 DB00446 Anti-Bacterial Agents.Protein Synthesis Inhibitors 20 0.399 69 5311297 DB00471 Anti-Asthmatic Agents.Antiarrhythmic Agents.Leukotriene Antagonists 20 0.391 62 3007 DB00182 Adrenergic Agents.Adrenergic Uptake Inhibitors.Amphetamines.Central Nervous System Stimulants.Dopamine Agents.Dopamine Uptake Inhibitors.Sympathomimetics 20 0.387 50 5472 DB00208 Fibrinolytic Agents.Platelet Aggregation Inhibitors 20 0.377 24 5503 DB00839 Hypoglycemic Agents 20 0.377 19 5505 DB01124 Hypoglycemic Agents.Sulfonylureas 20 0.377 38 3488 DB01016 Antiarrhythmic Agents.Hypoglycemic Agents.Sulfonylureas 20 0.377 24 2727 DB00672 Hypoglycemic Agents.Sulfonylureas 20 0.369 7 2551 DB00411 Analgesics, Non-Narcotic.Cardiotonic Agents.Cholinergic Agonists.Miotics 20 0.369 5 10548 DB01057 Cholinesterase Inhibitors.Miotics.Parasympathomimetics 20 0.369 23 3821 DB01221 Analgesics.Anesthetics, Dissociative.Excitatory Amino Acid Antagonists.General Anesthetics 20 0.369 12 60169 DB01334 Neuromuscular Nondepolarizing Agents 20 0.369 10 47320 DB00565 Neuromuscular Blocking Agents 20 0.366 39 104741 DB00947 Antineoplastic Agents.Antineoplastic Agents, Hormonal.Estrogen Antagonists 20 0.366 41 5493444 DB01258 Antihypertensive Agents 20 0.366 10 4630253 DB00240 Anti-inflammatory Agents.Antipruritic Agents.Corticosteroids.Glucocorticoids 20 0.366 6 4174 DB01011 Antimetabolites.Enzyme Inhibitors 20 0.366 3 47641 DB00735 Anti-Inflammatory Agents, Non-Steroidal.Antifungal Agents 20 0.366 29 2308 DB00394 Anti-Asthmatic Agents.Anti-inflammatory Agents.Antiarrhythmic Agents.Corticosteroids.Glucocorticoids 20 0.366 40 5717 DB00549 Anti-Asthmatic Agents.Leukotriene Antagonists 20 0.366 4 119 DB02530 GABA Agents 20 0.366 9 2733 DB00356 Muscle Relaxants, Central 20 0.366 7 5404 DB00251 Antifungal Agents.Antifungals 20 0.366 11 157922 DB00992 Antineoplastic Agents 20 0.366 18 3698 DB01427 Calcium Channel Blockers.Cardiotonic Agents.Phosphodiesterase Inhibitors.Vasodilator Agents 20 0.366 41 2315 DB00436 Antihypertensive Agents.Diuretics.Diuretics, Thiazide.Sodium Chloride Symporter Inhibitors 20 0.366 40 2617 DB01327 Anti-Bacterial Agents.Cephalosporins 20 0.366 11 4043 DB00253 Topical anti-inflammatory Agent 20 0.366 10 5526 DB00302 Antifibrinolytic Agents 20 0.366 27 3647 DB00774 Antihypertensive Agents.Diuretics.Diuretics, Thiazide.Sodium Chloride Symporter Inhibitors 20 0.366 4 5878 DB00621 Anabolic Agents.Androgens 20 0.366 22 60164 DB00210 Anti-Inflammatory Agents, Non-Steroidal.Dermatologic Agents 20 0.366 28 443871 DB00731 Hypoglycemic Agents.Meglitinides 20 0.366 5 51577 DB00491 Anti-Bacterial Agents.Enzyme Inhibitors.Hypoglycemic Agents 20 0.366 3 2484 DB01091 Antifungal Agents 20 0.366 21 4114 DB00553 Antineoplastic Agents.Cross-Linking Reagents.Photosensitizing Agents.Pigmenting Agents 20 0.366 38 150311 DB00973 Anticholesteremic Agents.Cholesterol Absorption Inhibitors 20 0.366 9 3219 DB01084 Anti-Allergic Agents.Histamine H1 Antagonists 20 0.366 28 4870 DB01324 Antihypertensive Agents.Diuretics.Sodium Chloride Symporter Inhibitors 20 0.366 15 3739 DB04711 Contrast Media 20 0.366 3 247 DB04455 Gastrointestinal Agents.Lipotropic Agents 20 0.366 7 5359 DB00870 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 20 0.366 2 1071 DB00162 Anti-acne Agents.Essential Vitamin.Vitamins.Vitamins (Vitamin A) 20 0.366 9 5342 DB01138 Uricosuric Agents 20 0.366 78 6447131 DB00337 Anti-Inflammatory Agents, Non-Steroidal.Dermatologic Agents.Enzyme Inhibitors.Immunosuppressive Agents 20 0.366 11 2522 DB02300 Antipsoriatic Agents.Dermatologic Agents.Vitamin D3 Receptor inhibitor 20 0.366 6 4908 DB01087 Antimalarial Agents.Antimalarials.Antiprotozoal Agents 20 0.366 12 3384 DB00324 Anti-Allergic Agents.Anti-inflammatory Agents.Glucocorticoids 20 0.366 16 3763 DB00753 Anesthetics.Anesthetics, Inhalation.General Anesthetics 20 0.366 16 41774 DB00284 Enzyme Inhibitors.Hypoglycemic Agents 20 0.366 14 4993 DB00205 Antimalarials.Antiprotozoal Agents.Antiprotozoals.Folic Acid Antagonists 20 0.366 47 74989 DB01117 Anti-Infective Agents.Antifungal Agents.Antimalarials.Antiprotozoal Agents.Enzyme Inhibitors 20 0.366 6 12555 Not Available Not Available 20 0.366 16 3382 DB01047 Anti-Allergic Agents.Anti-inflammatory Agents.Glucocorticoids 20 0.366 31 50294 DB00716 Anti-Allergic Agents.Anti-Asthmatic Agents.Anti-inflammatory Agents 20 0.366 26 12536 DB01260 Anti-inflammatory Agents 20 0.366 21 5311082 DB00063 Anticoagulants.Antiplatelet Agents.Platelet Aggregation Inhibitors 20 0.366 11 3375 DB00223 Anti-inflammatory Agents.Glucocorticoids 20 0.366 15 39507 DB00896 Anti-inflammatory Agents.Corticosteroids 20 0.366 14 2955 DB00250 Anti-Infective Agents.Anti-Infectives.Anti-inflammatory Agents.Antimalarials.Antimycobacterials.Folic Acid Antagonists.Leprostatic Agents 20 0.366 13 137 DB00855 Photosensitizing Agents 20 0.366 9 232 DB00125 Conditionally Essential Amino Acids.Dietary supplement.Micronutrient 20 0.366 10 3392 DB00846 Anti-inflammatory Agents.Glucocorticoids 20 0.366 17 48175 DB00596 Anti-inflammatory Agents.Vasoconstrictor Agents 20 0.366 17 52421 DB01130 Anti Inflammatory.Anti-inflammatory Agents.Corticosteroid.Glucocorticoids.Steroidal 20 0.366 34 4536 DB00717 Contraceptives, Oral, Synthetic.Progestins 20 0.366 40 2610 DB01140 Anti-Bacterial Agents.Cephalosporins 20 0.366 15 4189 DB01110 Antifungal Agents 20 0.366 5 2283 DB00626 Anti-Bacterial Agents.Anti-Infective Agents, Local 20 0.366 14 2133 DB00288 Corticosteroids, topical 20 0.366 17 3000 DB00547 Anti-inflammatory Agents.Glucocorticoids 20 0.366 23 5578 DB00440 Anti-Infective Agents, Urinary.Anti-Infectives.Antimalarials.Folic Acid Antagonists 20 0.366 12 4812 DB01022 Antifibrinolytic Agents.Vitamins.Vitamins (Vitamin K) #### component 21: positive weight features and high scoring objects #### # positive weight on target proteins 21 0.177 1 PSA6_HUMAN Proteasome subunit alpha type-6; 21 0.177 1 PRS6A_HUMAN 26S protease regulatory subunit 6A; 21 0.177 1 PSMD9_HUMAN 26S proteasome non-ATPase regulatory subunit 9; 21 0.177 1 PSB6_HUMAN Proteasome subunit beta type-6; 21 0.177 1 PSME3_HUMAN Proteasome activator complex subunit 3; 21 0.177 1 PSB2_HUMAN Proteasome subunit beta type-2; 21 0.177 1 PSB8_HUMAN Proteasome subunit beta type-8; 21 0.177 1 PSB4_HUMAN Proteasome subunit beta type-4; 21 0.177 1 PSMD2_HUMAN 26S proteasome non-ATPase regulatory subunit 2; 21 0.177 1 PSMD8_HUMAN 26S proteasome non-ATPase regulatory subunit 8; 21 0.177 1 PSA1_HUMAN Proteasome subunit alpha type-1; 21 0.177 1 PSA7_HUMAN Proteasome subunit alpha type-7; 21 0.177 1 DSS1_HUMAN 26S proteasome complex subunit DSS1; 21 0.177 1 PSDE_HUMAN 26S proteasome non-ATPase regulatory subunit 14; 21 0.177 1 PSB3_HUMAN Proteasome subunit beta type-3; 21 0.177 1 PSB5_HUMAN Proteasome subunit beta type-5; 21 0.177 1 PSD13_HUMAN 26S proteasome non-ATPase regulatory subunit 13; 21 0.177 1 CTRL_HUMAN Chymotrypsin-like protease CTRL-1; 21 0.177 1 PSA7L_HUMAN Proteasome subunit alpha type-7-like; 21 0.177 1 PSA5_HUMAN Proteasome subunit alpha type-5; 21 0.177 1 PSB10_HUMAN Proteasome subunit beta type-10; 21 0.177 1 PSMD4_HUMAN 26S proteasome non-ATPase regulatory subunit 4; 21 0.177 1 PSA3_HUMAN Proteasome subunit alpha type-3; 21 0.177 1 PRS7_HUMAN 26S protease regulatory subunit 7; 21 0.177 1 PSB9_HUMAN Proteasome subunit beta type-9; 21 0.177 1 PRS6B_HUMAN 26S protease regulatory subunit 6B; 21 0.177 1 PSB1_HUMAN Proteasome subunit beta type-1; 21 0.177 1 PSA2_HUMAN Proteasome subunit alpha type-2; 21 0.177 1 PSB7_HUMAN Proteasome subunit beta type-7; 21 0.177 1 PSMD1_HUMAN 26S proteasome non-ATPase regulatory subunit 1; 21 0.177 1 IKBA_HUMAN NF-kappa-B inhibitor alpha; 21 0.177 1 PSA4_HUMAN Proteasome subunit alpha type-4; # positive weight on side effects 21 0.361 1 failure to thrive 21 0.361 1 aspergillosis 21 0.361 1 bilateral hearing loss 21 0.361 1 postherpetic neuralgia 21 0.265 2 toxoplasmosis 21 0.265 2 ophthalmic herpes simplex 21 0.265 2 meningoencephalitis 21 0.265 2 polyarthritis 21 0.265 2 portal vein thrombosis 21 0.169 3 small intestinal obstruction 21 0.169 3 Sterility 21 0.169 3 autonomic neuropathy 21 0.169 3 renal tubular acidosis 21 0.073 4 bacteremia 21 0.073 4 acute pulmonary edema 21 0.073 4 amyloidosis # high scoring drugs for both targets and side effects 21 4.648 211 93860 DB00188 Antineoplastic Agents.Protease Inhibitors 21 0.123 215 60787 DB01232 Anti-HIV Agents.HIV Protease Inhibitors 21 0.123 91 3902 DB01006 Antineoplastic Agents.Aromatase Inhibitors 21 0.123 135 5544 DB00620 Adrenergic Agents.Anti-inflammatory Agents.Glucocorticoids 21 0.123 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 21 0.123 145 3672 DB01050 Analgesics.Analgesics, Non-Narcotic.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 21 0.111 234 216326 DB00480 Antineoplastic Agents #### component 22: positive weight features and high scoring objects #### # positive weight on target proteins 22 0.342 18 SCNND_HUMAN Amiloride-sensitive sodium channel subunit delta; 22 0.342 18 SCNNG_HUMAN Amiloride-sensitive sodium channel subunit gamma; 22 0.342 18 SCNNB_HUMAN Amiloride-sensitive sodium channel subunit beta; 22 0.243 17 ACCN3_HUMAN Amiloride-sensitive cation channel 3; 22 0.243 17 EF1B_HUMAN Elongation factor 1-beta; 22 0.243 17 SCNAA_HUMAN Sodium channel protein type 10 subunit alpha; 22 0.243 17 SCN1B_HUMAN Sodium channel subunit beta-1; 22 0.243 17 SCN4A_HUMAN Sodium channel protein type 4 subunit alpha; 22 0.243 17 SCN3A_HUMAN Sodium channel protein type 3 subunit alpha; 22 0.243 17 SCN7A_HUMAN Sodium channel protein type 7 subunit alpha; 22 0.243 17 ACCN4_HUMAN Amiloride-sensitive cation channel 4; 22 0.243 17 SCN3B_HUMAN Sodium channel subunit beta-3; 22 0.243 17 SCN4B_HUMAN Sodium channel subunit beta-4; 22 0.243 17 DB124_HUMAN Beta-defensin 124; # positive weight on side effects 22 0.469 105 psychosis 22 0.434 44 acidosis 22 0.322 38 loss of consciousness 22 0.277 42 encephalopathy 22 0.267 63 lupus 22 0.244 121 heart failure 22 0.23 8 meningismus 22 0.22 85 pulmonary embolism 22 0.211 162 urinary frequency 22 0.192 52 ventricular fibrillation 22 0.184 12 sinus arrest 22 0.15 55 dyskinesia 22 0.129 99 photophobia 22 0.118 123 urinary incontinence 22 0.078 233 tinnitus 22 0.061 64 AV block 22 0.026 159 increased sweating 22 0.023 40 fecal incontinence 22 0.017 191 peripheral edema 22 0.005 218 rhinitis 22 0.004 173 hyperglycemia # high scoring drugs for both targets and side effects 22 2.886 150 1775 DB00252 Anticonvulsants 22 2.704 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 22 2.697 135 5734 DB00909 Anticonvulsants.Antioxidants 22 2.693 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 22 2.68 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 22 2.503 112 71273 DB00296 Anesthetics.Anesthetics, Local.Local Anesthetics 22 2.358 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 22 2.316 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 22 2.294 74 3676 DB00281 Anesthetics.Anesthetics, Local.Anti-Arrhythmia Agents.Antiarrhythmic Agents 22 2.202 61 3114 DB00280 Anti-Arrhythmia Agents.Antiarrhythmic Agents 22 2.126 36 4914 DB00721 Anesthetics.Anesthetics, Local.Local Anesthetics 22 2.083 43 4913 DB01035 Anti-Arrhythmia Agents.Antiarrhythmic Agents 22 2.071 75 4178 DB00379 Anti-Arrhythmia Agents 22 2.006 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 22 1.949 95 16231 DB00594 Diuretics.Sodium channel blockers 22 1.93 91 3355 DB01195 Anti-Arrhythmia Agents.Antiarrhythmic Agents 22 1.926 51 48041 DB01228 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Sodium channel blockers 22 1.193 453 125889 DB00230 Analgesics.Anticonvulsants 22 0.999 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 22 0.947 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 22 0.847 201 5538 DB00755 Antineoplastic Agents.Cell Stimulants and Proliferants.Keratolytic Agents 22 0.845 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 22 0.835 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 22 0.832 264 5372 DB00864 Immunosuppressive Agents 22 0.81 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 22 0.762 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 22 0.732 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 22 0.728 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 22 0.723 143 4054 DB01043 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agents.Excitatory Amino Acid Antagonists 22 0.674 161 5487 DB00697 Adrenergic alpha-Agonists.Analgesics.Anticonvulsants.Muscle Relaxants.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 22 0.665 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 22 0.65 157 4659569 DB00323 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Enzyme Inhibitors 22 0.629 147 71158 DB00659 Alcohol Deterrents 22 0.621 183 3648 DB00327 Analgesics, Opioid.Narcotics 22 0.611 136 56339 DB01320 Anticonvulsants 22 0.608 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 22 0.578 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 22 0.564 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 22 0.556 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 22 0.551 181 4932 DB01182 Anti-Arrhythmia Agents 22 0.54 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 22 0.533 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 22 0.524 196 1935 DB00382 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 22 0.522 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 22 0.511 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 22 0.509 211 93860 DB00188 Antineoplastic Agents.Protease Inhibitors 22 0.494 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 22 0.487 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 22 0.472 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 22 0.46 158 34312 DB00776 Anticonvulsants 22 0.444 65 2474 DB00297 Anesthetics, Local 22 0.425 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 22 0.42 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 22 0.409 188 5040 DB00877 Anti-Bacterial Agents.Antibiotics, Antineoplastic.Antifungal Agents.Antifungals.Immunosuppressive Agents 22 0.409 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 22 0.409 161 122316 DB01367 Monoamine Oxidase Inhibitors.Neuroprotective Agents 22 0.399 84 3016 DB00829 Adjuvants, Anesthesia.Anesthetics, Intravenous.Anti-anxiety Agents.Anticonvulsants.Antiemetics.GABA Modulators.Hypnotics and Sedatives.Muscle Relaxants, Central 22 0.398 75 1978 DB01193 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents 22 0.386 63 3690 DB01181 Antineoplastic Agents.Antineoplastic Agents, Alkylating.Immunosuppressive Agents 22 0.365 78 2249 DB00335 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Sympatholytics 22 0.361 77 39860 DB00486 Anti-anxiety Agents.Antiemetics 22 0.36 211 60953 DB01101 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Prodrugs 22 0.355 138 2369 DB00195 Adrenergic beta-Antagonists.Antihypertensive Agents.EENT Drugs.Sympatholytics 22 0.324 146 3075 DB00343 Antihypertensive Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Cardiovascular Agents.Vasodilator Agents 22 0.314 132 3948 DB00978 Anti-Infective Agents.Anti-Infective Agents, Urinary.Antitubercular Agents.Photosensitizing Agents 22 0.312 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 22 0.31 132 4739 DB00552 Antibiotics.Antineoplastic Agents.Enzyme Inhibitors.Immunosuppressive Agents 22 0.301 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 22 0.301 154 3157 DB00590 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Anticholesteremic Agents.Antihypertensive Agents.Vasodilator Agents 22 0.297 101 2800 DB00822 Alcohol Deterrents.Enzyme Inhibitors 22 0.281 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 22 0.279 140 3143 DB01248 Antimalarials.Antineoplastic Agents.Antineoplastic Agents, Phytogenic.Radiation-Sensitizing Agents 22 0.276 119 5064 DB00811 Antimetabolites.Antiviral Agents 22 0.271 111 5281104 DB00910 Not Available 22 0.27 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 22 0.267 133 2802 DB01068 Anticonvulsants.Benzodiazepines.GABA Modulators 22 0.265 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists 22 0.264 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 22 0.264 102 4943 DB00818 Anesthetics, Intravenous.Anticonvulsants.Antiemetics.Free Radical Scavengers.Hypnotics and Sedatives 22 0.262 90 2477 DB00490 Anti-anxiety Agents.Anxiolytics sedatives and hypnotics.Serotonin Agonists 22 0.26 145 3672 DB01050 Analgesics.Analgesics, Non-Narcotic.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 22 0.256 68 27686 DB01003 Anti-Asthmatic Agents 22 0.256 103 2751 DB01340 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 22 0.256 21 5546 DB00384 Diuretics.Potassium-sparing Diuretics 22 0.254 73 3958 DB00186 Anti-anxiety Agents.Anticonvulsants.Antiemetics.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 22 0.252 25 3767 DB00951 Antitubercular Agents.Fatty Acid Synthesis Inhibitors 22 0.25 137 62959 DB00685 Anti-Infective Agents.Anti-Infectives.Fluoroquinolones 22 0.239 125 596 DB02097 Not Available 22 0.237 47 4927 DB01069 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists.Phenothiazine Derivatives 22 0.237 142 3826 DB00465 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 22 0.235 49 4078 DB00933 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 22 0.234 108 3015 DB04839 Androgen Antagonists 22 0.226 73 2769 DB00604 Anti-Ulcer Agents.Gastrointestinal Agents.Prokinetic Agents.Serotonin Agonists 22 0.225 171 2909 DB00091 Antifungal Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Immunomodulatory Agents.Immunosuppressive Agents 22 0.219 84 2995 DB01151 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Enzyme Inhibitors.Norepinephrine-Reuptake Inhibitors 22 0.215 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 22 0.207 215 60787 DB01232 Anti-HIV Agents.HIV Protease Inhibitors 22 0.205 196 3911 DB00007 Anti-Estrogen Agents.Antineoplastic Agents 22 0.194 117 2405 DB00612 Adrenergic Agents.Adrenergic beta-Antagonists.Antihypertensive Agents.Sympatholytics 22 0.192 52 5452 DB00679 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines #### component 23: positive weight features and high scoring objects #### # positive weight on target proteins 23 0.399 42 ADA1A_HUMAN Alpha-1A adrenergic receptor; 23 0.39 38 ADA2A_HUMAN Alpha-2A adrenergic receptor; 23 0.386 34 ADA1B_HUMAN Alpha-1B adrenergic receptor; 23 0.346 33 ADA2B_HUMAN Alpha-2B adrenergic receptor; 23 0.328 30 ADA1D_HUMAN Alpha-1D adrenergic receptor; 23 0.24 26 SC6A4_HUMAN Sodium-dependent serotonin transporter; 23 0.234 28 DRD3_HUMAN D(3) dopamine receptor; 23 0.229 28 DRD1_HUMAN D(1A) dopamine receptor; 23 0.202 35 DRD2_HUMAN D(2) dopamine receptor; 23 0.198 21 DRD5_HUMAN D(1B) dopamine receptor; 23 0.129 28 SC6A2_HUMAN Sodium-dependent noradrenaline transporter; 23 0.123 38 ADRB1_HUMAN Beta-1 adrenergic receptor; 23 0.097 9 GABR2_HUMAN Gamma-aminobutyric acid type B receptor subunit 2; 23 0.096 8 GBRR2_HUMAN Gamma-aminobutyric acid receptor subunit rho-2; 23 0.096 8 TSPOA_HUMAN Translocator protein; 23 0.062 12 AOFB_HUMAN Amine oxidase [flavin-containing] B; 23 0.041 6 DRD4_HUMAN D(4) dopamine receptor; 23 0.014 5 ATP4A_HUMAN Potassium-transporting ATPase alpha chain 1; 23 0.006 8 CALL3_HUMAN Calmodulin-like protein 3; # positive weight on side effects 23 0.494 301 dry mouth 23 0.376 73 ventricular tachycardia 23 0.33 123 urinary incontinence 23 0.29 185 impotence 23 0.267 146 abnormal vision 23 0.259 186 weight gain 23 0.208 244 arrhythmia 23 0.193 107 amnesia 23 0.139 134 cerebrovascular accident 23 0.086 322 hypotension 23 0.08 77 breast pain 23 0.034 170 angina pectoris 23 0.024 70 delirium 23 0.005 152 postural hypotension # high scoring drugs for both targets and side effects 23 2.174 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 23 2.116 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 23 1.852 87 5533 DB00656 Anti-anxiety Agents.Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 23 1.808 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 23 1.685 135 2585 DB01136 Adrenergic Agents.Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 23 1.638 52 5452 DB00679 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 23 1.599 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 23 1.555 51 3559 DB00502 Anti-Dyskinesia Agents.Antidyskinetics.Antiemetics.Antipsychotic Agents.Antipsychotics.Butyrophenones.Dopamine Antagonists 23 1.465 72 4893 DB00457 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Antihypertensive Agents 23 1.384 34 3518 DB01170 Adrenergic Agents.Antihypertensive Agents.Sympatholytics 23 1.381 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 23 1.334 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 23 1.326 76 2803 DB00575 Adrenergic alpha-Agonists.Analgesics.Antihypertensive Agents.Central Alpha-Agonists.Sympatholytics 23 1.306 61 4828 DB00960 Adrenergic beta-Antagonists.Antihypertensive Agents.Serotonin Antagonists.Vasodilator Agents 23 1.299 154 3157 DB00590 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Anticholesteremic Agents.Antihypertensive Agents.Vasodilator Agents 23 1.262 84 5401 DB01162 Adrenergic alpha-Antagonists.Antineoplastic Agents.Platelet Aggregation Inhibitors 23 1.231 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 23 1.217 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 23 1.188 84 2995 DB01151 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Enzyme Inhibitors.Norepinephrine-Reuptake Inhibitors 23 1.173 20 5775 DB00692 Adrenergic alpha-Antagonists.Antihypertensive Agents.Sympatholytics 23 1.172 77 3066 DB00320 Analgesics.Analgesics, Non-Narcotic.Anti-migraine Agents.Dopamine Agonists.Sympatholytics.Vasoconstrictor Agents 23 1.103 49 4078 DB00933 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 23 1.082 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 23 1.07 11 3251 DB00696 Adrenergic alpha-Agonists.Analgesics, Non-Narcotic.Sympatholytics.Vasoconstrictor Agents 23 1.069 60 3519 DB01018 Adrenergic alpha-Agonists.Antihypertensive Agents.Sympatholytics 23 1.056 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 23 1.054 64 2726 DB00477 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 23 1.006 69 3869 DB00598 Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Sympatholytics 23 1.005 118 4236 DB00745 Anorexigenic Agents.Central Nervous System Agents.Central Nervous System Stimulants.Neuroprotective Agents.Stimulants 23 1.0 167 5719 DB00962 Anticonvulsants.Anxiolytics sedatives and hypnotics.Hypnotics and Sedatives 23 0.971 62 3007 DB00182 Adrenergic Agents.Adrenergic Uptake Inhibitors.Amphetamines.Central Nervous System Stimulants.Dopamine Agents.Dopamine Uptake Inhibitors.Sympathomimetics 23 0.952 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 23 0.947 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 23 0.933 76 3661 DB00572 Adjuvants, Anesthesia.Anti-Arrhythmia Agents.Bronchodilator Agents.Muscarinic Antagonists.Mydriatics.Parasympatholytics 23 0.923 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 23 0.905 16 3168 DB00450 Adjuvants, Anesthesia.Antiemetics.Antipsychotic Agents.Dopamine Antagonists 23 0.901 453 125889 DB00230 Analgesics.Anticonvulsants 23 0.877 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 23 0.876 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 23 0.861 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 23 0.849 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 23 0.831 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists 23 0.82 34 4195 DB00211 Adrenergic alpha-Agonists.Sympathomimetics.Vasoconstrictor Agents 23 0.804 14 951 DB00368 Adrenergic alpha-Agonists.Sympathomimetics.Vasoconstrictor Agents 23 0.781 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 23 0.773 120 2284 DB00181 GABA Agonists.Muscle Relaxants.Muscle Relaxants, Central.Skeletal Muscle Relaxants 23 0.769 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 23 0.726 161 122316 DB01367 Monoamine Oxidase Inhibitors.Neuroprotective Agents 23 0.722 62 5566 DB00831 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 23 0.721 147 71158 DB00659 Alcohol Deterrents 23 0.721 16 5504 DB00797 Adrenergic alpha-Antagonists.Antihypertensive Agents.Vasodilator Agents 23 0.707 196 3911 DB00007 Anti-Estrogen Agents.Antineoplastic Agents 23 0.706 72 2160 DB00321 Adrenergic Uptake Inhibitors.Analgesics, Non-Narcotic.Antidepressive Agents, Tricyclic 23 0.705 53 2092 DB00346 Adrenergic alpha-Antagonists.Antihypertensive Agents 23 0.681 69 2512 DB00248 Antineoplastic Agents.Antiparkinson Agents.Dopamine Agonists 23 0.681 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 23 0.648 71 3372 DB00623 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 23 0.644 57 2443 DB01200 Antidyskinetics.Antiparkinson Agents.Dopamine Agonists.Hormone Antagonists 23 0.635 10 4436 Not Available Not Available 23 0.62 133 2802 DB01068 Anticonvulsants.Benzodiazepines.GABA Modulators 23 0.616 154 27661 DB01020 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 23 0.616 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 23 0.615 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 23 0.604 149 5394 DB00853 Antineoplastic Agents.Antineoplastic Agents, Alkylating 23 0.598 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 23 0.591 73 4493 DB00665 Androgen Antagonists.Antineoplastic Agents 23 0.576 4 4768 DB00925 Adrenergic alpha-Antagonists.Antihypertensive Agents.Vasodilator Agents 23 0.574 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 23 0.574 8 3241 DB00751 Antihistamines.Histamine H1 Antagonists.Ophthalmics 23 0.573 67 4976 DB00344 Adrenergic Uptake Inhibitors.Antidepressive Agents.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 23 0.572 61 60612 DB00633 Adrenergic alpha-Agonists.Analgesics.Analgesics, Non-Narcotic.Hypnotics and Sedatives 23 0.572 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 23 0.57 64 5584 DB00726 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 23 0.567 94 4171 DB00264 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Sympatholytics 23 0.567 138 2369 DB00195 Adrenergic beta-Antagonists.Antihypertensive Agents.EENT Drugs.Sympatholytics 23 0.565 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 23 0.562 129 5210 DB01105 Anorexigenic Agents.Antidepressants.Antidepressive Agents.Appetite Depressants.Stimulants 23 0.561 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 23 0.551 66 4011 DB00934 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Second-Generation 23 0.549 157 4659569 DB00323 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Enzyme Inhibitors 23 0.545 61 2435 DB00484 Adrenergic alpha-Agonists.Antihypertensive Agents.EENT Drugs 23 0.54 136 2375 DB01128 Androgen Antagonists.Antineoplastic Agents 23 0.54 161 5487 DB00697 Adrenergic alpha-Agonists.Analgesics.Anticonvulsants.Muscle Relaxants.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 23 0.54 76 4748 DB00850 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 23 0.533 69 3696 DB00458 Adrenergic Uptake Inhibitors.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 23 0.527 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 23 0.522 183 3648 DB00327 Analgesics, Opioid.Narcotics 23 0.519 35 16362 DB01100 Anti-Dyskinesia Agents.Antipsychotic Agents.Dopamine Antagonists 23 0.517 117 2182 DB00261 Antithrombotic Agents.Fibrinolytic Agents.Platelet Aggregation Inhibitors 23 0.517 69 2170 DB00543 Adrenergic Uptake Inhibitors.Antidepressive Agents, Second-Generation.Dopamine Antagonists.Neurotransmitter Uptake Inhibitors.Serotonin Uptake Inhibitors 23 0.516 57 5454 DB01623 Antipsychotic Agents.Dopamine Antagonists 23 0.516 17 1206 DB01577 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Agents.Dopamine Uptake Inhibitors.Sympathomimetics 23 0.512 157 3937 DB00722 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents.Cardiotonic Agents 23 0.511 33 3340 DB00800 Antihypertensive Agents.Dopamine Agonists.Vasodilator Agents 23 0.51 137 62959 DB00685 Anti-Infective Agents.Anti-Infectives.Fluoroquinolones 23 0.498 90 2162 DB00381 Antianginals.Antihypertensive Agents.Calcium Channel Blockers.Vasodilator Agents 23 0.484 128 2250 DB01076 Anticholesteremic Agents.Hydroxymethylglutaryl-CoA Reductase Inhibitors 23 0.483 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 23 0.48 73 2769 DB00604 Anti-Ulcer Agents.Gastrointestinal Agents.Prokinetic Agents.Serotonin Agonists 23 0.479 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) #### component 24: positive weight features and high scoring objects #### # positive weight on target proteins 24 0.59 35 DRD2_HUMAN D(2) dopamine receptor; 24 0.448 28 DRD3_HUMAN D(3) dopamine receptor; 24 0.432 28 DRD1_HUMAN D(1A) dopamine receptor; 24 0.171 21 DRD5_HUMAN D(1B) dopamine receptor; 24 0.167 36 ACM1_HUMAN Muscarinic acetylcholine receptor M1; 24 0.15 34 ACM2_HUMAN Muscarinic acetylcholine receptor M2; 24 0.135 29 GBRA1_HUMAN Gamma-aminobutyric acid receptor subunit alpha-1; 24 0.123 35 HRH1_HUMAN Histamine H1 receptor; 24 0.115 17 ACH10_HUMAN Neuronal acetylcholine receptor subunit alpha-10; 24 0.066 23 GBRA2_HUMAN Gamma-aminobutyric acid receptor subunit alpha-2; 24 0.052 15 ACHA4_HUMAN Neuronal acetylcholine receptor subunit alpha-4; 24 0.049 20 ACHA2_HUMAN Neuronal acetylcholine receptor subunit alpha-2; 24 0.042 14 ACHB2_HUMAN Neuronal acetylcholine receptor subunit beta-2; 24 0.042 14 ACHA6_HUMAN Neuronal acetylcholine receptor subunit alpha-6; 24 0.042 14 ACHA3_HUMAN Neuronal acetylcholine receptor subunit alpha-3; 24 0.042 14 ACHE_HUMAN Acetylcholine receptor subunit epsilon; 24 0.042 14 ACHA9_HUMAN Neuronal acetylcholine receptor subunit alpha-9; 24 0.039 16 G109B_HUMAN G-protein coupled receptor 109B; 24 0.038 21 GBRB3_HUMAN Gamma-aminobutyric acid receptor subunit beta-3; 24 0.038 21 GBRB1_HUMAN Gamma-aminobutyric acid receptor subunit beta-1; 24 0.038 21 GBRT_HUMAN Gamma-aminobutyric acid receptor subunit theta; 24 0.038 21 GBRD_HUMAN Gamma-aminobutyric acid receptor subunit delta; 24 0.038 21 GBRE_HUMAN Gamma-aminobutyric acid receptor subunit epsilon; 24 0.038 21 GBRB2_HUMAN Gamma-aminobutyric acid receptor subunit beta-2; 24 0.038 21 GBRG3_HUMAN Gamma-aminobutyric acid receptor subunit gamma-3; 24 0.038 21 GBRR1_HUMAN Gamma-aminobutyric acid receptor subunit rho-1; 24 0.038 21 GBRG2_HUMAN Gamma-aminobutyric acid receptor subunit gamma-2; 24 0.033 22 GBRA6_HUMAN Gamma-aminobutyric acid receptor subunit alpha-6; 24 0.033 22 GBRA3_HUMAN Gamma-aminobutyric acid receptor subunit alpha-3; 24 0.033 22 GBRA5_HUMAN Gamma-aminobutyric acid receptor subunit alpha-5; 24 0.033 22 GBRA4_HUMAN Gamma-aminobutyric acid receptor subunit alpha-4; # positive weight on side effects 24 0.17 205 bradycardia 24 0.154 210 agitation 24 0.134 70 delirium 24 0.062 71 glaucoma 24 0.05 55 dyskinesia 24 0.012 68 paralysis # high scoring drugs for both targets and side effects 24 1.369 20 5775 DB00692 Adrenergic alpha-Antagonists.Antihypertensive Agents.Sympatholytics 24 1.19 31 2215 DB00714 Antidyskinetics.Antiparkinson Agents.Dopamine Agonists 24 1.19 11 3251 DB00696 Adrenergic alpha-Agonists.Analgesics, Non-Narcotic.Sympatholytics.Vasoconstrictor Agents 24 1.064 23 3821 DB01221 Analgesics.Anesthetics, Dissociative.Excitatory Amino Acid Antagonists.General Anesthetics 24 1.05 33 3340 DB00800 Antihypertensive Agents.Dopamine Agonists.Vasodilator Agents 24 1.023 23 4737 DB00312 Adjuvants, Anesthesia.Barbiturates.GABA Modulators.Hypnotics and Sedatives 24 1.02 49 4168 DB01233 Antiemetics.Dopamine Antagonists.Prokinetic Agents 24 1.015 90 2477 DB00490 Anti-anxiety Agents.Anxiolytics sedatives and hypnotics.Serotonin Agonists 24 0.982 71 3372 DB00623 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 24 0.955 35 16362 DB01100 Anti-Dyskinesia Agents.Antipsychotic Agents.Dopamine Antagonists 24 0.941 59 4917 DB00433 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 24 0.922 57 2443 DB01200 Antidyskinetics.Antiparkinson Agents.Dopamine Agonists.Hormone Antagonists 24 0.921 57 5454 DB01623 Antipsychotic Agents.Dopamine Antagonists 24 0.905 49 4078 DB00933 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 24 0.905 52 5452 DB00679 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 24 0.904 62 5566 DB00831 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 24 0.896 26 3151 DB01184 Antiemetics.Dopamine Antagonists 24 0.871 76 4748 DB00850 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 24 0.858 61 4192 DB00683 Adjuvants, Anesthesia.Anesthetics, Intravenous.Anti-anxiety Agents.GABA Modulators.Hypnotics and Sedatives 24 0.846 69 2512 DB00248 Antineoplastic Agents.Antiparkinson Agents.Dopamine Agonists 24 0.836 51 3964 DB00408 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists 24 0.825 13 36339 DB00292 Anesthetics, Intravenous.Hypnotics and Sedatives 24 0.803 51 3559 DB00502 Anti-Dyskinesia Agents.Antidyskinetics.Antiemetics.Antipsychotic Agents.Antipsychotics.Butyrophenones.Dopamine Antagonists 24 0.802 64 2726 DB00477 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 24 0.801 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 24 0.799 47 4927 DB01069 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists.Phenothiazine Derivatives 24 0.795 7 2551 DB00411 Analgesics, Non-Narcotic.Cardiotonic Agents.Cholinergic Agonists.Miotics 24 0.795 11 4919 DB00387 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists 24 0.789 23 5193 DB00418 Adjuvants.Adjuvants, Anesthesia.Barbiturates.GABA Modulators.Hypnotics and Sedatives 24 0.789 55 2130 DB00915 Analgesics, Non-Narcotic.Antiparkinson Agents.Antiviral Agents.Dopamine Agents 24 0.774 16 3168 DB00450 Adjuvants, Anesthesia.Antiemetics.Antipsychotic Agents.Dopamine Antagonists 24 0.77 102 4943 DB00818 Anesthetics, Intravenous.Anticonvulsants.Antiemetics.Free Radical Scavengers.Hypnotics and Sedatives 24 0.753 73 3958 DB00186 Anti-anxiety Agents.Anticonvulsants.Antiemetics.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 24 0.747 8 2381 DB00810 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists.Parasympatholytics 24 0.74 7 3562 DB01159 Anesthetics.Anesthetics, Inhalation.General Anesthetics 24 0.738 58 5206 DB01236 Anesthetics, Inhalation.Platelet Aggregation Inhibitors 24 0.721 14 47319 DB00732 Neuromuscular Nondepolarizing Agents.Nicotinic Antagonists 24 0.703 24 4140 DB00353 Oxytocics 24 0.703 15 681 DB00988 Cardiotonic Agents.Dopamine Agents.Sympathomimetic.Sympathomimetics 24 0.696 16 3763 DB00753 Anesthetics.Anesthetics, Inhalation.General Anesthetics 24 0.678 16 5314 DB00202 Neuromuscular Depolarizing Agents.Skeletal Muscle Relaxants 24 0.673 60 3373 DB01205 Antidotes.GABA Modulators 24 0.67 17 1206 DB01577 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Agents.Dopamine Uptake Inhibitors.Sympathomimetics 24 0.669 25 5572 DB00376 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists 24 0.667 25 9034 DB00474 Anesthetics.Anesthetics, Intravenous.Barbiturates 24 0.662 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 24 0.648 84 2995 DB01151 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Enzyme Inhibitors.Norepinephrine-Reuptake Inhibitors 24 0.643 76 3661 DB00572 Adjuvants, Anesthesia.Anti-Arrhythmia Agents.Bronchodilator Agents.Muscarinic Antagonists.Mydriatics.Parasympatholytics 24 0.636 19 4032 DB00657 Antihypertensive Agents.Ganglionic Blockers.Nicotinic Antagonists 24 0.636 5 10548 DB01057 Cholinesterase Inhibitors.Miotics.Parasympathomimetics 24 0.629 10 2712 DB00475 Adjuvants, Anesthesia.Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 24 0.622 4 4768 DB00925 Adrenergic alpha-Antagonists.Antihypertensive Agents.Vasodilator Agents 24 0.611 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 24 0.598 36 2564 DB00748 Antihistamines 24 0.594 30 8612 DB01161 Anesthetics, Local 24 0.587 14 104803 DB01226 Neuromuscular Nondepolarizing Agents 24 0.57 28 4058 DB00454 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 24 0.569 16 2905 DB00979 Antimuscarinic eye preparations.Muscarinic Antagonists.Mydriatics.Parasympatholytics 24 0.566 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 24 0.564 23 51263 DB00802 Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 24 0.561 15 2370 DB01019 Muscarinic Agonists.Parasympathomimetics 24 0.561 9 5593 DB00809 Diagnostic aid, cycloplegic.Diagnostic aid, mydriatic.Muscarinic Antagonists.Mydriatics 24 0.561 19 2344 DB00245 Antidyskinetics.Antiparkinson Agents.Dopamine Uptake Inhibitors.Muscarinic Antagonists.Parasympatholytics 24 0.545 11 2131 DB01122 Antiarrhythmic Agents.Antimyasthenics 24 0.542 38 3393 DB00690 Anti-anxiety Agents.GABA Modulators.Hypnotics and Sedatives 24 0.537 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 24 0.536 86 115237 DB01267 Antipsychotic Agents 24 0.535 19 4934 DB00782 Anti-Ulcer Agents.Antimuscarinics.Antispasmodics.Muscarinic Antagonists 24 0.52 91 60815 DB00899 Analgesics, Opioid.Anesthetics, Intravenous.Hypnotics and Sedatives 24 0.518 44 191 DB00640 Analgesics.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Cardiac drugs.Vasodilator Agents 24 0.518 31 5052 DB00206 Adrenergic Uptake Inhibitors.Antihypertensive Agents.Antipsychotic Agents.Antipsychotics.Peripheral Adrenergic Inhibitors 24 0.517 27 23897 DB01618 Antipsychotic Agents 24 0.515 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 24 0.515 32 2725 DB01114 Anti-Allergic Agents.Antihistamines.Antipruritics.Histamine H1 Antagonists 24 0.515 37 2781 DB00283 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists 24 0.515 36 4914 DB00721 Anesthetics.Anesthetics, Local.Local Anesthetics 24 0.515 37 3100 DB01075 Anesthetics.Anesthetics, Local.Anti-Allergic Agents.Antidyskinetics.Antiemetics.Antiparkinson Agents.Antipruritics.Antitussives.Ethanolamine Derivatives.Histamine H1 Antagonists.Hypnotics and Sedatives 24 0.512 31 2441 DB01558 Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 24 0.508 12 60169 DB01334 Neuromuscular Nondepolarizing Agents 24 0.508 21 60696 DB00728 Neuromuscular Nondepolarizing Agents.Skeletal Muscle Relaxants 24 0.501 69 3696 DB00458 Adrenergic Uptake Inhibitors.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 24 0.5 120 2284 DB00181 GABA Agonists.Muscle Relaxants.Muscle Relaxants, Central.Skeletal Muscle Relaxants 24 0.494 62 59768 DB00187 Adrenergic beta-Antagonists 24 0.487 14 951 DB00368 Adrenergic alpha-Agonists.Sympathomimetics.Vasoconstrictor Agents 24 0.487 23 41693 DB00708 Adjuvants, Anesthesia.Analgesics, Opioid.Anesthetics, Intravenous.Narcotics.Opiate Agonists 24 0.487 30 42113 DB01189 Anesthetics, Inhalation.Neuroprotective Agents 24 0.479 20 838 DB00668 Adrenergic Agonists.Adrenergic alpha-Agonists.Adrenergic beta-Agonists.Bronchodilator Agents.Mydriatics.Sympathomimetics.Vasoconstrictor Agents 24 0.479 33 4425 DB01183 Antinarcotic Agents.Depressants.Narcotic Antagonists.Opiate Antagonists 24 0.47 12 4909 DB00794 Anticonvulsants.Barbiturates 24 0.47 10 3226 DB00228 Anesthetics, Inhalation.General Anesthetics 24 0.469 10 271 DB01373 Not Available 24 0.469 28 2719 DB00608 Amebicides.Antimalarials.Antirheumatic Agents 24 0.465 74 4894 DB00860 Adrenergic Agents.Anti-inflammatory Agents.Antineoplastic Agents.Antineoplastic Agents, Hormonal.Glucocorticoids 24 0.465 86 3003 DB01234 Adrenergic Agents.Anti-inflammatory Agents.Antiemetics.Antineoplastic Agents, Hormonal.Glucocorticoids 24 0.464 9 3658 DB00557 Antipruritics.Anxiolytics sedatives and hypnotics.Histamine H1 Antagonists 24 0.464 3 4034 DB00737 Anti-Allergic Agents.Antiemetics.Antihistamines.Histamine H1 Antagonists 24 0.458 65 2474 DB00297 Anesthetics, Local 24 0.458 74 3676 DB00281 Anesthetics.Anesthetics, Local.Anti-Arrhythmia Agents.Antiarrhythmic Agents 24 0.456 20 4601 DB01173 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 24 0.453 12 4771 DB00191 Adrenergic Agents.Anorexigenic Agents.Appetite Depressants.Central Nervous System Agents.Central Nervous System Stimulants.Stimulants.Sympathomimetics #### component 25: positive weight features and high scoring objects #### # positive weight on target proteins 25 0.628 29 PGH2_HUMAN Prostaglandin G/H synthase 2; 25 0.562 23 PGH1_HUMAN Prostaglandin G/H synthase 1; 25 0.231 14 LOX5_HUMAN Arachidonate 5-lipoxygenase; 25 0.18 14 TTHY_HUMAN Transthyretin; 25 0.177 10 LKHA4_HUMAN Leukotriene A-4 hydrolase; 25 0.171 8 LOX12_HUMAN Arachidonate 12-lipoxygenase, 12S-type; 25 0.171 8 LX12B_HUMAN Arachidonate 12-lipoxygenase, 12R-type; 25 0.171 8 LOXE3_HUMAN Epidermis-type lipoxygenase 3; 25 0.129 26 SC6A4_HUMAN Sodium-dependent serotonin transporter; 25 0.108 7 LX15B_HUMAN Arachidonate 15-lipoxygenase B; 25 0.096 8 LOX15_HUMAN Arachidonate 15-lipoxygenase; 25 0.064 6 CRP_HUMAN C-reactive protein; 25 0.062 9 GABR2_HUMAN Gamma-aminobutyric acid type B receptor subunit 2; 25 0.057 6 DRD4_HUMAN D(4) dopamine receptor; 25 0.044 5 ATP4A_HUMAN Potassium-transporting ATPase alpha chain 1; 25 0.041 4 NPTXR_HUMAN Neuronal pentraxin receptor; 25 0.041 4 NPTX1_HUMAN Neuronal pentraxin-1; 25 0.041 4 NPTX2_HUMAN Neuronal pentraxin-2; 25 0.034 13 CAC1A_HUMAN Voltage-dependent P/Q-type calcium channel subunit alpha-1A; 25 0.024 9 CHLE_HUMAN Cholinesterase; 25 0.019 16 TOP2A_HUMAN DNA topoisomerase 2-alpha; 25 0.016 8 TSPOA_HUMAN Translocator protein; 25 0.016 8 GBRR2_HUMAN Gamma-aminobutyric acid receptor subunit rho-2; 25 0.011 11 ACES_HUMAN Acetylcholinesterase; 25 0.01 18 SCNNB_HUMAN Amiloride-sensitive sodium channel subunit beta; 25 0.01 18 SCNNG_HUMAN Amiloride-sensitive sodium channel subunit gamma; 25 0.01 18 SCNND_HUMAN Amiloride-sensitive sodium channel subunit delta; 25 0.01 5 SCN1A_HUMAN Sodium channel protein type 1 subunit alpha; 25 0.009 5 GABT_HUMAN 4-aminobutyrate aminotransferase, mitochondrial; 25 0.004 15 CAC1H_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1H; 25 0.004 15 CAC1I_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1I; 25 0.002 5 VEGFA_HUMAN Vascular endothelial growth factor A; 25 0.001 17 SCN3B_HUMAN Sodium channel subunit beta-3; 25 0.001 17 SCN7A_HUMAN Sodium channel protein type 7 subunit alpha; 25 0.001 17 SCN3A_HUMAN Sodium channel protein type 3 subunit alpha; 25 0.001 17 SCN1B_HUMAN Sodium channel subunit beta-1; 25 0.001 17 SCNAA_HUMAN Sodium channel protein type 10 subunit alpha; 25 0.001 17 EF1B_HUMAN Elongation factor 1-beta; 25 0.001 17 ACCN3_HUMAN Amiloride-sensitive cation channel 3; 25 0.001 17 SCN4B_HUMAN Sodium channel subunit beta-4; 25 0.001 17 SCN4A_HUMAN Sodium channel protein type 4 subunit alpha; 25 0.001 17 ACCN4_HUMAN Amiloride-sensitive cation channel 4; 25 0.001 17 DB124_HUMAN Beta-defensin 124; # positive weight on side effects 25 0.468 82 rectal hemorrhage 25 0.366 59 heartburn 25 0.364 107 melena 25 0.331 101 cystitis 25 0.321 23 nephrotic syndrome 25 0.29 15 aseptic meningitis 25 0.197 208 anaphylaxis 25 0.195 68 hearing loss 25 0.157 43 elevated liver enzymes 25 0.157 252 malaise 25 0.155 195 conjunctivitis 25 0.149 62 hematemesis 25 0.138 190 epistaxis 25 0.086 144 gastritis 25 0.085 90 colitis 25 0.081 101 esophagitis 25 0.055 118 exfoliative dermatitis 25 0.032 119 gastroenteritis 25 0.021 53 proteinuria 25 0.006 48 ulcerative stomatitis 25 0.004 101 ulcer # high scoring drugs for both targets and side effects 25 2.78 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 25 2.457 145 3672 DB01050 Analgesics.Analgesics, Non-Narcotic.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 25 2.331 92 3825 DB01009 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 25 2.217 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 25 2.053 166 3394 DB00712 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Carbonic Anhydrase Inhibitors.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 25 1.833 120 3715 DB00328 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cardiovascular Agents.Cyclooxygenase Inhibitors.Gout Suppressants.Nonsteroidal Antiinflammatory Agents (NSAIDs).Tocolytic Agents 25 1.831 142 3826 DB00465 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 25 1.736 119 3308 DB00749 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 25 1.66 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 25 1.606 108 4856 DB00554 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 25 1.592 89 4044 DB00784 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 25 1.57 104 4614 DB00991 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Nonsteroidal Antiinflammatory Agents (NSAIDs) 25 1.183 46 4036 DB00939 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 25 1.166 103 5352 DB00605 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents.Cyclooxygenase Inhibitors 25 1.11 94 4409 DB00461 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents 25 1.083 154 5090 DB00533 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase 2 Inhibitors.Cyclooxygenase Inhibitors 25 1.032 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 25 1.0 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 25 0.935 24 2244 DB00945 Anti-Inflammatory Agents, Non-Steroidal.Anticoagulants.Cyclooxygenase Inhibitors.Fibrinolytic Agents.Platelet Aggregation Inhibitors.Salicylates 25 0.932 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 25 0.921 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 25 0.918 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 25 0.918 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 25 0.91 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 25 0.895 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 25 0.886 234 216326 DB00480 Antineoplastic Agents 25 0.865 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 25 0.852 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 25 0.847 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 25 0.836 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 25 0.825 60 3059 DB00861 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 25 0.821 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 25 0.819 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 25 0.812 199 5358 DB00669 Selective Serotonin Agonists.Serotonin Agonists.Vasoconstrictor Agents 25 0.808 71 3342 DB00573 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Propionic acid derivatives 25 0.805 81 5353980 DB00795 Anti-Infective Agents.Anti-Inflammatory Agents, Non-Steroidal.Antirheumatic Agents.Gastrointestinal Agents.Sulfonamides 25 0.783 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 25 0.775 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 25 0.773 453 125889 DB00230 Analgesics.Anticonvulsants 25 0.76 34 3827 DB00920 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists 25 0.759 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 25 0.746 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 25 0.721 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 25 0.715 133 4112 DB00563 Abortifacient Agents.Abortifacient Agents, Nonsteroidal.Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Folic Acid Antagonists.Immunosuppressive Agents.Nucleic Acid Synthesis Inhibitors 25 0.713 181 4932 DB01182 Anti-Arrhythmia Agents 25 0.713 144 3899 DB01097 Adjuvants.Anti-inflammatory Agents.Antineoplastic Agents.Antiparasitic Agents.Antirheumatic Agents.Antiviral Agents.Enzyme Inhibitors.Immunosuppressive Agents 25 0.713 215 60787 DB01232 Anti-HIV Agents.HIV Protease Inhibitors 25 0.709 128 2250 DB01076 Anticholesteremic Agents.Hydroxymethylglutaryl-CoA Reductase Inhibitors 25 0.705 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 25 0.702 167 5719 DB00962 Anticonvulsants.Anxiolytics sedatives and hypnotics.Hypnotics and Sedatives 25 0.7 236 10631 DB00603 Contraceptives.Contraceptives, Oral, Synthetic.Progestins 25 0.688 211 93860 DB00188 Antineoplastic Agents.Protease Inhibitors 25 0.685 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 25 0.683 119 4052 DB00814 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Antiemetics.Antineoplastic Agents.Cyclooxygenase Inhibitors.Growth Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 25 0.666 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 25 0.656 142 2678 DB00341 Anti-Allergic Agents.Antihistamines.Histamine H1 Antagonists, Non-Sedating 25 0.645 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 25 0.643 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 25 0.643 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 25 0.632 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 25 0.605 43 5508 DB00500 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 25 0.6 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 25 0.594 161 5212 DB00203 Phosphodiesterase Inhibitors.Vasodilator Agents 25 0.591 201 5538 DB00755 Antineoplastic Agents.Cell Stimulants and Proliferants.Keratolytic Agents 25 0.584 166 54374 DB00104 Anabolic Agents.Antineoplastic Agents, Hormonal.Gastrointestinal Agents.Hormone Replacement Agents 25 0.567 158 34312 DB00776 Anticonvulsants 25 0.567 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 25 0.566 154 3157 DB00590 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Anticholesteremic Agents.Antihypertensive Agents.Vasodilator Agents 25 0.557 147 71158 DB00659 Alcohol Deterrents 25 0.549 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 25 0.548 104 3449 DB00674 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 25 0.532 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 25 0.531 46 5362070 DB01014 Anti-Inflammatory Agents, Non-Steroidal.Anti-Ulcer Agents.Gastrointestinal Agents 25 0.528 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 25 0.522 135 5734 DB00909 Anticonvulsants.Antioxidants 25 0.52 107 3410 DB00983 Adrenergic beta-Agonists.Bronchodilator Agents.Sympathomimetic 25 0.516 146 3475 DB01120 Hypoglycemic Agents.Sulfonylureas 25 0.501 211 60953 DB01101 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Prodrugs 25 0.499 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 25 0.496 128 3793 DB01167 Antifungal Agents.Antifungals.Antiprotozoal Agents.Antiprotozoals 25 0.495 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 25 0.471 183 3648 DB00327 Analgesics, Opioid.Narcotics 25 0.465 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 25 0.439 147 5645 DB01586 Cholagogues and Choleretics 25 0.433 118 65999 DB00966 Angiotensin II Type 1 Receptor Blockers.Angiotensin-converting Enzyme Inhibitors 25 0.429 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 25 0.426 185 4594 DB00338 Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 25 0.408 161 5487 DB00697 Adrenergic alpha-Agonists.Analgesics.Anticonvulsants.Muscle Relaxants.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 25 0.407 85 3385 DB00544 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Immunosuppressive Agents 25 0.402 106 216239 DB00398 Anticancer Agents.Antineoplastic Agents.Protein Kinase Inhibitors 25 0.4 134 3339 DB01039 Antilipemic Agents.Fribic Acid Derivatives 25 0.395 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 25 0.394 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 25 0.388 133 2802 DB01068 Anticonvulsants.Benzodiazepines.GABA Modulators 25 0.363 97 159 DB01240 Antihypertensive Agents.Platelet Aggregation Inhibitors 25 0.363 126 104865 DB00559 Antihypertensive Agents 25 0.362 264 5372 DB00864 Immunosuppressive Agents 25 0.358 171 2909 DB00091 Antifungal Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Immunomodulatory Agents.Immunosuppressive Agents 25 0.351 114 5379 DB01044 Anti-Infective Agents.Antibiotics 25 0.346 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists #### component 26: positive weight features and high scoring objects #### # positive weight on target proteins 26 0.546 12 ACE_HUMAN Angiotensin-converting enzyme; 26 0.375 18 CAC1C_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1C; 26 0.34 17 CCG1_HUMAN Voltage-dependent calcium channel gamma-1 subunit; 26 0.31 16 CAC1F_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1F; 26 0.31 16 CAC1D_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1D; 26 0.31 16 CACB2_HUMAN Voltage-dependent L-type calcium channel subunit beta-2; 26 0.231 13 CAC1B_HUMAN Voltage-dependent N-type calcium channel subunit alpha-1B; 26 0.15 13 CAC1A_HUMAN Voltage-dependent P/Q-type calcium channel subunit alpha-1A; 26 0.149 16 CAC1G_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1G; 26 0.09 15 CAC1I_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1I; 26 0.09 15 CAC1H_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1H; 26 0.081 13 CACB1_HUMAN Voltage-dependent L-type calcium channel subunit beta-1; 26 0.051 12 PKD1_HUMAN Polycystin-1; 26 0.051 12 ITPR1_HUMAN Inositol 1,4,5-trisphosphate receptor type 1; 26 0.051 12 ITPR3_HUMAN Inositol 1,4,5-trisphosphate receptor type 3; 26 0.051 12 CA2D1_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-1; 26 0.051 12 CACB4_HUMAN Voltage-dependent L-type calcium channel subunit beta-4; 26 0.051 12 PKD2_HUMAN Polycystin-2; 26 0.051 12 TRPA1_HUMAN Transient receptor potential cation channel subfamily A member 1; 26 0.051 12 TRPV6_HUMAN Transient receptor potential cation channel subfamily V member 6; 26 0.051 12 CAC1S_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1S; 26 0.051 12 CACB3_HUMAN Voltage-dependent L-type calcium channel subunit beta-3; 26 0.051 12 CCG4_HUMAN Voltage-dependent calcium channel gamma-4 subunit; 26 0.051 12 CAC1E_HUMAN Voltage-dependent R-type calcium channel subunit alpha-1E; 26 0.051 12 CCG2_HUMAN Voltage-dependent calcium channel gamma-2 subunit; 26 0.051 12 CCG7_HUMAN Voltage-dependent calcium channel gamma-7 subunit; # positive weight on side effects 26 0.592 191 hepatitis 26 0.376 135 muscle cramps 26 0.346 282 arthralgia 26 0.289 280 myalgia 26 0.277 128 gastrointestinal hemorrhage 26 0.221 222 flushing 26 0.145 222 flatulence 26 0.142 122 erythema multiforme 26 0.138 274 palpitations 26 0.134 179 myocardial infarction 26 0.133 377 constipation 26 0.132 205 angioedema 26 0.118 121 heart failure 26 0.102 131 diplopia 26 0.1 152 postural hypotension 26 0.097 280 chest pain 26 0.095 107 amnesia 26 0.082 320 fatigue 26 0.071 304 Dyspepsia 26 0.034 301 dry mouth 26 0.024 284 syncope 26 0.009 159 increased sweating 26 0.003 75 amblyopia # high scoring drugs for both targets and side effects 26 2.727 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 26 2.527 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 26 2.49 146 3075 DB00343 Antihypertensive Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Cardiovascular Agents.Vasodilator Agents 26 2.464 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 26 2.444 73 3333 DB01023 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Calcium Channel Blockers.Dihydropyridines.Vasodilator Agents 26 2.3 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 26 2.19 150 1775 DB00252 Anticonvulsants 26 2.054 95 16231 DB00594 Diuretics.Sodium channel blockers 26 1.949 90 2162 DB00381 Antianginals.Antihypertensive Agents.Calcium Channel Blockers.Vasodilator Agents 26 1.753 57 2951 DB01219 Muscle Relaxants, Central 26 1.423 53 3784 DB00270 Antihypertensive Agents.Calcium Channel Blockers.Vasodilator Agents 26 1.327 29 3954 DB00836 Antidiarrheals 26 1.212 31 4497 DB00393 Antihypertensive Agents.Calcium Channel Blockers.Vasodilator Agents 26 1.208 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 26 1.167 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 26 1.155 152 60184 DB00790 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 26 1.137 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 26 1.129 103 2751 DB01340 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 26 1.122 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 26 1.112 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 26 1.11 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 26 1.107 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 26 1.103 157 3937 DB00722 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents.Cardiotonic Agents 26 1.071 154 3157 DB00590 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Anticholesteremic Agents.Antihypertensive Agents.Vasodilator Agents 26 1.047 98 3222 DB00584 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 26 1.045 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 26 1.042 264 5372 DB00864 Immunosuppressive Agents 26 1.04 35 16362 DB01100 Anti-Dyskinesia Agents.Antipsychotic Agents.Dopamine Antagonists 26 1.029 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 26 1.028 100 5038 DB00178 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 26 1.017 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 26 1.013 111 3419 DB00492 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 26 0.961 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 26 0.957 7 3562 DB01159 Anesthetics.Anesthetics, Inhalation.General Anesthetics 26 0.937 87 5005 DB00881 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 26 0.936 185 4594 DB00338 Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 26 0.933 151 60835 DB00476 Adrenergic Uptake Inhibitors.Antidepressive Agents.Dopamine Uptake Inhibitors.Serotonin Uptake Inhibitors 26 0.927 116 5525 DB00519 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 26 0.926 154 5090 DB00533 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase 2 Inhibitors.Cyclooxygenase Inhibitors 26 0.918 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 26 0.917 103 5352 DB00605 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents.Cyclooxygenase Inhibitors 26 0.914 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 26 0.903 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 26 0.903 161 5291 DB00619 Antineoplastic Agents.Protein Kinase Inhibitors 26 0.894 131 4428 DB00704 Alcohol Antagonists.Anti-craving Agents.Depressants.Narcotic Antagonists.Opiate Antagonists 26 0.89 144 3702 DB00808 Antihypertensive Agents.Diuretics 26 0.88 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 26 0.879 211 93860 DB00188 Antineoplastic Agents.Protease Inhibitors 26 0.875 453 125889 DB00230 Analgesics.Anticonvulsants 26 0.872 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 26 0.869 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 26 0.862 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 26 0.862 123 2806 DB00758 Antiplatelet Agents.Fibrinolytic Agents.Platelet Aggregation Inhibitors 26 0.849 55 91270 DB00691 Angiotensin-converting Enzyme Inhibitors 26 0.847 172 4920 DB00396 Contraceptives.Progestins 26 0.841 131 3961 DB00678 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents 26 0.84 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 26 0.839 79 2311 DB00542 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 26 0.828 126 104865 DB00559 Antihypertensive Agents 26 0.823 137 62959 DB00685 Anti-Infective Agents.Anti-Infectives.Fluoroquinolones 26 0.813 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 26 0.794 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 26 0.794 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 26 0.792 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 26 0.791 87 2676 DB00439 Anticholesteremic Agents.Antilipemic Agents.Hydroxymethylglutaryl-CoA Reductase Inhibitors 26 0.787 75 2550 DB01197 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 26 0.787 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 26 0.783 132 3948 DB00978 Anti-Infective Agents.Anti-Infective Agents, Urinary.Antitubercular Agents.Photosensitizing Agents 26 0.78 128 2250 DB01076 Anticholesteremic Agents.Hydroxymethylglutaryl-CoA Reductase Inhibitors 26 0.775 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 26 0.76 137 3062316 DB01254 Protein Kinase Inhibitors 26 0.749 99 4889 DB00175 Anticholesteremic Agents.HMG-CoA Reductase Inhibitors.Hydroxymethylglutaryl-CoA Reductase Inhibitors 26 0.736 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 26 0.735 201 5538 DB00755 Antineoplastic Agents.Cell Stimulants and Proliferants.Keratolytic Agents 26 0.728 147 71158 DB00659 Alcohol Deterrents 26 0.725 236 10631 DB00603 Contraceptives.Contraceptives, Oral, Synthetic.Progestins 26 0.718 183 3648 DB00327 Analgesics, Opioid.Narcotics 26 0.716 191 450 DB00783 Anti-menopausal Agents.Anticholesteremic Agents.Estrogens 26 0.711 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 26 0.71 140 3143 DB01248 Antimalarials.Antineoplastic Agents.Antineoplastic Agents, Phytogenic.Radiation-Sensitizing Agents 26 0.708 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 26 0.705 116 5376 DB00675 Antineoplastic Agents, Hormonal.Bone Density Conservation Agents.Estrogen Antagonists.Selective Estrogen Receptor Modulators 26 0.697 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 26 0.694 94 3403 DB01095 Anticholesteremic Agents.Antioxidants.Free Radical Scavengers.HMG-CoA Reductase Inhibitors.Hydroxymethylglutaryl-CoA Reductase Inhibitors 26 0.691 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 26 0.691 211 60953 DB01101 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Prodrugs 26 0.686 157 4659569 DB00323 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Enzyme Inhibitors 26 0.682 128 3793 DB01167 Antifungal Agents.Antifungals.Antiprotozoal Agents.Antiprotozoals 26 0.678 234 216326 DB00480 Antineoplastic Agents 26 0.669 77 3962 DB00227 Anticholesteremic Agents.Antineoplastic Agents.HMG-CoA Reductase Inhibitors.Hydroxymethylglutaryl-CoA Reductase Inhibitors 26 0.66 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 26 0.649 106 4539 DB01059 Anti-Bacterial Agents.Anti-Infectives.Enzyme Inhibitors.Nucleic Acid Synthesis Inhibitors.Quinolones 26 0.645 142 3826 DB00465 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 26 0.645 199 5358 DB00669 Selective Serotonin Agonists.Serotonin Agonists.Vasoconstrictor Agents 26 0.644 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 26 0.643 142 2678 DB00341 Anti-Allergic Agents.Antihistamines.Histamine H1 Antagonists, Non-Sedating 26 0.638 154 27661 DB01020 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 26 0.638 82 3749 DB01029 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 26 0.637 215 60787 DB01232 Anti-HIV Agents.HIV Protease Inhibitors 26 0.634 144 3899 DB01097 Adjuvants.Anti-inflammatory Agents.Antineoplastic Agents.Antiparasitic Agents.Antirheumatic Agents.Antiviral Agents.Enzyme Inhibitors.Immunosuppressive Agents #### component 27: positive weight features and high scoring objects #### # positive weight on target proteins 27 0.782 29 PGH2_HUMAN Prostaglandin G/H synthase 2; 27 0.077 16 ANDR_HUMAN Androgen receptor; 27 0.033 29 GBRA1_HUMAN Gamma-aminobutyric acid receptor subunit alpha-1; # positive weight on side effects # high scoring drugs for both targets and side effects 27 0.797 14 2749 DB01188 Antifungal Agents 27 0.797 7 5359 DB00870 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 27 0.797 9 5342 DB01138 Uricosuric Agents 27 0.774 24 2244 DB00945 Anti-Inflammatory Agents, Non-Steroidal.Anticoagulants.Cyclooxygenase Inhibitors.Fibrinolytic Agents.Platelet Aggregation Inhibitors.Salicylates 27 0.702 46 5362070 DB01014 Anti-Inflammatory Agents, Non-Steroidal.Anti-Ulcer Agents.Gastrointestinal Agents 27 0.67 103 5352 DB00605 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents.Cyclooxygenase Inhibitors 27 0.631 60 3059 DB00861 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 27 0.602 46 4036 DB00939 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 27 0.581 43 5508 DB00500 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 27 0.518 92 3825 DB01009 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 27 0.453 154 5090 DB00533 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase 2 Inhibitors.Cyclooxygenase Inhibitors 27 0.444 4 5878 DB00621 Anabolic Agents.Androgens 27 0.444 53 5035 DB00481 Antihypocalcemic Agents.Bone Density Conservation Agents.Estrogen Antagonists.Osteoporosis Prophylactic.Selective Estrogen Receptor Modulators 27 0.428 17 9904 DB00984 Anabolic Agents.Androgens 27 0.428 16 4160 DB00624 Androgens 27 0.428 19 3387 DB01185 Anabolic Agents.Antineoplastic Agents, Hormonal 27 0.422 10 3226 DB00228 Anesthetics, Inhalation.General Anesthetics 27 0.406 21 4114 DB00553 Antineoplastic Agents.Cross-Linking Reagents.Photosensitizing Agents.Pigmenting Agents 27 0.406 18 2266 DB00548 Antineoplastic Agents.Dermatologic Agents 27 0.406 41 39042 DB01393 Antilipemic Agents 27 0.406 11 4919 DB00387 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists 27 0.406 31 4900 DB00635 Adrenergic Agents.Anti-inflammatory Agents.Antineoplastic Agents.Antineoplastic Agents, Hormonal.Glucocorticoids 27 0.406 54 4159 DB00959 Adrenergic Agents.Anti-inflammatory Agents.Antiemetics.Glucocorticoids.Neuroprotective Agents 27 0.406 4 119 DB02530 GABA Agents 27 0.406 17 52421 DB01130 Anti Inflammatory.Anti-inflammatory Agents.Corticosteroid.Glucocorticoids.Steroidal 27 0.406 16 41774 DB00284 Enzyme Inhibitors.Hypoglycemic Agents 27 0.406 13 137 DB00855 Photosensitizing Agents 27 0.406 10 5526 DB00302 Antifibrinolytic Agents 27 0.406 7 5404 DB00251 Antifungal Agents.Antifungals 27 0.406 34 4536 DB00717 Contraceptives, Oral, Synthetic.Progestins 27 0.406 10 3392 DB00846 Anti-inflammatory Agents.Glucocorticoids 27 0.406 32 2265 DB00993 Antimetabolites.Antimetabolites, Antineoplastic.Antirheumatic Agents.Immunosuppressive Agents 27 0.406 19 2344 DB00245 Antidyskinetics.Antiparkinson Agents.Dopamine Uptake Inhibitors.Muscarinic Antagonists.Parasympatholytics 27 0.406 17 48175 DB00596 Anti-inflammatory Agents.Vasoconstrictor Agents 27 0.406 5 51577 DB00491 Anti-Bacterial Agents.Enzyme Inhibitors.Hypoglycemic Agents 27 0.406 11 157922 DB00992 Antineoplastic Agents 27 0.406 8 3105 DB00449 Adrenergic Agonists.Ophthalmologicals.Sympathomimetics 27 0.406 28 25419 DB00720 Antihypocalcemic Agents.Antineoplastic Agents.Bisphosphonates.Bone Density Conservation Agents.Osteoporosis Prophylactic 27 0.406 3 6256 DB00432 Antimetabolites.Antiviral Agents 27 0.406 19 5505 DB01124 Hypoglycemic Agents.Sulfonylureas 27 0.406 9 232 DB00125 Conditionally Essential Amino Acids.Dietary supplement.Micronutrient 27 0.406 5 2283 DB00626 Anti-Bacterial Agents.Anti-Infective Agents, Local 27 0.406 7 2551 DB00411 Analgesics, Non-Narcotic.Cardiotonic Agents.Cholinergic Agonists.Miotics 27 0.406 16 5504 DB00797 Adrenergic alpha-Antagonists.Antihypertensive Agents.Vasodilator Agents 27 0.406 12 3384 DB00324 Anti-Allergic Agents.Anti-inflammatory Agents.Glucocorticoids 27 0.406 11 4043 DB00253 Topical anti-inflammatory Agent 27 0.406 8 3241 DB00751 Antihistamines.Histamine H1 Antagonists.Ophthalmics 27 0.406 15 39507 DB00896 Anti-inflammatory Agents.Corticosteroids 27 0.406 11 3375 DB00223 Anti-inflammatory Agents.Glucocorticoids 27 0.406 12 4812 DB01022 Antifibrinolytic Agents.Vitamins.Vitamins (Vitamin K) 27 0.406 14 2133 DB00288 Corticosteroids, topical 27 0.406 18 3698 DB01427 Calcium Channel Blockers.Cardiotonic Agents.Phosphodiesterase Inhibitors.Vasodilator Agents 27 0.406 6 4908 DB01087 Antimalarial Agents.Antimalarials.Antiprotozoal Agents 27 0.406 3 175 DB04184 Indicators and Reagents 27 0.406 22 60164 DB00210 Anti-Inflammatory Agents, Non-Steroidal.Dermatologic Agents 27 0.406 16 3405 DB00158 Dietary supplement.Hematinics.Micronutrient.Vitamin B Complex 27 0.406 25 150310 DB00700 Aldosterone Antagonists.Antihypertensive Agents 27 0.406 6 4174 DB01011 Antimetabolites.Enzyme Inhibitors 27 0.406 33 154059 DB01591 Anti-Incontinence Agents.Antispasmodics.Muscarinic Antagonists 27 0.406 11 5381 DB00799 Dermatologic Agents.Keratolytic Agents.Prodrugs.Teratogens 27 0.406 3 2484 DB01091 Antifungal Agents 27 0.406 18 3636 DB00747 Adjuvants.Adjuvants, Anesthesia.Antimuscarinics.Antispasmodics.Cholinergic Antagonists.Muscarinic Antagonists.Mydriatics 27 0.406 11 2522 DB02300 Antipsoriatic Agents.Dermatologic Agents.Vitamin D3 Receptor inhibitor 27 0.406 10 4630253 DB00240 Anti-inflammatory Agents.Antipruritic Agents.Corticosteroids.Glucocorticoids 27 0.406 15 5582 DB01157 Antibiotics.Antifungal Agents.Antimetabolites, Antineoplastic.Antiprotozoals.Folic Acid Antagonists 27 0.406 10 271 DB01373 Not Available 27 0.406 50 2973 DB00746 Chelating agent.Iron Chelating Agents.Siderophores 27 0.406 14 2955 DB00250 Anti-Infective Agents.Anti-Infectives.Anti-inflammatory Agents.Antimalarials.Antimycobacterials.Folic Acid Antagonists.Leprostatic Agents 27 0.406 6 888 DB01378 Not Available 27 0.406 15 4189 DB01110 Antifungal Agents 27 0.406 6 3780 DB00883 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 27 0.406 3 47641 DB00735 Anti-Inflammatory Agents, Non-Steroidal.Antifungal Agents 27 0.406 20 667490 DB01033 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Immunosuppressive Agents.Nucleic Acid Synthesis Inhibitors.Purine analogues 27 0.406 2 1071 DB00162 Anti-acne Agents.Essential Vitamin.Vitamins.Vitamins (Vitamin A) 27 0.406 27 1003 DB02831 Not Available 27 0.406 9 5593 DB00809 Diagnostic aid, cycloplegic.Diagnostic aid, mydriatic.Muscarinic Antagonists.Mydriatics 27 0.406 3 247 DB04455 Gastrointestinal Agents.Lipotropic Agents 27 0.406 18 1046 DB00339 Antitubercular Agents 27 0.4 82 47725 DB00014 Antineoplastic Agents.Antineoplastic Agents, Hormonal 27 0.396 31 3062 DB00390 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Cardiotonic Agents.Enzyme Inhibitors 27 0.396 21 5546 DB00384 Diuretics.Potassium-sparing Diuretics 27 0.396 24 5503 DB00839 Hypoglycemic Agents 27 0.396 28 2719 DB00608 Amebicides.Antimalarials.Antirheumatic Agents 27 0.389 15 4865 DB01179 Antimitotic agent.Antineoplastic Agents, Phytogenic.Keratolytic Agents.Tubulin Modulators 27 0.389 40 18140 DB01196 Antineoplastic Agents.Antineoplastic Agents, Alkylating.Antineoplastic Agents, Hormonal.Radiation-Protective Agents 27 0.389 17 152945 DB01126 Anti-baldness Agents.Antihyperplasia Agents.Enzyme Inhibitors 27 0.387 14 4993 DB00205 Antimalarials.Antiprotozoal Agents.Antiprotozoals.Folic Acid Antagonists 27 0.387 54 4599 DB01083 Anti-Obesity Agents.Enzyme Inhibitors 27 0.387 61 5402 DB00857 Allylamines.Antifungal Agents.Antifungals.Enzyme Inhibitors.Trypanocidal Agents 27 0.387 23 5578 DB00440 Anti-Infective Agents, Urinary.Anti-Infectives.Antimalarials.Folic Acid Antagonists 27 0.387 40 4547 DB00912 Hypoglycemic Agents.Meglitinides 27 0.387 63 3381 DB00591 Anti-inflammatory Agents.Antipruritics.Glucocorticoids 27 0.387 38 150311 DB00973 Anticholesteremic Agents.Cholesterol Absorption Inhibitors 27 0.387 24 2727 DB00672 Hypoglycemic Agents.Sulfonylureas 27 0.387 46 738 DB00130 Dietary supplement.Micronutrient.Non-Essential Amino Acids 27 0.387 29 2308 DB00394 Anti-Asthmatic Agents.Anti-inflammatory Agents.Antiarrhythmic Agents.Corticosteroids.Glucocorticoids 27 0.385 4 6503 DB03754 Buffers.Excipients 27 0.385 9 861 DB00279 Hormone Replacement Agents 27 0.385 21 5311082 DB00063 Anticoagulants.Antiplatelet Agents.Platelet Aggregation Inhibitors 27 0.385 14 36811 DB00841 Adrenergic beta-Agonists.Cardiotonic Agents.Sympathomimetic.Sympathomimetics #### component 28: positive weight features and high scoring objects #### # positive weight on target proteins 28 0.634 17 ANXA1_HUMAN Annexin A1; 28 0.369 18 GCR_HUMAN Glucocorticoid receptor; 28 0.341 17 CBG_HUMAN Corticosteroid-binding globulin; 28 0.218 29 GBRA1_HUMAN Gamma-aminobutyric acid receptor subunit alpha-1; 28 0.182 23 GBRA2_HUMAN Gamma-aminobutyric acid receptor subunit alpha-2; 28 0.163 22 GBRA5_HUMAN Gamma-aminobutyric acid receptor subunit alpha-5; 28 0.163 22 GBRA3_HUMAN Gamma-aminobutyric acid receptor subunit alpha-3; 28 0.163 22 GBRA6_HUMAN Gamma-aminobutyric acid receptor subunit alpha-6; 28 0.163 22 GBRA4_HUMAN Gamma-aminobutyric acid receptor subunit alpha-4; 28 0.13 21 GBRD_HUMAN Gamma-aminobutyric acid receptor subunit delta; 28 0.13 21 GBRR1_HUMAN Gamma-aminobutyric acid receptor subunit rho-1; 28 0.13 21 GBRT_HUMAN Gamma-aminobutyric acid receptor subunit theta; 28 0.13 21 GBRB1_HUMAN Gamma-aminobutyric acid receptor subunit beta-1; 28 0.13 21 GBRB3_HUMAN Gamma-aminobutyric acid receptor subunit beta-3; 28 0.13 21 GBRE_HUMAN Gamma-aminobutyric acid receptor subunit epsilon; 28 0.13 21 GBRG3_HUMAN Gamma-aminobutyric acid receptor subunit gamma-3; 28 0.13 21 GBRG2_HUMAN Gamma-aminobutyric acid receptor subunit gamma-2; 28 0.13 21 GBRB2_HUMAN Gamma-aminobutyric acid receptor subunit beta-2; 28 0.061 35 HRH1_HUMAN Histamine H1 receptor; 28 0.048 36 ACM1_HUMAN Muscarinic acetylcholine receptor M1; 28 0.021 34 ACM2_HUMAN Muscarinic acetylcholine receptor M2; # positive weight on side effects 28 0.664 368 somnolence 28 0.324 71 glaucoma 28 0.297 254 nervousness 28 0.207 301 confusion 28 0.064 76 nightmares 28 0.043 513 vomiting 28 0.042 47 osteoporosis 28 0.031 87 thrombophlebitis 28 0.028 301 dry mouth 28 0.004 52 abscess # high scoring drugs for both targets and side effects 28 1.671 23 5193 DB00418 Adjuvants.Adjuvants, Anesthesia.Barbiturates.GABA Modulators.Hypnotics and Sedatives 28 1.671 23 4737 DB00312 Adjuvants, Anesthesia.Barbiturates.GABA Modulators.Hypnotics and Sedatives 28 1.632 61 4192 DB00683 Adjuvants, Anesthesia.Anesthetics, Intravenous.Anti-anxiety Agents.GABA Modulators.Hypnotics and Sedatives 28 1.596 58 5206 DB01236 Anesthetics, Inhalation.Platelet Aggregation Inhibitors 28 1.556 84 3016 DB00829 Adjuvants, Anesthesia.Anesthetics, Intravenous.Anti-anxiety Agents.Anticonvulsants.Antiemetics.GABA Modulators.Hypnotics and Sedatives.Muscle Relaxants, Central 28 1.445 38 3393 DB00690 Anti-anxiety Agents.GABA Modulators.Hypnotics and Sedatives 28 1.432 86 2118 DB00404 Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 28 1.411 133 2802 DB01068 Anticonvulsants.Benzodiazepines.GABA Modulators 28 1.403 167 5719 DB00962 Anticonvulsants.Anxiolytics sedatives and hypnotics.Hypnotics and Sedatives 28 1.355 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 28 1.344 10 2712 DB00475 Adjuvants, Anesthesia.Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 28 1.282 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 28 1.252 147 71158 DB00659 Alcohol Deterrents 28 1.189 23 3821 DB01221 Analgesics.Anesthetics, Dissociative.Excitatory Amino Acid Antagonists.General Anesthetics 28 1.107 102 4943 DB00818 Anesthetics, Intravenous.Anticonvulsants.Antiemetics.Free Radical Scavengers.Hypnotics and Sedatives 28 1.071 13 36339 DB00292 Anesthetics, Intravenous.Hypnotics and Sedatives 28 1.056 120 2284 DB00181 GABA Agonists.Muscle Relaxants.Muscle Relaxants, Central.Skeletal Muscle Relaxants 28 1.055 7 3562 DB01159 Anesthetics.Anesthetics, Inhalation.General Anesthetics 28 1.028 16 3763 DB00753 Anesthetics.Anesthetics, Inhalation.General Anesthetics 28 1.021 73 3958 DB00186 Anti-anxiety Agents.Anticonvulsants.Antiemetics.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 28 1.019 25 9034 DB00474 Anesthetics.Anesthetics, Intravenous.Barbiturates 28 0.776 31 4900 DB00635 Adrenergic Agents.Anti-inflammatory Agents.Antineoplastic Agents.Antineoplastic Agents, Hormonal.Glucocorticoids 28 0.766 40 4064 DB00371 Anti-anxiety Agents.Anticonvulsants.Hypnotics and Sedatives.Muscle Relaxants, Central 28 0.723 25 5572 DB00376 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists 28 0.673 135 5544 DB00620 Adrenergic Agents.Anti-inflammatory Agents.Glucocorticoids 28 0.647 26 4506 DB01595 Anti-anxiety Agents.Anticonvulsants.GABA Modulators.Hypnotics and Sedatives 28 0.618 54 4159 DB00959 Adrenergic Agents.Anti-inflammatory Agents.Antiemetics.Glucocorticoids.Neuroprotective Agents 28 0.575 14 3354 DB01148 Parasympatholytics 28 0.563 21 5267 DB00421 Aldosterone Antagonists.Diuretics 28 0.562 29 2308 DB00394 Anti-Asthmatic Agents.Anti-inflammatory Agents.Antiarrhythmic Agents.Corticosteroids.Glucocorticoids 28 0.561 19 4934 DB00782 Anti-Ulcer Agents.Antimuscarinics.Antispasmodics.Muscarinic Antagonists 28 0.561 86 3003 DB01234 Adrenergic Agents.Anti-inflammatory Agents.Antiemetics.Antineoplastic Agents, Hormonal.Glucocorticoids 28 0.541 21 4057 DB04843 Anticholinergic Agents.Parasympatholytics 28 0.54 83 3640 DB00741 Anti-inflammatory Agents 28 0.535 35 3042 DB00804 Anticholinergic Agents.Antimuscarinics.Antispasmodics.Muscarinic Antagonists.Parasympatholytics 28 0.504 37 6058 DB00847 Nephropathic cystinosis therapy.Radiation-Protective Agents 28 0.493 66 123620 DB00764 Anti-Allergic Agents.Anti-inflammatory Agents 28 0.469 57 2951 DB01219 Muscle Relaxants, Central 28 0.45 37 3494 DB00986 Adjuvants, Anesthesia.Anti-cholinergic Agents.Muscarinic Antagonists 28 0.443 31 5052 DB00206 Adrenergic Uptake Inhibitors.Antihypertensive Agents.Antipsychotic Agents.Antipsychotics.Peripheral Adrenergic Inhibitors 28 0.441 74 4894 DB00860 Adrenergic Agents.Anti-inflammatory Agents.Antineoplastic Agents.Antineoplastic Agents, Hormonal.Glucocorticoids 28 0.439 31 2441 DB01558 Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 28 0.438 143 4054 DB01043 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agents.Excitatory Amino Acid Antagonists 28 0.437 17 5403 DB00871 Adrenergic beta-Agonists.Bronchodilator Agents.Sympathomimetic.Sympathomimetics.Tocolytic Agents 28 0.422 14 2133 DB00288 Corticosteroids, topical 28 0.42 60 3373 DB01205 Antidotes.GABA Modulators 28 0.409 36 2564 DB00748 Antihistamines 28 0.409 20 4601 DB01173 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 28 0.408 10 4630253 DB00240 Anti-inflammatory Agents.Antipruritic Agents.Corticosteroids.Glucocorticoids 28 0.402 10 4436 Not Available Not Available 28 0.398 52 5311027 DB00905 Antiglaucomic Agents.Antihypertensive Agents 28 0.385 37 3100 DB01075 Anesthetics.Anesthetics, Local.Anti-Allergic Agents.Antidyskinetics.Antiemetics.Antiparkinson Agents.Antipruritics.Antitussives.Ethanolamine Derivatives.Histamine H1 Antagonists.Hypnotics and Sedatives 28 0.385 32 2725 DB01114 Anti-Allergic Agents.Antihistamines.Antipruritics.Histamine H1 Antagonists 28 0.385 37 2781 DB00283 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists 28 0.378 23 51263 DB00802 Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 28 0.373 14 27400 Not Available Not Available 28 0.373 17 48175 DB00596 Anti-inflammatory Agents.Vasoconstrictor Agents 28 0.37 23 41693 DB00708 Adjuvants, Anesthesia.Analgesics, Opioid.Anesthetics, Intravenous.Narcotics.Opiate Agonists 28 0.369 111 5281104 DB00910 Not Available 28 0.364 24 2244 DB00945 Anti-Inflammatory Agents, Non-Steroidal.Anticoagulants.Cyclooxygenase Inhibitors.Fibrinolytic Agents.Platelet Aggregation Inhibitors.Salicylates 28 0.363 12 4909 DB00794 Anticonvulsants.Barbiturates 28 0.36 61 60612 DB00633 Adrenergic alpha-Agonists.Analgesics.Analgesics, Non-Narcotic.Hypnotics and Sedatives 28 0.354 54 4513 DB00585 Anti-Ulcer Agents.Histamine H2 Antagonists 28 0.342 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 28 0.335 18 3957 DB00455 Anti-Allergic Agents.Antihistamines.Antipruritics.Histamine H1 Antagonists, Non-Sedating 28 0.332 137 2462 DB01222 Anti-inflammatory Agents.Bronchodilator Agents.Corticosteroids.Glucocorticoids 28 0.326 55 2130 DB00915 Analgesics, Non-Narcotic.Antiparkinson Agents.Antiviral Agents.Dopamine Agents 28 0.315 51 48041 DB01228 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Sodium channel blockers 28 0.308 112 71273 DB00296 Anesthetics.Anesthetics, Local.Local Anesthetics 28 0.306 73 34633 DB00680 Anti-Arrhythmia Agents 28 0.302 8 2381 DB00810 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists.Parasympatholytics 28 0.301 42 3675 DB00780 Antidepressants.Antidepressive Agents.Monoamine Oxidase Inhibitors 28 0.301 71 2487 DB00611 Analgesics, Opioid.Antitussive Agents.Narcotic Antagonists.Narcotics 28 0.298 33 2978 DB00470 Analgesics.Analgesics, Non-Narcotic.Antiemetics.Hallucinogens.Psychotropic Drugs 28 0.298 3 4034 DB00737 Anti-Allergic Agents.Antiemetics.Antihistamines.Histamine H1 Antagonists 28 0.298 36 4914 DB00721 Anesthetics.Anesthetics, Local.Local Anesthetics 28 0.298 4 4768 DB00925 Adrenergic alpha-Antagonists.Antihypertensive Agents.Vasodilator Agents 28 0.297 63 3690 DB01181 Antineoplastic Agents.Antineoplastic Agents, Alkylating.Immunosuppressive Agents 28 0.29 9 3658 DB00557 Antipruritics.Anxiolytics sedatives and hypnotics.Histamine H1 Antagonists 28 0.288 59 5665 DB01080 Anticonvulsants.Enzyme Inhibitors.GABA Agents 28 0.287 135 5734 DB00909 Anticonvulsants.Antioxidants 28 0.285 61 3114 DB00280 Anti-Arrhythmia Agents.Antiarrhythmic Agents 28 0.284 9 2366 Not Available Not Available 28 0.283 76 3661 DB00572 Adjuvants, Anesthesia.Anti-Arrhythmia Agents.Bronchodilator Agents.Muscarinic Antagonists.Mydriatics.Parasympatholytics 28 0.283 15 39507 DB00896 Anti-inflammatory Agents.Corticosteroids 28 0.28 107 3410 DB00983 Adrenergic beta-Agonists.Bronchodilator Agents.Sympathomimetic 28 0.28 59 2476 DB00921 Analgesics, Opioid.Narcotic Antagonists.Narcotics 28 0.277 44 191 DB00640 Analgesics.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Cardiac drugs.Vasodilator Agents 28 0.276 42 4991 DB00545 Antimyasthenics.Cholinesterase Inhibitors.Parasympathomimetics 28 0.275 6 12555 Not Available Not Available 28 0.274 39 7029 DB00937 Anorexigenic Agents.Appetite Depressants.Stimulants 28 0.27 54 444033 DB01410 Anti-Allergic Agents.Glucocorticoids 28 0.27 16 4211 DB00648 Antineoplastic Agents.Antineoplastic Agents, Hormonal 28 0.27 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 28 0.268 34 4195 DB00211 Adrenergic alpha-Agonists.Sympathomimetics.Vasoconstrictor Agents 28 0.267 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 28 0.266 21 6398525 DB00364 Anti-Ulcer Agents 28 0.258 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 28 0.257 63 3381 DB00591 Anti-inflammatory Agents.Antipruritics.Glucocorticoids 28 0.256 47 4927 DB01069 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists.Phenothiazine Derivatives #### component 29: positive weight features and high scoring objects #### # positive weight on target proteins 29 0.518 36 ACM1_HUMAN Muscarinic acetylcholine receptor M1; 29 0.468 35 HRH1_HUMAN Histamine H1 receptor; 29 0.432 34 ACM2_HUMAN Muscarinic acetylcholine receptor M2; 29 0.287 20 ACHA2_HUMAN Neuronal acetylcholine receptor subunit alpha-2; 29 0.17 17 ACH10_HUMAN Neuronal acetylcholine receptor subunit alpha-10; 29 0.155 38 ADA2A_HUMAN Alpha-2A adrenergic receptor; 29 0.111 13 CAH2_HUMAN Carbonic anhydrase 2; 29 0.107 14 ACHA9_HUMAN Neuronal acetylcholine receptor subunit alpha-9; 29 0.107 14 ACHA3_HUMAN Neuronal acetylcholine receptor subunit alpha-3; 29 0.107 14 ACHA6_HUMAN Neuronal acetylcholine receptor subunit alpha-6; 29 0.107 14 ACHB2_HUMAN Neuronal acetylcholine receptor subunit beta-2; 29 0.107 16 G109B_HUMAN G-protein coupled receptor 109B; 29 0.107 14 ACHE_HUMAN Acetylcholine receptor subunit epsilon; 29 0.098 12 KCMA1_HUMAN Calcium-activated potassium channel subunit alpha-1; 29 0.09 14 CALM_HUMAN Calmodulin; 29 0.088 13 CAH1_HUMAN Carbonic anhydrase 1; 29 0.081 11 CAH4_HUMAN Carbonic anhydrase 4; 29 0.079 15 ACHA4_HUMAN Neuronal acetylcholine receptor subunit alpha-4; 29 0.044 10 AT1A1_HUMAN Sodium/potassium-transporting ATPase subunit alpha-1; 29 0.033 33 ADA2B_HUMAN Alpha-2B adrenergic receptor; # positive weight on side effects 29 0.223 89 increased salivation 29 0.205 249 blurred vision 29 0.035 68 paralysis # high scoring drugs for both targets and side effects 29 1.782 76 3661 DB00572 Adjuvants, Anesthesia.Anti-Arrhythmia Agents.Bronchodilator Agents.Muscarinic Antagonists.Mydriatics.Parasympatholytics 29 1.648 11 4919 DB00387 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists 29 1.648 16 5314 DB00202 Neuromuscular Depolarizing Agents.Skeletal Muscle Relaxants 29 1.546 7 2551 DB00411 Analgesics, Non-Narcotic.Cardiotonic Agents.Cholinergic Agonists.Miotics 29 1.333 84 2995 DB01151 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Enzyme Inhibitors.Norepinephrine-Reuptake Inhibitors 29 1.331 4 4768 DB00925 Adrenergic alpha-Antagonists.Antihypertensive Agents.Vasodilator Agents 29 1.316 49 4168 DB01233 Antiemetics.Dopamine Antagonists.Prokinetic Agents 29 1.289 47 4927 DB01069 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists.Phenothiazine Derivatives 29 1.218 23 3821 DB01221 Analgesics.Anesthetics, Dissociative.Excitatory Amino Acid Antagonists.General Anesthetics 29 1.174 19 4032 DB00657 Antihypertensive Agents.Ganglionic Blockers.Nicotinic Antagonists 29 1.101 8 2381 DB00810 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists.Parasympatholytics 29 1.078 36 2564 DB00748 Antihistamines 29 1.071 5 10548 DB01057 Cholinesterase Inhibitors.Miotics.Parasympathomimetics 29 1.069 15 2370 DB01019 Muscarinic Agonists.Parasympathomimetics 29 1.062 23 4737 DB00312 Adjuvants, Anesthesia.Barbiturates.GABA Modulators.Hypnotics and Sedatives 29 1.06 9 5593 DB00809 Diagnostic aid, cycloplegic.Diagnostic aid, mydriatic.Muscarinic Antagonists.Mydriatics 29 1.06 19 2344 DB00245 Antidyskinetics.Antiparkinson Agents.Dopamine Uptake Inhibitors.Muscarinic Antagonists.Parasympatholytics 29 1.06 25 5572 DB00376 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists 29 1.056 72 2160 DB00321 Adrenergic Uptake Inhibitors.Analgesics, Non-Narcotic.Antidepressive Agents, Tricyclic 29 1.047 19 4934 DB00782 Anti-Ulcer Agents.Antimuscarinics.Antispasmodics.Muscarinic Antagonists 29 1.047 14 3354 DB01148 Parasympatholytics 29 1.003 11 2131 DB01122 Antiarrhythmic Agents.Antimyasthenics 29 0.939 69 3696 DB00458 Adrenergic Uptake Inhibitors.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 29 0.894 35 3042 DB00804 Anticholinergic Agents.Antimuscarinics.Antispasmodics.Muscarinic Antagonists.Parasympatholytics 29 0.862 16 2905 DB00979 Antimuscarinic eye preparations.Muscarinic Antagonists.Mydriatics.Parasympatholytics 29 0.846 12 60169 DB01334 Neuromuscular Nondepolarizing Agents 29 0.839 14 47319 DB00732 Neuromuscular Nondepolarizing Agents.Nicotinic Antagonists 29 0.819 37 3100 DB01075 Anesthetics.Anesthetics, Local.Anti-Allergic Agents.Antidyskinetics.Antiemetics.Antiparkinson Agents.Antipruritics.Antitussives.Ethanolamine Derivatives.Histamine H1 Antagonists.Hypnotics and Sedatives 29 0.819 37 2781 DB00283 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists 29 0.819 32 2725 DB01114 Anti-Allergic Agents.Antihistamines.Antipruritics.Histamine H1 Antagonists 29 0.819 50 3158 DB01142 Anti-anxiety Agents.Antidepressants.Antidepressive Agents, Tricyclic.Antipruritics.Histamine Antagonists.Norepinephrine-Reuptake Inhibitors 29 0.819 3 4034 DB00737 Anti-Allergic Agents.Antiemetics.Antihistamines.Histamine H1 Antagonists 29 0.819 44 2913 DB00434 Anti-Allergic Agents.Antihistamine derivatives.Antipruritics.Gastrointestinal Agents.Histamine H1 Antagonists.Serotonin Antagonists 29 0.778 66 4011 DB00934 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Second-Generation 29 0.774 38 4121 DB00232 Diuretics.Diuretics, Thiazide.Sodium Chloride Symporter Inhibitors 29 0.762 14 104803 DB01226 Neuromuscular Nondepolarizing Agents 29 0.752 43 2720 DB00880 Antihypertensive Agents.Diuretics.Diuretics, Thiazide.Sodium Chloride Symporter Inhibitors 29 0.746 10 4675 DB01337 Neuromuscular Nondepolarizing Agents.Nicotinic Antagonists 29 0.738 37 3494 DB00986 Adjuvants, Anesthesia.Anti-cholinergic Agents.Muscarinic Antagonists 29 0.724 51 3559 DB00502 Anti-Dyskinesia Agents.Antidyskinetics.Antiemetics.Antipsychotic Agents.Antipsychotics.Butyrophenones.Dopamine Antagonists 29 0.719 18 3636 DB00747 Adjuvants.Adjuvants, Anesthesia.Antimuscarinics.Antispasmodics.Cholinergic Antagonists.Muscarinic Antagonists.Mydriatics 29 0.707 21 60696 DB00728 Neuromuscular Nondepolarizing Agents.Skeletal Muscle Relaxants 29 0.697 27 23897 DB01618 Antipsychotic Agents 29 0.695 87 5533 DB00656 Anti-anxiety Agents.Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 29 0.679 34 3518 DB01170 Adrenergic Agents.Antihypertensive Agents.Sympatholytics 29 0.672 27 3647 DB00774 Antihypertensive Agents.Diuretics.Diuretics, Thiazide.Sodium Chloride Symporter Inhibitors 29 0.667 9 3219 DB01084 Anti-Allergic Agents.Histamine H1 Antagonists 29 0.661 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 29 0.646 64 3746 DB00332 Antimuscarinics.Antispasmodics.Bronchodilator Agents.Cholinergic Antagonists 29 0.645 20 4601 DB01173 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 29 0.637 9 3658 DB00557 Antipruritics.Anxiolytics sedatives and hypnotics.Histamine H1 Antagonists 29 0.627 27 4100 DB00703 Carbonic Anhydrase Inhibitors.Diuretics 29 0.617 21 4057 DB04843 Anticholinergic Agents.Parasympatholytics 29 0.599 18 3957 DB00455 Anti-Allergic Agents.Antihistamines.Antipruritics.Histamine H1 Antagonists, Non-Sedating 29 0.599 31 50294 DB00716 Anti-Allergic Agents.Anti-Asthmatic Agents.Anti-inflammatory Agents 29 0.598 54 3639 DB00999 Antihypertensive Agents.Diuretics.Sodium Chloride Symporter Inhibitors 29 0.586 41 2315 DB00436 Antihypertensive Agents.Diuretics.Diuretics, Thiazide.Sodium Chloride Symporter Inhibitors 29 0.586 15 3739 DB04711 Contrast Media 29 0.585 26 4506 DB01595 Anti-anxiety Agents.Anticonvulsants.GABA Modulators.Hypnotics and Sedatives 29 0.585 55 3019 DB01119 Antihypertensive Agents.Diuretics, Thiazide.Vasodilator Agents 29 0.585 12 3384 DB00324 Anti-Allergic Agents.Anti-inflammatory Agents.Glucocorticoids 29 0.585 11 4043 DB00253 Topical anti-inflammatory Agent 29 0.578 20 5775 DB00692 Adrenergic alpha-Antagonists.Antihypertensive Agents.Sympatholytics 29 0.577 10 4436 Not Available Not Available 29 0.577 16 3168 DB00450 Adjuvants, Anesthesia.Antiemetics.Antipsychotic Agents.Dopamine Antagonists 29 0.576 52 5452 DB00679 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 29 0.571 41 5530 DB00752 Anti-anxiety Agents.Antidepressants.Antidepressive Agents.Monoamine Oxidase Inhibitors 29 0.571 20 4616 DB00842 Anti-anxiety Agents.GABA Modulators.Hypnotics and Sedatives 29 0.571 29 3125 DB00765 Enzyme Inhibitors 29 0.569 35 16362 DB01100 Anti-Dyskinesia Agents.Antipsychotic Agents.Dopamine Antagonists 29 0.56 25 68844 DB01194 Antiglaucomic Agents.Carbonic Anhydrase Inhibitors.Ophthalmics 29 0.546 43 1986 DB00819 Anticonvulsants.Carbonic Anhydrase Inhibitors.Diuretics 29 0.544 51 3964 DB00408 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists 29 0.543 9 2366 Not Available Not Available 29 0.539 8 3241 DB00751 Antihistamines.Histamine H1 Antagonists.Ophthalmics 29 0.532 12 3915 DB01106 Histamine H1 Antagonists.Histamine H1 Antagonists, Non-Sedating 29 0.532 10 3226 DB00228 Anesthetics, Inhalation.General Anesthetics 29 0.532 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 29 0.525 37 5512 DB01036 Anti-Incontinence Agents.Antispasmodics.Genitourinary Smooth Muscle Relaxants.Muscarinic Antagonists 29 0.522 16 3763 DB00753 Anesthetics.Anesthetics, Inhalation.General Anesthetics 29 0.522 6 888 DB01378 Not Available 29 0.515 34 3827 DB00920 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists 29 0.497 14 951 DB00368 Adrenergic alpha-Agonists.Sympathomimetics.Vasoconstrictor Agents 29 0.497 31 3062 DB00390 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Cardiotonic Agents.Enzyme Inhibitors 29 0.487 36 124087 DB00967 Antihistamines.Cholinergic Antagonists.Histamine H1 Antagonists, Non-Sedating 29 0.486 32 3278 DB00903 Diuretics.Enzyme Inhibitors 29 0.483 9 232 DB00125 Conditionally Essential Amino Acids.Dietary supplement.Micronutrient 29 0.483 7 3562 DB01159 Anesthetics.Anesthetics, Inhalation.General Anesthetics 29 0.483 9 1148 DB00150 Antidepressive Agents, Second-Generation.Dietary supplement.Essential Amino Acids.Micronutrient 29 0.483 9 861 DB00279 Hormone Replacement Agents 29 0.483 16 4211 DB00648 Antineoplastic Agents.Antineoplastic Agents, Hormonal 29 0.483 18 3292 DB00754 Anticonvulsants 29 0.483 15 681 DB00988 Cardiotonic Agents.Dopamine Agents.Sympathomimetic.Sympathomimetics 29 0.483 10 5526 DB00302 Antifibrinolytic Agents 29 0.483 6 3780 DB00883 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 29 0.483 25 3767 DB00951 Antitubercular Agents.Fatty Acid Synthesis Inhibitors 29 0.483 9 5342 DB01138 Uricosuric Agents 29 0.483 21 5473385 DB00352 Antimetabolites, Antineoplastic 29 0.483 6 4908 DB01087 Antimalarial Agents.Antimalarials.Antiprotozoal Agents 29 0.483 2 1071 DB00162 Anti-acne Agents.Essential Vitamin.Vitamins.Vitamins (Vitamin A) #### component 30: positive weight features and high scoring objects #### # positive weight on target proteins 30 0.519 16 TOP2A_HUMAN DNA topoisomerase 2-alpha; 30 0.244 17 SCN4B_HUMAN Sodium channel subunit beta-4; 30 0.244 17 SCN4A_HUMAN Sodium channel protein type 4 subunit alpha; 30 0.244 17 ACCN3_HUMAN Amiloride-sensitive cation channel 3; 30 0.244 17 DB124_HUMAN Beta-defensin 124; 30 0.244 17 ACCN4_HUMAN Amiloride-sensitive cation channel 4; 30 0.244 17 EF1B_HUMAN Elongation factor 1-beta; 30 0.244 17 SCNAA_HUMAN Sodium channel protein type 10 subunit alpha; 30 0.244 17 SCN7A_HUMAN Sodium channel protein type 7 subunit alpha; 30 0.244 17 SCN3B_HUMAN Sodium channel subunit beta-3; 30 0.244 17 SCN3A_HUMAN Sodium channel protein type 3 subunit alpha; 30 0.244 17 SCN1B_HUMAN Sodium channel subunit beta-1; 30 0.159 18 SCNNG_HUMAN Amiloride-sensitive sodium channel subunit gamma; 30 0.159 18 SCNNB_HUMAN Amiloride-sensitive sodium channel subunit beta; 30 0.159 18 SCNND_HUMAN Amiloride-sensitive sodium channel subunit delta; 30 0.015 13 CAC1A_HUMAN Voltage-dependent P/Q-type calcium channel subunit alpha-1A; 30 0.004 6 DRD4_HUMAN D(4) dopamine receptor; # positive weight on side effects 30 0.399 31 vaginal moniliasis 30 0.389 155 dysphagia 30 0.381 87 phlebitis 30 0.369 173 hyperglycemia 30 0.356 67 albuminuria 30 0.23 236 allergic reaction 30 0.196 298 asthenia 30 0.141 218 rhinitis 30 0.127 115 hypokalemia 30 0.125 129 neutropenia 30 0.121 191 peripheral edema 30 0.107 29 hemiplegia 30 0.091 282 vertigo 30 0.082 326 paresthesia 30 0.071 191 hepatitis 30 0.064 109 neuropathy 30 0.049 280 chest pain 30 0.041 205 angioedema 30 0.032 67 amenorrhea # high scoring drugs for both targets and side effects 30 2.456 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 30 2.433 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 30 2.312 112 71273 DB00296 Anesthetics.Anesthetics, Local.Local Anesthetics 30 2.273 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 30 2.22 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 30 2.215 150 1775 DB00252 Anticonvulsants 30 1.981 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 30 1.919 135 5734 DB00909 Anticonvulsants.Antioxidants 30 1.562 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 30 1.554 95 16231 DB00594 Diuretics.Sodium channel blockers 30 1.546 75 4178 DB00379 Anti-Arrhythmia Agents 30 1.541 74 3676 DB00281 Anesthetics.Anesthetics, Local.Anti-Arrhythmia Agents.Antiarrhythmic Agents 30 1.488 51 48041 DB01228 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Sodium channel blockers 30 1.469 91 3355 DB01195 Anti-Arrhythmia Agents.Antiarrhythmic Agents 30 1.323 36 4914 DB00721 Anesthetics.Anesthetics, Local.Local Anesthetics 30 1.302 61 3114 DB00280 Anti-Arrhythmia Agents.Antiarrhythmic Agents 30 1.301 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 30 1.278 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 30 1.277 264 5372 DB00864 Immunosuppressive Agents 30 1.271 43 4913 DB01035 Anti-Arrhythmia Agents.Antiarrhythmic Agents 30 1.245 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 30 1.234 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 30 1.12 132 3948 DB00978 Anti-Infective Agents.Anti-Infective Agents, Urinary.Antitubercular Agents.Photosensitizing Agents 30 1.109 161 5487 DB00697 Adrenergic alpha-Agonists.Analgesics.Anticonvulsants.Muscle Relaxants.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 30 1.096 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 30 1.094 453 125889 DB00230 Analgesics.Anticonvulsants 30 1.089 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 30 0.967 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 30 0.93 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 30 0.889 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 30 0.855 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 30 0.836 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 30 0.822 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 30 0.807 144 3899 DB01097 Adjuvants.Anti-inflammatory Agents.Antineoplastic Agents.Antiparasitic Agents.Antirheumatic Agents.Antiviral Agents.Enzyme Inhibitors.Immunosuppressive Agents 30 0.801 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 30 0.787 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 30 0.772 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 30 0.771 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 30 0.769 110 4212 DB01204 Analgesics.Antineoplastic Agents 30 0.768 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 30 0.762 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 30 0.749 114 5379 DB01044 Anti-Infective Agents.Antibiotics 30 0.743 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 30 0.722 161 122316 DB01367 Monoamine Oxidase Inhibitors.Neuroprotective Agents 30 0.711 211 60953 DB01101 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Prodrugs 30 0.707 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 30 0.689 128 3793 DB01167 Antifungal Agents.Antifungals.Antiprotozoal Agents.Antiprotozoals 30 0.686 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 30 0.668 70 2179 DB00276 Antineoplastic Agents.Intercalating Agents 30 0.656 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 30 0.653 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 30 0.643 128 2250 DB01076 Anticholesteremic Agents.Hydroxymethylglutaryl-CoA Reductase Inhibitors 30 0.64 196 3911 DB00007 Anti-Estrogen Agents.Antineoplastic Agents 30 0.638 188 5040 DB00877 Anti-Bacterial Agents.Antibiotics, Antineoplastic.Antifungal Agents.Antifungals.Immunosuppressive Agents 30 0.623 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 30 0.622 106 4539 DB01059 Anti-Bacterial Agents.Anti-Infectives.Enzyme Inhibitors.Nucleic Acid Synthesis Inhibitors.Quinolones 30 0.621 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 30 0.613 137 62959 DB00685 Anti-Infective Agents.Anti-Infectives.Fluoroquinolones 30 0.605 71 3310 DB00773 Antineoplastic Agents, Phytogenic.Nucleic Acid Synthesis Inhibitors 30 0.595 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 30 0.594 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 30 0.594 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 30 0.592 136 56339 DB01320 Anticonvulsants 30 0.592 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 30 0.586 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 30 0.584 100 2578 DB00262 Antineoplastic Agents.Antineoplastic Agents, Alkylating 30 0.575 215 60787 DB01232 Anti-HIV Agents.HIV Protease Inhibitors 30 0.572 109 60879 DB00876 Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 30 0.563 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 30 0.562 144 3702 DB00808 Antihypertensive Agents.Diuretics 30 0.558 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 30 0.552 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 30 0.538 236 10631 DB00603 Contraceptives.Contraceptives, Oral, Synthetic.Progestins 30 0.532 146 3075 DB00343 Antihypertensive Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Cardiovascular Agents.Vasodilator Agents 30 0.524 147 71158 DB00659 Alcohol Deterrents 30 0.511 136 2375 DB01128 Androgen Antagonists.Antineoplastic Agents 30 0.505 185 4594 DB00338 Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 30 0.504 166 3394 DB00712 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Carbonic Anhydrase Inhibitors.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 30 0.496 132 4739 DB00552 Antibiotics.Antineoplastic Agents.Enzyme Inhibitors.Immunosuppressive Agents 30 0.492 211 93860 DB00188 Antineoplastic Agents.Protease Inhibitors 30 0.492 97 2541 DB00796 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 30 0.49 125 3285 DB00977 Estrogens 30 0.489 134 3339 DB01039 Antilipemic Agents.Fribic Acid Derivatives 30 0.483 201 5538 DB00755 Antineoplastic Agents.Cell Stimulants and Proliferants.Keratolytic Agents 30 0.48 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 30 0.48 166 54374 DB00104 Anabolic Agents.Antineoplastic Agents, Hormonal.Gastrointestinal Agents.Hormone Replacement Agents 30 0.478 140 3143 DB01248 Antimalarials.Antineoplastic Agents.Antineoplastic Agents, Phytogenic.Radiation-Sensitizing Agents 30 0.477 138 2369 DB00195 Adrenergic beta-Antagonists.Antihypertensive Agents.EENT Drugs.Sympatholytics 30 0.474 120 82146 DB00307 Anticarcinogenic Agents 30 0.471 106 2083 DB01001 Adrenergic beta-Agonists.Bronchodilator Agents.Tocolytic Agents 30 0.458 131 4635 DB00497 Analgesics, Opioid.Antitussives.Narcotics.Opiate Agonists 30 0.447 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 30 0.447 141 4819 DB01085 Cholinergic Agents.Miotics.Muscarinic Agonists 30 0.446 118 4236 DB00745 Anorexigenic Agents.Central Nervous System Agents.Central Nervous System Stimulants.Neuroprotective Agents.Stimulants 30 0.434 171 2909 DB00091 Antifungal Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Immunomodulatory Agents.Immunosuppressive Agents 30 0.433 94 4409 DB00461 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents 30 0.432 72 5672 DB00361 Antineoplastic Agents.Antineoplastic Agents, Phytogenic.Radiation-Sensitizing Agents 30 0.43 149 5394 DB00853 Antineoplastic Agents.Antineoplastic Agents, Alkylating 30 0.426 104 3449 DB00674 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 30 0.395 135 2585 DB01136 Adrenergic Agents.Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents #### component 31: positive weight features and high scoring objects #### # positive weight on target proteins 31 0.724 29 PGH2_HUMAN Prostaglandin G/H synthase 2; 31 0.394 16 TOP2A_HUMAN DNA topoisomerase 2-alpha; 31 0.211 18 SCNNB_HUMAN Amiloride-sensitive sodium channel subunit beta; 31 0.211 18 SCNND_HUMAN Amiloride-sensitive sodium channel subunit delta; 31 0.211 18 SCNNG_HUMAN Amiloride-sensitive sodium channel subunit gamma; 31 0.103 15 RYR3_HUMAN Ryanodine receptor 3; 31 0.103 15 RYR2_HUMAN Ryanodine receptor 2; 31 0.101 12 TRPV6_HUMAN Transient receptor potential cation channel subfamily V member 6; 31 0.101 12 CAC1E_HUMAN Voltage-dependent R-type calcium channel subunit alpha-1E; 31 0.101 12 CACB3_HUMAN Voltage-dependent L-type calcium channel subunit beta-3; 31 0.101 12 CACB4_HUMAN Voltage-dependent L-type calcium channel subunit beta-4; 31 0.101 12 ITPR1_HUMAN Inositol 1,4,5-trisphosphate receptor type 1; 31 0.101 12 CCG4_HUMAN Voltage-dependent calcium channel gamma-4 subunit; 31 0.101 12 TRPA1_HUMAN Transient receptor potential cation channel subfamily A member 1; 31 0.101 12 CAC1S_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1S; 31 0.101 12 CA2D1_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-1; 31 0.101 12 PKD1_HUMAN Polycystin-1; 31 0.101 12 CCG2_HUMAN Voltage-dependent calcium channel gamma-2 subunit; 31 0.101 12 PKD2_HUMAN Polycystin-2; 31 0.101 12 CCG7_HUMAN Voltage-dependent calcium channel gamma-7 subunit; 31 0.101 12 ITPR3_HUMAN Inositol 1,4,5-trisphosphate receptor type 3; 31 0.088 13 CAC1A_HUMAN Voltage-dependent P/Q-type calcium channel subunit alpha-1A; 31 0.078 14 RYR1_HUMAN Ryanodine receptor 1; 31 0.077 13 CACB1_HUMAN Voltage-dependent L-type calcium channel subunit beta-1; 31 0.039 26 SC6A4_HUMAN Sodium-dependent serotonin transporter; 31 0.026 16 CAC1G_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1G; 31 0.015 16 OPRK_HUMAN Kappa-type opioid receptor; # positive weight on side effects 31 0.757 131 diplopia 31 0.307 58 nystagmus 31 0.24 304 Dyspepsia 31 0.236 377 urticaria 31 0.194 229 Pharyngitis 31 0.179 123 urinary incontinence 31 0.17 342 insomnia 31 0.136 101 esophagitis 31 0.118 326 paresthesia 31 0.109 85 acute renal failure 31 0.096 198 Sinusitis 31 0.084 222 flatulence 31 0.083 179 myocardial infarction 31 0.083 252 malaise 31 0.082 152 urinary retention 31 0.081 166 purpura 31 0.069 247 tremor 31 0.066 159 increased sweating 31 0.061 377 constipation 31 0.059 133 bronchospasm 31 0.059 90 colitis 31 0.047 205 angioedema 31 0.043 320 fatigue 31 0.043 172 chills 31 0.041 162 dysuria 31 0.039 75 amblyopia 31 0.036 204 sweating 31 0.036 232 hemorrhage 31 0.034 254 nervousness 31 0.022 31 lymphoma 31 0.021 56 kidney calculus 31 0.018 86 sepsis 31 0.002 107 amnesia # high scoring drugs for both targets and side effects 31 2.512 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 31 2.403 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 31 2.154 150 1775 DB00252 Anticonvulsants 31 2.018 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 31 1.897 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 31 1.697 146 3075 DB00343 Antihypertensive Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Cardiovascular Agents.Vasodilator Agents 31 1.439 95 16231 DB00594 Diuretics.Sodium channel blockers 31 1.373 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 31 1.369 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 31 1.362 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 31 1.352 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 31 1.324 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 31 1.27 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 31 1.262 166 3394 DB00712 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Carbonic Anhydrase Inhibitors.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 31 1.261 57 2951 DB01219 Muscle Relaxants, Central 31 1.237 135 5734 DB00909 Anticonvulsants.Antioxidants 31 1.183 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 31 1.167 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 31 1.161 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 31 1.155 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 31 1.151 234 216326 DB00480 Antineoplastic Agents 31 1.131 145 3672 DB01050 Analgesics.Analgesics, Non-Narcotic.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 31 1.129 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 31 1.11 453 125889 DB00230 Analgesics.Anticonvulsants 31 1.108 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 31 1.106 73 3333 DB01023 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Calcium Channel Blockers.Dihydropyridines.Vasodilator Agents 31 1.093 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 31 1.092 142 3826 DB00465 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 31 1.074 183 3648 DB00327 Analgesics, Opioid.Narcotics 31 1.074 132 3948 DB00978 Anti-Infective Agents.Anti-Infective Agents, Urinary.Antitubercular Agents.Photosensitizing Agents 31 1.021 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 31 1.02 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 31 1.016 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 31 1.009 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 31 1.0 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 31 0.989 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 31 0.964 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 31 0.96 91 3355 DB01195 Anti-Arrhythmia Agents.Antiarrhythmic Agents 31 0.959 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 31 0.942 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 31 0.94 137 62959 DB00685 Anti-Infective Agents.Anti-Infectives.Fluoroquinolones 31 0.93 196 1935 DB00382 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 31 0.925 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 31 0.918 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 31 0.9 154 3157 DB00590 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Anticholesteremic Agents.Antihypertensive Agents.Vasodilator Agents 31 0.886 136 56339 DB01320 Anticonvulsants 31 0.879 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 31 0.863 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 31 0.858 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists 31 0.85 158 34312 DB00776 Anticonvulsants 31 0.831 119 4052 DB00814 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Antiemetics.Antineoplastic Agents.Cyclooxygenase Inhibitors.Growth Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 31 0.827 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 31 0.823 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 31 0.818 147 71158 DB00659 Alcohol Deterrents 31 0.805 157 4659569 DB00323 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Enzyme Inhibitors 31 0.804 71 3342 DB00573 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Propionic acid derivatives 31 0.798 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 31 0.794 120 3715 DB00328 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cardiovascular Agents.Cyclooxygenase Inhibitors.Gout Suppressants.Nonsteroidal Antiinflammatory Agents (NSAIDs).Tocolytic Agents 31 0.785 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 31 0.781 161 5212 DB00203 Phosphodiesterase Inhibitors.Vasodilator Agents 31 0.78 133 2802 DB01068 Anticonvulsants.Benzodiazepines.GABA Modulators 31 0.78 147 5645 DB01586 Cholagogues and Choleretics 31 0.776 264 5372 DB00864 Immunosuppressive Agents 31 0.776 167 5719 DB00962 Anticonvulsants.Anxiolytics sedatives and hypnotics.Hypnotics and Sedatives 31 0.775 29 3954 DB00836 Antidiarrheals 31 0.774 119 3308 DB00749 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 31 0.766 61 3114 DB00280 Anti-Arrhythmia Agents.Antiarrhythmic Agents 31 0.761 106 4539 DB01059 Anti-Bacterial Agents.Anti-Infectives.Enzyme Inhibitors.Nucleic Acid Synthesis Inhibitors.Quinolones 31 0.76 154 5090 DB00533 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase 2 Inhibitors.Cyclooxygenase Inhibitors 31 0.753 73 34633 DB00680 Anti-Arrhythmia Agents 31 0.753 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 31 0.743 120 2284 DB00181 GABA Agonists.Muscle Relaxants.Muscle Relaxants, Central.Skeletal Muscle Relaxants 31 0.725 128 4253 DB00295 Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 31 0.717 146 3475 DB01120 Hypoglycemic Agents.Sulfonylureas 31 0.714 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 31 0.714 35 16362 DB01100 Anti-Dyskinesia Agents.Antipsychotic Agents.Dopamine Antagonists 31 0.713 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 31 0.712 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 31 0.709 99 4889 DB00175 Anticholesteremic Agents.HMG-CoA Reductase Inhibitors.Hydroxymethylglutaryl-CoA Reductase Inhibitors 31 0.705 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 31 0.699 151 60835 DB00476 Adrenergic Uptake Inhibitors.Antidepressive Agents.Dopamine Uptake Inhibitors.Serotonin Uptake Inhibitors 31 0.693 157 3937 DB00722 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents.Cardiotonic Agents 31 0.692 128 3793 DB01167 Antifungal Agents.Antifungals.Antiprotozoal Agents.Antiprotozoals 31 0.69 117 2182 DB00261 Antithrombotic Agents.Fibrinolytic Agents.Platelet Aggregation Inhibitors 31 0.685 151 41317 DB00459 Keratolytic Agents 31 0.684 104 4614 DB00991 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Nonsteroidal Antiinflammatory Agents (NSAIDs) 31 0.663 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 31 0.66 161 122316 DB01367 Monoamine Oxidase Inhibitors.Neuroprotective Agents 31 0.638 105 4659568 DB00494 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Enzyme Inhibitors 31 0.63 154 27661 DB01020 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 31 0.628 59 2476 DB00921 Analgesics, Opioid.Narcotic Antagonists.Narcotics 31 0.618 199 5358 DB00669 Selective Serotonin Agonists.Serotonin Agonists.Vasoconstrictor Agents 31 0.613 211 93860 DB00188 Antineoplastic Agents.Protease Inhibitors 31 0.61 172 4920 DB00396 Contraceptives.Progestins 31 0.607 102 4943 DB00818 Anesthetics, Intravenous.Anticonvulsants.Antiemetics.Free Radical Scavengers.Hypnotics and Sedatives 31 0.605 112 71273 DB00296 Anesthetics.Anesthetics, Local.Local Anesthetics 31 0.603 74 3676 DB00281 Anesthetics.Anesthetics, Local.Anti-Arrhythmia Agents.Antiarrhythmic Agents 31 0.597 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 31 0.597 146 4158 DB00422 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Uptake Inhibitors.Sympathomimetics 31 0.586 97 159 DB01240 Antihypertensive Agents.Platelet Aggregation Inhibitors #### component 32: positive weight features and high scoring objects #### # positive weight on target proteins 32 0.559 18 ESR1_HUMAN Estrogen receptor; 32 0.528 26 SC6A4_HUMAN Sodium-dependent serotonin transporter; 32 0.294 28 DRD3_HUMAN D(3) dopamine receptor; 32 0.277 35 DRD2_HUMAN D(2) dopamine receptor; 32 0.262 8 PRGR_HUMAN Progesterone receptor; 32 0.237 28 SC6A2_HUMAN Sodium-dependent noradrenaline transporter; 32 0.161 10 ESR2_HUMAN Estrogen receptor beta; 32 0.129 6 DRD4_HUMAN D(4) dopamine receptor; 32 0.109 28 DRD1_HUMAN D(1A) dopamine receptor; 32 0.108 21 DRD5_HUMAN D(1B) dopamine receptor; 32 0.098 29 PGH2_HUMAN Prostaglandin G/H synthase 2; 32 0.086 9 GABR2_HUMAN Gamma-aminobutyric acid type B receptor subunit 2; 32 0.069 16 ANDR_HUMAN Androgen receptor; 32 0.056 4 MPRG_HUMAN Membrane progestin receptor gamma; 32 0.046 7 MCR_HUMAN Mineralocorticoid receptor; 32 0.043 5 OSR2_HUMAN Protein odd-skipped-related 2; 32 0.043 5 SAFB1_HUMAN Scaffold attachment factor B1; 32 0.043 5 ERR1_HUMAN Steroid hormone receptor ERR1; 32 0.043 5 ERR3_HUMAN Estrogen-related receptor gamma; 32 0.043 5 NR2F6_HUMAN Nuclear receptor subfamily 2 group F member 6; 32 0.043 5 COT2_HUMAN COUP transcription factor 2; 32 0.043 5 COT1_HUMAN COUP transcription factor 1; 32 0.043 5 ARFRP_HUMAN ADP-ribosylation factor-related protein 1; 32 0.043 5 OSBP1_HUMAN Oxysterol-binding protein 1; 32 0.043 5 NR2C2_HUMAN Nuclear receptor subfamily 2 group C member 2; 32 0.043 5 ERR2_HUMAN Steroid hormone receptor ERR2; 32 0.043 5 SAFB2_HUMAN Scaffold attachment factor B2; 32 0.043 5 DFNA5_HUMAN Non-syndromic hearing impairment protein 5; 32 0.021 5 ATP4A_HUMAN Potassium-transporting ATPase alpha chain 1; 32 0.013 5 GABT_HUMAN 4-aminobutyrate aminotransferase, mitochondrial; 32 0.012 8 GBRR2_HUMAN Gamma-aminobutyric acid receptor subunit rho-2; 32 0.012 8 TSPOA_HUMAN Translocator protein; 32 0.002 29 GBRA1_HUMAN Gamma-aminobutyric acid receptor subunit alpha-1; # positive weight on side effects 32 0.596 57 vaginal hemorrhage 32 0.393 61 metrorrhagia 32 0.327 77 breast pain 32 0.288 119 acne 32 0.227 152 weight loss 32 0.214 85 pulmonary embolism 32 0.204 86 vaginitis 32 0.185 85 dysmenorrhea 32 0.163 46 galactorrhea 32 0.143 280 anxiety 32 0.121 124 migraine 32 0.106 57 hot flashes 32 0.095 52 menorrhagia 32 0.084 373 fever 32 0.079 29 varicose vein 32 0.063 54 hypothyroidism 32 0.061 111 swelling 32 0.046 49 pelvic pain 32 0.039 92 heart disease 32 0.039 15 ovarian cyst 32 0.033 83 hypercholesterolemia 32 0.01 198 Sinusitis # high scoring drugs for both targets and side effects 32 1.772 172 4920 DB00396 Contraceptives.Progestins 32 1.751 236 10631 DB00603 Contraceptives.Contraceptives, Oral, Synthetic.Progestins 32 1.736 61 40976 DB00294 Contraceptive Agents, Female.Contraceptives 32 1.687 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 32 1.651 132 4542 DB00367 Contraceptive Agents, Female.Contraceptives.Contraceptives, Oral, Synthetic 32 1.647 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 32 1.634 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 32 1.597 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 32 1.556 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 32 1.528 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 32 1.474 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 32 1.471 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 32 1.446 116 5376 DB00675 Antineoplastic Agents, Hormonal.Bone Density Conservation Agents.Estrogen Antagonists.Selective Estrogen Receptor Modulators 32 1.438 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 32 1.333 53 5035 DB00481 Antihypocalcemic Agents.Bone Density Conservation Agents.Estrogen Antagonists.Osteoporosis Prophylactic.Selective Estrogen Receptor Modulators 32 1.331 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 32 1.305 125 3285 DB00977 Estrogens 32 1.304 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 32 1.303 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 32 1.291 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 32 1.249 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 32 1.245 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 32 1.238 191 450 DB00783 Anti-menopausal Agents.Anticholesteremic Agents.Estrogens 32 1.223 167 5719 DB00962 Anticonvulsants.Anxiolytics sedatives and hypnotics.Hypnotics and Sedatives 32 1.203 453 125889 DB00230 Analgesics.Anticonvulsants 32 1.192 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 32 1.184 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 32 1.139 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 32 1.116 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 32 1.087 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 32 1.074 42 4196 DB00834 Abortifacient Agents, Steroidal.Contraceptives, Oral, Synthetic.Contraceptives, Postcoital, Synthetic.Hormone Antagonists.Luteolytic Agents.Menstruation-Inducing Agents 32 1.063 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 32 1.06 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 32 1.025 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 32 1.005 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 32 0.956 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 32 0.879 91 3902 DB01006 Antineoplastic Agents.Aromatase Inhibitors 32 0.862 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 32 0.843 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists 32 0.817 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 32 0.808 166 54374 DB00104 Anabolic Agents.Antineoplastic Agents, Hormonal.Gastrointestinal Agents.Hormone Replacement Agents 32 0.758 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 32 0.742 60 62819 DB00094 Fertility Agents 32 0.74 72 4183806 DB00929 Abortifacient Agents.Abortifacient Agents, Nonsteroidal.Anti-Ulcer Agents.Oxytocics.Prostaglandins 32 0.74 129 5210 DB01105 Anorexigenic Agents.Antidepressants.Antidepressive Agents.Appetite Depressants.Stimulants 32 0.739 82 47725 DB00014 Antineoplastic Agents.Antineoplastic Agents, Hormonal 32 0.738 196 3911 DB00007 Anti-Estrogen Agents.Antineoplastic Agents 32 0.707 69 2512 DB00248 Antineoplastic Agents.Antiparkinson Agents.Dopamine Agonists 32 0.699 196 1935 DB00382 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 32 0.69 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 32 0.689 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 32 0.685 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 32 0.679 149 5394 DB00853 Antineoplastic Agents.Antineoplastic Agents, Alkylating 32 0.672 161 5487 DB00697 Adrenergic alpha-Agonists.Analgesics.Anticonvulsants.Muscle Relaxants.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 32 0.663 101 2800 DB00822 Alcohol Deterrents.Enzyme Inhibitors 32 0.661 147 71158 DB00659 Alcohol Deterrents 32 0.65 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 32 0.636 141 4819 DB01085 Cholinergic Agents.Miotics.Muscarinic Agonists 32 0.627 142 2678 DB00341 Anti-Allergic Agents.Antihistamines.Histamine H1 Antagonists, Non-Sedating 32 0.621 158 34312 DB00776 Anticonvulsants 32 0.621 90 2477 DB00490 Anti-anxiety Agents.Anxiolytics sedatives and hypnotics.Serotonin Agonists 32 0.61 146 4158 DB00422 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Uptake Inhibitors.Sympathomimetics 32 0.604 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 32 0.564 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 32 0.559 133 2802 DB01068 Anticonvulsants.Benzodiazepines.GABA Modulators 32 0.555 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 32 0.539 41 5516 DB00539 Antineoplastic Agents.Antineoplastic Agents, Hormonal.Bone Density Conservation Agents.Selective Estrogen Receptor Modulators 32 0.528 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 32 0.515 39 104741 DB00947 Antineoplastic Agents.Antineoplastic Agents, Hormonal.Estrogen Antagonists 32 0.512 57 2949 DB01406 Estrogen Antagonists 32 0.499 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 32 0.495 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 32 0.492 264 5372 DB00864 Immunosuppressive Agents 32 0.492 151 41317 DB00459 Keratolytic Agents 32 0.482 151 60835 DB00476 Adrenergic Uptake Inhibitors.Antidepressive Agents.Dopamine Uptake Inhibitors.Serotonin Uptake Inhibitors 32 0.48 234 216326 DB00480 Antineoplastic Agents 32 0.471 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 32 0.467 128 2250 DB01076 Anticholesteremic Agents.Hydroxymethylglutaryl-CoA Reductase Inhibitors 32 0.461 101 14888 DB01169 Antineoplastic Agents.Homeopathic Agents 32 0.458 21 5267 DB00421 Aldosterone Antagonists.Diuretics 32 0.445 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 32 0.44 199 5358 DB00669 Selective Serotonin Agonists.Serotonin Agonists.Vasoconstrictor Agents 32 0.44 94 4409 DB00461 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents 32 0.436 161 122316 DB01367 Monoamine Oxidase Inhibitors.Neuroprotective Agents 32 0.415 188 5040 DB00877 Anti-Bacterial Agents.Antibiotics, Antineoplastic.Antifungal Agents.Antifungals.Immunosuppressive Agents 32 0.379 34 4536 DB00717 Contraceptives, Oral, Synthetic.Progestins 32 0.37 154 27661 DB01020 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 32 0.365 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 32 0.351 62 3007 DB00182 Adrenergic Agents.Adrenergic Uptake Inhibitors.Amphetamines.Central Nervous System Stimulants.Dopamine Agents.Dopamine Uptake Inhibitors.Sympathomimetics 32 0.345 144 3702 DB00808 Antihypertensive Agents.Diuretics 32 0.338 185 4594 DB00338 Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 32 0.335 211 60953 DB01101 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Prodrugs 32 0.333 64 19090 DB00351 Antineoplastic Agents, Hormonal.Contraceptives, Oral, Synthetic 32 0.324 136 2375 DB01128 Androgen Antagonists.Antineoplastic Agents 32 0.323 132 3948 DB00978 Anti-Infective Agents.Anti-Infective Agents, Urinary.Antitubercular Agents.Photosensitizing Agents 32 0.321 171 2909 DB00091 Antifungal Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Immunomodulatory Agents.Immunosuppressive Agents 32 0.308 111 5281104 DB00910 Not Available 32 0.301 38 125017 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 32 0.288 86 115237 DB01267 Antipsychotic Agents 32 0.267 54 4599 DB01083 Anti-Obesity Agents.Enzyme Inhibitors #### component 33: positive weight features and high scoring objects #### # positive weight on target proteins 33 0.82 26 SC6A4_HUMAN Sodium-dependent serotonin transporter; 33 0.333 28 SC6A2_HUMAN Sodium-dependent noradrenaline transporter; 33 0.148 9 GABR2_HUMAN Gamma-aminobutyric acid type B receptor subunit 2; 33 0.144 6 DRD4_HUMAN D(4) dopamine receptor; 33 0.119 18 SCN5A_HUMAN Sodium channel protein type 5 subunit alpha; 33 0.108 5 SCN1A_HUMAN Sodium channel protein type 1 subunit alpha; 33 0.102 8 GBRR2_HUMAN Gamma-aminobutyric acid receptor subunit rho-2; 33 0.102 8 TSPOA_HUMAN Translocator protein; 33 0.096 17 SCN1B_HUMAN Sodium channel subunit beta-1; 33 0.096 17 SCNAA_HUMAN Sodium channel protein type 10 subunit alpha; 33 0.096 17 SCN7A_HUMAN Sodium channel protein type 7 subunit alpha; 33 0.096 17 SCN4A_HUMAN Sodium channel protein type 4 subunit alpha; 33 0.096 17 DB124_HUMAN Beta-defensin 124; 33 0.096 17 SCN3B_HUMAN Sodium channel subunit beta-3; 33 0.096 17 EF1B_HUMAN Elongation factor 1-beta; 33 0.096 17 ACCN4_HUMAN Amiloride-sensitive cation channel 4; 33 0.096 17 SCN4B_HUMAN Sodium channel subunit beta-4; 33 0.096 17 ACCN3_HUMAN Amiloride-sensitive cation channel 3; 33 0.096 17 SCN3A_HUMAN Sodium channel protein type 3 subunit alpha; 33 0.07 13 CAC1A_HUMAN Voltage-dependent P/Q-type calcium channel subunit alpha-1A; 33 0.045 15 RYR3_HUMAN Ryanodine receptor 3; 33 0.045 15 RYR2_HUMAN Ryanodine receptor 2; 33 0.04 18 SCNNG_HUMAN Amiloride-sensitive sodium channel subunit gamma; 33 0.04 18 SCNNB_HUMAN Amiloride-sensitive sodium channel subunit beta; 33 0.04 18 SCNND_HUMAN Amiloride-sensitive sodium channel subunit delta; 33 0.037 28 DRD3_HUMAN D(3) dopamine receptor; 33 0.031 13 CACB1_HUMAN Voltage-dependent L-type calcium channel subunit beta-1; 33 0.024 12 CA2D1_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-1; 33 0.024 12 ITPR3_HUMAN Inositol 1,4,5-trisphosphate receptor type 3; 33 0.024 12 TRPA1_HUMAN Transient receptor potential cation channel subfamily A member 1; 33 0.024 12 ITPR1_HUMAN Inositol 1,4,5-trisphosphate receptor type 1; 33 0.024 12 CCG7_HUMAN Voltage-dependent calcium channel gamma-7 subunit; 33 0.024 12 PKD2_HUMAN Polycystin-2; 33 0.024 12 CCG4_HUMAN Voltage-dependent calcium channel gamma-4 subunit; 33 0.024 12 CAC1E_HUMAN Voltage-dependent R-type calcium channel subunit alpha-1E; 33 0.024 12 CAC1S_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1S; 33 0.024 12 CCG2_HUMAN Voltage-dependent calcium channel gamma-2 subunit; 33 0.024 12 CACB4_HUMAN Voltage-dependent L-type calcium channel subunit beta-4; 33 0.024 12 CACB3_HUMAN Voltage-dependent L-type calcium channel subunit beta-3; 33 0.024 12 PKD1_HUMAN Polycystin-1; 33 0.024 12 TRPV6_HUMAN Transient receptor potential cation channel subfamily V member 6; 33 0.022 14 RYR1_HUMAN Ryanodine receptor 1; 33 0.018 16 CAC1G_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1G; 33 0.001 9 CHLE_HUMAN Cholinesterase; # positive weight on side effects 33 0.456 152 postural hypotension 33 0.429 70 abnormal gait 33 0.31 125 dehydration 33 0.272 152 urinary retention 33 0.26 69 tooth disorder 33 0.252 85 hiccup 33 0.252 222 flushing 33 0.24 101 coma 33 0.219 284 syncope 33 0.212 31 neurosis 33 0.191 93 eructation 33 0.185 147 decreased libido 33 0.104 34 goiter 33 0.058 56 kidney calculus 33 0.049 55 menstrual disorder 33 0.047 49 urinary urgency 33 0.034 377 constipation 33 0.031 46 bursitis 33 0.024 94 arthrosis 33 0.023 60 neuralgia 33 0.012 41 bundle branch block # high scoring drugs for both targets and side effects 33 2.12 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 33 2.035 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 33 1.911 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 33 1.895 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 33 1.857 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 33 1.854 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 33 1.798 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 33 1.783 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 33 1.724 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 33 1.7 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 33 1.698 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 33 1.539 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 33 1.487 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 33 1.478 150 1775 DB00252 Anticonvulsants 33 1.467 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 33 1.461 95 16231 DB00594 Diuretics.Sodium channel blockers 33 1.42 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 33 1.389 151 60835 DB00476 Adrenergic Uptake Inhibitors.Antidepressive Agents.Dopamine Uptake Inhibitors.Serotonin Uptake Inhibitors 33 1.353 453 125889 DB00230 Analgesics.Anticonvulsants 33 1.243 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 33 1.236 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 33 1.224 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 33 1.2 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 33 1.118 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 33 1.115 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 33 1.104 146 4158 DB00422 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Uptake Inhibitors.Sympathomimetics 33 1.09 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 33 1.09 129 5210 DB01105 Anorexigenic Agents.Antidepressants.Antidepressive Agents.Appetite Depressants.Stimulants 33 1.089 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 33 1.065 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 33 1.027 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 33 1.014 135 5734 DB00909 Anticonvulsants.Antioxidants 33 0.99 183 3648 DB00327 Analgesics, Opioid.Narcotics 33 0.961 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 33 0.959 167 5719 DB00962 Anticonvulsants.Anxiolytics sedatives and hypnotics.Hypnotics and Sedatives 33 0.94 128 4253 DB00295 Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 33 0.932 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists 33 0.926 120 2284 DB00181 GABA Agonists.Muscle Relaxants.Muscle Relaxants, Central.Skeletal Muscle Relaxants 33 0.9 69 3696 DB00458 Adrenergic Uptake Inhibitors.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 33 0.894 72 2160 DB00321 Adrenergic Uptake Inhibitors.Analgesics, Non-Narcotic.Antidepressive Agents, Tricyclic 33 0.888 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 33 0.882 146 3075 DB00343 Antihypertensive Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Cardiovascular Agents.Vasodilator Agents 33 0.88 181 4932 DB01182 Anti-Arrhythmia Agents 33 0.862 91 3355 DB01195 Anti-Arrhythmia Agents.Antiarrhythmic Agents 33 0.85 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 33 0.813 112 71273 DB00296 Anesthetics.Anesthetics, Local.Local Anesthetics 33 0.801 131 4635 DB00497 Analgesics, Opioid.Antitussives.Narcotics.Opiate Agonists 33 0.801 264 5372 DB00864 Immunosuppressive Agents 33 0.79 67 4976 DB00344 Adrenergic Uptake Inhibitors.Antidepressive Agents.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 33 0.786 62 3007 DB00182 Adrenergic Agents.Adrenergic Uptake Inhibitors.Amphetamines.Central Nervous System Stimulants.Dopamine Agents.Dopamine Uptake Inhibitors.Sympathomimetics 33 0.774 87 5533 DB00656 Anti-anxiety Agents.Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 33 0.77 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 33 0.737 211 60953 DB01101 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Prodrugs 33 0.733 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 33 0.724 158 34312 DB00776 Anticonvulsants 33 0.723 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 33 0.713 143 4054 DB01043 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agents.Excitatory Amino Acid Antagonists 33 0.701 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 33 0.669 133 2802 DB01068 Anticonvulsants.Benzodiazepines.GABA Modulators 33 0.662 84 2995 DB01151 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Enzyme Inhibitors.Norepinephrine-Reuptake Inhibitors 33 0.654 65 4543 DB00540 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 33 0.648 157 4659569 DB00323 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Enzyme Inhibitors 33 0.638 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 33 0.637 154 3157 DB00590 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Anticholesteremic Agents.Antihypertensive Agents.Vasodilator Agents 33 0.633 74 3676 DB00281 Anesthetics.Anesthetics, Local.Anti-Arrhythmia Agents.Antiarrhythmic Agents 33 0.626 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 33 0.625 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 33 0.624 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 33 0.614 89 3148 DB00757 Antiemetics.Serotonin Antagonists 33 0.607 75 4178 DB00379 Anti-Arrhythmia Agents 33 0.603 51 48041 DB01228 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Sodium channel blockers 33 0.592 161 122316 DB01367 Monoamine Oxidase Inhibitors.Neuroprotective Agents 33 0.584 196 3911 DB00007 Anti-Estrogen Agents.Antineoplastic Agents 33 0.582 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 33 0.578 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 33 0.563 64 5584 DB00726 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 33 0.562 137 62959 DB00685 Anti-Infective Agents.Anti-Infectives.Fluoroquinolones 33 0.562 84 3016 DB00829 Adjuvants, Anesthesia.Anesthetics, Intravenous.Anti-anxiety Agents.Anticonvulsants.Antiemetics.GABA Modulators.Hypnotics and Sedatives.Muscle Relaxants, Central 33 0.558 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 33 0.555 147 71158 DB00659 Alcohol Deterrents 33 0.552 136 56339 DB01320 Anticonvulsants 33 0.547 211 93860 DB00188 Antineoplastic Agents.Protease Inhibitors 33 0.546 69 2170 DB00543 Adrenergic Uptake Inhibitors.Antidepressive Agents, Second-Generation.Dopamine Antagonists.Neurotransmitter Uptake Inhibitors.Serotonin Uptake Inhibitors 33 0.539 111 5281104 DB00910 Not Available 33 0.539 188 5040 DB00877 Anti-Bacterial Agents.Antibiotics, Antineoplastic.Antifungal Agents.Antifungals.Immunosuppressive Agents 33 0.536 38 125017 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 33 0.524 61 3114 DB00280 Anti-Arrhythmia Agents.Antiarrhythmic Agents 33 0.496 73 3333 DB01023 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Calcium Channel Blockers.Dihydropyridines.Vasodilator Agents 33 0.47 50 3158 DB01142 Anti-anxiety Agents.Antidepressants.Antidepressive Agents, Tricyclic.Antipruritics.Histamine Antagonists.Norepinephrine-Reuptake Inhibitors 33 0.46 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 33 0.459 196 1935 DB00382 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 33 0.459 154 27661 DB01020 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 33 0.455 144 3702 DB00808 Antihypertensive Agents.Diuretics 33 0.449 102 4943 DB00818 Anesthetics, Intravenous.Anticonvulsants.Antiemetics.Free Radical Scavengers.Hypnotics and Sedatives 33 0.448 171 2909 DB00091 Antifungal Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Immunomodulatory Agents.Immunosuppressive Agents 33 0.424 172 4920 DB00396 Contraceptives.Progestins 33 0.422 104 3449 DB00674 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 33 0.421 89 59708 DB01202 Anticonvulsants.Nootropic Agents 33 0.399 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 33 0.39 199 5358 DB00669 Selective Serotonin Agonists.Serotonin Agonists.Vasoconstrictor Agents #### component 34: positive weight features and high scoring objects #### # positive weight on target proteins 34 0.523 22 CP51A_HUMAN Lanosterol 14-alpha demethylase; 34 0.342 18 CP2R1_HUMAN Vitamin D 25-hydroxylase; 34 0.335 19 CP27B_HUMAN 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; 34 0.219 17 CP8B1_HUMAN 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase; 34 0.219 17 PTGIS_HUMAN Prostacyclin synthase; 34 0.219 17 CP7A1_HUMAN Cholesterol 7-alpha-monooxygenase; 34 0.219 17 CP24A_HUMAN 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; 34 0.219 17 CP4F3_HUMAN Leukotriene-B(4) omega-hydroxylase 2; 34 0.219 17 CP46A_HUMAN Cholesterol 24-hydroxylase; 34 0.219 17 CP4F2_HUMAN Leukotriene-B(4) omega-hydroxylase 1; 34 0.219 17 CP27A_HUMAN Sterol 26-hydroxylase, mitochondrial; 34 0.181 16 CP39A_HUMAN 24-hydroxycholesterol 7-alpha-hydroxylase; 34 0.181 16 CP7B1_HUMAN 25-hydroxycholesterol 7-alpha-hydroxylase; 34 0.181 16 COQ6_HUMAN Ubiquinone biosynthesis monooxygenase COQ6; 34 0.101 16 CP11A_HUMAN Cholesterol side-chain cleavage enzyme, mitochondrial; 34 0.055 18 CP17A_HUMAN Steroid 17-alpha-hydroxylase/17,20 lyase; 34 0.048 16 CP21A_HUMAN Steroid 21-hydroxylase; # positive weight on side effects 34 0.112 244 arrhythmia 34 0.089 209 jaundice 34 0.084 131 diplopia 34 0.055 15 corneal opacity 34 0.023 112 gynecomastia # high scoring drugs for both targets and side effects 34 2.579 41 5516 DB00539 Antineoplastic Agents.Antineoplastic Agents, Hormonal.Bone Density Conservation Agents.Selective Estrogen Receptor Modulators 34 2.559 28 2583 DB00521 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents.Sympatholytics 34 2.517 21 4114 DB00553 Antineoplastic Agents.Cross-Linking Reagents.Photosensitizing Agents.Pigmenting Agents 34 2.517 7 3562 DB01159 Anesthetics.Anesthetics, Inhalation.General Anesthetics 34 2.505 14 10100 DB00647 Analgesics.Analgesics, Opioid.Antitussives.Narcotics 34 2.491 19 5505 DB01124 Hypoglycemic Agents.Sulfonylureas 34 2.461 11 2519 DB00201 Anorexigenic Agents.Central Nervous System Stimulants.Phosphodiesterase Inhibitors 34 2.417 28 2145 DB00357 Adrenergic Agents.Antineoplastic Agents.Antineoplastic Agents, Hormonal.Aromatase Inhibitors 34 2.302 86 2118 DB00404 Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 34 2.191 6 4174 DB01011 Antimetabolites.Enzyme Inhibitors 34 2.183 42 4196 DB00834 Abortifacient Agents, Steroidal.Contraceptives, Oral, Synthetic.Contraceptives, Postcoital, Synthetic.Hormone Antagonists.Luteolytic Agents.Menstruation-Inducing Agents 34 1.889 73 3333 DB01023 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Calcium Channel Blockers.Dihydropyridines.Vasodilator Agents 34 1.884 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 34 1.864 64 5584 DB00726 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 34 1.671 50 2973 DB00746 Chelating agent.Iron Chelating Agents.Siderophores 34 1.591 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 34 1.155 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 34 0.765 15 4189 DB01110 Antifungal Agents 34 0.751 19 3249 DB00153 Antihypocalcemic Agents.Antihypoparathyroid Agents.Bone Density Conservation Agents.Essential Vitamin.Vitamins.Vitamins (Vitamin D) 34 0.702 49 3365 DB00196 Antifungal Agents.Antifungals 34 0.689 23 3821 DB01221 Analgesics.Anesthetics, Dissociative.Excitatory Amino Acid Antagonists.General Anesthetics 34 0.681 20 4616 DB00842 Anti-anxiety Agents.GABA Modulators.Hypnotics and Sedatives 34 0.672 44 4060 DB00532 Anticonvulsants 34 0.668 10 3226 DB00228 Anesthetics, Inhalation.General Anesthetics 34 0.656 4 5878 DB00621 Anabolic Agents.Androgens 34 0.656 10 2712 DB00475 Adjuvants, Anesthesia.Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 34 0.654 7 5404 DB00251 Antifungal Agents.Antifungals 34 0.642 23 5578 DB00440 Anti-Infective Agents, Urinary.Anti-Infectives.Antimalarials.Folic Acid Antagonists 34 0.641 12 60169 DB01334 Neuromuscular Nondepolarizing Agents 34 0.639 7 2551 DB00411 Analgesics, Non-Narcotic.Cardiotonic Agents.Cholinergic Agonists.Miotics 34 0.636 16 5591 DB00197 Antineoplastic Agents.Fibrinolytic Agents.Hypoglycemic Agents.Platelet Aggregation Inhibitors.Vasodilator Agents 34 0.633 19 3387 DB01185 Anabolic Agents.Antineoplastic Agents, Hormonal 34 0.633 16 4160 DB00624 Androgens 34 0.625 24 5503 DB00839 Hypoglycemic Agents 34 0.623 17 152945 DB01126 Anti-baldness Agents.Antihyperplasia Agents.Enzyme Inhibitors 34 0.616 12 4909 DB00794 Anticonvulsants.Barbiturates 34 0.611 4 6503 DB03754 Buffers.Excipients 34 0.611 16 2812 DB00257 Anti-Infective Agents, Local.Antifungal Agents.Growth Inhibitors 34 0.611 14 2133 DB00288 Corticosteroids, topical 34 0.611 11 2522 DB02300 Antipsoriatic Agents.Dermatologic Agents.Vitamin D3 Receptor inhibitor 34 0.611 14 47319 DB00732 Neuromuscular Nondepolarizing Agents.Nicotinic Antagonists 34 0.611 2 1071 DB00162 Anti-acne Agents.Essential Vitamin.Vitamins.Vitamins (Vitamin A) 34 0.611 6 888 DB01378 Not Available 34 0.611 16 3382 DB01047 Anti-Allergic Agents.Anti-inflammatory Agents.Glucocorticoids 34 0.611 9 2733 DB00356 Muscle Relaxants, Central 34 0.611 5 10548 DB01057 Cholinesterase Inhibitors.Miotics.Parasympathomimetics 34 0.611 3 2484 DB01091 Antifungal Agents 34 0.611 18 2266 DB00548 Antineoplastic Agents.Dermatologic Agents 34 0.611 10 4630253 DB00240 Anti-inflammatory Agents.Antipruritic Agents.Corticosteroids.Glucocorticoids 34 0.611 11 3117 DB00822 Alcohol Deterrents.Enzyme Inhibitors 34 0.611 6 4908 DB01087 Antimalarial Agents.Antimalarials.Antiprotozoal Agents 34 0.611 19 4934 DB00782 Anti-Ulcer Agents.Antimuscarinics.Antispasmodics.Muscarinic Antagonists 34 0.611 11 4043 DB00253 Topical anti-inflammatory Agent 34 0.611 11 3375 DB00223 Anti-inflammatory Agents.Glucocorticoids 34 0.611 10 3392 DB00846 Anti-inflammatory Agents.Glucocorticoids 34 0.611 9 5593 DB00809 Diagnostic aid, cycloplegic.Diagnostic aid, mydriatic.Muscarinic Antagonists.Mydriatics 34 0.611 9 232 DB00125 Conditionally Essential Amino Acids.Dietary supplement.Micronutrient 34 0.611 3 6256 DB00432 Antimetabolites.Antiviral Agents 34 0.611 3 47641 DB00735 Anti-Inflammatory Agents, Non-Steroidal.Antifungal Agents 34 0.611 9 2366 Not Available Not Available 34 0.611 4 4768 DB00925 Adrenergic alpha-Antagonists.Antihypertensive Agents.Vasodilator Agents 34 0.611 11 5381 DB00799 Dermatologic Agents.Keratolytic Agents.Prodrugs.Teratogens 34 0.611 17 3000 DB00547 Anti-inflammatory Agents.Glucocorticoids 34 0.609 12 3384 DB00324 Anti-Allergic Agents.Anti-inflammatory Agents.Glucocorticoids 34 0.605 16 5771 DB00107 Anti-tocolytic Agents.Labor Induction Agents.Oxytocics 34 0.605 14 104803 DB01226 Neuromuscular Nondepolarizing Agents 34 0.6 10 47320 DB00565 Neuromuscular Blocking Agents 34 0.6 10 4675 DB01337 Neuromuscular Nondepolarizing Agents.Nicotinic Antagonists 34 0.599 25 3767 DB00951 Antitubercular Agents.Fatty Acid Synthesis Inhibitors 34 0.597 15 5582 DB01157 Antibiotics.Antifungal Agents.Antimetabolites, Antineoplastic.Antiprotozoals.Folic Acid Antagonists 34 0.597 9 5342 DB01138 Uricosuric Agents 34 0.595 21 5311082 DB00063 Anticoagulants.Antiplatelet Agents.Platelet Aggregation Inhibitors 34 0.594 41 2088 DB00630 Antihypocalcemic Agents.Antiresorptives.Bisphosphonates.Bone Density Conservation Agents 34 0.591 16 3405 DB00158 Dietary supplement.Hematinics.Micronutrient.Vitamin B Complex 34 0.591 10 271 DB01373 Not Available 34 0.59 33 657298 DB00550 Antimetabolites.Antithyroid Agents 34 0.59 24 1349907 DB00763 Antithyroid Agents 34 0.577 14 4993 DB00205 Antimalarials.Antiprotozoal Agents.Antiprotozoals.Folic Acid Antagonists 34 0.577 17 48175 DB00596 Anti-inflammatory Agents.Vasoconstrictor Agents 34 0.577 18 1046 DB00339 Antitubercular Agents 34 0.567 16 3763 DB00753 Anesthetics.Anesthetics, Inhalation.General Anesthetics 34 0.566 35 3042 DB00804 Anticholinergic Agents.Antimuscarinics.Antispasmodics.Muscarinic Antagonists.Parasympatholytics 34 0.564 18 3698 DB01427 Calcium Channel Blockers.Cardiotonic Agents.Phosphodiesterase Inhibitors.Vasodilator Agents 34 0.558 9 3219 DB01084 Anti-Allergic Agents.Histamine H1 Antagonists 34 0.558 15 39507 DB00896 Anti-inflammatory Agents.Corticosteroids 34 0.556 19 4032 DB00657 Antihypertensive Agents.Ganglionic Blockers.Nicotinic Antagonists 34 0.555 35 16362 DB01100 Anti-Dyskinesia Agents.Antipsychotic Agents.Dopamine Antagonists 34 0.55 24 145068 DB00435 Bronchodilator Agents.Endothelium-Dependent Relaxing Factors.Free Radical Scavengers 34 0.544 29 3954 DB00836 Antidiarrheals 34 0.544 21 4057 DB04843 Anticholinergic Agents.Parasympatholytics 34 0.544 3 4034 DB00737 Anti-Allergic Agents.Antiemetics.Antihistamines.Histamine H1 Antagonists 34 0.544 14 27400 Not Available Not Available 34 0.538 30 8612 DB01161 Anesthetics, Local 34 0.532 11 4919 DB00387 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists 34 0.526 14 3354 DB01148 Parasympatholytics 34 0.524 9 1148 DB00150 Antidepressive Agents, Second-Generation.Dietary supplement.Essential Amino Acids.Micronutrient 34 0.524 19 2344 DB00245 Antidyskinetics.Antiparkinson Agents.Dopamine Uptake Inhibitors.Muscarinic Antagonists.Parasympatholytics 34 0.52 57 2949 DB01406 Estrogen Antagonists 34 0.493 49 4078 DB00933 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 34 0.489 9 861 DB00279 Hormone Replacement Agents #### component 35: positive weight features and high scoring objects #### # positive weight on target proteins 35 0.519 29 GBRA1_HUMAN Gamma-aminobutyric acid receptor subunit alpha-1; 35 0.3 23 GBRA2_HUMAN Gamma-aminobutyric acid receptor subunit alpha-2; 35 0.231 21 GBRD_HUMAN Gamma-aminobutyric acid receptor subunit delta; 35 0.231 21 GBRB2_HUMAN Gamma-aminobutyric acid receptor subunit beta-2; 35 0.231 21 GBRR1_HUMAN Gamma-aminobutyric acid receptor subunit rho-1; 35 0.231 21 GBRG3_HUMAN Gamma-aminobutyric acid receptor subunit gamma-3; 35 0.231 21 GBRG2_HUMAN Gamma-aminobutyric acid receptor subunit gamma-2; 35 0.231 21 GBRE_HUMAN Gamma-aminobutyric acid receptor subunit epsilon; 35 0.231 21 GBRT_HUMAN Gamma-aminobutyric acid receptor subunit theta; 35 0.231 21 GBRB1_HUMAN Gamma-aminobutyric acid receptor subunit beta-1; 35 0.231 21 GBRB3_HUMAN Gamma-aminobutyric acid receptor subunit beta-3; 35 0.2 22 GBRA6_HUMAN Gamma-aminobutyric acid receptor subunit alpha-6; 35 0.2 22 GBRA3_HUMAN Gamma-aminobutyric acid receptor subunit alpha-3; 35 0.2 22 GBRA5_HUMAN Gamma-aminobutyric acid receptor subunit alpha-5; 35 0.2 22 GBRA4_HUMAN Gamma-aminobutyric acid receptor subunit alpha-4; # positive weight on side effects 35 0.558 180 seizures 35 0.378 16 bigeminy 35 0.278 205 bradycardia 35 0.26 57 hypoxia 35 0.198 76 nightmares 35 0.195 187 weakness 35 0.189 87 phlebitis 35 0.189 123 urinary incontinence 35 0.177 284 syncope 35 0.13 28 respiratory arrest 35 0.12 62 ventricular extrasystoles 35 0.092 87 thrombophlebitis 35 0.038 13 strabismus 35 0.019 6 psychomotor retardation 35 0.008 105 psychosis # high scoring drugs for both targets and side effects 35 2.77 61 4192 DB00683 Adjuvants, Anesthesia.Anesthetics, Intravenous.Anti-anxiety Agents.GABA Modulators.Hypnotics and Sedatives 35 2.695 102 4943 DB00818 Anesthetics, Intravenous.Anticonvulsants.Antiemetics.Free Radical Scavengers.Hypnotics and Sedatives 35 2.45 58 5206 DB01236 Anesthetics, Inhalation.Platelet Aggregation Inhibitors 35 2.368 120 2284 DB00181 GABA Agonists.Muscle Relaxants.Muscle Relaxants, Central.Skeletal Muscle Relaxants 35 2.244 73 3958 DB00186 Anti-anxiety Agents.Anticonvulsants.Antiemetics.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 35 2.199 84 3016 DB00829 Adjuvants, Anesthesia.Anesthetics, Intravenous.Anti-anxiety Agents.Anticonvulsants.Antiemetics.GABA Modulators.Hypnotics and Sedatives.Muscle Relaxants, Central 35 2.128 86 2118 DB00404 Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 35 2.113 147 71158 DB00659 Alcohol Deterrents 35 2.101 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 35 2.087 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 35 2.064 13 36339 DB00292 Anesthetics, Intravenous.Hypnotics and Sedatives 35 2.04 167 5719 DB00962 Anticonvulsants.Anxiolytics sedatives and hypnotics.Hypnotics and Sedatives 35 1.982 23 3821 DB01221 Analgesics.Anesthetics, Dissociative.Excitatory Amino Acid Antagonists.General Anesthetics 35 1.927 23 5193 DB00418 Adjuvants.Adjuvants, Anesthesia.Barbiturates.GABA Modulators.Hypnotics and Sedatives 35 1.927 23 4737 DB00312 Adjuvants, Anesthesia.Barbiturates.GABA Modulators.Hypnotics and Sedatives 35 1.906 133 2802 DB01068 Anticonvulsants.Benzodiazepines.GABA Modulators 35 1.889 25 9034 DB00474 Anesthetics.Anesthetics, Intravenous.Barbiturates 35 1.755 38 3393 DB00690 Anti-anxiety Agents.GABA Modulators.Hypnotics and Sedatives 35 1.689 10 2712 DB00475 Adjuvants, Anesthesia.Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 35 1.666 7 3562 DB01159 Anesthetics.Anesthetics, Inhalation.General Anesthetics 35 1.564 16 3763 DB00753 Anesthetics.Anesthetics, Inhalation.General Anesthetics 35 0.827 112 71273 DB00296 Anesthetics.Anesthetics, Local.Local Anesthetics 35 0.78 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 35 0.708 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 35 0.702 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 35 0.689 40 4064 DB00371 Anti-anxiety Agents.Anticonvulsants.Hypnotics and Sedatives.Muscle Relaxants, Central 35 0.633 65 2474 DB00297 Anesthetics, Local 35 0.632 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 35 0.629 91 60815 DB00899 Analgesics, Opioid.Anesthetics, Intravenous.Hypnotics and Sedatives 35 0.62 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 35 0.612 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 35 0.587 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists 35 0.581 74 3676 DB00281 Anesthetics.Anesthetics, Local.Anti-Arrhythmia Agents.Antiarrhythmic Agents 35 0.565 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 35 0.556 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 35 0.556 161 5487 DB00697 Adrenergic alpha-Agonists.Analgesics.Anticonvulsants.Muscle Relaxants.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 35 0.545 196 3911 DB00007 Anti-Estrogen Agents.Antineoplastic Agents 35 0.536 128 4253 DB00295 Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 35 0.527 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 35 0.516 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 35 0.513 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 35 0.508 161 122316 DB01367 Monoamine Oxidase Inhibitors.Neuroprotective Agents 35 0.508 59 4095 DB00333 Analgesics.Analgesics, Opioid.Antitussive Agents.Antitussives.Narcotics.Opiate Agonists 35 0.505 60 3373 DB01205 Antidotes.GABA Modulators 35 0.5 183 3648 DB00327 Analgesics, Opioid.Narcotics 35 0.496 264 5372 DB00864 Immunosuppressive Agents 35 0.491 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 35 0.49 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 35 0.485 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 35 0.484 181 4932 DB01182 Anti-Arrhythmia Agents 35 0.483 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 35 0.481 47 4927 DB01069 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists.Phenothiazine Derivatives 35 0.473 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 35 0.461 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 35 0.432 30 42113 DB01189 Anesthetics, Inhalation.Neuroprotective Agents 35 0.421 47 4419 DB00844 Analgesics, Opioid.Narcotic Antagonists.Narcotics 35 0.42 10 3226 DB00228 Anesthetics, Inhalation.General Anesthetics 35 0.402 166 54374 DB00104 Anabolic Agents.Antineoplastic Agents, Hormonal.Gastrointestinal Agents.Hormone Replacement Agents 35 0.398 167 170361 DB01273 Nicotinic Agonists 35 0.388 36 2141 DB01143 Radiation-Protective Agents 35 0.377 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 35 0.375 97 159 DB01240 Antihypertensive Agents.Platelet Aggregation Inhibitors 35 0.371 31 2441 DB01558 Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 35 0.371 42 4991 DB00545 Antimyasthenics.Cholinesterase Inhibitors.Parasympathomimetics 35 0.37 211 93860 DB00188 Antineoplastic Agents.Protease Inhibitors 35 0.37 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 35 0.358 236 10631 DB00603 Contraceptives.Contraceptives, Oral, Synthetic.Progestins 35 0.355 62 59768 DB00187 Adrenergic beta-Antagonists 35 0.352 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 35 0.352 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 35 0.352 129 5210 DB01105 Anorexigenic Agents.Antidepressants.Antidepressive Agents.Appetite Depressants.Stimulants 35 0.348 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 35 0.345 110 4666 DB01229 Antineoplastic Agents.Antineoplastic Agents, Phytogenic.Tubulin Modulators 35 0.336 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 35 0.335 57 2951 DB01219 Muscle Relaxants, Central 35 0.328 211 60953 DB01101 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Prodrugs 35 0.326 101 2800 DB00822 Alcohol Deterrents.Enzyme Inhibitors 35 0.325 77 28112 DB01356 Not Available 35 0.324 112 151165 DB00673 Antiemetics 35 0.321 90 2477 DB00490 Anti-anxiety Agents.Anxiolytics sedatives and hypnotics.Serotonin Agonists 35 0.32 44 191 DB00640 Analgesics.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Cardiac drugs.Vasodilator Agents 35 0.318 86 115237 DB01267 Antipsychotic Agents 35 0.315 161 5212 DB00203 Phosphodiesterase Inhibitors.Vasodilator Agents 35 0.315 29 2153 DB00277 Bronchodilator Agents.Phosphodiesterase Inhibitors.Respiratory Smooth Muscle Relaxants.Vasodilator Agents 35 0.309 101 14888 DB01169 Antineoplastic Agents.Homeopathic Agents 35 0.303 72 2160 DB00321 Adrenergic Uptake Inhibitors.Analgesics, Non-Narcotic.Antidepressive Agents, Tricyclic 35 0.303 199 5358 DB00669 Selective Serotonin Agonists.Serotonin Agonists.Vasoconstrictor Agents 35 0.3 26 4506 DB01595 Anti-anxiety Agents.Anticonvulsants.GABA Modulators.Hypnotics and Sedatives 35 0.299 61 60612 DB00633 Adrenergic alpha-Agonists.Analgesics.Analgesics, Non-Narcotic.Hypnotics and Sedatives 35 0.294 80 3325 DB00927 Anti-Ulcer Agents.Histamine H2 Antagonists 35 0.292 84 5401 DB01162 Adrenergic alpha-Antagonists.Antineoplastic Agents.Platelet Aggregation Inhibitors 35 0.291 137 62959 DB00685 Anti-Infective Agents.Anti-Infectives.Fluoroquinolones 35 0.29 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 35 0.287 84 2995 DB01151 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Enzyme Inhibitors.Norepinephrine-Reuptake Inhibitors 35 0.285 76 4748 DB00850 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 35 0.283 66 4011 DB00934 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Second-Generation 35 0.278 119 5064 DB00811 Antimetabolites.Antiviral Agents 35 0.273 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 35 0.27 453 125889 DB00230 Analgesics.Anticonvulsants 35 0.27 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens #### component 36: positive weight features and high scoring objects #### # positive weight on target proteins 36 0.605 23 PGH1_HUMAN Prostaglandin G/H synthase 1; 36 0.429 14 TTHY_HUMAN Transthyretin; 36 0.294 8 LOXE3_HUMAN Epidermis-type lipoxygenase 3; 36 0.294 8 LOX12_HUMAN Arachidonate 12-lipoxygenase, 12S-type; 36 0.294 8 LX12B_HUMAN Arachidonate 12-lipoxygenase, 12R-type; 36 0.197 7 LX15B_HUMAN Arachidonate 15-lipoxygenase B; 36 0.19 14 LOX5_HUMAN Arachidonate 5-lipoxygenase; 36 0.164 8 LOX15_HUMAN Arachidonate 15-lipoxygenase; 36 0.127 13 CAC1A_HUMAN Voltage-dependent P/Q-type calcium channel subunit alpha-1A; 36 0.121 10 LKHA4_HUMAN Leukotriene A-4 hydrolase; 36 0.113 13 CAC1B_HUMAN Voltage-dependent N-type calcium channel subunit alpha-1B; 36 0.073 15 CAC1I_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1I; 36 0.073 15 CAC1H_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1H; 36 0.05 12 CA2D1_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-1; 36 0.05 12 ITPR3_HUMAN Inositol 1,4,5-trisphosphate receptor type 3; 36 0.05 12 PKD1_HUMAN Polycystin-1; 36 0.05 12 ITPR1_HUMAN Inositol 1,4,5-trisphosphate receptor type 1; 36 0.05 12 CCG7_HUMAN Voltage-dependent calcium channel gamma-7 subunit; 36 0.05 12 PKD2_HUMAN Polycystin-2; 36 0.05 12 TRPA1_HUMAN Transient receptor potential cation channel subfamily A member 1; 36 0.05 12 CAC1S_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1S; 36 0.05 12 CACB4_HUMAN Voltage-dependent L-type calcium channel subunit beta-4; 36 0.05 12 CCG4_HUMAN Voltage-dependent calcium channel gamma-4 subunit; 36 0.05 12 CACB3_HUMAN Voltage-dependent L-type calcium channel subunit beta-3; 36 0.05 12 CCG2_HUMAN Voltage-dependent calcium channel gamma-2 subunit; 36 0.05 12 CAC1E_HUMAN Voltage-dependent R-type calcium channel subunit alpha-1E; 36 0.05 12 TRPV6_HUMAN Transient receptor potential cation channel subfamily V member 6; 36 0.024 13 CACB1_HUMAN Voltage-dependent L-type calcium channel subunit beta-1; 36 0.001 16 CAC1G_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1G; # positive weight on side effects 36 0.527 166 purpura 36 0.394 60 peptic ulcer 36 0.299 122 erythema multiforme 36 0.286 112 hemolytic anemia 36 0.274 104 vasculitis 36 0.273 254 nervousness 36 0.253 108 toxic epidermal necrolysis 36 0.198 118 exfoliative dermatitis 36 0.19 93 eructation 36 0.163 136 renal failure 36 0.153 274 palpitations 36 0.131 101 ulcer 36 0.096 204 sweating 36 0.089 97 aplastic anemia 36 0.088 129 eosinophilia 36 0.066 12 ulcerative colitis 36 0.061 108 ecchymosis 36 0.03 53 proteinuria # high scoring drugs for both targets and side effects 36 2.704 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 36 2.565 120 3715 DB00328 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cardiovascular Agents.Cyclooxygenase Inhibitors.Gout Suppressants.Nonsteroidal Antiinflammatory Agents (NSAIDs).Tocolytic Agents 36 2.225 92 3825 DB01009 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 36 1.966 145 3672 DB01050 Analgesics.Analgesics, Non-Narcotic.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 36 1.928 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 36 1.895 166 3394 DB00712 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Carbonic Anhydrase Inhibitors.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 36 1.763 46 4036 DB00939 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 36 1.714 142 3826 DB00465 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 36 1.681 119 3308 DB00749 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 36 1.594 95 16231 DB00594 Diuretics.Sodium channel blockers 36 1.534 146 3075 DB00343 Antihypertensive Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Cardiovascular Agents.Vasodilator Agents 36 1.506 89 4044 DB00784 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 36 1.424 81 5353980 DB00795 Anti-Infective Agents.Anti-Inflammatory Agents, Non-Steroidal.Antirheumatic Agents.Gastrointestinal Agents.Sulfonamides 36 1.407 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 36 1.367 103 5352 DB00605 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents.Cyclooxygenase Inhibitors 36 1.355 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 36 1.31 60 3059 DB00861 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 36 1.275 108 4856 DB00554 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 36 1.24 104 4614 DB00991 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Nonsteroidal Antiinflammatory Agents (NSAIDs) 36 1.234 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 36 1.184 43 5508 DB00500 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 36 1.096 71 3342 DB00573 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Propionic acid derivatives 36 1.019 119 4052 DB00814 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Antiemetics.Antineoplastic Agents.Cyclooxygenase Inhibitors.Growth Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 36 0.978 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 36 0.977 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 36 0.972 94 4409 DB00461 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents 36 0.963 131 3961 DB00678 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents 36 0.931 453 125889 DB00230 Analgesics.Anticonvulsants 36 0.918 97 1065 DB00908 Adrenergic alpha-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antimalarials.Enzyme Inhibitors.Muscarinic Antagonists 36 0.906 150 1775 DB00252 Anticonvulsants 36 0.888 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 36 0.852 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 36 0.851 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 36 0.833 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 36 0.832 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 36 0.816 152 60184 DB00790 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 36 0.815 102 83786 DB00437 Antimetabolites.Enzyme Inhibitors.Enzyme Inhibitors Antimetabolites.Free Radical Scavengers.Gout Suppressants 36 0.78 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 36 0.743 65 4727 DB00859 Antidotes.Antirheumatic Agents.Chelating Agents 36 0.737 50 5472 DB00208 Fibrinolytic Agents.Platelet Aggregation Inhibitors 36 0.726 123 2806 DB00758 Antiplatelet Agents.Fibrinolytic Agents.Platelet Aggregation Inhibitors 36 0.725 72 3440 DB00695 Diuretics.Sodium Potassium Chloride Symporter Inhibitors 36 0.719 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 36 0.717 100 5038 DB00178 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 36 0.714 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 36 0.704 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 36 0.687 34 3827 DB00920 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists 36 0.68 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 36 0.671 94 3403 DB01095 Anticholesteremic Agents.Antioxidants.Free Radical Scavengers.HMG-CoA Reductase Inhibitors.Hydroxymethylglutaryl-CoA Reductase Inhibitors 36 0.67 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 36 0.661 43 2720 DB00880 Antihypertensive Agents.Diuretics.Diuretics, Thiazide.Sodium Chloride Symporter Inhibitors 36 0.661 54 3639 DB00999 Antihypertensive Agents.Diuretics.Sodium Chloride Symporter Inhibitors 36 0.649 72 6398970 DB00535 Anti-Bacterial Agents.Anti-Infectives 36 0.634 98 3222 DB00584 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 36 0.634 106 4539 DB01059 Anti-Bacterial Agents.Anti-Infectives.Enzyme Inhibitors.Nucleic Acid Synthesis Inhibitors.Quinolones 36 0.627 74 130881 DB00275 Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 36 0.623 132 3948 DB00978 Anti-Infective Agents.Anti-Infective Agents, Urinary.Antitubercular Agents.Photosensitizing Agents 36 0.621 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 36 0.617 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 36 0.608 135 2585 DB01136 Adrenergic Agents.Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 36 0.601 144 3702 DB00808 Antihypertensive Agents.Diuretics 36 0.596 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 36 0.593 158 34312 DB00776 Anticonvulsants 36 0.584 103 2751 DB01340 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 36 0.582 99 4889 DB00175 Anticholesteremic Agents.HMG-CoA Reductase Inhibitors.Hydroxymethylglutaryl-CoA Reductase Inhibitors 36 0.576 146 4158 DB00422 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Uptake Inhibitors.Sympathomimetics 36 0.569 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 36 0.565 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 36 0.546 75 2550 DB01197 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 36 0.544 73 3333 DB01023 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Calcium Channel Blockers.Dihydropyridines.Vasodilator Agents 36 0.535 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 36 0.534 35 16362 DB01100 Anti-Dyskinesia Agents.Antipsychotic Agents.Dopamine Antagonists 36 0.528 57 2951 DB01219 Muscle Relaxants, Central 36 0.519 264 5372 DB00864 Immunosuppressive Agents 36 0.502 185 4594 DB00338 Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 36 0.499 171 2909 DB00091 Antifungal Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Immunomodulatory Agents.Immunosuppressive Agents 36 0.49 67 2267 DB00972 Anti-Allergic Agents.Anti-Inflammatory Agents, Non-Steroidal.Bronchodilator Agents.Histamine H1 Antagonists.Histamine H1 Antagonists, Non-Sedating.Lipoxygenase Inhibitors.Platelet Aggregation Inhibitors 36 0.488 157 3937 DB00722 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents.Cardiotonic Agents 36 0.488 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 36 0.482 167 5719 DB00962 Anticonvulsants.Anxiolytics sedatives and hypnotics.Hypnotics and Sedatives 36 0.48 80 54454 DB00641 Anticholesteremic Agents.Antilipemic Agents.Hydroxymethylglutaryl-CoA Reductase Inhibitors 36 0.48 87 2676 DB00439 Anticholesteremic Agents.Antilipemic Agents.Hydroxymethylglutaryl-CoA Reductase Inhibitors 36 0.467 97 4200 DB01017 Anti-Bacterial Agents.Tetracyclines 36 0.466 236 10631 DB00603 Contraceptives.Contraceptives, Oral, Synthetic.Progestins 36 0.464 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 36 0.464 147 5645 DB01586 Cholagogues and Choleretics 36 0.458 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 36 0.458 29 3954 DB00836 Antidiarrheals 36 0.446 77 3962 DB00227 Anticholesteremic Agents.Antineoplastic Agents.HMG-CoA Reductase Inhibitors.Hydroxymethylglutaryl-CoA Reductase Inhibitors 36 0.436 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 36 0.43 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 36 0.43 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 36 0.428 81 2022 DB00787 Antiviral Agents.Nucleosides and Nucleotides 36 0.424 133 4112 DB00563 Abortifacient Agents.Abortifacient Agents, Nonsteroidal.Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Folic Acid Antagonists.Immunosuppressive Agents.Nucleic Acid Synthesis Inhibitors 36 0.414 196 3911 DB00007 Anti-Estrogen Agents.Antineoplastic Agents 36 0.41 90 2162 DB00381 Antianginals.Antihypertensive Agents.Calcium Channel Blockers.Vasodilator Agents 36 0.403 117 2405 DB00612 Adrenergic Agents.Adrenergic beta-Antagonists.Antihypertensive Agents.Sympatholytics 36 0.402 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 36 0.399 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 36 0.394 127 2156 DB01118 Anti-Arrhythmia Agents.Enzyme Inhibitors.Vasodilator Agents #### component 37: positive weight features and high scoring objects #### # positive weight on target proteins 37 0.659 29 PGH2_HUMAN Prostaglandin G/H synthase 2; 37 0.458 23 PGH1_HUMAN Prostaglandin G/H synthase 1; 37 0.16 19 OPRM_HUMAN Mu-type opioid receptor; 37 0.159 21 GBRD_HUMAN Gamma-aminobutyric acid receptor subunit delta; 37 0.159 21 GBRR1_HUMAN Gamma-aminobutyric acid receptor subunit rho-1; 37 0.159 21 GBRG3_HUMAN Gamma-aminobutyric acid receptor subunit gamma-3; 37 0.159 21 GBRB2_HUMAN Gamma-aminobutyric acid receptor subunit beta-2; 37 0.159 21 GBRG2_HUMAN Gamma-aminobutyric acid receptor subunit gamma-2; 37 0.159 21 GBRB3_HUMAN Gamma-aminobutyric acid receptor subunit beta-3; 37 0.159 21 GBRE_HUMAN Gamma-aminobutyric acid receptor subunit epsilon; 37 0.159 21 GBRT_HUMAN Gamma-aminobutyric acid receptor subunit theta; 37 0.159 21 GBRB1_HUMAN Gamma-aminobutyric acid receptor subunit beta-1; 37 0.125 22 GBRA6_HUMAN Gamma-aminobutyric acid receptor subunit alpha-6; 37 0.125 22 GBRA3_HUMAN Gamma-aminobutyric acid receptor subunit alpha-3; 37 0.125 22 GBRA5_HUMAN Gamma-aminobutyric acid receptor subunit alpha-5; 37 0.125 22 GBRA4_HUMAN Gamma-aminobutyric acid receptor subunit alpha-4; 37 0.124 23 GBRA2_HUMAN Gamma-aminobutyric acid receptor subunit alpha-2; 37 0.112 17 OPRD_HUMAN Delta-type opioid receptor; 37 0.079 16 OPRK_HUMAN Kappa-type opioid receptor; 37 0.068 29 GBRA1_HUMAN Gamma-aminobutyric acid receptor subunit alpha-1; 37 0.052 30 ADA1D_HUMAN Alpha-1D adrenergic receptor; 37 0.007 42 ADA1A_HUMAN Alpha-1A adrenergic receptor; 37 0.001 9 OPRX_HUMAN Nociceptin receptor; # positive weight on side effects 37 0.311 280 anxiety 37 0.208 513 vomiting 37 0.162 172 chills 37 0.137 322 tachycardia 37 0.126 133 bronchospasm 37 0.111 152 urinary retention 37 0.103 152 weight loss 37 0.101 244 arrhythmia 37 0.074 119 gastroenteritis 37 0.05 56 kidney calculus 37 0.048 99 polyuria 37 0.034 50 Clotting 37 0.017 114 lymphadenopathy 37 0.014 39 duodenal ulcer 37 0.009 249 blurred vision 37 0.005 85 pulmonary embolism 37 0.002 45 hepatic necrosis 37 0.001 83 leukocytosis # high scoring drugs for both targets and side effects 37 1.592 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 37 1.586 120 2284 DB00181 GABA Agonists.Muscle Relaxants.Muscle Relaxants, Central.Skeletal Muscle Relaxants 37 1.441 23 3821 DB01221 Analgesics.Anesthetics, Dissociative.Excitatory Amino Acid Antagonists.General Anesthetics 37 1.427 61 4192 DB00683 Adjuvants, Anesthesia.Anesthetics, Intravenous.Anti-anxiety Agents.GABA Modulators.Hypnotics and Sedatives 37 1.381 102 4943 DB00818 Anesthetics, Intravenous.Anticonvulsants.Antiemetics.Free Radical Scavengers.Hypnotics and Sedatives 37 1.38 133 2802 DB01068 Anticonvulsants.Benzodiazepines.GABA Modulators 37 1.342 147 71158 DB00659 Alcohol Deterrents 37 1.341 25 9034 DB00474 Anesthetics.Anesthetics, Intravenous.Barbiturates 37 1.285 58 5206 DB01236 Anesthetics, Inhalation.Platelet Aggregation Inhibitors 37 1.228 23 4737 DB00312 Adjuvants, Anesthesia.Barbiturates.GABA Modulators.Hypnotics and Sedatives 37 1.228 23 5193 DB00418 Adjuvants.Adjuvants, Anesthesia.Barbiturates.GABA Modulators.Hypnotics and Sedatives 37 1.217 84 3016 DB00829 Adjuvants, Anesthesia.Anesthetics, Intravenous.Anti-anxiety Agents.Anticonvulsants.Antiemetics.GABA Modulators.Hypnotics and Sedatives.Muscle Relaxants, Central 37 1.216 167 5719 DB00962 Anticonvulsants.Anxiolytics sedatives and hypnotics.Hypnotics and Sedatives 37 1.173 13 36339 DB00292 Anesthetics, Intravenous.Hypnotics and Sedatives 37 1.124 16 3763 DB00753 Anesthetics.Anesthetics, Inhalation.General Anesthetics 37 1.124 7 3562 DB01159 Anesthetics.Anesthetics, Inhalation.General Anesthetics 37 1.063 86 2118 DB00404 Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 37 1.012 73 3958 DB00186 Anti-anxiety Agents.Anticonvulsants.Antiemetics.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 37 0.976 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 37 0.82 38 3393 DB00690 Anti-anxiety Agents.GABA Modulators.Hypnotics and Sedatives 37 0.726 97 159 DB01240 Antihypertensive Agents.Platelet Aggregation Inhibitors 37 0.712 10 2712 DB00475 Adjuvants, Anesthesia.Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 37 0.679 128 4253 DB00295 Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 37 0.655 91 60815 DB00899 Analgesics, Opioid.Anesthetics, Intravenous.Hypnotics and Sedatives 37 0.617 59 2476 DB00921 Analgesics, Opioid.Narcotic Antagonists.Narcotics 37 0.577 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 37 0.563 24 2244 DB00945 Anti-Inflammatory Agents, Non-Steroidal.Anticoagulants.Cyclooxygenase Inhibitors.Fibrinolytic Agents.Platelet Aggregation Inhibitors.Salicylates 37 0.552 131 4428 DB00704 Alcohol Antagonists.Anti-craving Agents.Depressants.Narcotic Antagonists.Opiate Antagonists 37 0.531 71 2487 DB00611 Analgesics, Opioid.Antitussive Agents.Narcotic Antagonists.Narcotics 37 0.526 154 3157 DB00590 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Anticholesteremic Agents.Antihypertensive Agents.Vasodilator Agents 37 0.505 59 4095 DB00333 Analgesics.Analgesics, Opioid.Antitussive Agents.Antitussives.Narcotics.Opiate Agonists 37 0.472 154 27661 DB01020 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 37 0.469 112 71273 DB00296 Anesthetics.Anesthetics, Local.Local Anesthetics 37 0.468 14 2749 DB01188 Antifungal Agents 37 0.468 7 5359 DB00870 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 37 0.462 47 4419 DB00844 Analgesics, Opioid.Narcotic Antagonists.Narcotics 37 0.456 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 37 0.437 167 170361 DB01273 Nicotinic Agonists 37 0.434 131 4635 DB00497 Analgesics, Opioid.Antitussives.Narcotics.Opiate Agonists 37 0.429 157 4659569 DB00323 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Enzyme Inhibitors 37 0.415 106 2083 DB01001 Adrenergic beta-Agonists.Bronchodilator Agents.Tocolytic Agents 37 0.413 82 47725 DB00014 Antineoplastic Agents.Antineoplastic Agents, Hormonal 37 0.412 23 41693 DB00708 Adjuvants, Anesthesia.Analgesics, Opioid.Anesthetics, Intravenous.Narcotics.Opiate Agonists 37 0.411 65 2474 DB00297 Anesthetics, Local 37 0.406 83 54841 DB00289 Adrenergic Uptake Inhibitors.Antidepressants.Central Nervous System Agents 37 0.402 104 3449 DB00674 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 37 0.401 154 5090 DB00533 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase 2 Inhibitors.Cyclooxygenase Inhibitors 37 0.397 67 2267 DB00972 Anti-Allergic Agents.Anti-Inflammatory Agents, Non-Steroidal.Bronchodilator Agents.Histamine H1 Antagonists.Histamine H1 Antagonists, Non-Sedating.Lipoxygenase Inhibitors.Platelet Aggregation Inhibitors 37 0.39 60 3373 DB01205 Antidotes.GABA Modulators 37 0.382 136 2375 DB01128 Androgen Antagonists.Antineoplastic Agents 37 0.376 23 51263 DB00802 Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 37 0.356 38 125017 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 37 0.355 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 37 0.354 89 3086258 DB00707 Antineoplastic Agents.Antiviral Agents.Dermatologic Agents.Photosensitizing Agents 37 0.345 199 5358 DB00669 Selective Serotonin Agonists.Serotonin Agonists.Vasoconstrictor Agents 37 0.342 82 3749 DB01029 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 37 0.34 118 65999 DB00966 Angiotensin II Type 1 Receptor Blockers.Angiotensin-converting Enzyme Inhibitors 37 0.338 196 3911 DB00007 Anti-Estrogen Agents.Antineoplastic Agents 37 0.336 50 158 DB00917 Oxytocics.Prostaglandins 37 0.334 134 3339 DB01039 Antilipemic Agents.Fribic Acid Derivatives 37 0.33 76 2803 DB00575 Adrenergic alpha-Agonists.Analgesics.Antihypertensive Agents.Central Alpha-Agonists.Sympatholytics 37 0.33 77 3066 DB00320 Analgesics.Analgesics, Non-Narcotic.Anti-migraine Agents.Dopamine Agonists.Sympatholytics.Vasoconstrictor Agents 37 0.329 71 4740 DB00806 Free Radical Scavengers.Hematologic Agents.Hemorrheologic Agents.Phosphodiesterase Inhibitors.Platelet Aggregation Inhibitors.Radiation-Protective Agents.Vasodilator Agents 37 0.325 90 5152 DB00938 Adrenergic beta-Agonists.Bronchodilator Agents.Sympathomimetic 37 0.324 76 3108 DB00975 Phosphodiesterase Inhibitors.Platelet Aggregation Inhibitors.Vasodilator Agents 37 0.323 56 5229711 DB00429 Abortifacient Agents, Nonsteroidal.Oxytocics 37 0.321 53 85 DB02648 Vitamin B Complex 37 0.321 101 14888 DB01169 Antineoplastic Agents.Homeopathic Agents 37 0.32 86 115237 DB01267 Antipsychotic Agents 37 0.319 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 37 0.318 42 4196 DB00834 Abortifacient Agents, Steroidal.Contraceptives, Oral, Synthetic.Contraceptives, Postcoital, Synthetic.Hormone Antagonists.Luteolytic Agents.Menstruation-Inducing Agents 37 0.315 97 5245 DB00884 Antihypocalcemic Agents.Antiresorptives.Bisphosphonates.Bone Density Conservation Agents.Calcium Channel Blockers 37 0.313 28 4058 DB00454 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 37 0.313 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 37 0.312 107 3410 DB00983 Adrenergic beta-Agonists.Bronchodilator Agents.Sympathomimetic 37 0.311 109 60879 DB00876 Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 37 0.308 76 3661 DB00572 Adjuvants, Anesthesia.Anti-Arrhythmia Agents.Bronchodilator Agents.Muscarinic Antagonists.Mydriatics.Parasympatholytics 37 0.308 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 37 0.307 16 3168 DB00450 Adjuvants, Anesthesia.Antiemetics.Antipsychotic Agents.Dopamine Antagonists 37 0.306 129 5210 DB01105 Anorexigenic Agents.Antidepressants.Antidepressive Agents.Appetite Depressants.Stimulants 37 0.303 77 39860 DB00486 Anti-anxiety Agents.Antiemetics 37 0.303 137 2462 DB01222 Anti-inflammatory Agents.Bronchodilator Agents.Corticosteroids.Glucocorticoids 37 0.3 72 4183806 DB00929 Abortifacient Agents.Abortifacient Agents, Nonsteroidal.Anti-Ulcer Agents.Oxytocics.Prostaglandins 37 0.296 84 5401 DB01162 Adrenergic alpha-Antagonists.Antineoplastic Agents.Platelet Aggregation Inhibitors 37 0.296 73 4493 DB00665 Androgen Antagonists.Antineoplastic Agents 37 0.292 30 8612 DB01161 Anesthetics, Local 37 0.292 36 4914 DB00721 Anesthetics.Anesthetics, Local.Local Anesthetics 37 0.288 15 681 DB00988 Cardiotonic Agents.Dopamine Agents.Sympathomimetic.Sympathomimetics 37 0.281 37 4736 DB00652 Adjuvants, Anesthesia.Analgesics, Opioid.Narcotic Antagonists.Narcotics 37 0.28 31 3062 DB00390 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Cardiotonic Agents.Enzyme Inhibitors 37 0.278 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 37 0.278 69 2512 DB00248 Antineoplastic Agents.Antiparkinson Agents.Dopamine Agonists 37 0.277 87 5533 DB00656 Anti-anxiety Agents.Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 37 0.275 61 119182 DB00631 Antimetabolites.Antineoplastic Agents.Purine analogues 37 0.275 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 37 0.274 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 37 0.274 82 110634 DB00862 Anti-Impotence Agents.Phosphodiesterase Inhibitors.Vasoconstrictor Agents 37 0.269 132 4542 DB00367 Contraceptive Agents, Female.Contraceptives.Contraceptives, Oral, Synthetic 37 0.262 60 62819 DB00094 Fertility Agents 37 0.259 61 60612 DB00633 Adrenergic alpha-Agonists.Analgesics.Analgesics, Non-Narcotic.Hypnotics and Sedatives #### component 38: positive weight features and high scoring objects #### # positive weight on target proteins 38 0.498 16 ANDR_HUMAN Androgen receptor; 38 0.44 18 ESR1_HUMAN Estrogen receptor; 38 0.351 18 GCR_HUMAN Glucocorticoid receptor; 38 0.298 8 SHBG_HUMAN Sex hormone-binding globulin; 38 0.213 17 CBG_HUMAN Corticosteroid-binding globulin; 38 0.206 10 ESR2_HUMAN Estrogen receptor beta; 38 0.196 17 ANXA1_HUMAN Annexin A1; 38 0.131 7 MCR_HUMAN Mineralocorticoid receptor; 38 0.113 8 PRGR_HUMAN Progesterone receptor; 38 0.107 29 GBRA1_HUMAN Gamma-aminobutyric acid receptor subunit alpha-1; 38 0.019 5 ARFRP_HUMAN ADP-ribosylation factor-related protein 1; 38 0.019 5 OSBP1_HUMAN Oxysterol-binding protein 1; 38 0.019 5 OSR2_HUMAN Protein odd-skipped-related 2; 38 0.019 5 ERR1_HUMAN Steroid hormone receptor ERR1; 38 0.019 5 ERR3_HUMAN Estrogen-related receptor gamma; 38 0.019 5 DFNA5_HUMAN Non-syndromic hearing impairment protein 5; 38 0.019 5 NR2F6_HUMAN Nuclear receptor subfamily 2 group F member 6; 38 0.019 5 COT1_HUMAN COUP transcription factor 1; 38 0.019 5 NR2C2_HUMAN Nuclear receptor subfamily 2 group C member 2; 38 0.019 5 ERR2_HUMAN Steroid hormone receptor ERR2; 38 0.019 5 SAFB2_HUMAN Scaffold attachment factor B2; 38 0.019 5 SAFB1_HUMAN Scaffold attachment factor B1; 38 0.019 5 COT2_HUMAN COUP transcription factor 2; # positive weight on side effects 38 0.325 52 hirsutism 38 0.297 232 hemorrhage 38 0.223 67 amenorrhea 38 0.146 186 weight gain 38 0.046 47 osteoporosis # high scoring drugs for both targets and side effects 38 1.689 116 5376 DB00675 Antineoplastic Agents, Hormonal.Bone Density Conservation Agents.Estrogen Antagonists.Selective Estrogen Receptor Modulators 38 1.517 57 2949 DB01406 Estrogen Antagonists 38 1.436 19 3387 DB01185 Anabolic Agents.Antineoplastic Agents, Hormonal 38 1.425 61 40976 DB00294 Contraceptive Agents, Female.Contraceptives 38 1.406 53 5035 DB00481 Antihypocalcemic Agents.Bone Density Conservation Agents.Estrogen Antagonists.Osteoporosis Prophylactic.Selective Estrogen Receptor Modulators 38 1.341 21 5267 DB00421 Aldosterone Antagonists.Diuretics 38 1.216 16 4160 DB00624 Androgens 38 1.184 121 5408 DB00624 Androgens 38 1.044 83 3640 DB00741 Anti-inflammatory Agents 38 1.012 17 9904 DB00984 Anabolic Agents.Androgens 38 0.985 34 4536 DB00717 Contraceptives, Oral, Synthetic.Progestins 38 0.981 132 4542 DB00367 Contraceptive Agents, Female.Contraceptives.Contraceptives, Oral, Synthetic 38 0.947 31 4900 DB00635 Adrenergic Agents.Anti-inflammatory Agents.Antineoplastic Agents.Antineoplastic Agents, Hormonal.Glucocorticoids 38 0.945 42 4196 DB00834 Abortifacient Agents, Steroidal.Contraceptives, Oral, Synthetic.Contraceptives, Postcoital, Synthetic.Hormone Antagonists.Luteolytic Agents.Menstruation-Inducing Agents 38 0.92 191 450 DB00783 Anti-menopausal Agents.Anticholesteremic Agents.Estrogens 38 0.895 86 3003 DB01234 Adrenergic Agents.Anti-inflammatory Agents.Antiemetics.Antineoplastic Agents, Hormonal.Glucocorticoids 38 0.894 54 444033 DB01410 Anti-Allergic Agents.Glucocorticoids 38 0.875 135 5544 DB00620 Adrenergic Agents.Anti-inflammatory Agents.Glucocorticoids 38 0.874 74 4894 DB00860 Adrenergic Agents.Anti-inflammatory Agents.Antineoplastic Agents.Antineoplastic Agents, Hormonal.Glucocorticoids 38 0.867 39 104741 DB00947 Antineoplastic Agents.Antineoplastic Agents, Hormonal.Estrogen Antagonists 38 0.797 63 3381 DB00591 Anti-inflammatory Agents.Antipruritics.Glucocorticoids 38 0.795 43 31378 DB00687 Adrenergic Agents.Anti-inflammatory Agents 38 0.789 64 19090 DB00351 Antineoplastic Agents, Hormonal.Contraceptives, Oral, Synthetic 38 0.777 136 2375 DB01128 Androgen Antagonists.Antineoplastic Agents 38 0.669 14 2133 DB00288 Corticosteroids, topical 38 0.669 41 5516 DB00539 Antineoplastic Agents.Antineoplastic Agents, Hormonal.Bone Density Conservation Agents.Selective Estrogen Receptor Modulators 38 0.656 79 176870 DB00530 Protein Kinase Inhibitors 38 0.644 4 5878 DB00621 Anabolic Agents.Androgens 38 0.641 66 123620 DB00764 Anti-Allergic Agents.Anti-inflammatory Agents 38 0.622 124 62924 DB00588 Adrenergic Agents.Anti-Allergic Agents.Anti-inflammatory Agents.Bronchodilator Agents.Dermatologic Agents 38 0.6 10 4630253 DB00240 Anti-inflammatory Agents.Antipruritic Agents.Corticosteroids.Glucocorticoids 38 0.6 17 48175 DB00596 Anti-inflammatory Agents.Vasoconstrictor Agents 38 0.6 29 2308 DB00394 Anti-Asthmatic Agents.Anti-inflammatory Agents.Antiarrhythmic Agents.Corticosteroids.Glucocorticoids 38 0.577 125 3285 DB00977 Estrogens 38 0.571 54 4159 DB00959 Adrenergic Agents.Anti-inflammatory Agents.Antiemetics.Glucocorticoids.Neuroprotective Agents 38 0.557 60 5515 DB01030 Antineoplastic Agents.Enzyme Inhibitors 38 0.544 11 5381 DB00799 Dermatologic Agents.Keratolytic Agents.Prodrugs.Teratogens 38 0.544 15 4865 DB01179 Antimitotic agent.Antineoplastic Agents, Phytogenic.Keratolytic Agents.Tubulin Modulators 38 0.544 13 137 DB00855 Photosensitizing Agents 38 0.544 40 2617 DB01327 Anti-Bacterial Agents.Cephalosporins 38 0.544 16 2812 DB00257 Anti-Infective Agents, Local.Antifungal Agents.Growth Inhibitors 38 0.544 11 157922 DB00992 Antineoplastic Agents 38 0.544 36 5636 Not Available Not Available 38 0.544 51 60852 DB00710 Antihypocalcemic Agents.Antiresorptives.Bisphosphonates.Bone Density Conservation Agents 38 0.544 49 51634 DB00419 Anti-HIV Agents.Enzyme Inhibitors 38 0.544 11 2519 DB00201 Anorexigenic Agents.Central Nervous System Stimulants.Phosphodiesterase Inhibitors 38 0.544 7 5359 DB00870 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 38 0.53 77 3379 DB00180 Anti-Asthmatic Agents.Anti-inflammatory Agents 38 0.526 25 5486 DB00775 Fibrinolytic Agents.Platelet Aggregation Inhibitors 38 0.522 25 150310 DB00700 Aldosterone Antagonists.Antihypertensive Agents 38 0.52 108 3015 DB04839 Androgen Antagonists 38 0.516 41 5493444 DB01258 Antihypertensive Agents 38 0.512 40 18140 DB01196 Antineoplastic Agents.Antineoplastic Agents, Alkylating.Antineoplastic Agents, Hormonal.Radiation-Protective Agents 38 0.512 82 47725 DB00014 Antineoplastic Agents.Antineoplastic Agents, Hormonal 38 0.511 27 1125 DB00360 Cofactor.Dietary supplement 38 0.502 16 3382 DB01047 Anti-Allergic Agents.Anti-inflammatory Agents.Glucocorticoids 38 0.502 10 3392 DB00846 Anti-inflammatory Agents.Glucocorticoids 38 0.495 59 772 DB01109 Anticoagulants.Fibrinolytic Agents.Heparins 38 0.494 17 3000 DB00547 Anti-inflammatory Agents.Glucocorticoids 38 0.494 41 32797 DB01013 Anti-inflammatory Agents.Corticosteroids, topical.Glucocorticoids 38 0.494 17 52421 DB01130 Anti Inflammatory.Anti-inflammatory Agents.Corticosteroid.Glucocorticoids.Steroidal 38 0.494 11 3375 DB00223 Anti-inflammatory Agents.Glucocorticoids 38 0.494 26 12536 DB01260 Anti-inflammatory Agents 38 0.489 46 3685 DB01177 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 38 0.484 40 13342 DB00570 Antineoplastic Agents, Phytogenic.Tubulin Modulators 38 0.484 40 5717 DB00549 Anti-Asthmatic Agents.Leukotriene Antagonists 38 0.484 32 2265 DB00993 Antimetabolites.Antimetabolites, Antineoplastic.Antirheumatic Agents.Immunosuppressive Agents 38 0.481 91 3902 DB01006 Antineoplastic Agents.Aromatase Inhibitors 38 0.473 12 3384 DB00324 Anti-Allergic Agents.Anti-inflammatory Agents.Glucocorticoids 38 0.473 11 4043 DB00253 Topical anti-inflammatory Agent 38 0.469 21 5473385 DB00352 Antimetabolites, Antineoplastic 38 0.469 50 4138 DB00968 Adrenergic alpha-Agonists.Antihypertensive Agents.Sympatholytics 38 0.469 38 77999 DB00412 Fibrinolytic Agents.Hypoglycemic Agents.Thazolidinediones.Vasodilator Agents 38 0.468 29 4829 DB01132 Hypoglycemic Agents.Thazolidinediones 38 0.467 27 1003 DB02831 Not Available 38 0.462 38 30623 DB00380 Antineoplastic Agents.Cardiovascular Agents.Chelating Agents.Immunosuppressive Agents 38 0.454 60 62819 DB00094 Fertility Agents 38 0.443 30 42113 DB01189 Anesthetics, Inhalation.Neuroprotective Agents 38 0.44 34 3827 DB00920 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists 38 0.438 51 4603 DB00198 Antiviral Agents.Enzyme Inhibitors 38 0.428 65 5253 DB00489 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Sympatholytics 38 0.425 20 838 DB00668 Adrenergic Agonists.Adrenergic alpha-Agonists.Adrenergic beta-Agonists.Bronchodilator Agents.Mydriatics.Sympathomimetics.Vasoconstrictor Agents 38 0.419 19 3249 DB00153 Antihypocalcemic Agents.Antihypoparathyroid Agents.Bone Density Conservation Agents.Essential Vitamin.Vitamins.Vitamins (Vitamin D) 38 0.415 73 4493 DB00665 Androgen Antagonists.Antineoplastic Agents 38 0.41 90 5329102 DB01268 Angiogenesis Inhibitors.Antineoplastic Agents 38 0.408 16 5591 DB00197 Antineoplastic Agents.Fibrinolytic Agents.Hypoglycemic Agents.Platelet Aggregation Inhibitors.Vasodilator Agents 38 0.396 4 6503 DB03754 Buffers.Excipients 38 0.396 4 119 DB02530 GABA Agents 38 0.396 9 232 DB00125 Conditionally Essential Amino Acids.Dietary supplement.Micronutrient 38 0.396 7 5404 DB00251 Antifungal Agents.Antifungals 38 0.396 17 152945 DB01126 Anti-baldness Agents.Antihyperplasia Agents.Enzyme Inhibitors 38 0.396 22 60164 DB00210 Anti-Inflammatory Agents, Non-Steroidal.Dermatologic Agents 38 0.396 9 5342 DB01138 Uricosuric Agents 38 0.396 54 4599 DB01083 Anti-Obesity Agents.Enzyme Inhibitors 38 0.396 15 4189 DB01110 Antifungal Agents 38 0.396 5 10548 DB01057 Cholinesterase Inhibitors.Miotics.Parasympathomimetics 38 0.396 3 47641 DB00735 Anti-Inflammatory Agents, Non-Steroidal.Antifungal Agents 38 0.396 14 2749 DB01188 Antifungal Agents 38 0.396 46 5362070 DB01014 Anti-Inflammatory Agents, Non-Steroidal.Anti-Ulcer Agents.Gastrointestinal Agents 38 0.396 14 4993 DB00205 Antimalarials.Antiprotozoal Agents.Antiprotozoals.Folic Acid Antagonists #### component 39: positive weight features and high scoring objects #### # positive weight on target proteins 39 0.666 38 ADRB1_HUMAN Beta-1 adrenergic receptor; 39 0.484 34 ADRB2_HUMAN Beta-2 adrenergic receptor; 39 0.396 24 ADRB3_HUMAN Beta-3 adrenergic receptor; 39 0.137 13 CAH1_HUMAN Carbonic anhydrase 1; 39 0.135 38 ADA2A_HUMAN Alpha-2A adrenergic receptor; 39 0.134 15 KCNH2_HUMAN Potassium voltage-gated channel subfamily H member 2; 39 0.121 42 ADA1A_HUMAN Alpha-1A adrenergic receptor; 39 0.116 35 DRD2_HUMAN D(2) dopamine receptor; 39 0.088 33 ADA2B_HUMAN Alpha-2B adrenergic receptor; 39 0.081 28 DRD1_HUMAN D(1A) dopamine receptor; 39 0.08 28 DRD3_HUMAN D(3) dopamine receptor; 39 0.078 34 ADA1B_HUMAN Alpha-1B adrenergic receptor; 39 0.076 6 S12A3_HUMAN Solute carrier family 12 member 3; 39 0.07 11 CAH4_HUMAN Carbonic anhydrase 4; 39 0.069 13 CAH2_HUMAN Carbonic anhydrase 2; 39 0.069 18 CAC1C_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1C; 39 0.067 12 KCMA1_HUMAN Calcium-activated potassium channel subunit alpha-1; 39 0.065 17 CCG1_HUMAN Voltage-dependent calcium channel gamma-1 subunit; 39 0.064 16 CACB2_HUMAN Voltage-dependent L-type calcium channel subunit beta-2; 39 0.064 16 CAC1F_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1F; 39 0.064 16 CAC1D_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1D; 39 0.041 16 CAC1G_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1G; 39 0.035 30 ADA1D_HUMAN Alpha-1D adrenergic receptor; 39 0.026 9 S12A1_HUMAN Solute carrier family 12 member 1; 39 0.026 13 CACB1_HUMAN Voltage-dependent L-type calcium channel subunit beta-1; 39 0.023 15 RYR3_HUMAN Ryanodine receptor 3; 39 0.023 15 RYR2_HUMAN Ryanodine receptor 2; 39 0.023 14 RYR1_HUMAN Ryanodine receptor 1; 39 0.019 15 CAC1H_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1H; 39 0.019 15 CAC1I_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1I; 39 0.017 12 CAC1E_HUMAN Voltage-dependent R-type calcium channel subunit alpha-1E; 39 0.017 12 ITPR1_HUMAN Inositol 1,4,5-trisphosphate receptor type 1; 39 0.017 12 PKD1_HUMAN Polycystin-1; 39 0.017 12 TRPA1_HUMAN Transient receptor potential cation channel subfamily A member 1; 39 0.017 12 PKD2_HUMAN Polycystin-2; 39 0.017 12 TRPV6_HUMAN Transient receptor potential cation channel subfamily V member 6; 39 0.017 12 CACB4_HUMAN Voltage-dependent L-type calcium channel subunit beta-4; 39 0.017 12 CCG4_HUMAN Voltage-dependent calcium channel gamma-4 subunit; 39 0.017 12 CAC1S_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1S; 39 0.017 12 CA2D1_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-1; 39 0.017 12 CACB3_HUMAN Voltage-dependent L-type calcium channel subunit beta-3; 39 0.017 12 CCG2_HUMAN Voltage-dependent calcium channel gamma-2 subunit; 39 0.017 12 ITPR3_HUMAN Inositol 1,4,5-trisphosphate receptor type 3; 39 0.017 12 CCG7_HUMAN Voltage-dependent calcium channel gamma-7 subunit; 39 0.014 14 A1AG1_HUMAN Alpha-1-acid glycoprotein 1; 39 0.004 13 CAC1B_HUMAN Voltage-dependent N-type calcium channel subunit alpha-1B; # positive weight on side effects 39 0.47 273 leukopenia 39 0.378 528 headache 39 0.37 104 pulmonary edema 39 0.354 166 purpura 39 0.322 474 dizziness 39 0.246 52 heart block 39 0.225 79 lightheadedness 39 0.222 282 vertigo 39 0.139 20 claudication 39 0.111 122 congestive heart failure 39 0.074 35 mental depression 39 0.059 41 shortness of breath 39 0.048 76 nightmares 39 0.042 320 fatigue 39 0.041 121 heart failure 39 0.029 552 nausea 39 0.019 342 insomnia # high scoring drugs for both targets and side effects 39 2.128 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 39 1.586 61 4828 DB00960 Adrenergic beta-Antagonists.Antihypertensive Agents.Serotonin Antagonists.Vasodilator Agents 39 1.567 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 39 1.543 65 5253 DB00489 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Sympatholytics 39 1.513 78 2249 DB00335 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Sympatholytics 39 1.44 135 2585 DB01136 Adrenergic Agents.Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 39 1.4 99 5478 DB00373 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents 39 1.321 69 3869 DB00598 Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Sympatholytics 39 1.242 61 4946 DB00571 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Anti-anxiety Agents.Antiarrhythmic Agents.Antihypertensive Agents.Vasodilator Agents 39 1.158 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 39 1.141 75 1978 DB01193 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents 39 1.136 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 39 1.132 94 4171 DB00264 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Sympatholytics 39 1.093 76 3661 DB00572 Adjuvants, Anesthesia.Anti-Arrhythmia Agents.Bronchodilator Agents.Muscarinic Antagonists.Mydriatics.Parasympatholytics 39 1.058 95 16231 DB00594 Diuretics.Sodium channel blockers 39 1.05 117 2405 DB00612 Adrenergic Agents.Adrenergic beta-Antagonists.Antihypertensive Agents.Sympatholytics 39 0.977 84 2995 DB01151 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Enzyme Inhibitors.Norepinephrine-Reuptake Inhibitors 39 0.966 106 2083 DB01001 Adrenergic beta-Agonists.Bronchodilator Agents.Tocolytic Agents 39 0.946 42 4411 DB01203 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents.Sympatholytics 39 0.938 72 4893 DB00457 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Antihypertensive Agents 39 0.935 20 5775 DB00692 Adrenergic alpha-Antagonists.Antihypertensive Agents.Sympatholytics 39 0.919 146 3075 DB00343 Antihypertensive Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Cardiovascular Agents.Vasodilator Agents 39 0.873 19 3779 DB01064 Adrenergic beta-Agonists.Bronchodilator Agents.Cardiotonic Agents.Sympathomimetic.Sympathomimetics 39 0.849 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 39 0.797 10 4436 Not Available Not Available 39 0.795 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 39 0.788 57 2951 DB01219 Muscle Relaxants, Central 39 0.779 35 16362 DB01100 Anti-Dyskinesia Agents.Antipsychotic Agents.Dopamine Antagonists 39 0.778 34 71301 DB04861 Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 39 0.756 28 2583 DB00521 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents.Sympatholytics 39 0.712 54 3639 DB00999 Antihypertensive Agents.Diuretics.Sodium Chloride Symporter Inhibitors 39 0.712 43 2720 DB00880 Antihypertensive Agents.Diuretics.Diuretics, Thiazide.Sodium Chloride Symporter Inhibitors 39 0.7 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 39 0.687 38 4121 DB00232 Diuretics.Diuretics, Thiazide.Sodium Chloride Symporter Inhibitors 39 0.676 127 2156 DB01118 Anti-Arrhythmia Agents.Enzyme Inhibitors.Vasodilator Agents 39 0.646 62 59768 DB00187 Adrenergic beta-Antagonists 39 0.642 97 1065 DB00908 Adrenergic alpha-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antimalarials.Enzyme Inhibitors.Muscarinic Antagonists 39 0.638 138 2369 DB00195 Adrenergic beta-Antagonists.Antihypertensive Agents.EENT Drugs.Sympatholytics 39 0.637 90 2162 DB00381 Antianginals.Antihypertensive Agents.Calcium Channel Blockers.Vasodilator Agents 39 0.629 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 39 0.621 14 951 DB00368 Adrenergic alpha-Agonists.Sympathomimetics.Vasoconstrictor Agents 39 0.621 25 4724 DB01359 Adrenergic beta-Antagonists.Antihypertensive Agents 39 0.608 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 39 0.576 161 5291 DB00619 Antineoplastic Agents.Protein Kinase Inhibitors 39 0.575 120 3715 DB00328 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cardiovascular Agents.Cyclooxygenase Inhibitors.Gout Suppressants.Nonsteroidal Antiinflammatory Agents (NSAIDs).Tocolytic Agents 39 0.568 17 5403 DB00871 Adrenergic beta-Agonists.Bronchodilator Agents.Sympathomimetic.Sympathomimetics.Tocolytic Agents 39 0.549 38 3914 DB01210 Adrenergic beta-Antagonists.EENT Drugs.Sympatholytics 39 0.539 453 125889 DB00230 Analgesics.Anticonvulsants 39 0.537 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 39 0.534 40 4845 DB01291 Adrenergic beta-Agonists.Bronchodilator Agents.Cardiotonic Agents 39 0.527 41 2315 DB00436 Antihypertensive Agents.Diuretics.Diuretics, Thiazide.Sodium Chloride Symporter Inhibitors 39 0.513 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 39 0.512 76 4170 DB00524 Antihypertensive Agents.Diuretics.Diuretics, Sulfamyl 39 0.511 55 2130 DB00915 Analgesics, Non-Narcotic.Antiparkinson Agents.Antiviral Agents.Dopamine Agents 39 0.509 30 31477 DB01214 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents.Sympatholytics 39 0.502 27 3647 DB00774 Antihypertensive Agents.Diuretics.Diuretics, Thiazide.Sodium Chloride Symporter Inhibitors 39 0.488 181 4932 DB01182 Anti-Arrhythmia Agents 39 0.484 101 3154 DB00869 Antihypertensive Agents.Carbonic Anhydrase Inhibitors 39 0.484 150 1775 DB00252 Anticonvulsants 39 0.475 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 39 0.472 81 2022 DB00787 Antiviral Agents.Nucleosides and Nucleotides 39 0.467 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 39 0.466 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 39 0.464 72 3440 DB00695 Diuretics.Sodium Potassium Chloride Symporter Inhibitors 39 0.462 91 3355 DB01195 Anti-Arrhythmia Agents.Antiarrhythmic Agents 39 0.46 60 3519 DB01018 Adrenergic alpha-Agonists.Antihypertensive Agents.Sympatholytics 39 0.451 132 3948 DB00978 Anti-Infective Agents.Anti-Infective Agents, Urinary.Antitubercular Agents.Photosensitizing Agents 39 0.451 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 39 0.441 142 3826 DB00465 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 39 0.436 14 36811 DB00841 Adrenergic beta-Agonists.Cardiotonic Agents.Sympathomimetic.Sympathomimetics 39 0.434 24 2431 DB01158 Adrenergic Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents 39 0.431 20 838 DB00668 Adrenergic Agonists.Adrenergic alpha-Agonists.Adrenergic beta-Agonists.Bronchodilator Agents.Mydriatics.Sympathomimetics.Vasoconstrictor Agents 39 0.43 50 3158 DB01142 Anti-anxiety Agents.Antidepressants.Antidepressive Agents, Tricyclic.Antipruritics.Histamine Antagonists.Norepinephrine-Reuptake Inhibitors 39 0.422 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 39 0.421 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 39 0.416 211 93860 DB00188 Antineoplastic Agents.Protease Inhibitors 39 0.41 74 130881 DB00275 Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 39 0.41 131 3961 DB00678 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents 39 0.402 161 5487 DB00697 Adrenergic alpha-Agonists.Analgesics.Anticonvulsants.Muscle Relaxants.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 39 0.4 76 4748 DB00850 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 39 0.395 72 2160 DB00321 Adrenergic Uptake Inhibitors.Analgesics, Non-Narcotic.Antidepressive Agents, Tricyclic 39 0.395 264 5372 DB00864 Immunosuppressive Agents 39 0.392 183 3648 DB00327 Analgesics, Opioid.Narcotics 39 0.387 154 3157 DB00590 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Anticholesteremic Agents.Antihypertensive Agents.Vasodilator Agents 39 0.386 87 5533 DB00656 Anti-anxiety Agents.Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 39 0.373 62 5566 DB00831 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 39 0.367 52 32170 DB00668 Adrenergic Agonists.Adrenergic alpha-Agonists.Adrenergic beta-Agonists.Bronchodilator Agents.Mydriatics.Sympathomimetics.Vasoconstrictor Agents 39 0.357 55 3019 DB01119 Antihypertensive Agents.Diuretics, Thiazide.Vasodilator Agents 39 0.356 28 4870 DB01324 Antihypertensive Agents.Diuretics.Sodium Chloride Symporter Inhibitors 39 0.356 51 3559 DB00502 Anti-Dyskinesia Agents.Antidyskinetics.Antiemetics.Antipsychotic Agents.Antipsychotics.Butyrophenones.Dopamine Antagonists 39 0.356 119 5064 DB00811 Antimetabolites.Antiviral Agents 39 0.355 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 39 0.348 99 4889 DB00175 Anticholesteremic Agents.HMG-CoA Reductase Inhibitors.Hydroxymethylglutaryl-CoA Reductase Inhibitors 39 0.347 61 119182 DB00631 Antimetabolites.Antineoplastic Agents.Purine analogues 39 0.339 100 5038 DB00178 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 39 0.339 154 27661 DB01020 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 39 0.336 128 4253 DB00295 Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 39 0.331 30 2732 DB00310 Antihypertensive Agents.Diuretics.Sodium Chloride Symporter Inhibitors 39 0.329 71 4740 DB00806 Free Radical Scavengers.Hematologic Agents.Hemorrheologic Agents.Phosphodiesterase Inhibitors.Platelet Aggregation Inhibitors.Radiation-Protective Agents.Vasodilator Agents 39 0.32 69 2170 DB00543 Adrenergic Uptake Inhibitors.Antidepressive Agents, Second-Generation.Dopamine Antagonists.Neurotransmitter Uptake Inhibitors.Serotonin Uptake Inhibitors #### component 40: positive weight features and high scoring objects #### # positive weight on target proteins 40 0.792 29 GBRA1_HUMAN Gamma-aminobutyric acid receptor subunit alpha-1; 40 0.105 17 CBG_HUMAN Corticosteroid-binding globulin; 40 0.091 17 ANXA1_HUMAN Annexin A1; 40 0.083 12 KCMA1_HUMAN Calcium-activated potassium channel subunit alpha-1; 40 0.053 16 ANDR_HUMAN Androgen receptor; 40 0.052 12 IRK1_HUMAN ATP-sensitive inward rectifier potassium channel 1; 40 0.045 9 S12A1_HUMAN Solute carrier family 12 member 1; 40 0.031 22 CP51A_HUMAN Lanosterol 14-alpha demethylase; 40 0.025 18 GCR_HUMAN Glucocorticoid receptor; # positive weight on side effects # high scoring drugs for both targets and side effects 40 0.831 10 3226 DB00228 Anesthetics, Inhalation.General Anesthetics 40 0.646 40 4064 DB00371 Anti-anxiety Agents.Anticonvulsants.Hypnotics and Sedatives.Muscle Relaxants, Central 40 0.644 12 4909 DB00794 Anticonvulsants.Barbiturates 40 0.51 10 4630253 DB00240 Anti-inflammatory Agents.Antipruritic Agents.Corticosteroids.Glucocorticoids 40 0.509 17 48175 DB00596 Anti-inflammatory Agents.Vasoconstrictor Agents 40 0.504 31 4900 DB00635 Adrenergic Agents.Anti-inflammatory Agents.Antineoplastic Agents.Antineoplastic Agents, Hormonal.Glucocorticoids 40 0.486 15 39507 DB00896 Anti-inflammatory Agents.Corticosteroids 40 0.482 29 2308 DB00394 Anti-Asthmatic Agents.Anti-inflammatory Agents.Antiarrhythmic Agents.Corticosteroids.Glucocorticoids 40 0.469 14 2133 DB00288 Corticosteroids, topical 40 0.464 12 3384 DB00324 Anti-Allergic Agents.Anti-inflammatory Agents.Glucocorticoids 40 0.464 11 4043 DB00253 Topical anti-inflammatory Agent 40 0.464 16 4211 DB00648 Antineoplastic Agents.Antineoplastic Agents, Hormonal 40 0.464 10 3392 DB00846 Anti-inflammatory Agents.Glucocorticoids 40 0.464 16 3382 DB01047 Anti-Allergic Agents.Anti-inflammatory Agents.Glucocorticoids 40 0.457 11 3375 DB00223 Anti-inflammatory Agents.Glucocorticoids 40 0.457 17 52421 DB01130 Anti Inflammatory.Anti-inflammatory Agents.Corticosteroid.Glucocorticoids.Steroidal 40 0.457 17 3000 DB00547 Anti-inflammatory Agents.Glucocorticoids 40 0.453 19 5505 DB01124 Hypoglycemic Agents.Sulfonylureas 40 0.45 13 36339 DB00292 Anesthetics, Intravenous.Hypnotics and Sedatives 40 0.45 9 2733 DB00356 Muscle Relaxants, Central 40 0.441 26 12536 DB01260 Anti-inflammatory Agents 40 0.438 4 5878 DB00621 Anabolic Agents.Androgens 40 0.437 41 32797 DB01013 Anti-inflammatory Agents.Corticosteroids, topical.Glucocorticoids 40 0.437 24 2727 DB00672 Hypoglycemic Agents.Sulfonylureas 40 0.436 24 5503 DB00839 Hypoglycemic Agents 40 0.429 7 3562 DB01159 Anesthetics.Anesthetics, Inhalation.General Anesthetics 40 0.428 74 4894 DB00860 Adrenergic Agents.Anti-inflammatory Agents.Antineoplastic Agents.Antineoplastic Agents, Hormonal.Glucocorticoids 40 0.427 21 4114 DB00553 Antineoplastic Agents.Cross-Linking Reagents.Photosensitizing Agents.Pigmenting Agents 40 0.427 15 4189 DB01110 Antifungal Agents 40 0.427 6 4174 DB01011 Antimetabolites.Enzyme Inhibitors 40 0.427 38 3823 DB01026 Antifungal Agents.Antifungals 40 0.427 7 5404 DB00251 Antifungal Agents.Antifungals 40 0.424 27 3647 DB00774 Antihypertensive Agents.Diuretics.Diuretics, Thiazide.Sodium Chloride Symporter Inhibitors 40 0.424 38 4121 DB00232 Diuretics.Diuretics, Thiazide.Sodium Chloride Symporter Inhibitors 40 0.42 19 3387 DB01185 Anabolic Agents.Antineoplastic Agents, Hormonal 40 0.42 16 4160 DB00624 Androgens 40 0.42 17 9904 DB00984 Anabolic Agents.Androgens 40 0.418 57 2949 DB01406 Estrogen Antagonists 40 0.412 46 4201 DB00350 Antihypertensive Agents.Vasodilator Agents 40 0.411 8 3105 DB00449 Adrenergic Agonists.Ophthalmologicals.Sympathomimetics 40 0.411 17 5403 DB00871 Adrenergic beta-Agonists.Bronchodilator Agents.Sympathomimetic.Sympathomimetics.Tocolytic Agents 40 0.411 2 1071 DB00162 Anti-acne Agents.Essential Vitamin.Vitamins.Vitamins (Vitamin A) 40 0.411 9 232 DB00125 Conditionally Essential Amino Acids.Dietary supplement.Micronutrient 40 0.411 9 1148 DB00150 Antidepressive Agents, Second-Generation.Dietary supplement.Essential Amino Acids.Micronutrient 40 0.411 14 2749 DB01188 Antifungal Agents 40 0.411 17 152945 DB01126 Anti-baldness Agents.Antihyperplasia Agents.Enzyme Inhibitors 40 0.411 6 12555 Not Available Not Available 40 0.411 10 4436 Not Available Not Available 40 0.411 3 247 DB04455 Gastrointestinal Agents.Lipotropic Agents 40 0.411 22 60164 DB00210 Anti-Inflammatory Agents, Non-Steroidal.Dermatologic Agents 40 0.411 10 5526 DB00302 Antifibrinolytic Agents 40 0.411 14 4993 DB00205 Antimalarials.Antiprotozoal Agents.Antiprotozoals.Folic Acid Antagonists 40 0.411 21 5473385 DB00352 Antimetabolites, Antineoplastic 40 0.411 3 175 DB04184 Indicators and Reagents 40 0.411 6 4908 DB01087 Antimalarial Agents.Antimalarials.Antiprotozoal Agents 40 0.411 11 2522 DB02300 Antipsoriatic Agents.Dermatologic Agents.Vitamin D3 Receptor inhibitor 40 0.411 18 3636 DB00747 Adjuvants.Adjuvants, Anesthesia.Antimuscarinics.Antispasmodics.Cholinergic Antagonists.Muscarinic Antagonists.Mydriatics 40 0.411 4 119 DB02530 GABA Agents 40 0.411 3 47641 DB00735 Anti-Inflammatory Agents, Non-Steroidal.Antifungal Agents 40 0.411 11 3117 DB00822 Alcohol Deterrents.Enzyme Inhibitors 40 0.411 3 4034 DB00737 Anti-Allergic Agents.Antiemetics.Antihistamines.Histamine H1 Antagonists 40 0.411 11 40704 Not Available Not Available 40 0.411 6 888 DB01378 Not Available 40 0.411 5 2283 DB00626 Anti-Bacterial Agents.Anti-Infective Agents, Local 40 0.411 12 4812 DB01022 Antifibrinolytic Agents.Vitamins.Vitamins (Vitamin K) 40 0.411 18 2266 DB00548 Antineoplastic Agents.Dermatologic Agents 40 0.411 3 2484 DB01091 Antifungal Agents 40 0.411 9 2366 Not Available Not Available 40 0.411 3 6256 DB00432 Antimetabolites.Antiviral Agents 40 0.41 12 3915 DB01106 Histamine H1 Antagonists.Histamine H1 Antagonists, Non-Sedating 40 0.407 63 3381 DB00591 Anti-inflammatory Agents.Antipruritics.Glucocorticoids 40 0.407 14 2955 DB00250 Anti-Infective Agents.Anti-Infectives.Anti-inflammatory Agents.Antimalarials.Antimycobacterials.Folic Acid Antagonists.Leprostatic Agents 40 0.405 6 3780 DB00883 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 40 0.404 19 4032 DB00657 Antihypertensive Agents.Ganglionic Blockers.Nicotinic Antagonists 40 0.401 41 2315 DB00436 Antihypertensive Agents.Diuretics.Diuretics, Thiazide.Sodium Chloride Symporter Inhibitors 40 0.398 25 3350 DB01216 Anti-baldness Agents.Antihyperplasia Agents.Enzyme Inhibitors.Skin and Mucous Membrane Agents 40 0.398 86 3003 DB01234 Adrenergic Agents.Anti-inflammatory Agents.Antiemetics.Antineoplastic Agents, Hormonal.Glucocorticoids 40 0.397 28 2145 DB00357 Adrenergic Agents.Antineoplastic Agents.Antineoplastic Agents, Hormonal.Aromatase Inhibitors 40 0.396 9 861 DB00279 Hormone Replacement Agents 40 0.396 28 2583 DB00521 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents.Sympatholytics 40 0.396 83 3640 DB00741 Anti-inflammatory Agents 40 0.394 7 5359 DB00870 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 40 0.394 7 2551 DB00411 Analgesics, Non-Narcotic.Cardiotonic Agents.Cholinergic Agonists.Miotics 40 0.394 9 5593 DB00809 Diagnostic aid, cycloplegic.Diagnostic aid, mydriatic.Muscarinic Antagonists.Mydriatics 40 0.394 11 157922 DB00992 Antineoplastic Agents 40 0.394 26 3151 DB01184 Antiemetics.Dopamine Antagonists 40 0.393 28 2719 DB00608 Amebicides.Antimalarials.Antirheumatic Agents 40 0.393 15 4865 DB01179 Antimitotic agent.Antineoplastic Agents, Phytogenic.Keratolytic Agents.Tubulin Modulators 40 0.393 16 2812 DB00257 Anti-Infective Agents, Local.Antifungal Agents.Growth Inhibitors 40 0.393 43 31378 DB00687 Adrenergic Agents.Anti-inflammatory Agents 40 0.393 19 3779 DB01064 Adrenergic beta-Agonists.Bronchodilator Agents.Cardiotonic Agents.Sympathomimetic.Sympathomimetics 40 0.393 13 137 DB00855 Photosensitizing Agents 40 0.393 11 4919 DB00387 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists 40 0.392 4 4768 DB00925 Adrenergic alpha-Antagonists.Antihypertensive Agents.Vasodilator Agents 40 0.391 23 143 DB00650 Antianemic Agents.Antidote (to folic acid antagonists).Antineoplastic Adjuncts.Vitamin B Complex.Vitamins/minerals 40 0.391 37 3637 DB01275 Antihypertensive Agents.Vasodilator Agents 40 0.39 16 5504 DB00797 Adrenergic alpha-Antagonists.Antihypertensive Agents.Vasodilator Agents 40 0.39 54 4159 DB00959 Adrenergic Agents.Anti-inflammatory Agents.Antiemetics.Glucocorticoids.Neuroprotective Agents 40 0.388 9 5342 DB01138 Uricosuric Agents 40 0.388 19 3249 DB00153 Antihypocalcemic Agents.Antihypoparathyroid Agents.Bone Density Conservation Agents.Essential Vitamin.Vitamins.Vitamins (Vitamin D) #### component 41: positive weight features and high scoring objects #### # positive weight on target proteins 41 0.569 29 PGH2_HUMAN Prostaglandin G/H synthase 2; 41 0.24 12 ACE_HUMAN Angiotensin-converting enzyme; 41 0.23 17 EF1B_HUMAN Elongation factor 1-beta; 41 0.23 17 SCN4A_HUMAN Sodium channel protein type 4 subunit alpha; 41 0.23 17 SCN4B_HUMAN Sodium channel subunit beta-4; 41 0.23 17 ACCN3_HUMAN Amiloride-sensitive cation channel 3; 41 0.23 17 DB124_HUMAN Beta-defensin 124; 41 0.23 17 SCNAA_HUMAN Sodium channel protein type 10 subunit alpha; 41 0.23 17 SCN3B_HUMAN Sodium channel subunit beta-3; 41 0.23 17 ACCN4_HUMAN Amiloride-sensitive cation channel 4; 41 0.23 17 SCN3A_HUMAN Sodium channel protein type 3 subunit alpha; 41 0.23 17 SCN7A_HUMAN Sodium channel protein type 7 subunit alpha; 41 0.23 17 SCN1B_HUMAN Sodium channel subunit beta-1; 41 0.105 18 SCNNG_HUMAN Amiloride-sensitive sodium channel subunit gamma; 41 0.105 18 SCNNB_HUMAN Amiloride-sensitive sodium channel subunit beta; 41 0.105 18 SCNND_HUMAN Amiloride-sensitive sodium channel subunit delta; 41 0.042 18 SCN5A_HUMAN Sodium channel protein type 5 subunit alpha; # positive weight on side effects 41 0.312 102 hyponatremia 41 0.31 28 meningitis 41 0.283 170 angina pectoris 41 0.249 270 alopecia 41 0.152 31 lymphoma 41 0.149 184 pneumonia 41 0.095 320 fatigue 41 0.082 218 rhinitis 41 0.08 280 chest pain 41 0.077 38 ptosis 41 0.076 67 amenorrhea 41 0.071 40 fecal incontinence 41 0.07 163 pancreatitis 41 0.07 84 muscle weakness 41 0.062 99 polyuria 41 0.062 293 cough 41 0.048 37 personality disorder 41 0.047 53 neuritis 41 0.041 19 positive ANA 41 0.037 159 increased sweating 41 0.036 26 iritis 41 0.036 107 amnesia 41 0.035 11 subdural hematoma 41 0.03 28 tenesmus 41 0.025 52 hirsutism 41 0.011 116 pancytopenia 41 0.011 326 paresthesia 41 0.009 118 exfoliative dermatitis 41 0.005 52 menorrhagia 41 0.004 58 visual field defect 41 0.003 64 mouth ulceration 41 0.001 9 apraxia 41 0.001 186 weight gain # high scoring drugs for both targets and side effects 41 1.947 95 16231 DB00594 Diuretics.Sodium channel blockers 41 1.826 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 41 1.692 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 41 1.66 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 41 1.6 112 71273 DB00296 Anesthetics.Anesthetics, Local.Local Anesthetics 41 1.555 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 41 1.438 75 4178 DB00379 Anti-Arrhythmia Agents 41 1.386 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 41 1.307 135 5734 DB00909 Anticonvulsants.Antioxidants 41 1.244 43 4913 DB01035 Anti-Arrhythmia Agents.Antiarrhythmic Agents 41 1.219 91 3355 DB01195 Anti-Arrhythmia Agents.Antiarrhythmic Agents 41 1.202 36 4914 DB00721 Anesthetics.Anesthetics, Local.Local Anesthetics 41 1.189 150 1775 DB00252 Anticonvulsants 41 1.084 74 3676 DB00281 Anesthetics.Anesthetics, Local.Anti-Arrhythmia Agents.Antiarrhythmic Agents 41 1.03 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 41 1.017 61 3114 DB00280 Anti-Arrhythmia Agents.Antiarrhythmic Agents 41 0.967 51 48041 DB01228 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Sodium channel blockers 41 0.802 154 5090 DB00533 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase 2 Inhibitors.Cyclooxygenase Inhibitors 41 0.768 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 41 0.764 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 41 0.716 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 41 0.69 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 41 0.674 152 60184 DB00790 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 41 0.656 75 2550 DB01197 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 41 0.617 100 5038 DB00178 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 41 0.598 98 3222 DB00584 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 41 0.595 79 2311 DB00542 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 41 0.59 55 91270 DB00691 Angiotensin-converting Enzyme Inhibitors 41 0.588 215 60787 DB01232 Anti-HIV Agents.HIV Protease Inhibitors 41 0.585 116 5525 DB00519 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 41 0.583 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 41 0.571 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 41 0.538 132 4739 DB00552 Antibiotics.Antineoplastic Agents.Enzyme Inhibitors.Immunosuppressive Agents 41 0.534 88 3750 DB00762 Antineoplastic Agents.Antineoplastic Agents, Phytogenic.Enzyme Inhibitors.Parasympathomimetics.Prodrugs.Radiation-Sensitizing Agents 41 0.519 111 3419 DB00492 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 41 0.511 87 5005 DB00881 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 41 0.51 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 41 0.508 234 216326 DB00480 Antineoplastic Agents 41 0.504 119 3308 DB00749 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 41 0.5 120 82146 DB00307 Anticarcinogenic Agents 41 0.492 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 41 0.486 135 2585 DB01136 Adrenergic Agents.Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 41 0.484 131 3961 DB00678 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents 41 0.482 104 4614 DB00991 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Nonsteroidal Antiinflammatory Agents (NSAIDs) 41 0.482 106 2958 DB00694 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 41 0.479 181 4932 DB01182 Anti-Arrhythmia Agents 41 0.472 119 4052 DB00814 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Antiemetics.Antineoplastic Agents.Cyclooxygenase Inhibitors.Growth Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 41 0.47 142 3826 DB00465 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 41 0.467 94 4409 DB00461 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents 41 0.464 89 4044 DB00784 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 41 0.461 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 41 0.452 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 41 0.45 97 159 DB01240 Antihypertensive Agents.Platelet Aggregation Inhibitors 41 0.448 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 41 0.437 103 5352 DB00605 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents.Cyclooxygenase Inhibitors 41 0.437 92 3825 DB01009 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 41 0.433 453 125889 DB00230 Analgesics.Anticonvulsants 41 0.417 46 5362070 DB01014 Anti-Inflammatory Agents, Non-Steroidal.Anti-Ulcer Agents.Gastrointestinal Agents 41 0.414 103 2751 DB01340 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 41 0.404 211 60953 DB01101 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Prodrugs 41 0.403 144 3702 DB00808 Antihypertensive Agents.Diuretics 41 0.401 166 3394 DB00712 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Carbonic Anhydrase Inhibitors.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 41 0.396 161 5487 DB00697 Adrenergic alpha-Agonists.Analgesics.Anticonvulsants.Muscle Relaxants.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 41 0.388 161 5291 DB00619 Antineoplastic Agents.Protein Kinase Inhibitors 41 0.378 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 41 0.374 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 41 0.372 66 4053 DB01042 Antineoplastic Agents, Alkylating.Myeloablative Agonists 41 0.37 125 596 DB02097 Not Available 41 0.355 63 5039 DB00863 Anti-Ulcer Agents.Histamine H2 Antagonists 41 0.35 171 2909 DB00091 Antifungal Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Immunomodulatory Agents.Immunosuppressive Agents 41 0.349 109 60879 DB00876 Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 41 0.346 264 5372 DB00864 Immunosuppressive Agents 41 0.341 108 4856 DB00554 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 41 0.336 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 41 0.332 119 5064 DB00811 Antimetabolites.Antiviral Agents 41 0.328 72 5672 DB00361 Antineoplastic Agents.Antineoplastic Agents, Phytogenic.Radiation-Sensitizing Agents 41 0.324 138 2369 DB00195 Adrenergic beta-Antagonists.Antihypertensive Agents.EENT Drugs.Sympatholytics 41 0.323 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 41 0.322 110 4212 DB01204 Analgesics.Antineoplastic Agents 41 0.32 196 3911 DB00007 Anti-Estrogen Agents.Antineoplastic Agents 41 0.32 144 3899 DB01097 Adjuvants.Anti-inflammatory Agents.Antineoplastic Agents.Antiparasitic Agents.Antirheumatic Agents.Antiviral Agents.Enzyme Inhibitors.Immunosuppressive Agents 41 0.32 134 3339 DB01039 Antilipemic Agents.Fribic Acid Derivatives 41 0.319 191 450 DB00783 Anti-menopausal Agents.Anticholesteremic Agents.Estrogens 41 0.317 157 3937 DB00722 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents.Cardiotonic Agents 41 0.317 116 5376 DB00675 Antineoplastic Agents, Hormonal.Bone Density Conservation Agents.Estrogen Antagonists.Selective Estrogen Receptor Modulators 41 0.315 72 4893 DB00457 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Antihypertensive Agents 41 0.296 137 3062316 DB01254 Protein Kinase Inhibitors 41 0.294 126 104865 DB00559 Antihypertensive Agents 41 0.291 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 41 0.289 131 4635 DB00497 Analgesics, Opioid.Antitussives.Narcotics.Opiate Agonists 41 0.288 142 2678 DB00341 Anti-Allergic Agents.Antihistamines.Histamine H1 Antagonists, Non-Sedating 41 0.278 141 4819 DB01085 Cholinergic Agents.Miotics.Muscarinic Agonists 41 0.275 110 4666 DB01229 Antineoplastic Agents.Antineoplastic Agents, Phytogenic.Tubulin Modulators 41 0.271 112 151165 DB00673 Antiemetics 41 0.268 73 4493 DB00665 Androgen Antagonists.Antineoplastic Agents 41 0.265 121 5408 DB00624 Androgens 41 0.264 46 4036 DB00939 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 41 0.262 136 2375 DB01128 Androgen Antagonists.Antineoplastic Agents 41 0.259 97 2541 DB00796 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 41 0.259 188 5040 DB00877 Anti-Bacterial Agents.Antibiotics, Antineoplastic.Antifungal Agents.Antifungals.Immunosuppressive Agents #### component 42: positive weight features and high scoring objects #### # positive weight on target proteins 42 0.426 13 CAH1_HUMAN Carbonic anhydrase 1; 42 0.411 11 CAH4_HUMAN Carbonic anhydrase 4; 42 0.39 13 CAH2_HUMAN Carbonic anhydrase 2; 42 0.371 9 S12A1_HUMAN Solute carrier family 12 member 1; 42 0.358 6 S12A3_HUMAN Solute carrier family 12 member 3; 42 0.275 12 KCMA1_HUMAN Calcium-activated potassium channel subunit alpha-1; 42 0.183 10 AT1A1_HUMAN Sodium/potassium-transporting ATPase subunit alpha-1; 42 0.087 6 CAH9_HUMAN Carbonic anhydrase 9; 42 0.076 8 AGTR1_HUMAN Type-1 angiotensin II receptor; 42 0.052 5 CAH12_HUMAN Carbonic anhydrase 12; 42 0.024 5 ATP4A_HUMAN Potassium-transporting ATPase alpha chain 1; 42 0.019 6 DRD4_HUMAN D(4) dopamine receptor; 42 0.008 4 CAH5A_HUMAN Carbonic anhydrase 5A, mitochondrial; 42 0.008 4 CAH6_HUMAN Carbonic anhydrase 6; 42 0.008 4 CAH13_HUMAN Carbonic anhydrase 13; 42 0.008 4 CAH7_HUMAN Carbonic anhydrase 7; 42 0.008 4 CAH3_HUMAN Carbonic anhydrase 3; 42 0.008 4 CAH8_HUMAN Carbonic anhydrase-related protein; 42 0.008 4 CAH5B_HUMAN Carbonic anhydrase 5B, mitochondrial; 42 0.008 4 CAH14_HUMAN Carbonic anhydrase 14; 42 0.004 5 VEGFA_HUMAN Vascular endothelial growth factor A; 42 0.002 17 ANXA1_HUMAN Annexin A1; # positive weight on side effects 42 0.383 173 hyperglycemia 42 0.382 81 hyperuricemia 42 0.378 187 photosensitivity 42 0.341 68 glycosuria 42 0.288 104 vasculitis 42 0.28 97 aplastic anemia 42 0.259 106 spasm 42 0.226 180 agranulocytosis 42 0.198 209 jaundice 42 0.187 459 diarrhea 42 0.186 330 anorexia 42 0.149 152 postural hypotension 42 0.123 187 weakness 42 0.114 377 urticaria 42 0.076 143 Stevens Johnson syndrome 42 0.052 15 sialadenitis 42 0.017 163 pancreatitis # high scoring drugs for both targets and side effects 42 2.385 54 3639 DB00999 Antihypertensive Agents.Diuretics.Sodium Chloride Symporter Inhibitors 42 2.38 38 4121 DB00232 Diuretics.Diuretics, Thiazide.Sodium Chloride Symporter Inhibitors 42 2.316 27 3647 DB00774 Antihypertensive Agents.Diuretics.Diuretics, Thiazide.Sodium Chloride Symporter Inhibitors 42 2.31 43 2720 DB00880 Antihypertensive Agents.Diuretics.Diuretics, Thiazide.Sodium Chloride Symporter Inhibitors 42 2.244 41 2315 DB00436 Antihypertensive Agents.Diuretics.Diuretics, Thiazide.Sodium Chloride Symporter Inhibitors 42 1.576 76 4170 DB00524 Antihypertensive Agents.Diuretics.Diuretics, Sulfamyl 42 1.565 72 3440 DB00695 Diuretics.Sodium Potassium Chloride Symporter Inhibitors 42 1.474 30 2732 DB00310 Antihypertensive Agents.Diuretics.Sodium Chloride Symporter Inhibitors 42 1.467 28 4870 DB01324 Antihypertensive Agents.Diuretics.Sodium Chloride Symporter Inhibitors 42 1.39 131 3961 DB00678 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents 42 1.352 144 3702 DB00808 Antihypertensive Agents.Diuretics 42 1.222 74 130881 DB00275 Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 42 1.208 43 1986 DB00819 Anticonvulsants.Carbonic Anhydrase Inhibitors.Diuretics 42 1.18 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 42 1.172 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 42 1.083 27 4100 DB00703 Carbonic Anhydrase Inhibitors.Diuretics 42 1.067 55 3019 DB01119 Antihypertensive Agents.Diuretics, Thiazide.Vasodilator Agents 42 1.05 95 16231 DB00594 Diuretics.Sodium channel blockers 42 1.032 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 42 1.028 453 125889 DB00230 Analgesics.Anticonvulsants 42 1.005 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 42 0.997 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 42 0.996 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 42 0.971 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 42 0.904 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 42 0.88 94 4409 DB00461 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents 42 0.88 166 3394 DB00712 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Carbonic Anhydrase Inhibitors.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 42 0.859 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 42 0.858 264 5372 DB00864 Immunosuppressive Agents 42 0.836 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 42 0.826 135 2585 DB01136 Adrenergic Agents.Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 42 0.821 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 42 0.82 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 42 0.82 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 42 0.819 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 42 0.797 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 42 0.794 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 42 0.783 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 42 0.781 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 42 0.763 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 42 0.756 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 42 0.75 104 4614 DB00991 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Nonsteroidal Antiinflammatory Agents (NSAIDs) 42 0.733 76 4748 DB00850 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 42 0.73 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 42 0.73 57 5454 DB01623 Antipsychotic Agents.Dopamine Antagonists 42 0.728 62 5566 DB00831 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 42 0.716 185 4594 DB00338 Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 42 0.706 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 42 0.697 64 2726 DB00477 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 42 0.689 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 42 0.689 119 3308 DB00749 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 42 0.689 142 3826 DB00465 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 42 0.689 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 42 0.689 108 4856 DB00554 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 42 0.686 157 3937 DB00722 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents.Cardiotonic Agents 42 0.667 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 42 0.662 120 3715 DB00328 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cardiovascular Agents.Cyclooxygenase Inhibitors.Gout Suppressants.Nonsteroidal Antiinflammatory Agents (NSAIDs).Tocolytic Agents 42 0.66 133 4112 DB00563 Abortifacient Agents.Abortifacient Agents, Nonsteroidal.Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Folic Acid Antagonists.Immunosuppressive Agents.Nucleic Acid Synthesis Inhibitors 42 0.649 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 42 0.635 97 1065 DB00908 Adrenergic alpha-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antimalarials.Enzyme Inhibitors.Muscarinic Antagonists 42 0.624 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 42 0.624 183 3648 DB00327 Analgesics, Opioid.Narcotics 42 0.622 59 4917 DB00433 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 42 0.617 103 5352 DB00605 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents.Cyclooxygenase Inhibitors 42 0.613 106 4539 DB01059 Anti-Bacterial Agents.Anti-Infectives.Enzyme Inhibitors.Nucleic Acid Synthesis Inhibitors.Quinolones 42 0.604 146 3075 DB00343 Antihypertensive Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Cardiovascular Agents.Vasodilator Agents 42 0.596 89 4044 DB00784 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 42 0.596 145 3672 DB01050 Analgesics.Analgesics, Non-Narcotic.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 42 0.59 32 3278 DB00903 Diuretics.Enzyme Inhibitors 42 0.582 154 3157 DB00590 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Anticholesteremic Agents.Antihypertensive Agents.Vasodilator Agents 42 0.581 135 5734 DB00909 Anticonvulsants.Antioxidants 42 0.577 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 42 0.572 116 5525 DB00519 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 42 0.566 211 93860 DB00188 Antineoplastic Agents.Protease Inhibitors 42 0.557 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 42 0.554 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 42 0.546 158 34312 DB00776 Anticonvulsants 42 0.545 137 62959 DB00685 Anti-Infective Agents.Anti-Infectives.Fluoroquinolones 42 0.544 90 2162 DB00381 Antianginals.Antihypertensive Agents.Calcium Channel Blockers.Vasodilator Agents 42 0.539 181 4932 DB01182 Anti-Arrhythmia Agents 42 0.538 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 42 0.534 154 5090 DB00533 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase 2 Inhibitors.Cyclooxygenase Inhibitors 42 0.523 161 5487 DB00697 Adrenergic alpha-Agonists.Analgesics.Anticonvulsants.Muscle Relaxants.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 42 0.519 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 42 0.502 128 3793 DB01167 Antifungal Agents.Antifungals.Antiprotozoal Agents.Antiprotozoals 42 0.497 151 60835 DB00476 Adrenergic Uptake Inhibitors.Antidepressive Agents.Dopamine Uptake Inhibitors.Serotonin Uptake Inhibitors 42 0.494 211 60953 DB01101 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Prodrugs 42 0.483 215 60787 DB01232 Anti-HIV Agents.HIV Protease Inhibitors 42 0.479 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 42 0.473 201 5538 DB00755 Antineoplastic Agents.Cell Stimulants and Proliferants.Keratolytic Agents 42 0.461 47 3476 DB00222 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Hypoglycemic Agents.Immunosuppressive Agents.Sulfonylureas 42 0.461 125 596 DB02097 Not Available 42 0.443 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 42 0.441 132 3948 DB00978 Anti-Infective Agents.Anti-Infective Agents, Urinary.Antitubercular Agents.Photosensitizing Agents 42 0.44 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 42 0.436 134 3339 DB01039 Antilipemic Agents.Fribic Acid Derivatives 42 0.431 51 3559 DB00502 Anti-Dyskinesia Agents.Antidyskinetics.Antiemetics.Antipsychotic Agents.Antipsychotics.Butyrophenones.Dopamine Antagonists 42 0.426 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 42 0.422 131 4635 DB00497 Analgesics, Opioid.Antitussives.Narcotics.Opiate Agonists 42 0.421 110 4212 DB01204 Analgesics.Antineoplastic Agents #### component 43: positive weight features and high scoring objects #### # positive weight on target proteins 43 0.428 34 ADRB2_HUMAN Beta-2 adrenergic receptor; 43 0.399 12 ACE_HUMAN Angiotensin-converting enzyme; 43 0.367 38 ADRB1_HUMAN Beta-1 adrenergic receptor; 43 0.331 24 ADRB3_HUMAN Beta-3 adrenergic receptor; 43 0.283 18 CAC1C_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1C; 43 0.228 17 CCG1_HUMAN Voltage-dependent calcium channel gamma-1 subunit; 43 0.193 16 CAC1F_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1F; 43 0.193 16 CACB2_HUMAN Voltage-dependent L-type calcium channel subunit beta-2; 43 0.193 16 CAC1D_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1D; 43 0.108 13 CAC1B_HUMAN Voltage-dependent N-type calcium channel subunit alpha-1B; 43 0.076 35 HRH1_HUMAN Histamine H1 receptor; 43 0.056 16 CAC1G_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1G; 43 0.028 15 CAC1I_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1I; 43 0.028 15 CAC1H_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1H; 43 0.009 13 CAC1A_HUMAN Voltage-dependent P/Q-type calcium channel subunit alpha-1A; 43 0.004 13 CACB1_HUMAN Voltage-dependent L-type calcium channel subunit beta-1; # positive weight on side effects 43 0.346 342 insomnia 43 0.322 233 tinnitus 43 0.233 205 bradycardia 43 0.205 147 decreased libido 43 0.204 107 nasal congestion 43 0.147 552 nausea 43 0.088 293 cough 43 0.084 254 nervousness 43 0.076 146 abnormal vision 43 0.063 298 asthenia 43 0.058 247 tremor 43 0.045 301 dry mouth 43 0.03 320 fatigue 43 0.02 222 flushing 43 0.016 133 bronchospasm 43 0.014 59 heartburn # high scoring drugs for both targets and side effects 43 1.589 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 43 1.279 95 16231 DB00594 Diuretics.Sodium channel blockers 43 1.269 99 5478 DB00373 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents 43 1.221 135 2585 DB01136 Adrenergic Agents.Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 43 1.198 78 2249 DB00335 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Sympatholytics 43 1.176 72 4893 DB00457 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Antihypertensive Agents 43 1.075 42 4411 DB01203 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents.Sympatholytics 43 1.042 61 4946 DB00571 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Anti-anxiety Agents.Antiarrhythmic Agents.Antihypertensive Agents.Vasodilator Agents 43 1.039 146 3075 DB00343 Antihypertensive Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Cardiovascular Agents.Vasodilator Agents 43 1.033 117 2405 DB00612 Adrenergic Agents.Adrenergic beta-Antagonists.Antihypertensive Agents.Sympatholytics 43 1.03 75 1978 DB01193 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents 43 1.013 61 4828 DB00960 Adrenergic beta-Antagonists.Antihypertensive Agents.Serotonin Antagonists.Vasodilator Agents 43 0.941 40 4845 DB01291 Adrenergic beta-Agonists.Bronchodilator Agents.Cardiotonic Agents 43 0.914 53 3784 DB00270 Antihypertensive Agents.Calcium Channel Blockers.Vasodilator Agents 43 0.898 106 2083 DB01001 Adrenergic beta-Agonists.Bronchodilator Agents.Tocolytic Agents 43 0.847 34 71301 DB04861 Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 43 0.833 73 3333 DB01023 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Calcium Channel Blockers.Dihydropyridines.Vasodilator Agents 43 0.832 28 2583 DB00521 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents.Sympatholytics 43 0.826 138 2369 DB00195 Adrenergic beta-Antagonists.Antihypertensive Agents.EENT Drugs.Sympatholytics 43 0.813 76 3661 DB00572 Adjuvants, Anesthesia.Anti-Arrhythmia Agents.Bronchodilator Agents.Muscarinic Antagonists.Mydriatics.Parasympatholytics 43 0.802 65 5253 DB00489 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Sympatholytics 43 0.738 90 2162 DB00381 Antianginals.Antihypertensive Agents.Calcium Channel Blockers.Vasodilator Agents 43 0.718 25 4724 DB01359 Adrenergic beta-Antagonists.Antihypertensive Agents 43 0.713 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 43 0.645 69 3869 DB00598 Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Sympatholytics 43 0.632 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 43 0.621 150 1775 DB00252 Anticonvulsants 43 0.613 157 3937 DB00722 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents.Cardiotonic Agents 43 0.602 7 3562 DB01159 Anesthetics.Anesthetics, Inhalation.General Anesthetics 43 0.597 17 5403 DB00871 Adrenergic beta-Agonists.Bronchodilator Agents.Sympathomimetic.Sympathomimetics.Tocolytic Agents 43 0.596 38 3914 DB01210 Adrenergic beta-Antagonists.EENT Drugs.Sympatholytics 43 0.595 29 3954 DB00836 Antidiarrheals 43 0.58 127 2156 DB01118 Anti-Arrhythmia Agents.Enzyme Inhibitors.Vasodilator Agents 43 0.572 30 31477 DB01214 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents.Sympatholytics 43 0.561 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 43 0.514 60 3519 DB01018 Adrenergic alpha-Agonists.Antihypertensive Agents.Sympatholytics 43 0.509 101 3154 DB00869 Antihypertensive Agents.Carbonic Anhydrase Inhibitors 43 0.503 118 65999 DB00966 Angiotensin II Type 1 Receptor Blockers.Angiotensin-converting Enzyme Inhibitors 43 0.503 14 36811 DB00841 Adrenergic beta-Agonists.Cardiotonic Agents.Sympathomimetic.Sympathomimetics 43 0.499 103 2751 DB01340 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 43 0.498 56 4473 DB00622 Antiarrhythmic Agents.Antihypertensive Agents.Calcium Channel Blockers.Dihydropyridines.Vasodilator Agents 43 0.493 11 40704 Not Available Not Available 43 0.492 36 2564 DB00748 Antihistamines 43 0.492 37 3100 DB01075 Anesthetics.Anesthetics, Local.Anti-Allergic Agents.Antidyskinetics.Antiemetics.Antiparkinson Agents.Antipruritics.Antitussives.Ethanolamine Derivatives.Histamine H1 Antagonists.Hypnotics and Sedatives 43 0.492 32 2725 DB01114 Anti-Allergic Agents.Antihistamines.Antipruritics.Histamine H1 Antagonists 43 0.492 37 2781 DB00283 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists 43 0.481 45 2216 DB00964 Adrenergic alpha-Agonists.Antiglaucomic Agents.EENT Drugs.Ophthalmics 43 0.467 84 5401 DB01162 Adrenergic alpha-Antagonists.Antineoplastic Agents.Platelet Aggregation Inhibitors 43 0.464 154 27661 DB01020 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 43 0.455 19 3779 DB01064 Adrenergic beta-Agonists.Bronchodilator Agents.Cardiotonic Agents.Sympathomimetic.Sympathomimetics 43 0.437 111 3419 DB00492 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 43 0.436 129 5210 DB01105 Anorexigenic Agents.Antidepressants.Antidepressive Agents.Appetite Depressants.Stimulants 43 0.436 91 3355 DB01195 Anti-Arrhythmia Agents.Antiarrhythmic Agents 43 0.432 52 32170 DB00668 Adrenergic Agonists.Adrenergic alpha-Agonists.Adrenergic beta-Agonists.Bronchodilator Agents.Mydriatics.Sympathomimetics.Vasoconstrictor Agents 43 0.423 158 34312 DB00776 Anticonvulsants 43 0.413 109 60879 DB00876 Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 43 0.412 100 5038 DB00178 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 43 0.408 24 2431 DB01158 Adrenergic Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents 43 0.407 84 2995 DB01151 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Enzyme Inhibitors.Norepinephrine-Reuptake Inhibitors 43 0.406 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 43 0.388 14 951 DB00368 Adrenergic alpha-Agonists.Sympathomimetics.Vasoconstrictor Agents 43 0.387 10 4436 Not Available Not Available 43 0.38 59 2476 DB00921 Analgesics, Opioid.Narcotic Antagonists.Narcotics 43 0.375 119 5064 DB00811 Antimetabolites.Antiviral Agents 43 0.375 80 3325 DB00927 Anti-Ulcer Agents.Histamine H2 Antagonists 43 0.37 35 16362 DB01100 Anti-Dyskinesia Agents.Antipsychotic Agents.Dopamine Antagonists 43 0.368 60 3373 DB01205 Antidotes.GABA Modulators 43 0.367 116 5525 DB00519 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 43 0.359 68 27686 DB01003 Anti-Asthmatic Agents 43 0.356 135 5734 DB00909 Anticonvulsants.Antioxidants 43 0.353 94 4171 DB00264 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Sympatholytics 43 0.349 87 5533 DB00656 Anti-anxiety Agents.Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 43 0.334 98 3222 DB00584 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 43 0.332 90 5152 DB00938 Adrenergic beta-Agonists.Bronchodilator Agents.Sympathomimetic 43 0.331 136 2375 DB01128 Androgen Antagonists.Antineoplastic Agents 43 0.33 36 60753 DB00308 Anti-Arrhythmia Agents 43 0.327 20 5775 DB00692 Adrenergic alpha-Antagonists.Antihypertensive Agents.Sympatholytics 43 0.324 66 4011 DB00934 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Second-Generation 43 0.324 91 937 DB00627 Antilipemic Agents.Vasodilator Agents.Vitamin B Complex.Vitamins (Vitamin B Complex) 43 0.323 83 54841 DB00289 Adrenergic Uptake Inhibitors.Antidepressants.Central Nervous System Agents 43 0.322 87 5005 DB00881 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 43 0.322 27 4086 DB00816 Adrenergic beta-Agonists.Bronchodilator Agents.Sympathomimetics.Tocolytic Agents 43 0.319 136 56339 DB01320 Anticonvulsants 43 0.317 64 3746 DB00332 Antimuscarinics.Antispasmodics.Bronchodilator Agents.Cholinergic Antagonists 43 0.317 66 54786 DB00374 Antihypertensive Agents.Antithrombotic Agents.Vitamin K antagonists 43 0.314 62 59768 DB00187 Adrenergic beta-Antagonists 43 0.31 61 3114 DB00280 Anti-Arrhythmia Agents.Antiarrhythmic Agents 43 0.307 58 60147 DB00706 Adrenergic alpha-Antagonists.Antineoplastic Agents 43 0.304 31 5052 DB00206 Adrenergic Uptake Inhibitors.Antihypertensive Agents.Antipsychotic Agents.Antipsychotics.Peripheral Adrenergic Inhibitors 43 0.301 57 2951 DB01219 Muscle Relaxants, Central 43 0.298 234 216326 DB00480 Antineoplastic Agents 43 0.293 120 2284 DB00181 GABA Agonists.Muscle Relaxants.Muscle Relaxants, Central.Skeletal Muscle Relaxants 43 0.289 79 2311 DB00542 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 43 0.289 196 3911 DB00007 Anti-Estrogen Agents.Antineoplastic Agents 43 0.289 68 110635 DB00820 Phosphodiesterase Inhibitors.Vasoconstrictor Agents 43 0.289 84 3016 DB00829 Adjuvants, Anesthesia.Anesthetics, Intravenous.Anti-anxiety Agents.Anticonvulsants.Antiemetics.GABA Modulators.Hypnotics and Sedatives.Muscle Relaxants, Central 43 0.282 29 3125 DB00765 Enzyme Inhibitors 43 0.278 131 4428 DB00704 Alcohol Antagonists.Anti-craving Agents.Depressants.Narcotic Antagonists.Opiate Antagonists 43 0.277 102 4943 DB00818 Anesthetics, Intravenous.Anticonvulsants.Antiemetics.Free Radical Scavengers.Hypnotics and Sedatives 43 0.276 48 3348 DB00950 Anti-Allergic Agents.Antihistamines.Histamine H1 Antagonists, Non-Sedating #### component 44: positive weight features and high scoring objects #### # positive weight on target proteins 44 0.473 16 CAC1G_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1G; 44 0.412 13 CAC1A_HUMAN Voltage-dependent P/Q-type calcium channel subunit alpha-1A; 44 0.348 15 CAC1I_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1I; 44 0.348 15 CAC1H_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1H; 44 0.333 15 RYR2_HUMAN Ryanodine receptor 2; 44 0.333 15 RYR3_HUMAN Ryanodine receptor 3; 44 0.145 14 RYR1_HUMAN Ryanodine receptor 1; 44 0.093 12 ITPR1_HUMAN Inositol 1,4,5-trisphosphate receptor type 1; 44 0.093 12 CCG2_HUMAN Voltage-dependent calcium channel gamma-2 subunit; 44 0.093 12 CAC1E_HUMAN Voltage-dependent R-type calcium channel subunit alpha-1E; 44 0.093 12 CCG4_HUMAN Voltage-dependent calcium channel gamma-4 subunit; 44 0.093 12 ITPR3_HUMAN Inositol 1,4,5-trisphosphate receptor type 3; 44 0.093 12 CA2D1_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-1; 44 0.093 12 PKD1_HUMAN Polycystin-1; 44 0.093 12 CACB4_HUMAN Voltage-dependent L-type calcium channel subunit beta-4; 44 0.093 12 PKD2_HUMAN Polycystin-2; 44 0.093 12 TRPA1_HUMAN Transient receptor potential cation channel subfamily A member 1; 44 0.093 12 TRPV6_HUMAN Transient receptor potential cation channel subfamily V member 6; 44 0.093 12 CACB3_HUMAN Voltage-dependent L-type calcium channel subunit beta-3; 44 0.093 12 CAC1S_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1S; 44 0.093 12 CCG7_HUMAN Voltage-dependent calcium channel gamma-7 subunit; # positive weight on side effects 44 0.525 75 amblyopia 44 0.434 108 ecchymosis 44 0.284 204 sweating 44 0.261 198 Sinusitis 44 0.256 70 petechiae 44 0.241 123 urinary incontinence 44 0.231 68 paralysis 44 0.228 121 heart failure 44 0.21 205 angioedema 44 0.202 128 gastrointestinal hemorrhage 44 0.153 87 neck pain 44 0.118 37 gum hemorrhage 44 0.118 439 pruritus 44 0.084 31 lymphoma 44 0.071 42 encephalopathy 44 0.06 191 peripheral edema 44 0.057 108 toxic epidermal necrolysis 44 0.048 29 hemiplegia 44 0.023 129 eosinophilia 44 0.02 31 vaginal moniliasis 44 0.014 104 pulmonary edema 44 0.008 105 leg cramps 44 0.007 90 gout 44 0.004 222 flatulence 44 0.002 368 somnolence # high scoring drugs for both targets and side effects 44 3.089 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 44 3.011 150 1775 DB00252 Anticonvulsants 44 2.908 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 44 2.87 146 3075 DB00343 Antihypertensive Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Cardiovascular Agents.Vasodilator Agents 44 2.734 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 44 2.383 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 44 2.061 57 2951 DB01219 Muscle Relaxants, Central 44 1.937 95 16231 DB00594 Diuretics.Sodium channel blockers 44 1.79 73 3333 DB01023 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Calcium Channel Blockers.Dihydropyridines.Vasodilator Agents 44 1.658 29 3954 DB00836 Antidiarrheals 44 1.62 453 125889 DB00230 Analgesics.Anticonvulsants 44 1.534 35 16362 DB01100 Anti-Dyskinesia Agents.Antipsychotic Agents.Dopamine Antagonists 44 1.463 7 3562 DB01159 Anesthetics.Anesthetics, Inhalation.General Anesthetics 44 1.372 135 5734 DB00909 Anticonvulsants.Antioxidants 44 1.244 264 5372 DB00864 Immunosuppressive Agents 44 1.193 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 44 1.146 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 44 1.137 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 44 1.073 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 44 1.062 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 44 1.053 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 44 1.047 196 3911 DB00007 Anti-Estrogen Agents.Antineoplastic Agents 44 1.036 166 3394 DB00712 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Carbonic Anhydrase Inhibitors.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 44 1.035 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 44 1.033 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 44 1.003 161 5487 DB00697 Adrenergic alpha-Agonists.Analgesics.Anticonvulsants.Muscle Relaxants.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 44 0.997 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 44 0.985 129 5210 DB01105 Anorexigenic Agents.Antidepressants.Antidepressive Agents.Appetite Depressants.Stimulants 44 0.966 136 56339 DB01320 Anticonvulsants 44 0.941 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 44 0.923 188 5040 DB00877 Anti-Bacterial Agents.Antibiotics, Antineoplastic.Antifungal Agents.Antifungals.Immunosuppressive Agents 44 0.923 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 44 0.921 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 44 0.908 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 44 0.906 128 2250 DB01076 Anticholesteremic Agents.Hydroxymethylglutaryl-CoA Reductase Inhibitors 44 0.903 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 44 0.901 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 44 0.873 117 2182 DB00261 Antithrombotic Agents.Fibrinolytic Agents.Platelet Aggregation Inhibitors 44 0.873 147 5645 DB01586 Cholagogues and Choleretics 44 0.856 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists 44 0.853 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 44 0.846 234 216326 DB00480 Antineoplastic Agents 44 0.842 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 44 0.818 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 44 0.815 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 44 0.809 183 3648 DB00327 Analgesics, Opioid.Narcotics 44 0.793 147 71158 DB00659 Alcohol Deterrents 44 0.785 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 44 0.771 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 44 0.766 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 44 0.742 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 44 0.741 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 44 0.717 89 59708 DB01202 Anticonvulsants.Nootropic Agents 44 0.712 196 1935 DB00382 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 44 0.694 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 44 0.689 84 3016 DB00829 Adjuvants, Anesthesia.Anesthetics, Intravenous.Anti-anxiety Agents.Anticonvulsants.Antiemetics.GABA Modulators.Hypnotics and Sedatives.Muscle Relaxants, Central 44 0.682 118 4236 DB00745 Anorexigenic Agents.Central Nervous System Agents.Central Nervous System Stimulants.Neuroprotective Agents.Stimulants 44 0.654 53 3784 DB00270 Antihypertensive Agents.Calcium Channel Blockers.Vasodilator Agents 44 0.638 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 44 0.63 136 2375 DB01128 Androgen Antagonists.Antineoplastic Agents 44 0.615 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 44 0.601 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 44 0.601 132 4739 DB00552 Antibiotics.Antineoplastic Agents.Enzyme Inhibitors.Immunosuppressive Agents 44 0.587 211 93860 DB00188 Antineoplastic Agents.Protease Inhibitors 44 0.571 111 5281104 DB00910 Not Available 44 0.564 161 5291 DB00619 Antineoplastic Agents.Protein Kinase Inhibitors 44 0.555 84 5401 DB01162 Adrenergic alpha-Antagonists.Antineoplastic Agents.Platelet Aggregation Inhibitors 44 0.55 144 3899 DB01097 Adjuvants.Anti-inflammatory Agents.Antineoplastic Agents.Antiparasitic Agents.Antirheumatic Agents.Antiviral Agents.Enzyme Inhibitors.Immunosuppressive Agents 44 0.549 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 44 0.525 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 44 0.524 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 44 0.521 152 60184 DB00790 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 44 0.515 145 3672 DB01050 Analgesics.Analgesics, Non-Narcotic.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 44 0.515 135 5544 DB00620 Adrenergic Agents.Anti-inflammatory Agents.Glucocorticoids 44 0.499 97 5245 DB00884 Antihypocalcemic Agents.Antiresorptives.Bisphosphonates.Bone Density Conservation Agents.Calcium Channel Blockers 44 0.487 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 44 0.486 134 3339 DB01039 Antilipemic Agents.Fribic Acid Derivatives 44 0.482 161 122316 DB01367 Monoamine Oxidase Inhibitors.Neuroprotective Agents 44 0.476 146 4158 DB00422 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Uptake Inhibitors.Sympathomimetics 44 0.472 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 44 0.465 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 44 0.451 141 4819 DB01085 Cholinergic Agents.Miotics.Muscarinic Agonists 44 0.447 101 14888 DB01169 Antineoplastic Agents.Homeopathic Agents 44 0.446 110 4212 DB01204 Analgesics.Antineoplastic Agents 44 0.443 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 44 0.442 97 159 DB01240 Antihypertensive Agents.Platelet Aggregation Inhibitors 44 0.441 36 4914 DB00721 Anesthetics.Anesthetics, Local.Local Anesthetics 44 0.436 102 83786 DB00437 Antimetabolites.Enzyme Inhibitors.Enzyme Inhibitors Antimetabolites.Free Radical Scavengers.Gout Suppressants 44 0.434 131 4635 DB00497 Analgesics, Opioid.Antitussives.Narcotics.Opiate Agonists 44 0.434 154 27661 DB01020 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 44 0.43 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 44 0.424 144 3702 DB00808 Antihypertensive Agents.Diuretics 44 0.42 58 60147 DB00706 Adrenergic alpha-Antagonists.Antineoplastic Agents 44 0.419 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 44 0.419 123 2806 DB00758 Antiplatelet Agents.Fibrinolytic Agents.Platelet Aggregation Inhibitors 44 0.411 119 3308 DB00749 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 44 0.404 120 3715 DB00328 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cardiovascular Agents.Cyclooxygenase Inhibitors.Gout Suppressants.Nonsteroidal Antiinflammatory Agents (NSAIDs).Tocolytic Agents 44 0.396 181 4932 DB01182 Anti-Arrhythmia Agents 44 0.39 171 2909 DB00091 Antifungal Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Immunomodulatory Agents.Immunosuppressive Agents 44 0.387 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones #### component 45: positive weight features and high scoring objects #### # positive weight on target proteins 45 0.47 28 SC6A2_HUMAN Sodium-dependent noradrenaline transporter; 45 0.394 34 ACM2_HUMAN Muscarinic acetylcholine receptor M2; 45 0.38 19 OPRM_HUMAN Mu-type opioid receptor; 45 0.351 36 ACM1_HUMAN Muscarinic acetylcholine receptor M1; 45 0.321 26 SC6A4_HUMAN Sodium-dependent serotonin transporter; 45 0.302 16 OPRK_HUMAN Kappa-type opioid receptor; 45 0.3 17 OPRD_HUMAN Delta-type opioid receptor; 45 0.071 13 CACB1_HUMAN Voltage-dependent L-type calcium channel subunit beta-1; 45 0.049 12 CCG7_HUMAN Voltage-dependent calcium channel gamma-7 subunit; 45 0.049 12 CCG4_HUMAN Voltage-dependent calcium channel gamma-4 subunit; 45 0.049 12 CCG2_HUMAN Voltage-dependent calcium channel gamma-2 subunit; 45 0.049 12 TRPA1_HUMAN Transient receptor potential cation channel subfamily A member 1; 45 0.049 12 TRPV6_HUMAN Transient receptor potential cation channel subfamily V member 6; 45 0.049 12 ITPR1_HUMAN Inositol 1,4,5-trisphosphate receptor type 1; 45 0.049 12 CAC1E_HUMAN Voltage-dependent R-type calcium channel subunit alpha-1E; 45 0.049 12 CACB4_HUMAN Voltage-dependent L-type calcium channel subunit beta-4; 45 0.049 12 CAC1S_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1S; 45 0.049 12 CA2D1_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-1; 45 0.049 12 PKD1_HUMAN Polycystin-1; 45 0.049 12 CACB3_HUMAN Voltage-dependent L-type calcium channel subunit beta-3; 45 0.049 12 PKD2_HUMAN Polycystin-2; 45 0.049 12 ITPR3_HUMAN Inositol 1,4,5-trisphosphate receptor type 3; 45 0.039 15 CAC1H_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1H; 45 0.039 15 CAC1I_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1I; 45 0.036 13 CAC1B_HUMAN Voltage-dependent N-type calcium channel subunit alpha-1B; 45 0.028 17 CCG1_HUMAN Voltage-dependent calcium channel gamma-1 subunit; 45 0.028 16 CAC1D_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1D; 45 0.028 16 CACB2_HUMAN Voltage-dependent L-type calcium channel subunit beta-2; 45 0.028 16 CAC1F_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1F; 45 0.017 14 RYR1_HUMAN Ryanodine receptor 1; 45 0.016 18 CAC1C_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1C; 45 0.008 9 GABR2_HUMAN Gamma-aminobutyric acid type B receptor subunit 2; 45 0.001 14 A1AG1_HUMAN Alpha-1-acid glycoprotein 1; # positive weight on side effects 45 0.436 49 urinary urgency 45 0.432 187 weakness 45 0.316 204 sweating 45 0.293 274 palpitations 45 0.282 38 abdominal cramps 45 0.262 513 vomiting 45 0.244 377 constipation 45 0.198 35 paralytic ileus 45 0.183 474 dizziness 45 0.168 439 pruritus 45 0.157 23 urinary hesitancy 45 0.102 377 urticaria 45 0.079 20 drug dependence 45 0.071 52 heart block 45 0.002 254 nervousness # high scoring drugs for both targets and side effects 45 1.458 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 45 1.429 69 3696 DB00458 Adrenergic Uptake Inhibitors.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 45 1.349 84 2995 DB01151 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Enzyme Inhibitors.Norepinephrine-Reuptake Inhibitors 45 1.312 183 3648 DB00327 Analgesics, Opioid.Narcotics 45 1.214 29 3954 DB00836 Antidiarrheals 45 1.203 72 2160 DB00321 Adrenergic Uptake Inhibitors.Analgesics, Non-Narcotic.Antidepressive Agents, Tricyclic 45 1.173 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 45 1.149 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 45 1.094 128 4253 DB00295 Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 45 1.055 65 4543 DB00540 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 45 1.055 64 5584 DB00726 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 45 1.055 67 4976 DB00344 Adrenergic Uptake Inhibitors.Antidepressive Agents.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 45 1.028 69 2170 DB00543 Adrenergic Uptake Inhibitors.Antidepressive Agents, Second-Generation.Dopamine Antagonists.Neurotransmitter Uptake Inhibitors.Serotonin Uptake Inhibitors 45 0.999 57 2951 DB01219 Muscle Relaxants, Central 45 0.995 131 4635 DB00497 Analgesics, Opioid.Antitussives.Narcotics.Opiate Agonists 45 0.984 59 4095 DB00333 Analgesics.Analgesics, Opioid.Antitussive Agents.Antitussives.Narcotics.Opiate Agonists 45 0.97 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 45 0.949 35 3042 DB00804 Anticholinergic Agents.Antimuscarinics.Antispasmodics.Muscarinic Antagonists.Parasympatholytics 45 0.925 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 45 0.916 71 2487 DB00611 Analgesics, Opioid.Antitussive Agents.Narcotic Antagonists.Narcotics 45 0.898 37 3494 DB00986 Adjuvants, Anesthesia.Anti-cholinergic Agents.Muscarinic Antagonists 45 0.894 87 5533 DB00656 Anti-anxiety Agents.Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 45 0.876 28 4058 DB00454 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 45 0.865 19 4934 DB00782 Anti-Ulcer Agents.Antimuscarinics.Antispasmodics.Muscarinic Antagonists 45 0.848 73 3333 DB01023 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Calcium Channel Blockers.Dihydropyridines.Vasodilator Agents 45 0.845 66 4011 DB00934 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Second-Generation 45 0.829 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 45 0.817 196 1935 DB00382 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 45 0.816 151 60835 DB00476 Adrenergic Uptake Inhibitors.Antidepressive Agents.Dopamine Uptake Inhibitors.Serotonin Uptake Inhibitors 45 0.808 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 45 0.782 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 45 0.764 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 45 0.754 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 45 0.73 59 2476 DB00921 Analgesics, Opioid.Narcotic Antagonists.Narcotics 45 0.71 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 45 0.708 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 45 0.698 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 45 0.696 146 4158 DB00422 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Uptake Inhibitors.Sympathomimetics 45 0.688 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 45 0.668 47 4419 DB00844 Analgesics, Opioid.Narcotic Antagonists.Narcotics 45 0.665 95 16231 DB00594 Diuretics.Sodium channel blockers 45 0.655 131 4428 DB00704 Alcohol Antagonists.Anti-craving Agents.Depressants.Narcotic Antagonists.Opiate Antagonists 45 0.624 146 3075 DB00343 Antihypertensive Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Cardiovascular Agents.Vasodilator Agents 45 0.622 141 4819 DB01085 Cholinergic Agents.Miotics.Muscarinic Agonists 45 0.621 62 3007 DB00182 Adrenergic Agents.Adrenergic Uptake Inhibitors.Amphetamines.Central Nervous System Stimulants.Dopamine Agents.Dopamine Uptake Inhibitors.Sympathomimetics 45 0.614 68 5596 DB00209 Analgesics.Parasympatholytics 45 0.612 50 3158 DB01142 Anti-anxiety Agents.Antidepressants.Antidepressive Agents, Tricyclic.Antipruritics.Histamine Antagonists.Norepinephrine-Reuptake Inhibitors 45 0.611 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 45 0.603 196 3911 DB00007 Anti-Estrogen Agents.Antineoplastic Agents 45 0.595 72 60831 DB01409 Anticholinergic Agents.Bronchodilator Agents.Cholinergic Antagonists.Muscarinic Antagonists.Parasympatholytics 45 0.589 150 1775 DB00252 Anticonvulsants 45 0.568 64 3746 DB00332 Antimuscarinics.Antispasmodics.Bronchodilator Agents.Cholinergic Antagonists 45 0.565 129 5210 DB01105 Anorexigenic Agents.Antidepressants.Antidepressive Agents.Appetite Depressants.Stimulants 45 0.562 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 45 0.555 76 3661 DB00572 Adjuvants, Anesthesia.Anti-Arrhythmia Agents.Bronchodilator Agents.Muscarinic Antagonists.Mydriatics.Parasympatholytics 45 0.549 14 10100 DB00647 Analgesics.Analgesics, Opioid.Antitussives.Narcotics 45 0.537 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 45 0.523 37 4736 DB00652 Adjuvants, Anesthesia.Analgesics, Opioid.Narcotic Antagonists.Narcotics 45 0.519 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 45 0.517 11 2131 DB01122 Antiarrhythmic Agents.Antimyasthenics 45 0.516 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 45 0.502 35 16362 DB01100 Anti-Dyskinesia Agents.Antipsychotic Agents.Dopamine Antagonists 45 0.501 91 60815 DB00899 Analgesics, Opioid.Anesthetics, Intravenous.Hypnotics and Sedatives 45 0.496 25 5572 DB00376 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists 45 0.495 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists 45 0.493 21 4057 DB04843 Anticholinergic Agents.Parasympatholytics 45 0.463 38 125017 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 45 0.462 453 125889 DB00230 Analgesics.Anticonvulsants 45 0.449 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 45 0.428 120 2284 DB00181 GABA Agonists.Muscle Relaxants.Muscle Relaxants, Central.Skeletal Muscle Relaxants 45 0.424 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 45 0.412 128 2250 DB01076 Anticholesteremic Agents.Hydroxymethylglutaryl-CoA Reductase Inhibitors 45 0.411 91 3902 DB01006 Antineoplastic Agents.Aromatase Inhibitors 45 0.411 77 3379 DB00180 Anti-Asthmatic Agents.Anti-inflammatory Agents 45 0.411 146 3475 DB01120 Hypoglycemic Agents.Sulfonylureas 45 0.411 134 3339 DB01039 Antilipemic Agents.Fribic Acid Derivatives 45 0.409 73 2769 DB00604 Anti-Ulcer Agents.Gastrointestinal Agents.Prokinetic Agents.Serotonin Agonists 45 0.403 61 4828 DB00960 Adrenergic beta-Antagonists.Antihypertensive Agents.Serotonin Antagonists.Vasodilator Agents 45 0.396 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 45 0.394 157 3937 DB00722 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents.Cardiotonic Agents 45 0.386 15 2370 DB01019 Muscarinic Agonists.Parasympathomimetics 45 0.385 71 4740 DB00806 Free Radical Scavengers.Hematologic Agents.Hemorrheologic Agents.Phosphodiesterase Inhibitors.Platelet Aggregation Inhibitors.Radiation-Protective Agents.Vasodilator Agents 45 0.385 76 2803 DB00575 Adrenergic alpha-Agonists.Analgesics.Antihypertensive Agents.Central Alpha-Agonists.Sympatholytics 45 0.371 33 4425 DB01183 Antinarcotic Agents.Depressants.Narcotic Antagonists.Opiate Antagonists 45 0.37 161 5487 DB00697 Adrenergic alpha-Agonists.Analgesics.Anticonvulsants.Muscle Relaxants.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 45 0.368 236 10631 DB00603 Contraceptives.Contraceptives, Oral, Synthetic.Progestins 45 0.368 125 3285 DB00977 Estrogens 45 0.367 94 4171 DB00264 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Sympatholytics 45 0.364 121 5408 DB00624 Androgens 45 0.361 84 5401 DB01162 Adrenergic alpha-Antagonists.Antineoplastic Agents.Platelet Aggregation Inhibitors 45 0.358 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 45 0.355 53 3784 DB00270 Antihypertensive Agents.Calcium Channel Blockers.Vasodilator Agents 45 0.352 57 2949 DB01406 Estrogen Antagonists 45 0.34 101 2800 DB00822 Alcohol Deterrents.Enzyme Inhibitors 45 0.34 104 4614 DB00991 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Nonsteroidal Antiinflammatory Agents (NSAIDs) 45 0.339 135 5734 DB00909 Anticonvulsants.Antioxidants 45 0.333 199 5358 DB00669 Selective Serotonin Agonists.Serotonin Agonists.Vasoconstrictor Agents 45 0.331 75 1978 DB01193 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents 45 0.327 90 2477 DB00490 Anti-anxiety Agents.Anxiolytics sedatives and hypnotics.Serotonin Agonists 45 0.325 101 3154 DB00869 Antihypertensive Agents.Carbonic Anhydrase Inhibitors #### component 46: positive weight features and high scoring objects #### # positive weight on target proteins 46 0.589 23 PGH1_HUMAN Prostaglandin G/H synthase 1; 46 0.485 29 PGH2_HUMAN Prostaglandin G/H synthase 2; 46 0.345 14 LOX5_HUMAN Arachidonate 5-lipoxygenase; 46 0.234 10 LKHA4_HUMAN Leukotriene A-4 hydrolase; 46 0.18 8 LOX12_HUMAN Arachidonate 12-lipoxygenase, 12S-type; 46 0.18 8 LOXE3_HUMAN Epidermis-type lipoxygenase 3; 46 0.18 8 LX12B_HUMAN Arachidonate 12-lipoxygenase, 12R-type; 46 0.147 8 LOX15_HUMAN Arachidonate 15-lipoxygenase; 46 0.132 7 LX15B_HUMAN Arachidonate 15-lipoxygenase B; 46 0.058 14 TTHY_HUMAN Transthyretin; 46 0.016 6 CRP_HUMAN C-reactive protein; 46 0.008 8 DYR_HUMAN Dihydrofolate reductase; # positive weight on side effects 46 0.291 53 proteinuria 46 0.242 279 infection 46 0.21 116 pancytopenia 46 0.198 48 ulcerative stomatitis 46 0.17 27 erythema nodosum 46 0.144 22 enterocolitis 46 0.118 5 renal papillary necrosis 46 0.105 86 sepsis 46 0.093 75 hyperkalemia 46 0.091 25 serum sickness 46 0.088 12 ulcerative colitis 46 0.056 113 eczema 46 0.036 163 pancreatitis 46 0.034 191 hepatitis 46 0.017 62 abdominal distention 46 0.005 6 fasciitis 46 0.003 270 alopecia # high scoring drugs for both targets and side effects 46 2.108 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 46 1.771 120 3715 DB00328 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cardiovascular Agents.Cyclooxygenase Inhibitors.Gout Suppressants.Nonsteroidal Antiinflammatory Agents (NSAIDs).Tocolytic Agents 46 1.634 145 3672 DB01050 Analgesics.Analgesics, Non-Narcotic.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 46 1.61 92 3825 DB01009 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 46 1.383 46 4036 DB00939 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 46 1.305 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 46 1.235 81 5353980 DB00795 Anti-Infective Agents.Anti-Inflammatory Agents, Non-Steroidal.Antirheumatic Agents.Gastrointestinal Agents.Sulfonamides 46 1.146 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 46 1.104 119 3308 DB00749 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 46 1.068 142 3826 DB00465 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 46 1.05 166 3394 DB00712 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Carbonic Anhydrase Inhibitors.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 46 1.018 154 5090 DB00533 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase 2 Inhibitors.Cyclooxygenase Inhibitors 46 0.969 34 3827 DB00920 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists 46 0.947 89 4044 DB00784 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 46 0.915 43 5508 DB00500 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 46 0.87 71 3342 DB00573 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Propionic acid derivatives 46 0.863 60 3059 DB00861 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 46 0.835 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 46 0.796 108 4856 DB00554 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 46 0.789 67 2267 DB00972 Anti-Allergic Agents.Anti-Inflammatory Agents, Non-Steroidal.Bronchodilator Agents.Histamine H1 Antagonists.Histamine H1 Antagonists, Non-Sedating.Lipoxygenase Inhibitors.Platelet Aggregation Inhibitors 46 0.786 46 5362070 DB01014 Anti-Inflammatory Agents, Non-Steroidal.Anti-Ulcer Agents.Gastrointestinal Agents 46 0.746 144 3899 DB01097 Adjuvants.Anti-inflammatory Agents.Antineoplastic Agents.Antiparasitic Agents.Antirheumatic Agents.Antiviral Agents.Enzyme Inhibitors.Immunosuppressive Agents 46 0.744 14 2749 DB01188 Antifungal Agents 46 0.741 103 5352 DB00605 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents.Cyclooxygenase Inhibitors 46 0.669 24 2244 DB00945 Anti-Inflammatory Agents, Non-Steroidal.Anticoagulants.Cyclooxygenase Inhibitors.Fibrinolytic Agents.Platelet Aggregation Inhibitors.Salicylates 46 0.669 7 5359 DB00870 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 46 0.649 97 4200 DB01017 Anti-Bacterial Agents.Tetracyclines 46 0.627 137 3062316 DB01254 Protein Kinase Inhibitors 46 0.562 50 3657 DB01005 Antineoplastic Agents.Antisickling Agents.Enzyme Inhibitors.Nucleic Acid Synthesis Inhibitors 46 0.561 151 41317 DB00459 Keratolytic Agents 46 0.542 4 6503 DB03754 Buffers.Excipients 46 0.538 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 46 0.457 72 6398970 DB00535 Anti-Bacterial Agents.Anti-Infectives 46 0.456 41 6918453 DB00995 Antirheumatic Agents, Gold 46 0.454 94 4409 DB00461 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents 46 0.443 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 46 0.439 104 4614 DB00991 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Nonsteroidal Antiinflammatory Agents (NSAIDs) 46 0.433 70 4475485 DB01098 Anticholesteremic Agents.HMG-CoA Reductase Inhibitors.Hydroxymethylglutaryl-CoA Reductase Inhibitors 46 0.416 46 4201 DB00350 Antihypertensive Agents.Vasodilator Agents 46 0.4 128 2250 DB01076 Anticholesteremic Agents.Hydroxymethylglutaryl-CoA Reductase Inhibitors 46 0.398 151 60835 DB00476 Adrenergic Uptake Inhibitors.Antidepressive Agents.Dopamine Uptake Inhibitors.Serotonin Uptake Inhibitors 46 0.398 28 25419 DB00720 Antihypocalcemic Agents.Antineoplastic Agents.Bisphosphonates.Bone Density Conservation Agents.Osteoporosis Prophylactic 46 0.396 41 39042 DB01393 Antilipemic Agents 46 0.396 90 5329102 DB01268 Angiogenesis Inhibitors.Antineoplastic Agents 46 0.379 46 3685 DB01177 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 46 0.377 32 2265 DB00993 Antimetabolites.Antimetabolites, Antineoplastic.Antirheumatic Agents.Immunosuppressive Agents 46 0.375 9 5342 DB01138 Uricosuric Agents 46 0.363 69 5311297 DB00471 Anti-Asthmatic Agents.Antiarrhythmic Agents.Leukotriene Antagonists 46 0.352 72 60831 DB01409 Anticholinergic Agents.Bronchodilator Agents.Cholinergic Antagonists.Muscarinic Antagonists.Parasympatholytics 46 0.352 50 5472 DB00208 Fibrinolytic Agents.Platelet Aggregation Inhibitors 46 0.348 70 2179 DB00276 Antineoplastic Agents.Intercalating Agents 46 0.342 116 5376 DB00675 Antineoplastic Agents, Hormonal.Bone Density Conservation Agents.Estrogen Antagonists.Selective Estrogen Receptor Modulators 46 0.324 25 150310 DB00700 Aldosterone Antagonists.Antihypertensive Agents 46 0.323 46 738 DB00130 Dietary supplement.Micronutrient.Non-Essential Amino Acids 46 0.322 79 2311 DB00542 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 46 0.317 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 46 0.317 27 298 DB00446 Anti-Bacterial Agents.Protein Synthesis Inhibitors 46 0.316 123 2806 DB00758 Antiplatelet Agents.Fibrinolytic Agents.Platelet Aggregation Inhibitors 46 0.316 54 4513 DB00585 Anti-Ulcer Agents.Histamine H2 Antagonists 46 0.311 47 60843 DB00642 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Enzyme Inhibitors.Folic Acid Antagonists 46 0.307 41 104758 DB00293 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Enzyme Inhibitors.Folic Acid Antagonists 46 0.307 38 30623 DB00380 Antineoplastic Agents.Cardiovascular Agents.Chelating Agents.Immunosuppressive Agents 46 0.3 121 5408 DB00624 Androgens 46 0.3 40 2617 DB01327 Anti-Bacterial Agents.Cephalosporins 46 0.298 54 4599 DB01083 Anti-Obesity Agents.Enzyme Inhibitors 46 0.298 112 151165 DB00673 Antiemetics 46 0.289 68 5596 DB00209 Analgesics.Parasympatholytics 46 0.288 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 46 0.288 38 150311 DB00973 Anticholesteremic Agents.Cholesterol Absorption Inhibitors 46 0.282 41 32797 DB01013 Anti-inflammatory Agents.Corticosteroids, topical.Glucocorticoids 46 0.281 90 5152 DB00938 Adrenergic beta-Agonists.Bronchodilator Agents.Sympathomimetic 46 0.279 43 31378 DB00687 Adrenergic Agents.Anti-inflammatory Agents 46 0.278 70 4091 DB00331 Hypoglycemic Agents 46 0.278 3 175 DB04184 Indicators and Reagents 46 0.278 133 4112 DB00563 Abortifacient Agents.Abortifacient Agents, Nonsteroidal.Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Folic Acid Antagonists.Immunosuppressive Agents.Nucleic Acid Synthesis Inhibitors 46 0.272 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 46 0.272 79 176870 DB00530 Protein Kinase Inhibitors 46 0.267 97 159 DB01240 Antihypertensive Agents.Platelet Aggregation Inhibitors 46 0.266 61 5402 DB00857 Allylamines.Antifungal Agents.Antifungals.Enzyme Inhibitors.Trypanocidal Agents 46 0.265 62 3478 DB01067 Hypoglycemic Agents 46 0.262 106 216239 DB00398 Anticancer Agents.Antineoplastic Agents.Protein Kinase Inhibitors 46 0.259 188 5040 DB00877 Anti-Bacterial Agents.Antibiotics, Antineoplastic.Antifungal Agents.Antifungals.Immunosuppressive Agents 46 0.258 23 143 DB00650 Antianemic Agents.Antidote (to folic acid antagonists).Antineoplastic Adjuncts.Vitamin B Complex.Vitamins/minerals 46 0.257 11 2519 DB00201 Anorexigenic Agents.Central Nervous System Stimulants.Phosphodiesterase Inhibitors 46 0.256 44 4060 DB00532 Anticonvulsants 46 0.254 41 2088 DB00630 Antihypocalcemic Agents.Antiresorptives.Bisphosphonates.Bone Density Conservation Agents 46 0.254 63 3381 DB00591 Anti-inflammatory Agents.Antipruritics.Glucocorticoids 46 0.254 73 2769 DB00604 Anti-Ulcer Agents.Gastrointestinal Agents.Prokinetic Agents.Serotonin Agonists 46 0.254 61 40976 DB00294 Contraceptive Agents, Female.Contraceptives 46 0.254 64 19090 DB00351 Antineoplastic Agents, Hormonal.Contraceptives, Oral, Synthetic 46 0.253 17 3000 DB00547 Anti-inflammatory Agents.Glucocorticoids 46 0.253 83 54841 DB00289 Adrenergic Uptake Inhibitors.Antidepressants.Central Nervous System Agents 46 0.253 66 123620 DB00764 Anti-Allergic Agents.Anti-inflammatory Agents 46 0.253 52 5311027 DB00905 Antiglaucomic Agents.Antihypertensive Agents 46 0.253 78 6447131 DB00337 Anti-Inflammatory Agents, Non-Steroidal.Dermatologic Agents.Enzyme Inhibitors.Immunosuppressive Agents 46 0.253 37 5512 DB01036 Anti-Incontinence Agents.Antispasmodics.Genitourinary Smooth Muscle Relaxants.Muscarinic Antagonists 46 0.253 17 52421 DB01130 Anti Inflammatory.Anti-inflammatory Agents.Corticosteroid.Glucocorticoids.Steroidal 46 0.253 11 3375 DB00223 Anti-inflammatory Agents.Glucocorticoids 46 0.253 16 3382 DB01047 Anti-Allergic Agents.Anti-inflammatory Agents.Glucocorticoids 46 0.253 26 12536 DB01260 Anti-inflammatory Agents #### component 47: positive weight features and high scoring objects #### # positive weight on target proteins 47 0.666 12 ACE_HUMAN Angiotensin-converting enzyme; 47 0.451 8 AGTR1_HUMAN Type-1 angiotensin II receptor; 47 0.226 6 ANGT_HUMAN Angiotensinogen; 47 0.195 26 SC6A4_HUMAN Sodium-dependent serotonin transporter; 47 0.17 6 DRD4_HUMAN D(4) dopamine receptor; 47 0.133 8 HMDH_HUMAN 3-hydroxy-3-methylglutaryl-coenzyme A reductase; 47 0.119 13 CAC1A_HUMAN Voltage-dependent P/Q-type calcium channel subunit alpha-1A; 47 0.101 34 ADA1B_HUMAN Alpha-1B adrenergic receptor; 47 0.093 5 VEGFA_HUMAN Vascular endothelial growth factor A; 47 0.088 9 GABR2_HUMAN Gamma-aminobutyric acid type B receptor subunit 2; 47 0.087 5 SCN1A_HUMAN Sodium channel protein type 1 subunit alpha; 47 0.061 3 PPIA_HUMAN Peptidyl-prolyl cis-trans isomerase A; 47 0.045 13 CAC1B_HUMAN Voltage-dependent N-type calcium channel subunit alpha-1B; 47 0.023 5 ATP4A_HUMAN Potassium-transporting ATPase alpha chain 1; 47 0.02 16 CAC1G_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1G; 47 0.005 12 PKD1_HUMAN Polycystin-1; 47 0.005 12 CA2D1_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-1; 47 0.005 12 ITPR3_HUMAN Inositol 1,4,5-trisphosphate receptor type 3; 47 0.005 12 ITPR1_HUMAN Inositol 1,4,5-trisphosphate receptor type 1; 47 0.005 12 PKD2_HUMAN Polycystin-2; 47 0.005 12 CCG4_HUMAN Voltage-dependent calcium channel gamma-4 subunit; 47 0.005 12 TRPA1_HUMAN Transient receptor potential cation channel subfamily A member 1; 47 0.005 12 TRPV6_HUMAN Transient receptor potential cation channel subfamily V member 6; 47 0.005 12 CACB3_HUMAN Voltage-dependent L-type calcium channel subunit beta-3; 47 0.005 12 CCG2_HUMAN Voltage-dependent calcium channel gamma-2 subunit; 47 0.005 12 CAC1E_HUMAN Voltage-dependent R-type calcium channel subunit alpha-1E; 47 0.005 12 CACB4_HUMAN Voltage-dependent L-type calcium channel subunit beta-4; 47 0.005 12 CAC1S_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1S; 47 0.005 12 CCG7_HUMAN Voltage-dependent calcium channel gamma-7 subunit; # positive weight on side effects 47 0.41 229 Pharyngitis 47 0.405 218 rhinitis 47 0.366 282 vertigo 47 0.352 75 hyperkalemia 47 0.296 139 arthritis 47 0.282 170 angina pectoris 47 0.26 169 bronchitis 47 0.246 90 gout 47 0.166 326 paresthesia 47 0.141 346 dyspnea 47 0.136 304 Dyspepsia 47 0.127 161 upper respiratory tract infection 47 0.121 190 epistaxis 47 0.064 214 Influenza 47 0.064 136 renal failure 47 0.059 187 photosensitivity 47 0.058 85 acute renal failure 47 0.039 175 urinary tract infection 47 0.034 275 hypersensitivity 47 0.033 13 pemphigus 47 0.002 191 peripheral edema 47 0.001 184 pneumonia # high scoring drugs for both targets and side effects 47 1.701 157 3937 DB00722 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents.Cardiotonic Agents 47 1.542 152 60184 DB00790 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 47 1.468 103 2751 DB01340 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 47 1.467 131 3961 DB00678 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents 47 1.447 97 2541 DB00796 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 47 1.438 109 60879 DB00876 Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 47 1.435 118 65999 DB00966 Angiotensin II Type 1 Receptor Blockers.Angiotensin-converting Enzyme Inhibitors 47 1.369 82 3749 DB01029 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 47 1.356 116 5525 DB00519 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 47 1.353 111 3419 DB00492 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 47 1.324 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 47 1.312 79 2311 DB00542 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 47 1.307 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 47 1.307 135 2585 DB01136 Adrenergic Agents.Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 47 1.25 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 47 1.239 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 47 1.239 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 47 1.237 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 47 1.221 264 5372 DB00864 Immunosuppressive Agents 47 1.219 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 47 1.211 87 5005 DB00881 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 47 1.203 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 47 1.182 453 125889 DB00230 Analgesics.Anticonvulsants 47 1.161 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 47 1.161 138 2369 DB00195 Adrenergic beta-Antagonists.Antihypertensive Agents.EENT Drugs.Sympatholytics 47 1.134 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 47 1.13 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 47 1.112 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 47 1.107 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 47 1.102 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 47 1.101 171 2909 DB00091 Antifungal Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Immunomodulatory Agents.Immunosuppressive Agents 47 1.086 215 60787 DB01232 Anti-HIV Agents.HIV Protease Inhibitors 47 1.084 154 3157 DB00590 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Anticholesteremic Agents.Antihypertensive Agents.Vasodilator Agents 47 1.08 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 47 1.077 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 47 1.066 234 216326 DB00480 Antineoplastic Agents 47 1.066 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 47 1.063 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 47 1.059 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 47 1.049 161 5212 DB00203 Phosphodiesterase Inhibitors.Vasodilator Agents 47 1.038 166 3394 DB00712 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Carbonic Anhydrase Inhibitors.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 47 1.038 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 47 1.004 84 5401 DB01162 Adrenergic alpha-Antagonists.Antineoplastic Agents.Platelet Aggregation Inhibitors 47 1.002 62 5650 DB00177 Angiotensin II Receptor Antagonists.Antihypertensive Agents 47 0.989 132 4739 DB00552 Antibiotics.Antineoplastic Agents.Enzyme Inhibitors.Immunosuppressive Agents 47 0.984 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 47 0.98 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 47 0.978 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 47 0.967 98 3222 DB00584 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 47 0.959 111 5281104 DB00910 Not Available 47 0.956 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 47 0.954 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists 47 0.944 129 5210 DB01105 Anorexigenic Agents.Antidepressants.Antidepressive Agents.Appetite Depressants.Stimulants 47 0.943 211 60953 DB01101 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Prodrugs 47 0.943 147 5645 DB01586 Cholagogues and Choleretics 47 0.942 144 3702 DB00808 Antihypertensive Agents.Diuretics 47 0.94 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 47 0.937 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 47 0.934 134 3339 DB01039 Antilipemic Agents.Fribic Acid Derivatives 47 0.922 87 2676 DB00439 Anticholesteremic Agents.Antilipemic Agents.Hydroxymethylglutaryl-CoA Reductase Inhibitors 47 0.919 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 47 0.917 107 3410 DB00983 Adrenergic beta-Agonists.Bronchodilator Agents.Sympathomimetic 47 0.914 70 4475485 DB01098 Anticholesteremic Agents.HMG-CoA Reductase Inhibitors.Hydroxymethylglutaryl-CoA Reductase Inhibitors 47 0.914 150 1775 DB00252 Anticonvulsants 47 0.897 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 47 0.896 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 47 0.894 146 3475 DB01120 Hypoglycemic Agents.Sulfonylureas 47 0.89 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 47 0.885 146 3075 DB00343 Antihypertensive Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Cardiovascular Agents.Vasodilator Agents 47 0.879 147 71158 DB00659 Alcohol Deterrents 47 0.865 157 4659569 DB00323 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Enzyme Inhibitors 47 0.864 154 27661 DB01020 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 47 0.863 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 47 0.862 100 5038 DB00178 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 47 0.86 146 4158 DB00422 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Uptake Inhibitors.Sympathomimetics 47 0.856 128 2250 DB01076 Anticholesteremic Agents.Hydroxymethylglutaryl-CoA Reductase Inhibitors 47 0.855 185 4594 DB00338 Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 47 0.843 74 130881 DB00275 Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 47 0.837 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 47 0.834 166 54374 DB00104 Anabolic Agents.Antineoplastic Agents, Hormonal.Gastrointestinal Agents.Hormone Replacement Agents 47 0.833 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 47 0.832 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 47 0.831 196 3911 DB00007 Anti-Estrogen Agents.Antineoplastic Agents 47 0.829 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 47 0.823 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 47 0.821 172 4920 DB00396 Contraceptives.Progestins 47 0.813 131 4635 DB00497 Analgesics, Opioid.Antitussives.Narcotics.Opiate Agonists 47 0.803 161 5291 DB00619 Antineoplastic Agents.Protein Kinase Inhibitors 47 0.802 97 5245 DB00884 Antihypocalcemic Agents.Antiresorptives.Bisphosphonates.Bone Density Conservation Agents.Calcium Channel Blockers 47 0.797 75 2550 DB01197 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 47 0.795 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 47 0.781 161 5487 DB00697 Adrenergic alpha-Agonists.Analgesics.Anticonvulsants.Muscle Relaxants.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 47 0.772 94 3403 DB01095 Anticholesteremic Agents.Antioxidants.Free Radical Scavengers.HMG-CoA Reductase Inhibitors.Hydroxymethylglutaryl-CoA Reductase Inhibitors 47 0.77 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 47 0.765 154 5090 DB00533 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase 2 Inhibitors.Cyclooxygenase Inhibitors 47 0.764 77 3066 DB00320 Analgesics.Analgesics, Non-Narcotic.Anti-migraine Agents.Dopamine Agonists.Sympatholytics.Vasoconstrictor Agents 47 0.759 136 2375 DB01128 Androgen Antagonists.Antineoplastic Agents 47 0.757 118 4236 DB00745 Anorexigenic Agents.Central Nervous System Agents.Central Nervous System Stimulants.Neuroprotective Agents.Stimulants 47 0.749 55 91270 DB00691 Angiotensin-converting Enzyme Inhibitors 47 0.746 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors #### component 48: positive weight features and high scoring objects #### # positive weight on target proteins 48 0.523 38 ADRB1_HUMAN Beta-1 adrenergic receptor; 48 0.438 20 ACHA2_HUMAN Neuronal acetylcholine receptor subunit alpha-2; 48 0.408 34 ADRB2_HUMAN Beta-2 adrenergic receptor; 48 0.276 24 ADRB3_HUMAN Beta-3 adrenergic receptor; 48 0.184 14 ACHA6_HUMAN Neuronal acetylcholine receptor subunit alpha-6; 48 0.184 14 ACHA9_HUMAN Neuronal acetylcholine receptor subunit alpha-9; 48 0.184 14 ACHB2_HUMAN Neuronal acetylcholine receptor subunit beta-2; 48 0.184 14 ACHE_HUMAN Acetylcholine receptor subunit epsilon; 48 0.184 14 ACHA3_HUMAN Neuronal acetylcholine receptor subunit alpha-3; 48 0.18 17 ACH10_HUMAN Neuronal acetylcholine receptor subunit alpha-10; 48 0.151 16 G109B_HUMAN G-protein coupled receptor 109B; 48 0.146 17 ANXA1_HUMAN Annexin A1; 48 0.13 15 ACHA4_HUMAN Neuronal acetylcholine receptor subunit alpha-4; 48 0.033 34 ACM2_HUMAN Muscarinic acetylcholine receptor M2; 48 0.004 12 KCMA1_HUMAN Calcium-activated potassium channel subunit alpha-1; # positive weight on side effects 48 0.161 222 flushing 48 0.112 62 wheezing # high scoring drugs for both targets and side effects 48 1.833 76 3661 DB00572 Adjuvants, Anesthesia.Anti-Arrhythmia Agents.Bronchodilator Agents.Muscarinic Antagonists.Mydriatics.Parasympatholytics 48 1.46 16 5314 DB00202 Neuromuscular Depolarizing Agents.Skeletal Muscle Relaxants 48 1.443 23 3821 DB01221 Analgesics.Anesthetics, Dissociative.Excitatory Amino Acid Antagonists.General Anesthetics 48 1.443 5 10548 DB01057 Cholinesterase Inhibitors.Miotics.Parasympathomimetics 48 1.443 19 4032 DB00657 Antihypertensive Agents.Ganglionic Blockers.Nicotinic Antagonists 48 1.375 11 4919 DB00387 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists 48 1.312 14 47319 DB00732 Neuromuscular Nondepolarizing Agents.Nicotinic Antagonists 48 1.311 7 2551 DB00411 Analgesics, Non-Narcotic.Cardiotonic Agents.Cholinergic Agonists.Miotics 48 1.213 23 4737 DB00312 Adjuvants, Anesthesia.Barbiturates.GABA Modulators.Hypnotics and Sedatives 48 1.108 68 942 DB00184 Anti-craving Agents.Autonomic drugs.Central Nervous System Agents.Ganglionic Stimulants.Nicotinic Agonists 48 1.081 24 2431 DB01158 Adrenergic Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents 48 1.045 40 4845 DB01291 Adrenergic beta-Agonists.Bronchodilator Agents.Cardiotonic Agents 48 1.045 61 4828 DB00960 Adrenergic beta-Antagonists.Antihypertensive Agents.Serotonin Antagonists.Vasodilator Agents 48 1.028 104 3449 DB00674 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 48 0.989 78 2249 DB00335 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Sympatholytics 48 0.989 19 3779 DB01064 Adrenergic beta-Agonists.Bronchodilator Agents.Cardiotonic Agents.Sympathomimetic.Sympathomimetics 48 0.989 20 5775 DB00692 Adrenergic alpha-Antagonists.Antihypertensive Agents.Sympatholytics 48 0.953 64 3746 DB00332 Antimuscarinics.Antispasmodics.Bronchodilator Agents.Cholinergic Antagonists 48 0.916 49 4168 DB01233 Antiemetics.Dopamine Antagonists.Prokinetic Agents 48 0.908 42 4411 DB01203 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents.Sympatholytics 48 0.908 10 4436 Not Available Not Available 48 0.908 28 2583 DB00521 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents.Sympatholytics 48 0.908 17 5403 DB00871 Adrenergic beta-Agonists.Bronchodilator Agents.Sympathomimetic.Sympathomimetics.Tocolytic Agents 48 0.908 14 36811 DB00841 Adrenergic beta-Agonists.Cardiotonic Agents.Sympathomimetic.Sympathomimetics 48 0.907 14 951 DB00368 Adrenergic alpha-Agonists.Sympathomimetics.Vasoconstrictor Agents 48 0.891 10 47320 DB00565 Neuromuscular Blocking Agents 48 0.835 10 4675 DB01337 Neuromuscular Nondepolarizing Agents.Nicotinic Antagonists 48 0.823 30 31477 DB01214 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents.Sympatholytics 48 0.771 8 2381 DB00810 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists.Parasympatholytics 48 0.77 25 4724 DB01359 Adrenergic beta-Antagonists.Antihypertensive Agents 48 0.758 20 838 DB00668 Adrenergic Agonists.Adrenergic alpha-Agonists.Adrenergic beta-Agonists.Bronchodilator Agents.Mydriatics.Sympathomimetics.Vasoconstrictor Agents 48 0.756 61 4946 DB00571 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Anti-anxiety Agents.Antiarrhythmic Agents.Antihypertensive Agents.Vasodilator Agents 48 0.742 21 60696 DB00728 Neuromuscular Nondepolarizing Agents.Skeletal Muscle Relaxants 48 0.726 34 71301 DB04861 Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 48 0.724 14 104803 DB01226 Neuromuscular Nondepolarizing Agents 48 0.724 12 60169 DB01334 Neuromuscular Nondepolarizing Agents 48 0.681 52 32170 DB00668 Adrenergic Agonists.Adrenergic alpha-Agonists.Adrenergic beta-Agonists.Bronchodilator Agents.Mydriatics.Sympathomimetics.Vasoconstrictor Agents 48 0.68 196 1935 DB00382 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 48 0.65 75 1978 DB01193 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents 48 0.632 72 4893 DB00457 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Antihypertensive Agents 48 0.62 69 3869 DB00598 Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Sympatholytics 48 0.616 12 4812 DB01022 Antifibrinolytic Agents.Vitamins.Vitamins (Vitamin K) 48 0.616 6 888 DB01378 Not Available 48 0.608 14 2133 DB00288 Corticosteroids, topical 48 0.608 17 3000 DB00547 Anti-inflammatory Agents.Glucocorticoids 48 0.608 11 3375 DB00223 Anti-inflammatory Agents.Glucocorticoids 48 0.608 10 4630253 DB00240 Anti-inflammatory Agents.Antipruritic Agents.Corticosteroids.Glucocorticoids 48 0.603 99 5478 DB00373 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents 48 0.588 38 3914 DB01210 Adrenergic beta-Antagonists.EENT Drugs.Sympatholytics 48 0.566 15 681 DB00988 Cardiotonic Agents.Dopamine Agents.Sympathomimetic.Sympathomimetics 48 0.554 65 5253 DB00489 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Sympatholytics 48 0.552 4 4768 DB00925 Adrenergic alpha-Antagonists.Antihypertensive Agents.Vasodilator Agents 48 0.537 117 2405 DB00612 Adrenergic Agents.Adrenergic beta-Antagonists.Antihypertensive Agents.Sympatholytics 48 0.537 10 3226 DB00228 Anesthetics, Inhalation.General Anesthetics 48 0.535 11 5381 DB00799 Dermatologic Agents.Keratolytic Agents.Prodrugs.Teratogens 48 0.535 16 2905 DB00979 Antimuscarinic eye preparations.Muscarinic Antagonists.Mydriatics.Parasympatholytics 48 0.535 13 137 DB00855 Photosensitizing Agents 48 0.535 12 4909 DB00794 Anticonvulsants.Barbiturates 48 0.535 19 3249 DB00153 Antihypocalcemic Agents.Antihypoparathyroid Agents.Bone Density Conservation Agents.Essential Vitamin.Vitamins.Vitamins (Vitamin D) 48 0.535 5 51577 DB00491 Anti-Bacterial Agents.Enzyme Inhibitors.Hypoglycemic Agents 48 0.535 11 2522 DB02300 Antipsoriatic Agents.Dermatologic Agents.Vitamin D3 Receptor inhibitor 48 0.535 3 2484 DB01091 Antifungal Agents 48 0.535 3 4034 DB00737 Anti-Allergic Agents.Antiemetics.Antihistamines.Histamine H1 Antagonists 48 0.535 5 2283 DB00626 Anti-Bacterial Agents.Anti-Infective Agents, Local 48 0.535 18 4873 DB00761 Not Available 48 0.535 10 5526 DB00302 Antifibrinolytic Agents 48 0.535 10 3392 DB00846 Anti-inflammatory Agents.Glucocorticoids 48 0.535 3 47641 DB00735 Anti-Inflammatory Agents, Non-Steroidal.Antifungal Agents 48 0.535 11 2519 DB00201 Anorexigenic Agents.Central Nervous System Stimulants.Phosphodiesterase Inhibitors 48 0.535 9 861 DB00279 Hormone Replacement Agents 48 0.535 3 247 DB04455 Gastrointestinal Agents.Lipotropic Agents 48 0.535 11 157922 DB00992 Antineoplastic Agents 48 0.535 17 9904 DB00984 Anabolic Agents.Androgens 48 0.535 3 6256 DB00432 Antimetabolites.Antiviral Agents 48 0.535 16 5771 DB00107 Anti-tocolytic Agents.Labor Induction Agents.Oxytocics 48 0.535 7 5359 DB00870 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 48 0.535 15 5582 DB01157 Antibiotics.Antifungal Agents.Antimetabolites, Antineoplastic.Antiprotozoals.Folic Acid Antagonists 48 0.532 9 5342 DB01138 Uricosuric Agents 48 0.532 6 4908 DB01087 Antimalarial Agents.Antimalarials.Antiprotozoal Agents 48 0.532 20 667490 DB01033 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Immunosuppressive Agents.Nucleic Acid Synthesis Inhibitors.Purine analogues 48 0.532 27 23897 DB01618 Antipsychotic Agents 48 0.531 34 3518 DB01170 Adrenergic Agents.Antihypertensive Agents.Sympatholytics 48 0.526 33 4425 DB01183 Antinarcotic Agents.Depressants.Narcotic Antagonists.Opiate Antagonists 48 0.524 13 36339 DB00292 Anesthetics, Intravenous.Hypnotics and Sedatives 48 0.52 4 6503 DB03754 Buffers.Excipients 48 0.519 16 4211 DB00648 Antineoplastic Agents.Antineoplastic Agents, Hormonal 48 0.517 16 5504 DB00797 Adrenergic alpha-Antagonists.Antihypertensive Agents.Vasodilator Agents 48 0.514 28 25419 DB00720 Antihypocalcemic Agents.Antineoplastic Agents.Bisphosphonates.Bone Density Conservation Agents.Osteoporosis Prophylactic 48 0.473 7 3562 DB01159 Anesthetics.Anesthetics, Inhalation.General Anesthetics 48 0.469 47 4927 DB01069 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists.Phenothiazine Derivatives 48 0.466 127 2156 DB01118 Anti-Arrhythmia Agents.Enzyme Inhibitors.Vasodilator Agents 48 0.463 62 59768 DB00187 Adrenergic beta-Antagonists 48 0.462 11 2131 DB01122 Antiarrhythmic Agents.Antimyasthenics 48 0.45 2 1071 DB00162 Anti-acne Agents.Essential Vitamin.Vitamins.Vitamins (Vitamin A) 48 0.45 10 271 DB01373 Not Available 48 0.45 12 3384 DB00324 Anti-Allergic Agents.Anti-inflammatory Agents.Glucocorticoids 48 0.45 11 4043 DB00253 Topical anti-inflammatory Agent 48 0.447 9 2733 DB00356 Muscle Relaxants, Central 48 0.445 16 3405 DB00158 Dietary supplement.Hematinics.Micronutrient.Vitamin B Complex 48 0.443 32 2265 DB00993 Antimetabolites.Antimetabolites, Antineoplastic.Antirheumatic Agents.Immunosuppressive Agents #### component 49: positive weight features and high scoring objects #### # positive weight on target proteins 49 0.758 17 ANXA1_HUMAN Annexin A1; 49 0.15 17 CBG_HUMAN Corticosteroid-binding globulin; 49 0.104 8 HMDH_HUMAN 3-hydroxy-3-methylglutaryl-coenzyme A reductase; 49 0.09 18 SCN5A_HUMAN Sodium channel protein type 5 subunit alpha; 49 0.042 5 VEGFA_HUMAN Vascular endothelial growth factor A; 49 0.035 17 DB124_HUMAN Beta-defensin 124; 49 0.035 17 SCN3B_HUMAN Sodium channel subunit beta-3; 49 0.035 17 SCN4B_HUMAN Sodium channel subunit beta-4; 49 0.035 17 SCN4A_HUMAN Sodium channel protein type 4 subunit alpha; 49 0.035 17 ACCN3_HUMAN Amiloride-sensitive cation channel 3; 49 0.035 17 SCN7A_HUMAN Sodium channel protein type 7 subunit alpha; 49 0.035 17 SCN3A_HUMAN Sodium channel protein type 3 subunit alpha; 49 0.035 17 SCN1B_HUMAN Sodium channel subunit beta-1; 49 0.035 17 SCNAA_HUMAN Sodium channel protein type 10 subunit alpha; 49 0.035 17 ACCN4_HUMAN Amiloride-sensitive cation channel 4; 49 0.035 8 AGTR1_HUMAN Type-1 angiotensin II receptor; 49 0.035 17 EF1B_HUMAN Elongation factor 1-beta; 49 0.033 5 SCN1A_HUMAN Sodium channel protein type 1 subunit alpha; 49 0.03 18 SCNND_HUMAN Amiloride-sensitive sodium channel subunit delta; 49 0.03 18 SCNNB_HUMAN Amiloride-sensitive sodium channel subunit beta; 49 0.03 18 SCNNG_HUMAN Amiloride-sensitive sodium channel subunit gamma; 49 0.014 9 TNFA_HUMAN Tumor necrosis factor; 49 0.01 6 RIR1_HUMAN Ribonucleoside-diphosphate reductase large subunit; 49 0.009 6 DRD4_HUMAN D(4) dopamine receptor; # positive weight on side effects 49 0.532 317 thrombocytopenia 49 0.395 459 diarrhea 49 0.295 279 infection 49 0.283 439 pruritus 49 0.266 301 dry mouth 49 0.245 373 fever 49 0.239 346 dyspnea 49 0.222 158 dermatitis 49 0.217 391 edema 49 0.191 87 contact dermatitis 49 0.16 331 pain 49 0.122 31 hypertrichosis 49 0.107 330 anorexia 49 0.074 205 angioedema 49 0.068 14 telangiectasia 49 0.058 513 vomiting 49 0.045 112 hemolytic anemia 49 0.042 280 myalgia 49 0.037 108 ecchymosis 49 0.034 84 muscle weakness 49 0.021 280 chest pain 49 0.004 163 pancreatitis # high scoring drugs for both targets and side effects 49 1.158 150 1775 DB00252 Anticonvulsants 49 1.046 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 49 1.029 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 49 1.019 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 49 0.89 91 3355 DB01195 Anti-Arrhythmia Agents.Antiarrhythmic Agents 49 0.871 124 62924 DB00588 Adrenergic Agents.Anti-Allergic Agents.Anti-inflammatory Agents.Bronchodilator Agents.Dermatologic Agents 49 0.867 146 3075 DB00343 Antihypertensive Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Cardiovascular Agents.Vasodilator Agents 49 0.864 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 49 0.852 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 49 0.85 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 49 0.847 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 49 0.847 264 5372 DB00864 Immunosuppressive Agents 49 0.847 146 4158 DB00422 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Uptake Inhibitors.Sympathomimetics 49 0.847 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 49 0.845 135 5544 DB00620 Adrenergic Agents.Anti-inflammatory Agents.Glucocorticoids 49 0.834 171 2909 DB00091 Antifungal Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Immunomodulatory Agents.Immunosuppressive Agents 49 0.825 134 3339 DB01039 Antilipemic Agents.Fribic Acid Derivatives 49 0.816 128 2250 DB01076 Anticholesteremic Agents.Hydroxymethylglutaryl-CoA Reductase Inhibitors 49 0.814 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 49 0.811 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 49 0.809 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 49 0.808 131 3961 DB00678 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents 49 0.806 66 123620 DB00764 Anti-Allergic Agents.Anti-inflammatory Agents 49 0.799 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 49 0.798 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 49 0.792 120 82146 DB00307 Anticarcinogenic Agents 49 0.789 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 49 0.788 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 49 0.776 181 4932 DB01182 Anti-Arrhythmia Agents 49 0.768 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 49 0.767 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 49 0.765 118 65999 DB00966 Angiotensin II Type 1 Receptor Blockers.Angiotensin-converting Enzyme Inhibitors 49 0.758 158 34312 DB00776 Anticonvulsants 49 0.755 138 2369 DB00195 Adrenergic beta-Antagonists.Antihypertensive Agents.EENT Drugs.Sympatholytics 49 0.754 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 49 0.752 135 2585 DB01136 Adrenergic Agents.Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 49 0.751 61 3114 DB00280 Anti-Arrhythmia Agents.Antiarrhythmic Agents 49 0.742 215 60787 DB01232 Anti-HIV Agents.HIV Protease Inhibitors 49 0.737 152 60184 DB00790 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 49 0.731 118 68740 DB00399 Antihypocalcemic Agents.Antiresorptives.Bisphosphonates.Bone Density Conservation Agents 49 0.729 211 60953 DB01101 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Prodrugs 49 0.728 126 104865 DB00559 Antihypertensive Agents 49 0.727 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 49 0.715 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 49 0.715 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 49 0.711 154 3157 DB00590 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Anticholesteremic Agents.Antihypertensive Agents.Vasodilator Agents 49 0.701 76 123631 DB00317 Antineoplastic Agents.Protein Kinase Inhibitors 49 0.7 149 5394 DB00853 Antineoplastic Agents.Antineoplastic Agents, Alkylating 49 0.698 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 49 0.697 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 49 0.696 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 49 0.696 201 5538 DB00755 Antineoplastic Agents.Cell Stimulants and Proliferants.Keratolytic Agents 49 0.696 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists 49 0.696 101 14888 DB01169 Antineoplastic Agents.Homeopathic Agents 49 0.694 140 3143 DB01248 Antimalarials.Antineoplastic Agents.Antineoplastic Agents, Phytogenic.Radiation-Sensitizing Agents 49 0.692 99 4889 DB00175 Anticholesteremic Agents.HMG-CoA Reductase Inhibitors.Hydroxymethylglutaryl-CoA Reductase Inhibitors 49 0.692 94 3403 DB01095 Anticholesteremic Agents.Antioxidants.Free Radical Scavengers.HMG-CoA Reductase Inhibitors.Hydroxymethylglutaryl-CoA Reductase Inhibitors 49 0.69 142 2678 DB00341 Anti-Allergic Agents.Antihistamines.Histamine H1 Antagonists, Non-Sedating 49 0.685 133 2802 DB01068 Anticonvulsants.Benzodiazepines.GABA Modulators 49 0.684 146 3475 DB01120 Hypoglycemic Agents.Sulfonylureas 49 0.684 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 49 0.677 117 2405 DB00612 Adrenergic Agents.Adrenergic beta-Antagonists.Antihypertensive Agents.Sympatholytics 49 0.673 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 49 0.671 453 125889 DB00230 Analgesics.Anticonvulsants 49 0.669 129 5210 DB01105 Anorexigenic Agents.Antidepressants.Antidepressive Agents.Appetite Depressants.Stimulants 49 0.665 111 3419 DB00492 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 49 0.659 141 4819 DB01085 Cholinergic Agents.Miotics.Muscarinic Agonists 49 0.657 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 49 0.648 119 4052 DB00814 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Antiemetics.Antineoplastic Agents.Cyclooxygenase Inhibitors.Growth Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 49 0.643 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 49 0.641 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 49 0.638 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 49 0.635 167 170361 DB01273 Nicotinic Agonists 49 0.631 108 4856 DB00554 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 49 0.628 144 3899 DB01097 Adjuvants.Anti-inflammatory Agents.Antineoplastic Agents.Antiparasitic Agents.Antirheumatic Agents.Antiviral Agents.Enzyme Inhibitors.Immunosuppressive Agents 49 0.626 147 5645 DB01586 Cholagogues and Choleretics 49 0.626 234 216326 DB00480 Antineoplastic Agents 49 0.618 161 5291 DB00619 Antineoplastic Agents.Protein Kinase Inhibitors 49 0.618 188 5040 DB00877 Anti-Bacterial Agents.Antibiotics, Antineoplastic.Antifungal Agents.Antifungals.Immunosuppressive Agents 49 0.616 136 2375 DB01128 Androgen Antagonists.Antineoplastic Agents 49 0.611 127 2156 DB01118 Anti-Arrhythmia Agents.Enzyme Inhibitors.Vasodilator Agents 49 0.608 157 3937 DB00722 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents.Cardiotonic Agents 49 0.604 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 49 0.604 117 2182 DB00261 Antithrombotic Agents.Fibrinolytic Agents.Platelet Aggregation Inhibitors 49 0.604 147 71158 DB00659 Alcohol Deterrents 49 0.604 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 49 0.602 137 62959 DB00685 Anti-Infective Agents.Anti-Infectives.Fluoroquinolones 49 0.6 154 27661 DB01020 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 49 0.6 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 49 0.597 112 151165 DB00673 Antiemetics 49 0.597 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 49 0.596 103 2751 DB01340 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 49 0.596 185 4594 DB00338 Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 49 0.593 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 49 0.591 112 71273 DB00296 Anesthetics.Anesthetics, Local.Local Anesthetics 49 0.591 199 5358 DB00669 Selective Serotonin Agonists.Serotonin Agonists.Vasoconstrictor Agents 49 0.588 77 3962 DB00227 Anticholesteremic Agents.Antineoplastic Agents.HMG-CoA Reductase Inhibitors.Hydroxymethylglutaryl-CoA Reductase Inhibitors 49 0.586 135 5734 DB00909 Anticonvulsants.Antioxidants 49 0.585 116 5525 DB00519 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 49 0.585 95 16231 DB00594 Diuretics.Sodium channel blockers #### component 50: positive weight features and high scoring objects #### # positive weight on target proteins 50 0.662 18 SCN5A_HUMAN Sodium channel protein type 5 subunit alpha; 50 0.207 18 SCNNG_HUMAN Amiloride-sensitive sodium channel subunit gamma; 50 0.207 18 SCNNB_HUMAN Amiloride-sensitive sodium channel subunit beta; 50 0.207 18 SCNND_HUMAN Amiloride-sensitive sodium channel subunit delta; 50 0.204 28 DRD3_HUMAN D(3) dopamine receptor; 50 0.187 17 SCNAA_HUMAN Sodium channel protein type 10 subunit alpha; 50 0.187 17 DB124_HUMAN Beta-defensin 124; 50 0.187 17 ACCN3_HUMAN Amiloride-sensitive cation channel 3; 50 0.187 17 SCN4B_HUMAN Sodium channel subunit beta-4; 50 0.187 17 EF1B_HUMAN Elongation factor 1-beta; 50 0.187 17 SCN4A_HUMAN Sodium channel protein type 4 subunit alpha; 50 0.187 17 SCN1B_HUMAN Sodium channel subunit beta-1; 50 0.187 17 SCN3B_HUMAN Sodium channel subunit beta-3; 50 0.187 17 ACCN4_HUMAN Amiloride-sensitive cation channel 4; 50 0.187 17 SCN7A_HUMAN Sodium channel protein type 7 subunit alpha; 50 0.187 17 SCN3A_HUMAN Sodium channel protein type 3 subunit alpha; 50 0.072 6 DRD4_HUMAN D(4) dopamine receptor; 50 0.045 35 DRD2_HUMAN D(2) dopamine receptor; 50 0.034 21 DRD5_HUMAN D(1B) dopamine receptor; 50 0.006 28 DRD1_HUMAN D(1A) dopamine receptor; # positive weight on side effects 50 0.582 64 AV block 50 0.36 149 ataxia 50 0.3 37 personality disorder 50 0.24 32 suicide attempt 50 0.228 58 visual field defect 50 0.2 29 hemiplegia 50 0.161 63 hemoptysis 50 0.156 70 delirium 50 0.142 115 hypokalemia 50 0.126 107 amnesia 50 0.122 84 muscle weakness 50 0.096 104 pulmonary edema 50 0.093 29 sinus bradycardia 50 0.079 37 gum hemorrhage 50 0.078 39 aphasia 50 0.078 30 hypothermia 50 0.06 99 photophobia 50 0.048 75 deafness 50 0.044 31 neurosis 50 0.039 11 subdural hematoma 50 0.027 41 bundle branch block 50 0.021 233 tinnitus # high scoring drugs for both targets and side effects 50 2.571 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 50 2.485 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 50 2.406 150 1775 DB00252 Anticonvulsants 50 2.238 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 50 2.224 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 50 2.209 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 50 2.208 91 3355 DB01195 Anti-Arrhythmia Agents.Antiarrhythmic Agents 50 2.073 51 48041 DB01228 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Sodium channel blockers 50 1.996 75 4178 DB00379 Anti-Arrhythmia Agents 50 1.938 61 3114 DB00280 Anti-Arrhythmia Agents.Antiarrhythmic Agents 50 1.925 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 50 1.663 135 5734 DB00909 Anticonvulsants.Antioxidants 50 1.525 74 3676 DB00281 Anesthetics.Anesthetics, Local.Anti-Arrhythmia Agents.Antiarrhythmic Agents 50 1.515 43 4913 DB01035 Anti-Arrhythmia Agents.Antiarrhythmic Agents 50 1.373 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 50 1.303 95 16231 DB00594 Diuretics.Sodium channel blockers 50 1.218 136 56339 DB01320 Anticonvulsants 50 1.187 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 50 1.178 112 71273 DB00296 Anesthetics.Anesthetics, Local.Local Anesthetics 50 1.165 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 50 1.12 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 50 1.113 158 34312 DB00776 Anticonvulsants 50 1.103 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 50 1.102 453 125889 DB00230 Analgesics.Anticonvulsants 50 1.068 143 4054 DB01043 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agents.Excitatory Amino Acid Antagonists 50 1.055 181 4932 DB01182 Anti-Arrhythmia Agents 50 1.005 36 4914 DB00721 Anesthetics.Anesthetics, Local.Local Anesthetics 50 0.95 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 50 0.939 97 1065 DB00908 Adrenergic alpha-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antimalarials.Enzyme Inhibitors.Muscarinic Antagonists 50 0.911 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 50 0.886 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 50 0.866 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 50 0.841 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 50 0.787 127 2156 DB01118 Anti-Arrhythmia Agents.Enzyme Inhibitors.Vasodilator Agents 50 0.748 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 50 0.732 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 50 0.697 73 34633 DB00680 Anti-Arrhythmia Agents 50 0.691 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 50 0.619 196 1935 DB00382 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 50 0.601 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 50 0.559 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 50 0.542 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 50 0.523 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 50 0.518 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 50 0.513 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 50 0.509 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 50 0.508 149 5394 DB00853 Antineoplastic Agents.Antineoplastic Agents, Alkylating 50 0.473 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 50 0.473 59 5665 DB01080 Anticonvulsants.Enzyme Inhibitors.GABA Agents 50 0.47 161 122316 DB01367 Monoamine Oxidase Inhibitors.Neuroprotective Agents 50 0.46 104 3449 DB00674 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 50 0.444 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 50 0.44 138 2369 DB00195 Adrenergic beta-Antagonists.Antihypertensive Agents.EENT Drugs.Sympatholytics 50 0.432 215 60787 DB01232 Anti-HIV Agents.HIV Protease Inhibitors 50 0.39 135 2585 DB01136 Adrenergic Agents.Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 50 0.387 44 4060 DB00532 Anticonvulsants 50 0.385 137 62959 DB00685 Anti-Infective Agents.Anti-Infectives.Fluoroquinolones 50 0.381 89 59708 DB01202 Anticonvulsants.Nootropic Agents 50 0.375 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 50 0.374 100 2578 DB00262 Antineoplastic Agents.Antineoplastic Agents, Alkylating 50 0.368 157 3937 DB00722 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents.Cardiotonic Agents 50 0.367 167 5719 DB00962 Anticonvulsants.Anxiolytics sedatives and hypnotics.Hypnotics and Sedatives 50 0.361 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 50 0.359 106 2958 DB00694 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 50 0.357 18 3292 DB00754 Anticonvulsants 50 0.344 161 5212 DB00203 Phosphodiesterase Inhibitors.Vasodilator Agents 50 0.319 146 3075 DB00343 Antihypertensive Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Cardiovascular Agents.Vasodilator Agents 50 0.311 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 50 0.294 131 3961 DB00678 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents 50 0.286 128 4253 DB00295 Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 50 0.273 90 2477 DB00490 Anti-anxiety Agents.Anxiolytics sedatives and hypnotics.Serotonin Agonists 50 0.266 183 3648 DB00327 Analgesics, Opioid.Narcotics 50 0.264 133 2802 DB01068 Anticonvulsants.Benzodiazepines.GABA Modulators 50 0.262 49 4168 DB01233 Antiemetics.Dopamine Antagonists.Prokinetic Agents 50 0.245 76 4748 DB00850 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 50 0.231 236 10631 DB00603 Contraceptives.Contraceptives, Oral, Synthetic.Progestins 50 0.227 21 5546 DB00384 Diuretics.Potassium-sparing Diuretics 50 0.223 81 2022 DB00787 Antiviral Agents.Nucleosides and Nucleotides 50 0.221 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 50 0.211 61 4946 DB00571 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Anti-anxiety Agents.Antiarrhythmic Agents.Antihypertensive Agents.Vasodilator Agents 50 0.21 154 3157 DB00590 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Anticholesteremic Agents.Antihypertensive Agents.Vasodilator Agents 50 0.208 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 50 0.197 154 27661 DB01020 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 50 0.197 36 60753 DB00308 Anti-Arrhythmia Agents 50 0.195 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 50 0.193 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 50 0.19 120 2284 DB00181 GABA Agonists.Muscle Relaxants.Muscle Relaxants, Central.Skeletal Muscle Relaxants 50 0.186 62 59768 DB00187 Adrenergic beta-Antagonists 50 0.185 110 4666 DB01229 Antineoplastic Agents.Antineoplastic Agents, Phytogenic.Tubulin Modulators 50 0.182 89 3148 DB00757 Antiemetics.Serotonin Antagonists 50 0.178 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 50 0.171 94 4171 DB00264 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Sympatholytics 50 0.169 102 4943 DB00818 Anesthetics, Intravenous.Anticonvulsants.Antiemetics.Free Radical Scavengers.Hypnotics and Sedatives 50 0.168 103 2751 DB01340 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 50 0.168 109 60879 DB00876 Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 50 0.157 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 50 0.151 43 71329 DB00204 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Potassium Channel Blockers 50 0.15 31 2441 DB01558 Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 50 0.15 84 3016 DB00829 Adjuvants, Anesthesia.Anesthetics, Intravenous.Anti-anxiety Agents.Anticonvulsants.Antiemetics.GABA Modulators.Hypnotics and Sedatives.Muscle Relaxants, Central 50 0.148 75 1978 DB01193 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents #### component 51: positive weight features and high scoring objects #### # positive weight on target proteins 51 0.761 18 GCR_HUMAN Glucocorticoid receptor; 51 0.491 26 SC6A4_HUMAN Sodium-dependent serotonin transporter; 51 0.157 17 CBG_HUMAN Corticosteroid-binding globulin; 51 0.144 3 PPIA_HUMAN Peptidyl-prolyl cis-trans isomerase A; 51 0.103 6 DRD4_HUMAN D(4) dopamine receptor; 51 0.099 5 ATP4A_HUMAN Potassium-transporting ATPase alpha chain 1; 51 0.083 3 FKB1A_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP1A; 51 0.072 9 GABR2_HUMAN Gamma-aminobutyric acid type B receptor subunit 2; 51 0.059 17 ANXA1_HUMAN Annexin A1; 51 0.054 2 FKB14_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP14; 51 0.054 2 PPIL1_HUMAN Peptidyl-prolyl cis-trans isomerase-like 1; 51 0.054 2 FKBP8_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP8; 51 0.054 2 FKB11_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP11; 51 0.054 2 PIN4_HUMAN Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4; 51 0.054 2 PIN1_HUMAN Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; 51 0.054 2 FKBP2_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP2; 51 0.054 2 FKB10_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP10; 51 0.054 2 PPIL3_HUMAN Peptidyl-prolyl cis-trans isomerase-like 3; 51 0.054 2 FKBP7_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP7; 51 0.054 2 FKBP6_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP6; 51 0.054 2 PPIC_HUMAN Peptidyl-prolyl cis-trans isomerase C; 51 0.054 2 FKBP5_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP5; 51 0.054 2 FKBP9_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP9; 51 0.054 2 PPIB_HUMAN Peptidyl-prolyl cis-trans isomerase B; 51 0.054 2 PPID_HUMAN Peptidyl-prolyl cis-trans isomerase D; 51 0.054 2 PPIF_HUMAN Peptidyl-prolyl cis-trans isomerase F, mitochondrial; 51 0.054 2 FKBP4_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP4; 51 0.054 2 PPIL2_HUMAN Peptidyl-prolyl cis-trans isomerase-like 2; 51 0.054 2 FKBP3_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP3; 51 0.054 2 FKB1B_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP1B; 51 0.054 2 PPIG_HUMAN Peptidyl-prolyl cis-trans isomerase G; 51 0.054 2 PPIE_HUMAN Peptidyl-prolyl cis-trans isomerase E; 51 0.051 9 CHLE_HUMAN Cholinesterase; 51 0.046 28 DRD3_HUMAN D(3) dopamine receptor; 51 0.026 5 GABT_HUMAN 4-aminobutyrate aminotransferase, mitochondrial; 51 0.012 28 SC6A2_HUMAN Sodium-dependent noradrenaline transporter; # positive weight on side effects 51 0.442 47 osteoporosis 51 0.429 96 diabetes mellitus 51 0.349 119 gastroenteritis 51 0.282 101 ulcer 51 0.264 68 otitis media 51 0.26 52 abscess 51 0.258 198 Sinusitis 51 0.242 108 ecchymosis 51 0.226 94 arthrosis 51 0.158 119 acne 51 0.157 163 pancreatitis 51 0.141 101 esophagitis 51 0.107 43 oral moniliasis 51 0.1 68 moniliasis 51 0.089 84 herpes simplex 51 0.071 14 exophthalmos 51 0.028 103 cataract 51 0.019 71 glaucoma 51 0.016 113 ear pain 51 0.014 205 angioedema 51 0.007 109 neuropathy # high scoring drugs for both targets and side effects 51 2.236 264 5372 DB00864 Immunosuppressive Agents 51 2.045 188 5040 DB00877 Anti-Bacterial Agents.Antibiotics, Antineoplastic.Antifungal Agents.Antifungals.Immunosuppressive Agents 51 1.741 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 51 1.664 135 5544 DB00620 Adrenergic Agents.Anti-inflammatory Agents.Glucocorticoids 51 1.605 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 51 1.559 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 51 1.507 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 51 1.456 74 4894 DB00860 Adrenergic Agents.Anti-inflammatory Agents.Antineoplastic Agents.Antineoplastic Agents, Hormonal.Glucocorticoids 51 1.435 124 62924 DB00588 Adrenergic Agents.Anti-Allergic Agents.Anti-inflammatory Agents.Bronchodilator Agents.Dermatologic Agents 51 1.407 86 3003 DB01234 Adrenergic Agents.Anti-inflammatory Agents.Antiemetics.Antineoplastic Agents, Hormonal.Glucocorticoids 51 1.406 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 51 1.403 453 125889 DB00230 Analgesics.Anticonvulsants 51 1.359 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 51 1.341 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 51 1.332 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 51 1.31 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 51 1.273 54 4159 DB00959 Adrenergic Agents.Anti-inflammatory Agents.Antiemetics.Glucocorticoids.Neuroprotective Agents 51 1.267 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 51 1.267 137 2462 DB01222 Anti-inflammatory Agents.Bronchodilator Agents.Corticosteroids.Glucocorticoids 51 1.239 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 51 1.222 83 3640 DB00741 Anti-inflammatory Agents 51 1.211 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 51 1.194 54 444033 DB01410 Anti-Allergic Agents.Glucocorticoids 51 1.152 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 51 1.112 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists 51 1.095 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 51 1.082 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 51 1.074 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 51 1.061 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 51 1.059 196 1935 DB00382 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 51 1.026 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 51 1.013 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 51 0.999 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 51 0.993 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 51 0.985 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 51 0.972 66 123620 DB00764 Anti-Allergic Agents.Anti-inflammatory Agents 51 0.953 146 4158 DB00422 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Uptake Inhibitors.Sympathomimetics 51 0.951 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 51 0.948 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 51 0.943 144 3899 DB01097 Adjuvants.Anti-inflammatory Agents.Antineoplastic Agents.Antiparasitic Agents.Antirheumatic Agents.Antiviral Agents.Enzyme Inhibitors.Immunosuppressive Agents 51 0.934 185 4594 DB00338 Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 51 0.901 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 51 0.894 171 2909 DB00091 Antifungal Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Immunomodulatory Agents.Immunosuppressive Agents 51 0.894 31 4900 DB00635 Adrenergic Agents.Anti-inflammatory Agents.Antineoplastic Agents.Antineoplastic Agents, Hormonal.Glucocorticoids 51 0.892 234 216326 DB00480 Antineoplastic Agents 51 0.883 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 51 0.873 166 54374 DB00104 Anabolic Agents.Antineoplastic Agents, Hormonal.Gastrointestinal Agents.Hormone Replacement Agents 51 0.869 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 51 0.854 63 3381 DB00591 Anti-inflammatory Agents.Antipruritics.Glucocorticoids 51 0.827 196 3911 DB00007 Anti-Estrogen Agents.Antineoplastic Agents 51 0.807 77 3379 DB00180 Anti-Asthmatic Agents.Anti-inflammatory Agents 51 0.806 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 51 0.79 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 51 0.779 167 5719 DB00962 Anticonvulsants.Anxiolytics sedatives and hypnotics.Hypnotics and Sedatives 51 0.776 144 3702 DB00808 Antihypertensive Agents.Diuretics 51 0.773 129 5210 DB01105 Anorexigenic Agents.Antidepressants.Antidepressive Agents.Appetite Depressants.Stimulants 51 0.766 211 60953 DB01101 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Prodrugs 51 0.757 157 4659569 DB00323 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Enzyme Inhibitors 51 0.755 151 41317 DB00459 Keratolytic Agents 51 0.754 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 51 0.739 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 51 0.738 147 5645 DB01586 Cholagogues and Choleretics 51 0.729 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 51 0.69 116 5376 DB00675 Antineoplastic Agents, Hormonal.Bone Density Conservation Agents.Estrogen Antagonists.Selective Estrogen Receptor Modulators 51 0.679 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 51 0.672 118 65999 DB00966 Angiotensin II Type 1 Receptor Blockers.Angiotensin-converting Enzyme Inhibitors 51 0.67 191 450 DB00783 Anti-menopausal Agents.Anticholesteremic Agents.Estrogens 51 0.662 215 60787 DB01232 Anti-HIV Agents.HIV Protease Inhibitors 51 0.658 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 51 0.618 147 71158 DB00659 Alcohol Deterrents 51 0.613 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 51 0.612 53 5035 DB00481 Antihypocalcemic Agents.Bone Density Conservation Agents.Estrogen Antagonists.Osteoporosis Prophylactic.Selective Estrogen Receptor Modulators 51 0.612 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 51 0.603 166 3394 DB00712 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Carbonic Anhydrase Inhibitors.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 51 0.6 134 3339 DB01039 Antilipemic Agents.Fribic Acid Derivatives 51 0.599 109 60879 DB00876 Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 51 0.595 161 5487 DB00697 Adrenergic alpha-Agonists.Analgesics.Anticonvulsants.Muscle Relaxants.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 51 0.586 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 51 0.572 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 51 0.569 133 4112 DB00563 Abortifacient Agents.Abortifacient Agents, Nonsteroidal.Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Folic Acid Antagonists.Immunosuppressive Agents.Nucleic Acid Synthesis Inhibitors 51 0.565 161 5212 DB00203 Phosphodiesterase Inhibitors.Vasodilator Agents 51 0.538 106 2083 DB01001 Adrenergic beta-Agonists.Bronchodilator Agents.Tocolytic Agents 51 0.533 82 47725 DB00014 Antineoplastic Agents.Antineoplastic Agents, Hormonal 51 0.505 151 60835 DB00476 Adrenergic Uptake Inhibitors.Antidepressive Agents.Dopamine Uptake Inhibitors.Serotonin Uptake Inhibitors 51 0.503 236 10631 DB00603 Contraceptives.Contraceptives, Oral, Synthetic.Progestins 51 0.492 97 5245 DB00884 Antihypocalcemic Agents.Antiresorptives.Bisphosphonates.Bone Density Conservation Agents.Calcium Channel Blockers 51 0.486 181 4932 DB01182 Anti-Arrhythmia Agents 51 0.484 154 5090 DB00533 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase 2 Inhibitors.Cyclooxygenase Inhibitors 51 0.478 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 51 0.464 201 5538 DB00755 Antineoplastic Agents.Cell Stimulants and Proliferants.Keratolytic Agents 51 0.46 142 2678 DB00341 Anti-Allergic Agents.Antihistamines.Histamine H1 Antagonists, Non-Sedating 51 0.45 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 51 0.449 167 170361 DB01273 Nicotinic Agonists 51 0.448 154 27661 DB01020 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 51 0.435 61 40976 DB00294 Contraceptive Agents, Female.Contraceptives 51 0.422 111 5281104 DB00910 Not Available 51 0.406 61 2435 DB00484 Adrenergic alpha-Agonists.Antihypertensive Agents.EENT Drugs 51 0.405 43 31378 DB00687 Adrenergic Agents.Anti-inflammatory Agents 51 0.383 128 2250 DB01076 Anticholesteremic Agents.Hydroxymethylglutaryl-CoA Reductase Inhibitors 51 0.365 131 4428 DB00704 Alcohol Antagonists.Anti-craving Agents.Depressants.Narcotic Antagonists.Opiate Antagonists #### component 52: positive weight features and high scoring objects #### # positive weight on target proteins 52 0.564 21 DRD5_HUMAN D(1B) dopamine receptor; 52 0.502 28 DRD1_HUMAN D(1A) dopamine receptor; 52 0.401 18 SCN5A_HUMAN Sodium channel protein type 5 subunit alpha; 52 0.262 12 AOFB_HUMAN Amine oxidase [flavin-containing] B; 52 0.249 12 SC6A3_HUMAN Sodium-dependent dopamine transporter; 52 0.208 28 DRD3_HUMAN D(3) dopamine receptor; 52 0.15 5 SCN1A_HUMAN Sodium channel protein type 1 subunit alpha; 52 0.097 13 CAC1A_HUMAN Voltage-dependent P/Q-type calcium channel subunit alpha-1A; 52 0.083 16 CAC1G_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1G; 52 0.066 8 CALL3_HUMAN Calmodulin-like protein 3; 52 0.056 15 RYR2_HUMAN Ryanodine receptor 2; 52 0.056 15 RYR3_HUMAN Ryanodine receptor 3; 52 0.053 15 CAC1I_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1I; 52 0.053 15 CAC1H_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1H; 52 0.045 12 CCG4_HUMAN Voltage-dependent calcium channel gamma-4 subunit; 52 0.045 12 CACB3_HUMAN Voltage-dependent L-type calcium channel subunit beta-3; 52 0.045 12 CCG2_HUMAN Voltage-dependent calcium channel gamma-2 subunit; 52 0.045 12 TRPA1_HUMAN Transient receptor potential cation channel subfamily A member 1; 52 0.045 12 CAC1E_HUMAN Voltage-dependent R-type calcium channel subunit alpha-1E; 52 0.045 12 CACB4_HUMAN Voltage-dependent L-type calcium channel subunit beta-4; 52 0.045 12 ITPR1_HUMAN Inositol 1,4,5-trisphosphate receptor type 1; 52 0.045 12 ITPR3_HUMAN Inositol 1,4,5-trisphosphate receptor type 3; 52 0.045 12 CA2D1_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-1; 52 0.045 12 PKD1_HUMAN Polycystin-1; 52 0.045 12 TRPV6_HUMAN Transient receptor potential cation channel subfamily V member 6; 52 0.045 12 CAC1S_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1S; 52 0.045 12 PKD2_HUMAN Polycystin-2; 52 0.045 12 CCG7_HUMAN Voltage-dependent calcium channel gamma-7 subunit; 52 0.039 5 ATP4A_HUMAN Potassium-transporting ATPase alpha chain 1; 52 0.035 13 CAC1B_HUMAN Voltage-dependent N-type calcium channel subunit alpha-1B; 52 0.033 14 RYR1_HUMAN Ryanodine receptor 1; 52 0.031 13 CACB1_HUMAN Voltage-dependent L-type calcium channel subunit beta-1; 52 0.022 5 GABT_HUMAN 4-aminobutyrate aminotransferase, mitochondrial; 52 0.002 6 DRD4_HUMAN D(4) dopamine receptor; # positive weight on side effects 52 0.601 247 tremor 52 0.459 105 psychosis 52 0.375 63 lupus 52 0.299 55 dyskinesia 52 0.215 155 dysphagia 52 0.141 130 cardiac arrest 52 0.133 152 urinary retention 52 0.133 187 photosensitivity 52 0.12 129 eosinophilia 52 0.113 116 pancytopenia 52 0.1 236 allergic reaction 52 0.094 85 dysmenorrhea 52 0.085 9 mitral insufficiency 52 0.078 108 toxic epidermal necrolysis 52 0.075 97 aplastic anemia 52 0.069 118 exfoliative dermatitis 52 0.066 46 bursitis 52 0.062 210 agitation 52 0.054 191 peripheral edema 52 0.054 31 neurosis 52 0.051 249 blurred vision 52 0.05 75 deafness 52 0.042 185 impotence 52 0.038 30 fungal dermatitis 52 0.034 52 ventricular fibrillation 52 0.031 35 paralytic ileus 52 0.015 114 lymphadenopathy 52 0.014 99 photophobia 52 0.006 14 hyperprolactinemia 52 0.004 41 bundle branch block # high scoring drugs for both targets and side effects 52 2.076 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 52 1.879 150 1775 DB00252 Anticonvulsants 52 1.646 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 52 1.598 62 5566 DB00831 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 52 1.512 64 2726 DB00477 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 52 1.496 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 52 1.479 71 3372 DB00623 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 52 1.43 52 5452 DB00679 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 52 1.429 59 4917 DB00433 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 52 1.366 35 16362 DB01100 Anti-Dyskinesia Agents.Antipsychotic Agents.Dopamine Antagonists 52 1.338 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 52 1.331 49 4078 DB00933 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 52 1.316 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 52 1.309 453 125889 DB00230 Analgesics.Anticonvulsants 52 1.252 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 52 1.224 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 52 1.172 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 52 1.149 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 52 1.139 90 2477 DB00490 Anti-anxiety Agents.Anxiolytics sedatives and hypnotics.Serotonin Agonists 52 1.123 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 52 1.11 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 52 1.107 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 52 1.051 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 52 1.021 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 52 1.002 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 52 0.988 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 52 0.981 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 52 0.972 135 5734 DB00909 Anticonvulsants.Antioxidants 52 0.971 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 52 0.97 158 34312 DB00776 Anticonvulsants 52 0.964 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 52 0.963 17 1206 DB01577 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Agents.Dopamine Uptake Inhibitors.Sympathomimetics 52 0.963 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 52 0.961 57 5454 DB01623 Antipsychotic Agents.Dopamine Antagonists 52 0.946 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 52 0.938 181 4932 DB01182 Anti-Arrhythmia Agents 52 0.938 161 122316 DB01367 Monoamine Oxidase Inhibitors.Neuroprotective Agents 52 0.927 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 52 0.925 146 3075 DB00343 Antihypertensive Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Cardiovascular Agents.Vasodilator Agents 52 0.919 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 52 0.884 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 52 0.88 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 52 0.867 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 52 0.863 183 3648 DB00327 Analgesics, Opioid.Narcotics 52 0.849 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 52 0.828 76 4748 DB00850 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 52 0.827 264 5372 DB00864 Immunosuppressive Agents 52 0.795 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 52 0.782 118 4236 DB00745 Anorexigenic Agents.Central Nervous System Agents.Central Nervous System Stimulants.Neuroprotective Agents.Stimulants 52 0.765 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 52 0.734 136 56339 DB01320 Anticonvulsants 52 0.731 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 52 0.726 55 2130 DB00915 Analgesics, Non-Narcotic.Antiparkinson Agents.Antiviral Agents.Dopamine Agents 52 0.72 196 1935 DB00382 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 52 0.699 97 1065 DB00908 Adrenergic alpha-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antimalarials.Enzyme Inhibitors.Muscarinic Antagonists 52 0.696 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 52 0.684 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 52 0.683 69 2512 DB00248 Antineoplastic Agents.Antiparkinson Agents.Dopamine Agonists 52 0.673 143 4054 DB01043 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agents.Excitatory Amino Acid Antagonists 52 0.671 157 4659569 DB00323 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Enzyme Inhibitors 52 0.661 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 52 0.642 95 16231 DB00594 Diuretics.Sodium channel blockers 52 0.62 146 4158 DB00422 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Uptake Inhibitors.Sympathomimetics 52 0.619 66 4011 DB00934 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Second-Generation 52 0.602 73 3333 DB01023 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Calcium Channel Blockers.Dihydropyridines.Vasodilator Agents 52 0.591 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 52 0.587 147 71158 DB00659 Alcohol Deterrents 52 0.585 42 3675 DB00780 Antidepressants.Antidepressive Agents.Monoamine Oxidase Inhibitors 52 0.572 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 52 0.566 106 4539 DB01059 Anti-Bacterial Agents.Anti-Infectives.Enzyme Inhibitors.Nucleic Acid Synthesis Inhibitors.Quinolones 52 0.566 142 3826 DB00465 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 52 0.565 73 34633 DB00680 Anti-Arrhythmia Agents 52 0.55 201 5538 DB00755 Antineoplastic Agents.Cell Stimulants and Proliferants.Keratolytic Agents 52 0.547 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 52 0.547 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 52 0.537 128 4253 DB00295 Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 52 0.536 51 3964 DB00408 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists 52 0.536 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 52 0.531 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 52 0.525 137 62959 DB00685 Anti-Infective Agents.Anti-Infectives.Fluoroquinolones 52 0.523 44 4060 DB00532 Anticonvulsants 52 0.512 75 4178 DB00379 Anti-Arrhythmia Agents 52 0.503 161 5487 DB00697 Adrenergic alpha-Agonists.Analgesics.Anticonvulsants.Muscle Relaxants.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 52 0.502 133 2802 DB01068 Anticonvulsants.Benzodiazepines.GABA Modulators 52 0.502 62 3007 DB00182 Adrenergic Agents.Adrenergic Uptake Inhibitors.Amphetamines.Central Nervous System Stimulants.Dopamine Agents.Dopamine Uptake Inhibitors.Sympathomimetics 52 0.502 151 60835 DB00476 Adrenergic Uptake Inhibitors.Antidepressive Agents.Dopamine Uptake Inhibitors.Serotonin Uptake Inhibitors 52 0.499 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 52 0.491 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists 52 0.476 89 59708 DB01202 Anticonvulsants.Nootropic Agents 52 0.47 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 52 0.462 215 60787 DB01232 Anti-HIV Agents.HIV Protease Inhibitors 52 0.459 167 170361 DB01273 Nicotinic Agonists 52 0.445 114 5379 DB01044 Anti-Infective Agents.Antibiotics 52 0.429 84 2995 DB01151 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Enzyme Inhibitors.Norepinephrine-Reuptake Inhibitors 52 0.428 91 3355 DB01195 Anti-Arrhythmia Agents.Antiarrhythmic Agents 52 0.425 57 2951 DB01219 Muscle Relaxants, Central 52 0.416 86 115237 DB01267 Antipsychotic Agents 52 0.407 145 3672 DB01050 Analgesics.Analgesics, Non-Narcotic.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 52 0.398 87 5533 DB00656 Anti-anxiety Agents.Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 52 0.394 61 3114 DB00280 Anti-Arrhythmia Agents.Antiarrhythmic Agents #### component 53: positive weight features and high scoring objects #### # positive weight on target proteins 53 0.47 17 ANXA1_HUMAN Annexin A1; 53 0.201 12 KCMA1_HUMAN Calcium-activated potassium channel subunit alpha-1; 53 0.154 17 CBG_HUMAN Corticosteroid-binding globulin; 53 0.146 20 ACHA2_HUMAN Neuronal acetylcholine receptor subunit alpha-2; 53 0.075 12 IRK1_HUMAN ATP-sensitive inward rectifier potassium channel 1; 53 0.064 9 S12A1_HUMAN Solute carrier family 12 member 1; # positive weight on side effects 53 0.327 192 erythema 53 0.178 112 hemolytic anemia 53 0.126 60 peptic ulcer 53 0.072 163 pancreatitis 53 0.008 155 stomatitis # high scoring drugs for both targets and side effects 53 1.078 31 4900 DB00635 Adrenergic Agents.Anti-inflammatory Agents.Antineoplastic Agents.Antineoplastic Agents, Hormonal.Glucocorticoids 53 0.99 10 4630253 DB00240 Anti-inflammatory Agents.Antipruritic Agents.Corticosteroids.Glucocorticoids 53 0.99 17 48175 DB00596 Anti-inflammatory Agents.Vasoconstrictor Agents 53 0.913 17 3000 DB00547 Anti-inflammatory Agents.Glucocorticoids 53 0.891 26 12536 DB01260 Anti-inflammatory Agents 53 0.84 86 3003 DB01234 Adrenergic Agents.Anti-inflammatory Agents.Antiemetics.Antineoplastic Agents, Hormonal.Glucocorticoids 53 0.835 54 4159 DB00959 Adrenergic Agents.Anti-inflammatory Agents.Antiemetics.Glucocorticoids.Neuroprotective Agents 53 0.826 29 2308 DB00394 Anti-Asthmatic Agents.Anti-inflammatory Agents.Antiarrhythmic Agents.Corticosteroids.Glucocorticoids 53 0.811 54 3639 DB00999 Antihypertensive Agents.Diuretics.Sodium Chloride Symporter Inhibitors 53 0.805 19 5505 DB01124 Hypoglycemic Agents.Sulfonylureas 53 0.772 38 4121 DB00232 Diuretics.Diuretics, Thiazide.Sodium Chloride Symporter Inhibitors 53 0.755 38 3488 DB01016 Antiarrhythmic Agents.Hypoglycemic Agents.Sulfonylureas 53 0.752 41 32797 DB01013 Anti-inflammatory Agents.Corticosteroids, topical.Glucocorticoids 53 0.751 14 104803 DB01226 Neuromuscular Nondepolarizing Agents 53 0.751 14 47319 DB00732 Neuromuscular Nondepolarizing Agents.Nicotinic Antagonists 53 0.749 11 3375 DB00223 Anti-inflammatory Agents.Glucocorticoids 53 0.749 14 2133 DB00288 Corticosteroids, topical 53 0.74 41 2315 DB00436 Antihypertensive Agents.Diuretics.Diuretics, Thiazide.Sodium Chloride Symporter Inhibitors 53 0.74 43 2720 DB00880 Antihypertensive Agents.Diuretics.Diuretics, Thiazide.Sodium Chloride Symporter Inhibitors 53 0.714 14 2955 DB00250 Anti-Infective Agents.Anti-Infectives.Anti-inflammatory Agents.Antimalarials.Antimycobacterials.Folic Acid Antagonists.Leprostatic Agents 53 0.687 135 5544 DB00620 Adrenergic Agents.Anti-inflammatory Agents.Glucocorticoids 53 0.683 27 3647 DB00774 Antihypertensive Agents.Diuretics.Diuretics, Thiazide.Sodium Chloride Symporter Inhibitors 53 0.682 74 4894 DB00860 Adrenergic Agents.Anti-inflammatory Agents.Antineoplastic Agents.Antineoplastic Agents, Hormonal.Glucocorticoids 53 0.682 46 3685 DB01177 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 53 0.678 3 2484 DB01091 Antifungal Agents 53 0.678 23 5578 DB00440 Anti-Infective Agents, Urinary.Anti-Infectives.Antimalarials.Folic Acid Antagonists 53 0.678 11 2522 DB02300 Antipsoriatic Agents.Dermatologic Agents.Vitamin D3 Receptor inhibitor 53 0.678 3 47641 DB00735 Anti-Inflammatory Agents, Non-Steroidal.Antifungal Agents 53 0.678 12 4812 DB01022 Antifibrinolytic Agents.Vitamins.Vitamins (Vitamin K) 53 0.678 16 3405 DB00158 Dietary supplement.Hematinics.Micronutrient.Vitamin B Complex 53 0.665 15 39507 DB00896 Anti-inflammatory Agents.Corticosteroids 53 0.647 24 5503 DB00839 Hypoglycemic Agents 53 0.641 24 2727 DB00672 Hypoglycemic Agents.Sulfonylureas 53 0.636 42 4510 DB00727 Explosive Agents.Nitrates and Nitrites.Tocolytic Agents.Vasodilator Agents 53 0.634 38 3823 DB01026 Antifungal Agents.Antifungals 53 0.63 23 4479097 DB00200 Anti-anemic Agents.Hematinics.Nutritional Supplement.Vitamin B Complex 53 0.615 10 3226 DB00228 Anesthetics, Inhalation.General Anesthetics 53 0.611 66 123620 DB00764 Anti-Allergic Agents.Anti-inflammatory Agents 53 0.604 6 4908 DB01087 Antimalarial Agents.Antimalarials.Antiprotozoal Agents 53 0.604 24 4911 DB01032 Adjuvants, Pharmaceutic.Uricosuric Agents 53 0.604 40 2617 DB01327 Anti-Bacterial Agents.Cephalosporins 53 0.594 39 5412 DB00759 Anti-Bacterial Agents.Antiprotozoals.Protein Synthesis Inhibitors.Tetracyclines 53 0.594 50 5472 DB00208 Fibrinolytic Agents.Platelet Aggregation Inhibitors 53 0.591 16 3382 DB01047 Anti-Allergic Agents.Anti-inflammatory Agents.Glucocorticoids 53 0.591 10 3392 DB00846 Anti-inflammatory Agents.Glucocorticoids 53 0.591 12 3384 DB00324 Anti-Allergic Agents.Anti-inflammatory Agents.Glucocorticoids 53 0.591 11 4043 DB00253 Topical anti-inflammatory Agent 53 0.591 63 3381 DB00591 Anti-inflammatory Agents.Antipruritics.Glucocorticoids 53 0.588 12 60169 DB01334 Neuromuscular Nondepolarizing Agents 53 0.588 11 4919 DB00387 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists 53 0.588 10 4675 DB01337 Neuromuscular Nondepolarizing Agents.Nicotinic Antagonists 53 0.588 17 52421 DB01130 Anti Inflammatory.Anti-inflammatory Agents.Corticosteroid.Glucocorticoids.Steroidal 53 0.588 5 10548 DB01057 Cholinesterase Inhibitors.Miotics.Parasympathomimetics 53 0.588 7 2551 DB00411 Analgesics, Non-Narcotic.Cardiotonic Agents.Cholinergic Agonists.Miotics 53 0.588 10 47320 DB00565 Neuromuscular Blocking Agents 53 0.583 30 2732 DB00310 Antihypertensive Agents.Diuretics.Sodium Chloride Symporter Inhibitors 53 0.578 9 5342 DB01138 Uricosuric Agents 53 0.577 16 5314 DB00202 Neuromuscular Depolarizing Agents.Skeletal Muscle Relaxants 53 0.577 40 4547 DB00912 Hypoglycemic Agents.Meglitinides 53 0.567 40 13342 DB00570 Antineoplastic Agents, Phytogenic.Tubulin Modulators 53 0.551 28 4870 DB01324 Antihypertensive Agents.Diuretics.Sodium Chloride Symporter Inhibitors 53 0.551 20 667490 DB01033 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Immunosuppressive Agents.Nucleic Acid Synthesis Inhibitors.Purine analogues 53 0.548 32 2265 DB00993 Antimetabolites.Antimetabolites, Antineoplastic.Antirheumatic Agents.Immunosuppressive Agents 53 0.546 18 4873 DB00761 Not Available 53 0.537 41 39042 DB01393 Antilipemic Agents 53 0.534 23 41693 DB00708 Adjuvants, Anesthesia.Analgesics, Opioid.Anesthetics, Intravenous.Narcotics.Opiate Agonists 53 0.532 47 3476 DB00222 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Hypoglycemic Agents.Immunosuppressive Agents.Sulfonylureas 53 0.531 41 2088 DB00630 Antihypocalcemic Agents.Antiresorptives.Bisphosphonates.Bone Density Conservation Agents 53 0.528 25 9034 DB00474 Anesthetics.Anesthetics, Intravenous.Barbiturates 53 0.524 23 143 DB00650 Antianemic Agents.Antidote (to folic acid antagonists).Antineoplastic Adjuncts.Vitamin B Complex.Vitamins/minerals 53 0.519 27 298 DB00446 Anti-Bacterial Agents.Protein Synthesis Inhibitors 53 0.519 83 3640 DB00741 Anti-inflammatory Agents 53 0.517 15 4189 DB01110 Antifungal Agents 53 0.517 13 137 DB00855 Photosensitizing Agents 53 0.517 22 60164 DB00210 Anti-Inflammatory Agents, Non-Steroidal.Dermatologic Agents 53 0.517 29 3890 DB00654 Antihypertensive Agents.Neuroprotective Agents 53 0.517 11 157922 DB00992 Antineoplastic Agents 53 0.517 14 2749 DB01188 Antifungal Agents 53 0.517 16 2812 DB00257 Anti-Infective Agents, Local.Antifungal Agents.Growth Inhibitors 53 0.515 4 6503 DB03754 Buffers.Excipients 53 0.515 14 4993 DB00205 Antimalarials.Antiprotozoal Agents.Antiprotozoals.Folic Acid Antagonists 53 0.515 6 4174 DB01011 Antimetabolites.Enzyme Inhibitors 53 0.515 9 5593 DB00809 Diagnostic aid, cycloplegic.Diagnostic aid, mydriatic.Muscarinic Antagonists.Mydriatics 53 0.515 10 271 DB01373 Not Available 53 0.515 15 3739 DB04711 Contrast Media 53 0.515 7 3562 DB01159 Anesthetics.Anesthetics, Inhalation.General Anesthetics 53 0.515 15 2370 DB01019 Muscarinic Agonists.Parasympathomimetics 53 0.515 10 5526 DB00302 Antifibrinolytic Agents 53 0.515 9 232 DB00125 Conditionally Essential Amino Acids.Dietary supplement.Micronutrient 53 0.515 24 145068 DB00435 Bronchodilator Agents.Endothelium-Dependent Relaxing Factors.Free Radical Scavengers 53 0.515 28 25419 DB00720 Antihypocalcemic Agents.Antineoplastic Agents.Bisphosphonates.Bone Density Conservation Agents.Osteoporosis Prophylactic 53 0.515 4 119 DB02530 GABA Agents 53 0.515 5 51577 DB00491 Anti-Bacterial Agents.Enzyme Inhibitors.Hypoglycemic Agents 53 0.515 16 3763 DB00753 Anesthetics.Anesthetics, Inhalation.General Anesthetics 53 0.515 7 5359 DB00870 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 53 0.515 14 11947681 DB00325 Antihypertensive Agents.Indicators and Reagents.Nitric Oxide Donors.Vasodilator Agents 53 0.515 28 4058 DB00454 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 53 0.515 3 175 DB04184 Indicators and Reagents 53 0.515 38 2232 DB00278 Anticoagulants.Platelet Aggregation Inhibitors 53 0.515 7 5404 DB00251 Antifungal Agents.Antifungals #### component 54: positive weight features and high scoring objects #### # positive weight on target proteins 54 0.577 35 DRD2_HUMAN D(2) dopamine receptor; 54 0.486 28 DRD3_HUMAN D(3) dopamine receptor; 54 0.424 28 DRD1_HUMAN D(1A) dopamine receptor; 54 0.274 21 DRD5_HUMAN D(1B) dopamine receptor; 54 0.148 19 OPRM_HUMAN Mu-type opioid receptor; 54 0.102 6 DRD4_HUMAN D(4) dopamine receptor; 54 0.08 17 OPRD_HUMAN Delta-type opioid receptor; 54 0.067 16 OPRK_HUMAN Kappa-type opioid receptor; 54 0.053 26 SC6A4_HUMAN Sodium-dependent serotonin transporter; # positive weight on side effects 54 0.464 106 spasm 54 0.339 19 fecal impaction 54 0.338 68 paralysis 54 0.206 34 Endocrine Disorders 54 0.197 115 hypokalemia 54 0.181 108 toxic epidermal necrolysis 54 0.171 9 mitral insufficiency 54 0.148 50 blepharitis 54 0.145 355 abdominal pain 54 0.103 41 Toothache 54 0.101 63 hemoptysis 54 0.077 103 Vascular Disorders 54 0.067 84 bone pain 54 0.027 330 anorexia 54 0.025 5 pigmentary retinopathy 54 0.021 81 hyperuricemia 54 0.008 45 SIADH 54 0.004 29 tooth caries # high scoring drugs for both targets and side effects 54 1.613 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 54 1.517 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 54 1.468 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 54 1.374 71 3372 DB00623 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 54 1.326 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 54 1.321 76 4748 DB00850 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 54 1.175 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 54 1.134 64 2726 DB00477 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 54 1.119 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 54 1.092 57 5454 DB01623 Antipsychotic Agents.Dopamine Antagonists 54 1.079 62 5566 DB00831 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 54 1.07 51 3559 DB00502 Anti-Dyskinesia Agents.Antidyskinetics.Antiemetics.Antipsychotic Agents.Antipsychotics.Butyrophenones.Dopamine Antagonists 54 1.066 59 4917 DB00433 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 54 1.064 33 3340 DB00800 Antihypertensive Agents.Dopamine Agonists.Vasodilator Agents 54 0.982 90 2477 DB00490 Anti-anxiety Agents.Anxiolytics sedatives and hypnotics.Serotonin Agonists 54 0.944 31 2215 DB00714 Antidyskinetics.Antiparkinson Agents.Dopamine Agonists 54 0.914 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 54 0.913 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 54 0.873 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 54 0.858 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 54 0.844 35 16362 DB01100 Anti-Dyskinesia Agents.Antipsychotic Agents.Dopamine Antagonists 54 0.82 453 125889 DB00230 Analgesics.Anticonvulsants 54 0.819 69 2512 DB00248 Antineoplastic Agents.Antiparkinson Agents.Dopamine Agonists 54 0.807 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 54 0.796 51 3964 DB00408 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists 54 0.715 49 4078 DB00933 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 54 0.715 52 5452 DB00679 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 54 0.681 20 5775 DB00692 Adrenergic alpha-Antagonists.Antihypertensive Agents.Sympatholytics 54 0.681 11 3251 DB00696 Adrenergic alpha-Agonists.Analgesics, Non-Narcotic.Sympatholytics.Vasoconstrictor Agents 54 0.673 183 3648 DB00327 Analgesics, Opioid.Narcotics 54 0.669 211 93860 DB00188 Antineoplastic Agents.Protease Inhibitors 54 0.609 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 54 0.566 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 54 0.558 57 2443 DB01200 Antidyskinetics.Antiparkinson Agents.Dopamine Agonists.Hormone Antagonists 54 0.555 131 4635 DB00497 Analgesics, Opioid.Antitussives.Narcotics.Opiate Agonists 54 0.545 26 3151 DB01184 Antiemetics.Dopamine Antagonists 54 0.512 128 4253 DB00295 Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 54 0.501 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 54 0.466 41 5530 DB00752 Anti-anxiety Agents.Antidepressants.Antidepressive Agents.Monoamine Oxidase Inhibitors 54 0.462 154 5090 DB00533 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase 2 Inhibitors.Cyclooxygenase Inhibitors 54 0.428 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 54 0.411 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 54 0.406 264 5372 DB00864 Immunosuppressive Agents 54 0.404 28 4058 DB00454 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 54 0.386 59 4095 DB00333 Analgesics.Analgesics, Opioid.Antitussive Agents.Antitussives.Narcotics.Opiate Agonists 54 0.384 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 54 0.378 215 60787 DB01232 Anti-HIV Agents.HIV Protease Inhibitors 54 0.37 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 54 0.37 196 1935 DB00382 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 54 0.366 236 10631 DB00603 Contraceptives.Contraceptives, Oral, Synthetic.Progestins 54 0.36 30 2732 DB00310 Antihypertensive Agents.Diuretics.Sodium Chloride Symporter Inhibitors 54 0.356 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 54 0.354 27 23897 DB01618 Antipsychotic Agents 54 0.352 196 3911 DB00007 Anti-Estrogen Agents.Antineoplastic Agents 54 0.352 49 4168 DB01233 Antiemetics.Dopamine Antagonists.Prokinetic Agents 54 0.343 24 4140 DB00353 Oxytocics 54 0.322 181 4932 DB01182 Anti-Arrhythmia Agents 54 0.321 71 2487 DB00611 Analgesics, Opioid.Antitussive Agents.Narcotic Antagonists.Narcotics 54 0.318 53 5035 DB00481 Antihypocalcemic Agents.Bone Density Conservation Agents.Estrogen Antagonists.Osteoporosis Prophylactic.Selective Estrogen Receptor Modulators 54 0.313 47 4927 DB01069 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists.Phenothiazine Derivatives 54 0.295 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 54 0.292 191 450 DB00783 Anti-menopausal Agents.Anticholesteremic Agents.Estrogens 54 0.288 46 3366 DB01099 Antifungal Agents.Antifungals.Antimetabolites 54 0.286 27 4100 DB00703 Carbonic Anhydrase Inhibitors.Diuretics 54 0.276 120 82146 DB00307 Anticarcinogenic Agents 54 0.273 50 4138 DB00968 Adrenergic alpha-Agonists.Antihypertensive Agents.Sympatholytics 54 0.269 28 4870 DB01324 Antihypertensive Agents.Diuretics.Sodium Chloride Symporter Inhibitors 54 0.269 83 5487301 DB01079 Gastrointestinal Agents.Serotonin Agonists 54 0.269 27 3647 DB00774 Antihypertensive Agents.Diuretics.Diuretics, Thiazide.Sodium Chloride Symporter Inhibitors 54 0.266 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 54 0.263 15 681 DB00988 Cardiotonic Agents.Dopamine Agents.Sympathomimetic.Sympathomimetics 54 0.262 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 54 0.256 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 54 0.256 55 2130 DB00915 Analgesics, Non-Narcotic.Antiparkinson Agents.Antiviral Agents.Dopamine Agents 54 0.255 42 4991 DB00545 Antimyasthenics.Cholinesterase Inhibitors.Parasympathomimetics 54 0.246 43 2720 DB00880 Antihypertensive Agents.Diuretics.Diuretics, Thiazide.Sodium Chloride Symporter Inhibitors 54 0.246 54 3639 DB00999 Antihypertensive Agents.Diuretics.Sodium Chloride Symporter Inhibitors 54 0.245 101 2800 DB00822 Alcohol Deterrents.Enzyme Inhibitors 54 0.244 157 3937 DB00722 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents.Cardiotonic Agents 54 0.239 76 123631 DB00317 Antineoplastic Agents.Protein Kinase Inhibitors 54 0.237 161 5487 DB00697 Adrenergic alpha-Agonists.Analgesics.Anticonvulsants.Muscle Relaxants.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 54 0.236 116 5525 DB00519 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 54 0.232 151 60835 DB00476 Adrenergic Uptake Inhibitors.Antidepressive Agents.Dopamine Uptake Inhibitors.Serotonin Uptake Inhibitors 54 0.231 17 1206 DB01577 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Agents.Dopamine Uptake Inhibitors.Sympathomimetics 54 0.224 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 54 0.221 33 154059 DB01591 Anti-Incontinence Agents.Antispasmodics.Muscarinic Antagonists 54 0.221 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 54 0.218 124 62924 DB00588 Adrenergic Agents.Anti-Allergic Agents.Anti-inflammatory Agents.Bronchodilator Agents.Dermatologic Agents 54 0.213 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 54 0.21 29 3954 DB00836 Antidiarrheals 54 0.208 60 62819 DB00094 Fertility Agents 54 0.208 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 54 0.204 76 4170 DB00524 Antihypertensive Agents.Diuretics.Diuretics, Sulfamyl 54 0.204 81 214 DB00770 Fibrinolytic Agents.Platelet Aggregation Inhibitors.Vasodilator Agents 54 0.201 167 170361 DB01273 Nicotinic Agonists 54 0.201 234 216326 DB00480 Antineoplastic Agents 54 0.199 131 4428 DB00704 Alcohol Antagonists.Anti-craving Agents.Depressants.Narcotic Antagonists.Opiate Antagonists 54 0.19 98 3222 DB00584 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 54 0.188 16 3168 DB00450 Adjuvants, Anesthesia.Antiemetics.Antipsychotic Agents.Dopamine Antagonists 54 0.186 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics #### component 55: positive weight features and high scoring objects #### # positive weight on target proteins 55 0.691 26 SC6A4_HUMAN Sodium-dependent serotonin transporter; 55 0.327 28 SC6A2_HUMAN Sodium-dependent noradrenaline transporter; 55 0.294 28 DRD3_HUMAN D(3) dopamine receptor; 55 0.246 6 DRD4_HUMAN D(4) dopamine receptor; 55 0.246 35 DRD2_HUMAN D(2) dopamine receptor; 55 0.232 29 PGH2_HUMAN Prostaglandin G/H synthase 2; 55 0.162 9 GABR2_HUMAN Gamma-aminobutyric acid type B receptor subunit 2; 55 0.143 11 ACES_HUMAN Acetylcholinesterase; 55 0.131 9 CHLE_HUMAN Cholinesterase; 55 0.12 5 ATP4A_HUMAN Potassium-transporting ATPase alpha chain 1; 55 0.111 21 DRD5_HUMAN D(1B) dopamine receptor; 55 0.089 5 GABT_HUMAN 4-aminobutyrate aminotransferase, mitochondrial; 55 0.079 28 DRD1_HUMAN D(1A) dopamine receptor; 55 0.057 8 TSPOA_HUMAN Translocator protein; 55 0.057 8 GBRR2_HUMAN Gamma-aminobutyric acid receptor subunit rho-2; 55 0.047 9 TNFA_HUMAN Tumor necrosis factor; 55 0.047 13 CAC1A_HUMAN Voltage-dependent P/Q-type calcium channel subunit alpha-1A; 55 0.044 12 SC6A3_HUMAN Sodium-dependent dopamine transporter; 55 0.019 3 PPIA_HUMAN Peptidyl-prolyl cis-trans isomerase A; 55 0.017 16 OPRK_HUMAN Kappa-type opioid receptor; 55 0.013 2 GFPT2_HUMAN Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2; # positive weight on side effects 55 0.468 83 hypercholesterolemia 55 0.435 68 laryngitis 55 0.36 54 hypothyroidism 55 0.285 48 hemorrhoids 55 0.275 109 eye pain 55 0.26 87 neck pain 55 0.227 114 lymphadenopathy 55 0.182 44 gastric ulcer 55 0.18 60 neuralgia 55 0.17 52 cholelithiasis 55 0.164 144 gastritis 55 0.125 46 cholecystitis 55 0.122 46 bursitis 55 0.106 48 ulcerative stomatitis 55 0.104 117 atrial fibrillation 55 0.08 41 bundle branch block 55 0.059 71 glaucoma 55 0.007 175 urinary tract infection # high scoring drugs for both targets and side effects 55 2.046 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 55 2.004 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 55 1.951 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 55 1.92 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 55 1.773 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 55 1.74 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 55 1.719 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 55 1.676 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 55 1.638 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 55 1.565 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 55 1.539 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 55 1.53 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 55 1.517 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 55 1.478 129 5210 DB01105 Anorexigenic Agents.Antidepressants.Antidepressive Agents.Appetite Depressants.Stimulants 55 1.467 151 60835 DB00476 Adrenergic Uptake Inhibitors.Antidepressive Agents.Dopamine Uptake Inhibitors.Serotonin Uptake Inhibitors 55 1.439 453 125889 DB00230 Analgesics.Anticonvulsants 55 1.43 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 55 1.411 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 55 1.361 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 55 1.35 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 55 1.33 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 55 1.215 167 5719 DB00962 Anticonvulsants.Anxiolytics sedatives and hypnotics.Hypnotics and Sedatives 55 1.209 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 55 1.159 196 1935 DB00382 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 55 1.158 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 55 1.155 264 5372 DB00864 Immunosuppressive Agents 55 1.118 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 55 1.099 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 55 1.072 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 55 1.066 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists 55 1.056 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 55 1.052 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 55 1.038 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 55 0.98 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 55 0.974 146 4158 DB00422 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Uptake Inhibitors.Sympathomimetics 55 0.974 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 55 0.923 234 216326 DB00480 Antineoplastic Agents 55 0.892 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 55 0.888 215 60787 DB01232 Anti-HIV Agents.HIV Protease Inhibitors 55 0.879 211 60953 DB01101 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Prodrugs 55 0.868 154 5090 DB00533 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase 2 Inhibitors.Cyclooxygenase Inhibitors 55 0.861 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 55 0.796 157 4659569 DB00323 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Enzyme Inhibitors 55 0.763 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 55 0.712 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 55 0.701 161 5487 DB00697 Adrenergic alpha-Agonists.Analgesics.Anticonvulsants.Muscle Relaxants.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 55 0.678 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 55 0.678 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 55 0.647 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 55 0.644 147 71158 DB00659 Alcohol Deterrents 55 0.642 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 55 0.639 138 2369 DB00195 Adrenergic beta-Antagonists.Antihypertensive Agents.EENT Drugs.Sympatholytics 55 0.634 131 4428 DB00704 Alcohol Antagonists.Anti-craving Agents.Depressants.Narcotic Antagonists.Opiate Antagonists 55 0.624 151 41317 DB00459 Keratolytic Agents 55 0.598 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 55 0.591 154 27661 DB01020 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 55 0.572 146 3475 DB01120 Hypoglycemic Agents.Sulfonylureas 55 0.559 88 365716 Not Available Not Available 55 0.553 141 4819 DB01085 Cholinergic Agents.Miotics.Muscarinic Agonists 55 0.541 158 34312 DB00776 Anticonvulsants 55 0.526 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 55 0.517 134 3339 DB01039 Antilipemic Agents.Fribic Acid Derivatives 55 0.515 83 5487301 DB01079 Gastrointestinal Agents.Serotonin Agonists 55 0.513 199 5358 DB00669 Selective Serotonin Agonists.Serotonin Agonists.Vasoconstrictor Agents 55 0.468 166 3394 DB00712 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Carbonic Anhydrase Inhibitors.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 55 0.443 191 450 DB00783 Anti-menopausal Agents.Anticholesteremic Agents.Estrogens 55 0.441 97 5245 DB00884 Antihypocalcemic Agents.Antiresorptives.Bisphosphonates.Bone Density Conservation Agents.Calcium Channel Blockers 55 0.441 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 55 0.425 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 55 0.422 185 4594 DB00338 Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 55 0.414 181 4932 DB01182 Anti-Arrhythmia Agents 55 0.4 166 54374 DB00104 Anabolic Agents.Antineoplastic Agents, Hormonal.Gastrointestinal Agents.Hormone Replacement Agents 55 0.38 17 1206 DB01577 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Agents.Dopamine Uptake Inhibitors.Sympathomimetics 55 0.372 144 3899 DB01097 Adjuvants.Anti-inflammatory Agents.Antineoplastic Agents.Antiparasitic Agents.Antirheumatic Agents.Antiviral Agents.Enzyme Inhibitors.Immunosuppressive Agents 55 0.37 105 4659568 DB00494 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Enzyme Inhibitors 55 0.343 72 60831 DB01409 Anticholinergic Agents.Bronchodilator Agents.Cholinergic Antagonists.Muscarinic Antagonists.Parasympatholytics 55 0.333 161 122316 DB01367 Monoamine Oxidase Inhibitors.Neuroprotective Agents 55 0.328 118 65999 DB00966 Angiotensin II Type 1 Receptor Blockers.Angiotensin-converting Enzyme Inhibitors 55 0.321 106 2958 DB00694 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 55 0.316 50 3158 DB01142 Anti-anxiety Agents.Antidepressants.Antidepressive Agents, Tricyclic.Antipruritics.Histamine Antagonists.Norepinephrine-Reuptake Inhibitors 55 0.315 142 2678 DB00341 Anti-Allergic Agents.Antihistamines.Histamine H1 Antagonists, Non-Sedating 55 0.315 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 55 0.315 87 5533 DB00656 Anti-anxiety Agents.Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 55 0.315 69 2170 DB00543 Adrenergic Uptake Inhibitors.Antidepressive Agents, Second-Generation.Dopamine Antagonists.Neurotransmitter Uptake Inhibitors.Serotonin Uptake Inhibitors 55 0.306 123 2806 DB00758 Antiplatelet Agents.Fibrinolytic Agents.Platelet Aggregation Inhibitors 55 0.302 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 55 0.292 183 3648 DB00327 Analgesics, Opioid.Narcotics 55 0.288 147 5645 DB01586 Cholagogues and Choleretics 55 0.288 62 3007 DB00182 Adrenergic Agents.Adrenergic Uptake Inhibitors.Amphetamines.Central Nervous System Stimulants.Dopamine Agents.Dopamine Uptake Inhibitors.Sympathomimetics 55 0.285 120 82146 DB00307 Anticarcinogenic Agents 55 0.285 12 4771 DB00191 Adrenergic Agents.Anorexigenic Agents.Appetite Depressants.Central Nervous System Agents.Central Nervous System Stimulants.Stimulants.Sympathomimetics 55 0.284 161 5212 DB00203 Phosphodiesterase Inhibitors.Vasodilator Agents 55 0.283 11 3251 DB00696 Adrenergic alpha-Agonists.Analgesics, Non-Narcotic.Sympatholytics.Vasoconstrictor Agents 55 0.282 167 170361 DB01273 Nicotinic Agonists 55 0.282 125 3285 DB00977 Estrogens 55 0.271 196 3911 DB00007 Anti-Estrogen Agents.Antineoplastic Agents 55 0.264 119 4052 DB00814 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Antiemetics.Antineoplastic Agents.Cyclooxygenase Inhibitors.Growth Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 55 0.263 65 4543 DB00540 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 55 0.263 64 5584 DB00726 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 55 0.263 38 125017 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors #### component 56: positive weight features and high scoring objects #### # positive weight on target proteins 56 0.47 34 ACM2_HUMAN Muscarinic acetylcholine receptor M2; 56 0.462 36 ACM1_HUMAN Muscarinic acetylcholine receptor M1; 56 0.414 35 HRH1_HUMAN Histamine H1 receptor; 56 0.182 17 CBG_HUMAN Corticosteroid-binding globulin; 56 0.181 17 ANXA1_HUMAN Annexin A1; 56 0.14 42 ADA1A_HUMAN Alpha-1A adrenergic receptor; 56 0.132 14 CALM_HUMAN Calmodulin; 56 0.1 38 ADA2A_HUMAN Alpha-2A adrenergic receptor; 56 0.06 20 ACHA2_HUMAN Neuronal acetylcholine receptor subunit alpha-2; 56 0.058 33 ADA2B_HUMAN Alpha-2B adrenergic receptor; 56 0.051 17 ACH10_HUMAN Neuronal acetylcholine receptor subunit alpha-10; 56 0.04 16 ANDR_HUMAN Androgen receptor; 56 0.029 18 GCR_HUMAN Glucocorticoid receptor; 56 0.023 35 DRD2_HUMAN D(2) dopamine receptor; 56 0.015 29 GBRA1_HUMAN Gamma-aminobutyric acid receptor subunit alpha-1; 56 0.01 12 IRK1_HUMAN ATP-sensitive inward rectifier potassium channel 1; 56 0.003 14 A1AG1_HUMAN Alpha-1-acid glycoprotein 1; 56 0.002 8 SHBG_HUMAN Sex hormone-binding globulin; # positive weight on side effects 56 0.214 71 numbness 56 0.125 46 breast enlargement # high scoring drugs for both targets and side effects 56 1.293 4 4768 DB00925 Adrenergic alpha-Antagonists.Antihypertensive Agents.Vasodilator Agents 56 1.03 47 4927 DB01069 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists.Phenothiazine Derivatives 56 0.982 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 56 0.927 7 2551 DB00411 Analgesics, Non-Narcotic.Cardiotonic Agents.Cholinergic Agonists.Miotics 56 0.901 8 2381 DB00810 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists.Parasympatholytics 56 0.871 11 2131 DB01122 Antiarrhythmic Agents.Antimyasthenics 56 0.871 37 5512 DB01036 Anti-Incontinence Agents.Antispasmodics.Genitourinary Smooth Muscle Relaxants.Muscarinic Antagonists 56 0.871 15 2370 DB01019 Muscarinic Agonists.Parasympathomimetics 56 0.871 9 5593 DB00809 Diagnostic aid, cycloplegic.Diagnostic aid, mydriatic.Muscarinic Antagonists.Mydriatics 56 0.871 14 3354 DB01148 Parasympatholytics 56 0.843 36 2564 DB00748 Antihistamines 56 0.783 19 2344 DB00245 Antidyskinetics.Antiparkinson Agents.Dopamine Uptake Inhibitors.Muscarinic Antagonists.Parasympatholytics 56 0.778 84 2995 DB01151 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Enzyme Inhibitors.Norepinephrine-Reuptake Inhibitors 56 0.761 8 3241 DB00751 Antihistamines.Histamine H1 Antagonists.Ophthalmics 56 0.75 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 56 0.738 73 2769 DB00604 Anti-Ulcer Agents.Gastrointestinal Agents.Prokinetic Agents.Serotonin Agonists 56 0.731 11 4919 DB00387 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists 56 0.674 68 5596 DB00209 Analgesics.Parasympatholytics 56 0.67 12 60169 DB01334 Neuromuscular Nondepolarizing Agents 56 0.612 32 2725 DB01114 Anti-Allergic Agents.Antihistamines.Antipruritics.Histamine H1 Antagonists 56 0.612 37 3100 DB01075 Anesthetics.Anesthetics, Local.Anti-Allergic Agents.Antidyskinetics.Antiemetics.Antiparkinson Agents.Antipruritics.Antitussives.Ethanolamine Derivatives.Histamine H1 Antagonists.Hypnotics and Sedatives 56 0.612 3 4034 DB00737 Anti-Allergic Agents.Antiemetics.Antihistamines.Histamine H1 Antagonists 56 0.612 37 2781 DB00283 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists 56 0.612 9 3219 DB01084 Anti-Allergic Agents.Histamine H1 Antagonists 56 0.608 19 4934 DB00782 Anti-Ulcer Agents.Antimuscarinics.Antispasmodics.Muscarinic Antagonists 56 0.588 25 5572 DB00376 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists 56 0.587 10 4630253 DB00240 Anti-inflammatory Agents.Antipruritic Agents.Corticosteroids.Glucocorticoids 56 0.583 59 4917 DB00433 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 56 0.577 64 3746 DB00332 Antimuscarinics.Antispasmodics.Bronchodilator Agents.Cholinergic Antagonists 56 0.57 90 4634 DB01062 Anticholinergic Agents.Antispasmodics.Genitourinary Smooth Muscle Relaxants.Muscarinic Antagonists.Parasympatholytics 56 0.566 16 3168 DB00450 Adjuvants, Anesthesia.Antiemetics.Antipsychotic Agents.Dopamine Antagonists 56 0.566 15 39507 DB00896 Anti-inflammatory Agents.Corticosteroids 56 0.56 69 3696 DB00458 Adrenergic Uptake Inhibitors.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 56 0.544 76 4748 DB00850 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 56 0.543 72 2160 DB00321 Adrenergic Uptake Inhibitors.Analgesics, Non-Narcotic.Antidepressive Agents, Tricyclic 56 0.536 52 5452 DB00679 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 56 0.523 64 2726 DB00477 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 56 0.513 6 12555 Not Available Not Available 56 0.51 14 2133 DB00288 Corticosteroids, topical 56 0.5 35 3042 DB00804 Anticholinergic Agents.Antimuscarinics.Antispasmodics.Muscarinic Antagonists.Parasympatholytics 56 0.497 10 3392 DB00846 Anti-inflammatory Agents.Glucocorticoids 56 0.497 16 3382 DB01047 Anti-Allergic Agents.Anti-inflammatory Agents.Glucocorticoids 56 0.497 11 4043 DB00253 Topical anti-inflammatory Agent 56 0.497 16 4211 DB00648 Antineoplastic Agents.Antineoplastic Agents, Hormonal 56 0.496 11 3375 DB00223 Anti-inflammatory Agents.Glucocorticoids 56 0.496 17 3000 DB00547 Anti-inflammatory Agents.Glucocorticoids 56 0.493 49 51634 DB00419 Anti-HIV Agents.Enzyme Inhibitors 56 0.488 49 4168 DB01233 Antiemetics.Dopamine Antagonists.Prokinetic Agents 56 0.479 14 951 DB00368 Adrenergic alpha-Agonists.Sympathomimetics.Vasoconstrictor Agents 56 0.477 33 3340 DB00800 Antihypertensive Agents.Dopamine Agonists.Vasodilator Agents 56 0.472 10 271 DB01373 Not Available 56 0.472 51 3559 DB00502 Anti-Dyskinesia Agents.Antidyskinetics.Antiemetics.Antipsychotic Agents.Antipsychotics.Butyrophenones.Dopamine Antagonists 56 0.461 5 10548 DB01057 Cholinesterase Inhibitors.Miotics.Parasympathomimetics 56 0.454 9 2366 Not Available Not Available 56 0.454 33 60865 DB00768 Anti-Allergic Agents.Anti-Inflammatory Agents, Non-Steroidal.Antihistamines.Histamine H1 Antagonists.Histamine H1 Antagonists, Non-Sedating 56 0.451 37 3494 DB00986 Adjuvants, Anesthesia.Anti-cholinergic Agents.Muscarinic Antagonists 56 0.445 41 32797 DB01013 Anti-inflammatory Agents.Corticosteroids, topical.Glucocorticoids 56 0.444 31 4900 DB00635 Adrenergic Agents.Anti-inflammatory Agents.Antineoplastic Agents.Antineoplastic Agents, Hormonal.Glucocorticoids 56 0.443 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 56 0.435 20 5775 DB00692 Adrenergic alpha-Antagonists.Antihypertensive Agents.Sympatholytics 56 0.433 54 4159 DB00959 Adrenergic Agents.Anti-inflammatory Agents.Antiemetics.Glucocorticoids.Neuroprotective Agents 56 0.426 16 4160 DB00624 Androgens 56 0.425 17 9904 DB00984 Anabolic Agents.Androgens 56 0.425 52 32170 DB00668 Adrenergic Agonists.Adrenergic alpha-Agonists.Adrenergic beta-Agonists.Bronchodilator Agents.Mydriatics.Sympathomimetics.Vasoconstrictor Agents 56 0.416 9 3658 DB00557 Antipruritics.Anxiolytics sedatives and hypnotics.Histamine H1 Antagonists 56 0.416 44 2913 DB00434 Anti-Allergic Agents.Antihistamine derivatives.Antipruritics.Gastrointestinal Agents.Histamine H1 Antagonists.Serotonin Antagonists 56 0.416 18 3957 DB00455 Anti-Allergic Agents.Antihistamines.Antipruritics.Histamine H1 Antagonists, Non-Sedating 56 0.413 12 4909 DB00794 Anticonvulsants.Barbiturates 56 0.413 10 2712 DB00475 Adjuvants, Anesthesia.Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 56 0.413 20 4616 DB00842 Anti-anxiety Agents.GABA Modulators.Hypnotics and Sedatives 56 0.412 12 3384 DB00324 Anti-Allergic Agents.Anti-inflammatory Agents.Glucocorticoids 56 0.41 19 5505 DB01124 Hypoglycemic Agents.Sulfonylureas 56 0.405 6 4908 DB01087 Antimalarial Agents.Antimalarials.Antiprotozoal Agents 56 0.405 10 5526 DB00302 Antifibrinolytic Agents 56 0.405 16 5591 DB00197 Antineoplastic Agents.Fibrinolytic Agents.Hypoglycemic Agents.Platelet Aggregation Inhibitors.Vasodilator Agents 56 0.405 11 157922 DB00992 Antineoplastic Agents 56 0.405 11 3117 DB00822 Alcohol Deterrents.Enzyme Inhibitors 56 0.405 14 36811 DB00841 Adrenergic beta-Agonists.Cardiotonic Agents.Sympathomimetic.Sympathomimetics 56 0.405 3 2484 DB01091 Antifungal Agents 56 0.405 4 119 DB02530 GABA Agents 56 0.405 27 750 DB00145 Dietary supplement.Glycine Agents.Micronutrient.Non-Essential Amino Acids 56 0.405 3 247 DB04455 Gastrointestinal Agents.Lipotropic Agents 56 0.405 6 888 DB01378 Not Available 56 0.405 2 1071 DB00162 Anti-acne Agents.Essential Vitamin.Vitamins.Vitamins (Vitamin A) 56 0.405 7 5404 DB00251 Antifungal Agents.Antifungals 56 0.405 14 2955 DB00250 Anti-Infective Agents.Anti-Infectives.Anti-inflammatory Agents.Antimalarials.Antimycobacterials.Folic Acid Antagonists.Leprostatic Agents 56 0.405 6 3780 DB00883 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 56 0.405 9 1148 DB00150 Antidepressive Agents, Second-Generation.Dietary supplement.Essential Amino Acids.Micronutrient 56 0.405 29 3759 DB01247 Antidepressants.Antidepressive Agents.Monoamine Oxidase Inhibitors 56 0.405 3 175 DB04184 Indicators and Reagents 56 0.405 5 2283 DB00626 Anti-Bacterial Agents.Anti-Infective Agents, Local 56 0.399 14 104803 DB01226 Neuromuscular Nondepolarizing Agents 56 0.399 21 60696 DB00728 Neuromuscular Nondepolarizing Agents.Skeletal Muscle Relaxants 56 0.397 12 3915 DB01106 Histamine H1 Antagonists.Histamine H1 Antagonists, Non-Sedating 56 0.397 31 50294 DB00716 Anti-Allergic Agents.Anti-Asthmatic Agents.Anti-inflammatory Agents 56 0.393 25 9034 DB00474 Anesthetics.Anesthetics, Intravenous.Barbiturates 56 0.391 38 3488 DB01016 Antiarrhythmic Agents.Hypoglycemic Agents.Sulfonylureas 56 0.391 17 48175 DB00596 Anti-inflammatory Agents.Vasoconstrictor Agents 56 0.39 12 4771 DB00191 Adrenergic Agents.Anorexigenic Agents.Appetite Depressants.Central Nervous System Agents.Central Nervous System Stimulants.Stimulants.Sympathomimetics 56 0.389 24 2727 DB00672 Hypoglycemic Agents.Sulfonylureas #### component 57: positive weight features and high scoring objects #### # positive weight on target proteins 57 0.55 38 ADRB1_HUMAN Beta-1 adrenergic receptor; 57 0.525 26 SC6A4_HUMAN Sodium-dependent serotonin transporter; 57 0.36 34 ADRB2_HUMAN Beta-2 adrenergic receptor; 57 0.28 24 ADRB3_HUMAN Beta-3 adrenergic receptor; 57 0.23 28 SC6A2_HUMAN Sodium-dependent noradrenaline transporter; 57 0.058 14 LOX5_HUMAN Arachidonate 5-lipoxygenase; 57 0.034 42 ADA1A_HUMAN Alpha-1A adrenergic receptor; 57 0.019 8 LOX12_HUMAN Arachidonate 12-lipoxygenase, 12S-type; 57 0.019 8 LX12B_HUMAN Arachidonate 12-lipoxygenase, 12R-type; 57 0.019 8 LOXE3_HUMAN Epidermis-type lipoxygenase 3; 57 0.009 10 LKHA4_HUMAN Leukotriene A-4 hydrolase; # positive weight on side effects 57 0.311 57 elevated blood pressure 57 0.281 87 dry eyes 57 0.25 18 cold extremities 57 0.213 191 hepatitis 57 0.196 528 headache 57 0.164 270 alopecia 57 0.144 52 ischemia 57 0.141 195 conjunctivitis 57 0.119 320 fatigue 57 0.043 135 muscle cramps 57 0.041 63 lupus 57 0.02 117 atrial fibrillation 57 0.009 35 mental depression # high scoring drugs for both targets and side effects 57 1.041 99 5478 DB00373 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents 57 0.916 76 3661 DB00572 Adjuvants, Anesthesia.Anti-Arrhythmia Agents.Bronchodilator Agents.Muscarinic Antagonists.Mydriatics.Parasympatholytics 57 0.879 14 951 DB00368 Adrenergic alpha-Agonists.Sympathomimetics.Vasoconstrictor Agents 57 0.868 138 2369 DB00195 Adrenergic beta-Antagonists.Antihypertensive Agents.EENT Drugs.Sympatholytics 57 0.831 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 57 0.827 40 4845 DB01291 Adrenergic beta-Agonists.Bronchodilator Agents.Cardiotonic Agents 57 0.827 106 2083 DB01001 Adrenergic beta-Agonists.Bronchodilator Agents.Tocolytic Agents 57 0.812 84 2995 DB01151 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Enzyme Inhibitors.Norepinephrine-Reuptake Inhibitors 57 0.811 61 4946 DB00571 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Anti-anxiety Agents.Antiarrhythmic Agents.Antihypertensive Agents.Vasodilator Agents 57 0.742 69 3869 DB00598 Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Sympatholytics 57 0.742 146 4158 DB00422 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Uptake Inhibitors.Sympathomimetics 57 0.738 42 4411 DB01203 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents.Sympatholytics 57 0.738 65 5253 DB00489 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Sympatholytics 57 0.723 34 71301 DB04861 Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 57 0.672 30 31477 DB01214 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents.Sympatholytics 57 0.642 75 1978 DB01193 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents 57 0.624 52 32170 DB00668 Adrenergic Agonists.Adrenergic alpha-Agonists.Adrenergic beta-Agonists.Bronchodilator Agents.Mydriatics.Sympathomimetics.Vasoconstrictor Agents 57 0.618 61 4828 DB00960 Adrenergic beta-Antagonists.Antihypertensive Agents.Serotonin Antagonists.Vasodilator Agents 57 0.613 17 5403 DB00871 Adrenergic beta-Agonists.Bronchodilator Agents.Sympathomimetic.Sympathomimetics.Tocolytic Agents 57 0.613 69 2170 DB00543 Adrenergic Uptake Inhibitors.Antidepressive Agents, Second-Generation.Dopamine Antagonists.Neurotransmitter Uptake Inhibitors.Serotonin Uptake Inhibitors 57 0.609 10 4436 Not Available Not Available 57 0.599 94 4171 DB00264 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Sympatholytics 57 0.598 25 4724 DB01359 Adrenergic beta-Antagonists.Antihypertensive Agents 57 0.592 28 2583 DB00521 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents.Sympatholytics 57 0.592 14 36811 DB00841 Adrenergic beta-Agonists.Cardiotonic Agents.Sympathomimetic.Sympathomimetics 57 0.592 19 3779 DB01064 Adrenergic beta-Agonists.Bronchodilator Agents.Cardiotonic Agents.Sympathomimetic.Sympathomimetics 57 0.582 78 2249 DB00335 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Sympatholytics 57 0.575 161 5291 DB00619 Antineoplastic Agents.Protein Kinase Inhibitors 57 0.569 145 3672 DB01050 Analgesics.Analgesics, Non-Narcotic.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 57 0.562 127 2156 DB01118 Anti-Arrhythmia Agents.Enzyme Inhibitors.Vasodilator Agents 57 0.544 135 2585 DB01136 Adrenergic Agents.Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 57 0.538 72 4893 DB00457 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Antihypertensive Agents 57 0.537 129 5210 DB01105 Anorexigenic Agents.Antidepressants.Antidepressive Agents.Appetite Depressants.Stimulants 57 0.534 38 3914 DB01210 Adrenergic beta-Antagonists.EENT Drugs.Sympatholytics 57 0.533 117 2405 DB00612 Adrenergic Agents.Adrenergic beta-Antagonists.Antihypertensive Agents.Sympatholytics 57 0.529 38 125017 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 57 0.524 62 3007 DB00182 Adrenergic Agents.Adrenergic Uptake Inhibitors.Amphetamines.Central Nervous System Stimulants.Dopamine Agents.Dopamine Uptake Inhibitors.Sympathomimetics 57 0.52 83 5487301 DB01079 Gastrointestinal Agents.Serotonin Agonists 57 0.503 83 54841 DB00289 Adrenergic Uptake Inhibitors.Antidepressants.Central Nervous System Agents 57 0.497 185 4594 DB00338 Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 57 0.49 151 60835 DB00476 Adrenergic Uptake Inhibitors.Antidepressive Agents.Dopamine Uptake Inhibitors.Serotonin Uptake Inhibitors 57 0.476 137 3062316 DB01254 Protein Kinase Inhibitors 57 0.438 20 5775 DB00692 Adrenergic alpha-Antagonists.Antihypertensive Agents.Sympatholytics 57 0.437 50 3158 DB01142 Anti-anxiety Agents.Antidepressants.Antidepressive Agents, Tricyclic.Antipruritics.Histamine Antagonists.Norepinephrine-Reuptake Inhibitors 57 0.432 62 5650 DB00177 Angiotensin II Receptor Antagonists.Antihypertensive Agents 57 0.421 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 57 0.415 191 450 DB00783 Anti-menopausal Agents.Anticholesteremic Agents.Estrogens 57 0.402 151 41317 DB00459 Keratolytic Agents 57 0.393 131 4428 DB00704 Alcohol Antagonists.Anti-craving Agents.Depressants.Narcotic Antagonists.Opiate Antagonists 57 0.388 20 838 DB00668 Adrenergic Agonists.Adrenergic alpha-Agonists.Adrenergic beta-Agonists.Bronchodilator Agents.Mydriatics.Sympathomimetics.Vasoconstrictor Agents 57 0.374 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 57 0.374 101 3154 DB00869 Antihypertensive Agents.Carbonic Anhydrase Inhibitors 57 0.371 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 57 0.36 110 4212 DB01204 Analgesics.Antineoplastic Agents 57 0.358 103 5352 DB00605 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents.Cyclooxygenase Inhibitors 57 0.358 94 3403 DB01095 Anticholesteremic Agents.Antioxidants.Free Radical Scavengers.HMG-CoA Reductase Inhibitors.Hydroxymethylglutaryl-CoA Reductase Inhibitors 57 0.349 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 57 0.338 90 5152 DB00938 Adrenergic beta-Agonists.Bronchodilator Agents.Sympathomimetic 57 0.327 73 4493 DB00665 Androgen Antagonists.Antineoplastic Agents 57 0.32 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 57 0.319 92 3825 DB01009 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 57 0.315 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 57 0.307 144 3899 DB01097 Adjuvants.Anti-inflammatory Agents.Antineoplastic Agents.Antiparasitic Agents.Antirheumatic Agents.Antiviral Agents.Enzyme Inhibitors.Immunosuppressive Agents 57 0.306 76 123631 DB00317 Antineoplastic Agents.Protein Kinase Inhibitors 57 0.306 34 3827 DB00920 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists 57 0.303 62 59768 DB00187 Adrenergic beta-Antagonists 57 0.295 97 4200 DB01017 Anti-Bacterial Agents.Tetracyclines 57 0.293 12 4771 DB00191 Adrenergic Agents.Anorexigenic Agents.Appetite Depressants.Central Nervous System Agents.Central Nervous System Stimulants.Stimulants.Sympathomimetics 57 0.29 25 68844 DB01194 Antiglaucomic Agents.Carbonic Anhydrase Inhibitors.Ophthalmics 57 0.288 46 4036 DB00939 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 57 0.287 99 4889 DB00175 Anticholesteremic Agents.HMG-CoA Reductase Inhibitors.Hydroxymethylglutaryl-CoA Reductase Inhibitors 57 0.278 141 4819 DB01085 Cholinergic Agents.Miotics.Muscarinic Agonists 57 0.277 97 2541 DB00796 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 57 0.275 121 5408 DB00624 Androgens 57 0.273 81 5353980 DB00795 Anti-Infective Agents.Anti-Inflammatory Agents, Non-Steroidal.Antirheumatic Agents.Gastrointestinal Agents.Sulfonamides 57 0.272 15 681 DB00988 Cardiotonic Agents.Dopamine Agents.Sympathomimetic.Sympathomimetics 57 0.268 39 7029 DB00937 Anorexigenic Agents.Appetite Depressants.Stimulants 57 0.268 119 4052 DB00814 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Antiemetics.Antineoplastic Agents.Cyclooxygenase Inhibitors.Growth Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 57 0.268 120 82146 DB00307 Anticarcinogenic Agents 57 0.267 45 2216 DB00964 Adrenergic alpha-Agonists.Antiglaucomic Agents.EENT Drugs.Ophthalmics 57 0.267 61 2435 DB00484 Adrenergic alpha-Agonists.Antihypertensive Agents.EENT Drugs 57 0.266 54 4599 DB01083 Anti-Obesity Agents.Enzyme Inhibitors 57 0.26 72 2160 DB00321 Adrenergic Uptake Inhibitors.Analgesics, Non-Narcotic.Antidepressive Agents, Tricyclic 57 0.259 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 57 0.258 40 4547 DB00912 Hypoglycemic Agents.Meglitinides 57 0.258 75 2550 DB01197 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 57 0.258 43 5508 DB00500 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 57 0.256 102 83786 DB00437 Antimetabolites.Enzyme Inhibitors.Enzyme Inhibitors Antimetabolites.Free Radical Scavengers.Gout Suppressants 57 0.256 108 4856 DB00554 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 57 0.256 104 4614 DB00991 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Nonsteroidal Antiinflammatory Agents (NSAIDs) 57 0.256 119 3308 DB00749 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 57 0.256 89 4044 DB00784 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 57 0.255 70 2179 DB00276 Antineoplastic Agents.Intercalating Agents 57 0.255 71 3342 DB00573 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Propionic acid derivatives 57 0.253 79 176870 DB00530 Protein Kinase Inhibitors 57 0.25 172 4920 DB00396 Contraceptives.Progestins 57 0.247 125 3285 DB00977 Estrogens 57 0.246 64 5584 DB00726 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 57 0.245 45 6691 DB00682 Anticoagulants.Coumarin and Indandione Derivatives.Rodenticides 57 0.243 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens #### component 58: positive weight features and high scoring objects #### # positive weight on target proteins 58 0.646 19 OPRM_HUMAN Mu-type opioid receptor; 58 0.494 17 OPRD_HUMAN Delta-type opioid receptor; 58 0.457 16 OPRK_HUMAN Kappa-type opioid receptor; 58 0.112 9 GABR2_HUMAN Gamma-aminobutyric acid type B receptor subunit 2; 58 0.103 18 SCNNB_HUMAN Amiloride-sensitive sodium channel subunit beta; 58 0.103 18 SCNND_HUMAN Amiloride-sensitive sodium channel subunit delta; 58 0.103 18 SCNNG_HUMAN Amiloride-sensitive sodium channel subunit gamma; 58 0.078 38 ADRB1_HUMAN Beta-1 adrenergic receptor; 58 0.074 14 A1AG1_HUMAN Alpha-1-acid glycoprotein 1; 58 0.069 8 GBRR2_HUMAN Gamma-aminobutyric acid receptor subunit rho-2; 58 0.069 8 TSPOA_HUMAN Translocator protein; 58 0.066 35 DRD2_HUMAN D(2) dopamine receptor; 58 0.064 6 DRD4_HUMAN D(4) dopamine receptor; 58 0.058 11 A1AG2_HUMAN Alpha-1-acid glycoprotein 2; 58 0.051 28 DRD3_HUMAN D(3) dopamine receptor; 58 0.044 13 CAC1A_HUMAN Voltage-dependent P/Q-type calcium channel subunit alpha-1A; 58 0.042 18 GCR_HUMAN Glucocorticoid receptor; 58 0.041 9 OPRX_HUMAN Nociceptin receptor; 58 0.032 8 OGFR_HUMAN Opioid growth factor receptor; 58 0.03 23 GBRA2_HUMAN Gamma-aminobutyric acid receptor subunit alpha-2; 58 0.027 9 NMD3A_HUMAN Glutamate [NMDA] receptor subunit 3A; 58 0.018 28 DRD1_HUMAN D(1A) dopamine receptor; 58 0.011 14 RYR1_HUMAN Ryanodine receptor 1; 58 0.01 5 GLRA2_HUMAN Glycine receptor subunit alpha-2; 58 0.01 34 ADRB2_HUMAN Beta-2 adrenergic receptor; 58 0.01 5 GLRB_HUMAN Glycine receptor subunit beta; 58 0.009 15 KCNH2_HUMAN Potassium voltage-gated channel subfamily H member 2; 58 0.006 17 ACH10_HUMAN Neuronal acetylcholine receptor subunit alpha-10; 58 0.006 1 UD2B7_HUMAN UDP-glucuronosyltransferase 2B7; 58 0.006 1 CAN1_HUMAN Calpain-1 catalytic subunit; 58 0.005 16 TOP2A_HUMAN DNA topoisomerase 2-alpha; 58 0.004 8 GLRA1_HUMAN Glycine receptor subunit alpha-1; 58 0.004 13 CACB1_HUMAN Voltage-dependent L-type calcium channel subunit beta-1; 58 0.003 24 ADRB3_HUMAN Beta-3 adrenergic receptor; 58 0.002 11 ACES_HUMAN Acetylcholinesterase; # positive weight on side effects 58 0.587 130 cardiac arrest 58 0.288 20 drug dependence 58 0.275 50 rhinorrhea 58 0.189 57 hypoxia 58 0.175 137 convulsions 58 0.174 79 lightheadedness 58 0.159 133 bronchospasm 58 0.148 35 sneezing 58 0.147 301 confusion 58 0.126 236 allergic reaction 58 0.11 208 anaphylaxis 58 0.106 280 anxiety 58 0.105 27 abuse 58 0.1 58 nystagmus 58 0.06 280 hypertension 58 0.046 377 urticaria 58 0.039 10 drug withdrawal 58 0.037 28 hypoventilation 58 0.031 346 dyspnea 58 0.021 172 chills 58 0.013 159 increased sweating 58 0.004 301 dry mouth 58 0.004 125 dehydration # high scoring drugs for both targets and side effects 58 1.88 128 4253 DB00295 Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 58 1.609 183 3648 DB00327 Analgesics, Opioid.Narcotics 58 1.553 91 60815 DB00899 Analgesics, Opioid.Anesthetics, Intravenous.Hypnotics and Sedatives 58 1.534 131 4635 DB00497 Analgesics, Opioid.Antitussives.Narcotics.Opiate Agonists 58 1.217 23 51263 DB00802 Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 58 1.196 59 4095 DB00333 Analgesics.Analgesics, Opioid.Antitussive Agents.Antitussives.Narcotics.Opiate Agonists 58 1.041 47 4419 DB00844 Analgesics, Opioid.Narcotic Antagonists.Narcotics 58 0.976 131 4428 DB00704 Alcohol Antagonists.Anti-craving Agents.Depressants.Narcotic Antagonists.Opiate Antagonists 58 0.945 28 4058 DB00454 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 58 0.933 59 2476 DB00921 Analgesics, Opioid.Narcotic Antagonists.Narcotics 58 0.896 71 2487 DB00611 Analgesics, Opioid.Antitussive Agents.Narcotic Antagonists.Narcotics 58 0.888 33 4425 DB01183 Antinarcotic Agents.Depressants.Narcotic Antagonists.Opiate Antagonists 58 0.882 23 3821 DB01221 Analgesics.Anesthetics, Dissociative.Excitatory Amino Acid Antagonists.General Anesthetics 58 0.873 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 58 0.838 37 4736 DB00652 Adjuvants, Anesthesia.Analgesics, Opioid.Narcotic Antagonists.Narcotics 58 0.826 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 58 0.813 29 3954 DB00836 Antidiarrheals 58 0.777 102 4943 DB00818 Anesthetics, Intravenous.Anticonvulsants.Antiemetics.Free Radical Scavengers.Hypnotics and Sedatives 58 0.775 74 3676 DB00281 Anesthetics.Anesthetics, Local.Anti-Arrhythmia Agents.Antiarrhythmic Agents 58 0.76 91 3355 DB01195 Anti-Arrhythmia Agents.Antiarrhythmic Agents 58 0.734 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 58 0.733 23 41693 DB00708 Adjuvants, Anesthesia.Analgesics, Opioid.Anesthetics, Intravenous.Narcotics.Opiate Agonists 58 0.716 112 71273 DB00296 Anesthetics.Anesthetics, Local.Local Anesthetics 58 0.679 14 10100 DB00647 Analgesics.Analgesics, Opioid.Antitussives.Narcotics 58 0.658 84 3016 DB00829 Adjuvants, Anesthesia.Anesthetics, Intravenous.Anti-anxiety Agents.Anticonvulsants.Antiemetics.GABA Modulators.Hypnotics and Sedatives.Muscle Relaxants, Central 58 0.636 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 58 0.613 135 5544 DB00620 Adrenergic Agents.Anti-inflammatory Agents.Glucocorticoids 58 0.612 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 58 0.592 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 58 0.559 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 58 0.543 211 60953 DB01101 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Prodrugs 58 0.54 132 4739 DB00552 Antibiotics.Antineoplastic Agents.Enzyme Inhibitors.Immunosuppressive Agents 58 0.509 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 58 0.508 99 5478 DB00373 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents 58 0.501 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 58 0.489 119 4052 DB00814 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Antiemetics.Antineoplastic Agents.Cyclooxygenase Inhibitors.Growth Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 58 0.481 101 3154 DB00869 Antihypertensive Agents.Carbonic Anhydrase Inhibitors 58 0.481 65 2474 DB00297 Anesthetics, Local 58 0.477 94 4171 DB00264 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Sympatholytics 58 0.467 61 4946 DB00571 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Anti-anxiety Agents.Antiarrhythmic Agents.Antihypertensive Agents.Vasodilator Agents 58 0.464 106 2958 DB00694 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 58 0.454 78 2249 DB00335 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Sympatholytics 58 0.453 61 4192 DB00683 Adjuvants, Anesthesia.Anesthetics, Intravenous.Anti-anxiety Agents.GABA Modulators.Hypnotics and Sedatives 58 0.448 157 3937 DB00722 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents.Cardiotonic Agents 58 0.443 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 58 0.436 98 3222 DB00584 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 58 0.429 66 4053 DB01042 Antineoplastic Agents, Alkylating.Myeloablative Agonists 58 0.429 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 58 0.429 133 2802 DB01068 Anticonvulsants.Benzodiazepines.GABA Modulators 58 0.414 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 58 0.409 36 2141 DB01143 Radiation-Protective Agents 58 0.407 127 2156 DB01118 Anti-Arrhythmia Agents.Enzyme Inhibitors.Vasodilator Agents 58 0.405 36 4914 DB00721 Anesthetics.Anesthetics, Local.Local Anesthetics 58 0.4 44 191 DB00640 Analgesics.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Cardiac drugs.Vasodilator Agents 58 0.394 453 125889 DB00230 Analgesics.Anticonvulsants 58 0.394 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 58 0.387 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 58 0.386 54 4159 DB00959 Adrenergic Agents.Anti-inflammatory Agents.Antiemetics.Glucocorticoids.Neuroprotective Agents 58 0.384 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 58 0.384 74 4894 DB00860 Adrenergic Agents.Anti-inflammatory Agents.Antineoplastic Agents.Antineoplastic Agents, Hormonal.Glucocorticoids 58 0.382 150 1775 DB00252 Anticonvulsants 58 0.379 85 3385 DB00544 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Immunosuppressive Agents 58 0.378 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 58 0.37 76 3108 DB00975 Phosphodiesterase Inhibitors.Platelet Aggregation Inhibitors.Vasodilator Agents 58 0.363 46 3366 DB01099 Antifungal Agents.Antifungals.Antimetabolites 58 0.361 86 3003 DB01234 Adrenergic Agents.Anti-inflammatory Agents.Antiemetics.Antineoplastic Agents, Hormonal.Glucocorticoids 58 0.361 83 3640 DB00741 Anti-inflammatory Agents 58 0.357 201 5538 DB00755 Antineoplastic Agents.Cell Stimulants and Proliferants.Keratolytic Agents 58 0.344 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 58 0.344 51 48041 DB01228 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Sodium channel blockers 58 0.335 64 2726 DB00477 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 58 0.334 38 3914 DB01210 Adrenergic beta-Antagonists.EENT Drugs.Sympatholytics 58 0.331 211 93860 DB00188 Antineoplastic Agents.Protease Inhibitors 58 0.325 37 3494 DB00986 Adjuvants, Anesthesia.Anti-cholinergic Agents.Muscarinic Antagonists 58 0.324 55 2130 DB00915 Analgesics, Non-Narcotic.Antiparkinson Agents.Antiviral Agents.Dopamine Agents 58 0.323 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 58 0.321 89 3148 DB00757 Antiemetics.Serotonin Antagonists 58 0.318 46 163742 DB00569 Anticoagulants.Antithrombotics 58 0.315 97 1065 DB00908 Adrenergic alpha-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antimalarials.Enzyme Inhibitors.Muscarinic Antagonists 58 0.312 146 4158 DB00422 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Uptake Inhibitors.Sympathomimetics 58 0.311 75 4178 DB00379 Anti-Arrhythmia Agents 58 0.305 234 216326 DB00480 Antineoplastic Agents 58 0.303 31 2441 DB01558 Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 58 0.299 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 58 0.286 43 4913 DB01035 Anti-Arrhythmia Agents.Antiarrhythmic Agents 58 0.282 61 3114 DB00280 Anti-Arrhythmia Agents.Antiarrhythmic Agents 58 0.282 14 47319 DB00732 Neuromuscular Nondepolarizing Agents.Nicotinic Antagonists 58 0.278 110 4666 DB01229 Antineoplastic Agents.Antineoplastic Agents, Phytogenic.Tubulin Modulators 58 0.275 62 59768 DB00187 Adrenergic beta-Antagonists 58 0.274 68 942 DB00184 Anti-craving Agents.Autonomic drugs.Central Nervous System Agents.Ganglionic Stimulants.Nicotinic Agonists 58 0.258 143 4054 DB01043 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agents.Excitatory Amino Acid Antagonists 58 0.254 111 5281104 DB00910 Not Available 58 0.252 40 18140 DB01196 Antineoplastic Agents.Antineoplastic Agents, Alkylating.Antineoplastic Agents, Hormonal.Radiation-Protective Agents 58 0.24 21 5311082 DB00063 Anticoagulants.Antiplatelet Agents.Platelet Aggregation Inhibitors 58 0.236 88 3750 DB00762 Antineoplastic Agents.Antineoplastic Agents, Phytogenic.Enzyme Inhibitors.Parasympathomimetics.Prodrugs.Radiation-Sensitizing Agents 58 0.232 77 3379 DB00180 Anti-Asthmatic Agents.Anti-inflammatory Agents 58 0.227 61 60612 DB00633 Adrenergic alpha-Agonists.Analgesics.Analgesics, Non-Narcotic.Hypnotics and Sedatives 58 0.226 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 58 0.225 31 3062 DB00390 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Cardiotonic Agents.Enzyme Inhibitors 58 0.22 114 5379 DB01044 Anti-Infective Agents.Antibiotics #### component 59: positive weight features and high scoring objects #### # positive weight on target proteins 59 0.854 12 ACE_HUMAN Angiotensin-converting enzyme; 59 0.074 28 DRD1_HUMAN D(1A) dopamine receptor; 59 0.071 16 ANDR_HUMAN Androgen receptor; 59 0.061 35 DRD2_HUMAN D(2) dopamine receptor; # positive weight on side effects 59 0.111 13 pemphigus 59 0.081 40 renal insufficiency # high scoring drugs for both targets and side effects 59 0.976 3 175 DB04184 Indicators and Reagents 59 0.616 20 5775 DB00692 Adrenergic alpha-Antagonists.Antihypertensive Agents.Sympatholytics 59 0.589 19 3249 DB00153 Antihypocalcemic Agents.Antihypoparathyroid Agents.Bone Density Conservation Agents.Essential Vitamin.Vitamins.Vitamins (Vitamin D) 59 0.586 15 681 DB00988 Cardiotonic Agents.Dopamine Agents.Sympathomimetic.Sympathomimetics 59 0.584 16 4160 DB00624 Androgens 59 0.584 19 3387 DB01185 Anabolic Agents.Antineoplastic Agents, Hormonal 59 0.584 4 5878 DB00621 Anabolic Agents.Androgens 59 0.584 35 3397 DB00499 Androgen Antagonists.Antineoplastic Agents, Hormonal 59 0.555 31 2215 DB00714 Antidyskinetics.Antiparkinson Agents.Dopamine Agonists 59 0.549 14 951 DB00368 Adrenergic alpha-Agonists.Sympathomimetics.Vasoconstrictor Agents 59 0.549 10 4630253 DB00240 Anti-inflammatory Agents.Antipruritic Agents.Corticosteroids.Glucocorticoids 59 0.549 15 3739 DB04711 Contrast Media 59 0.549 10 47320 DB00565 Neuromuscular Blocking Agents 59 0.549 22 60164 DB00210 Anti-Inflammatory Agents, Non-Steroidal.Dermatologic Agents 59 0.549 9 3658 DB00557 Antipruritics.Anxiolytics sedatives and hypnotics.Histamine H1 Antagonists 59 0.549 14 2133 DB00288 Corticosteroids, topical 59 0.549 15 2370 DB01019 Muscarinic Agonists.Parasympathomimetics 59 0.549 3 6256 DB00432 Antimetabolites.Antiviral Agents 59 0.549 6 888 DB01378 Not Available 59 0.549 17 52421 DB01130 Anti Inflammatory.Anti-inflammatory Agents.Corticosteroid.Glucocorticoids.Steroidal 59 0.549 13 137 DB00855 Photosensitizing Agents 59 0.549 7 5359 DB00870 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 59 0.549 11 3117 DB00822 Alcohol Deterrents.Enzyme Inhibitors 59 0.549 16 3382 DB01047 Anti-Allergic Agents.Anti-inflammatory Agents.Glucocorticoids 59 0.549 21 5473385 DB00352 Antimetabolites, Antineoplastic 59 0.549 6 3780 DB00883 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 59 0.549 38 3914 DB01210 Adrenergic beta-Antagonists.EENT Drugs.Sympatholytics 59 0.549 10 3392 DB00846 Anti-inflammatory Agents.Glucocorticoids 59 0.549 6 12555 Not Available Not Available 59 0.549 16 3763 DB00753 Anesthetics.Anesthetics, Inhalation.General Anesthetics 59 0.549 14 36811 DB00841 Adrenergic beta-Agonists.Cardiotonic Agents.Sympathomimetic.Sympathomimetics 59 0.549 6 4908 DB01087 Antimalarial Agents.Antimalarials.Antiprotozoal Agents 59 0.549 20 667490 DB01033 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Immunosuppressive Agents.Nucleic Acid Synthesis Inhibitors.Purine analogues 59 0.549 18 2266 DB00548 Antineoplastic Agents.Dermatologic Agents 59 0.549 4 4768 DB00925 Adrenergic alpha-Antagonists.Antihypertensive Agents.Vasodilator Agents 59 0.549 8 3105 DB00449 Adrenergic Agonists.Ophthalmologicals.Sympathomimetics 59 0.549 14 2749 DB01188 Antifungal Agents 59 0.549 10 3226 DB00228 Anesthetics, Inhalation.General Anesthetics 59 0.549 16 2812 DB00257 Anti-Infective Agents, Local.Antifungal Agents.Growth Inhibitors 59 0.549 11 3375 DB00223 Anti-inflammatory Agents.Glucocorticoids 59 0.549 11 157922 DB00992 Antineoplastic Agents 59 0.549 3 247 DB04455 Gastrointestinal Agents.Lipotropic Agents 59 0.549 7 2551 DB00411 Analgesics, Non-Narcotic.Cardiotonic Agents.Cholinergic Agonists.Miotics 59 0.549 15 5582 DB01157 Antibiotics.Antifungal Agents.Antimetabolites, Antineoplastic.Antiprotozoals.Folic Acid Antagonists 59 0.549 10 4675 DB01337 Neuromuscular Nondepolarizing Agents.Nicotinic Antagonists 59 0.549 17 48175 DB00596 Anti-inflammatory Agents.Vasoconstrictor Agents 59 0.549 9 1148 DB00150 Antidepressive Agents, Second-Generation.Dietary supplement.Essential Amino Acids.Micronutrient 59 0.549 28 4058 DB00454 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 59 0.549 3 2484 DB01091 Antifungal Agents 59 0.549 8 2381 DB00810 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists.Parasympatholytics 59 0.549 11 2522 DB02300 Antipsoriatic Agents.Dermatologic Agents.Vitamin D3 Receptor inhibitor 59 0.549 18 3698 DB01427 Calcium Channel Blockers.Cardiotonic Agents.Phosphodiesterase Inhibitors.Vasodilator Agents 59 0.549 10 2712 DB00475 Adjuvants, Anesthesia.Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 59 0.549 16 5591 DB00197 Antineoplastic Agents.Fibrinolytic Agents.Hypoglycemic Agents.Platelet Aggregation Inhibitors.Vasodilator Agents 59 0.549 31 5052 DB00206 Adrenergic Uptake Inhibitors.Antihypertensive Agents.Antipsychotic Agents.Antipsychotics.Peripheral Adrenergic Inhibitors 59 0.549 31 3062 DB00390 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Cardiotonic Agents.Enzyme Inhibitors 59 0.549 9 232 DB00125 Conditionally Essential Amino Acids.Dietary supplement.Micronutrient 59 0.549 14 47319 DB00732 Neuromuscular Nondepolarizing Agents.Nicotinic Antagonists 59 0.549 10 4436 Not Available Not Available 59 0.549 20 838 DB00668 Adrenergic Agonists.Adrenergic alpha-Agonists.Adrenergic beta-Agonists.Bronchodilator Agents.Mydriatics.Sympathomimetics.Vasoconstrictor Agents 59 0.549 23 143 DB00650 Antianemic Agents.Antidote (to folic acid antagonists).Antineoplastic Adjuncts.Vitamin B Complex.Vitamins/minerals 59 0.549 10 271 DB01373 Not Available 59 0.549 39 5396 DB00444 Antineoplastic Agents.Enzyme Inhibitors.Nucleic Acid Synthesis Inhibitors 59 0.549 21 5267 DB00421 Aldosterone Antagonists.Diuretics 59 0.549 5 2283 DB00626 Anti-Bacterial Agents.Anti-Infective Agents, Local 59 0.549 13 36339 DB00292 Anesthetics, Intravenous.Hypnotics and Sedatives 59 0.549 12 4812 DB01022 Antifibrinolytic Agents.Vitamins.Vitamins (Vitamin K) 59 0.549 17 3000 DB00547 Anti-inflammatory Agents.Glucocorticoids 59 0.549 5 10548 DB01057 Cholinesterase Inhibitors.Miotics.Parasympathomimetics 59 0.549 7 5404 DB00251 Antifungal Agents.Antifungals 59 0.549 33 4425 DB01183 Antinarcotic Agents.Depressants.Narcotic Antagonists.Opiate Antagonists 59 0.549 11 5381 DB00799 Dermatologic Agents.Keratolytic Agents.Prodrugs.Teratogens 59 0.549 29 3759 DB01247 Antidepressants.Antidepressive Agents.Monoamine Oxidase Inhibitors 59 0.549 3 47641 DB00735 Anti-Inflammatory Agents, Non-Steroidal.Antifungal Agents 59 0.549 14 10100 DB00647 Analgesics.Analgesics, Opioid.Antitussives.Narcotics 59 0.549 6 4174 DB01011 Antimetabolites.Enzyme Inhibitors 59 0.549 10 5526 DB00302 Antifibrinolytic Agents 59 0.544 16 3168 DB00450 Adjuvants, Anesthesia.Antiemetics.Antipsychotic Agents.Dopamine Antagonists 59 0.539 108 3015 DB04839 Androgen Antagonists 59 0.538 9 861 DB00279 Hormone Replacement Agents 59 0.538 61 60612 DB00633 Adrenergic alpha-Agonists.Analgesics.Analgesics, Non-Narcotic.Hypnotics and Sedatives 59 0.538 36 2141 DB01143 Radiation-Protective Agents 59 0.538 12 60169 DB01334 Neuromuscular Nondepolarizing Agents 59 0.534 50 3657 DB01005 Antineoplastic Agents.Antisickling Agents.Enzyme Inhibitors.Nucleic Acid Synthesis Inhibitors 59 0.534 4 6503 DB03754 Buffers.Excipients 59 0.525 17 1206 DB01577 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Agents.Dopamine Uptake Inhibitors.Sympathomimetics 59 0.523 17 9904 DB00984 Anabolic Agents.Androgens 59 0.521 11 3251 DB00696 Adrenergic alpha-Agonists.Analgesics, Non-Narcotic.Sympatholytics.Vasoconstrictor Agents 59 0.518 26 3151 DB01184 Antiemetics.Dopamine Antagonists 59 0.515 37 6058 DB00847 Nephropathic cystinosis therapy.Radiation-Protective Agents 59 0.515 41 104758 DB00293 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Enzyme Inhibitors.Folic Acid Antagonists 59 0.514 14 104803 DB01226 Neuromuscular Nondepolarizing Agents 59 0.514 14 4993 DB00205 Antimalarials.Antiprotozoal Agents.Antiprotozoals.Folic Acid Antagonists 59 0.514 23 41693 DB00708 Adjuvants, Anesthesia.Analgesics, Opioid.Anesthetics, Intravenous.Narcotics.Opiate Agonists 59 0.514 27 1003 DB02831 Not Available 59 0.514 46 3685 DB01177 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 59 0.514 21 5546 DB00384 Diuretics.Potassium-sparing Diuretics 59 0.514 2 1071 DB00162 Anti-acne Agents.Essential Vitamin.Vitamins.Vitamins (Vitamin A) 59 0.514 21 60696 DB00728 Neuromuscular Nondepolarizing Agents.Skeletal Muscle Relaxants 59 0.514 38 3823 DB01026 Antifungal Agents.Antifungals #### component 60: positive weight features and high scoring objects #### # positive weight on target proteins 60 0.286 17 DB124_HUMAN Beta-defensin 124; 60 0.286 17 ACCN4_HUMAN Amiloride-sensitive cation channel 4; 60 0.286 17 SCN4A_HUMAN Sodium channel protein type 4 subunit alpha; 60 0.286 17 SCN4B_HUMAN Sodium channel subunit beta-4; 60 0.286 17 ACCN3_HUMAN Amiloride-sensitive cation channel 3; 60 0.286 17 EF1B_HUMAN Elongation factor 1-beta; 60 0.286 17 SCNAA_HUMAN Sodium channel protein type 10 subunit alpha; 60 0.286 17 SCN7A_HUMAN Sodium channel protein type 7 subunit alpha; 60 0.286 17 SCN3B_HUMAN Sodium channel subunit beta-3; 60 0.286 17 SCN3A_HUMAN Sodium channel protein type 3 subunit alpha; 60 0.286 17 SCN1B_HUMAN Sodium channel subunit beta-1; 60 0.18 18 SCNNG_HUMAN Amiloride-sensitive sodium channel subunit gamma; 60 0.18 18 SCNNB_HUMAN Amiloride-sensitive sodium channel subunit beta; 60 0.18 18 SCNND_HUMAN Amiloride-sensitive sodium channel subunit delta; 60 0.007 9 GABR2_HUMAN Gamma-aminobutyric acid type B receptor subunit 2; # positive weight on side effects 60 0.576 131 diplopia 60 0.367 9 apraxia 60 0.315 12 arachnoiditis 60 0.297 13 strabismus 60 0.297 13 movement disorders 60 0.223 166 purpura 60 0.181 109 neuropathy 60 0.16 20 lymphocytosis 60 0.159 20 facial paralysis 60 0.153 52 menorrhagia 60 0.147 59 alkaline phosphatase increased 60 0.144 304 Dyspepsia 60 0.121 52 hirsutism 60 0.106 253 back pain 60 0.1 23 Vestibular Disorders 60 0.098 40 fecal incontinence 60 0.09 331 pain 60 0.054 38 ptosis 60 0.042 159 increased sweating 60 0.03 64 mouth ulceration # high scoring drugs for both targets and side effects 60 3.205 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 60 2.943 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 60 2.772 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 60 2.499 135 5734 DB00909 Anticonvulsants.Antioxidants 60 2.337 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 60 2.254 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 60 2.23 112 71273 DB00296 Anesthetics.Anesthetics, Local.Local Anesthetics 60 2.184 74 3676 DB00281 Anesthetics.Anesthetics, Local.Anti-Arrhythmia Agents.Antiarrhythmic Agents 60 2.112 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 60 2.091 91 3355 DB01195 Anti-Arrhythmia Agents.Antiarrhythmic Agents 60 2.032 150 1775 DB00252 Anticonvulsants 60 2.0 61 3114 DB00280 Anti-Arrhythmia Agents.Antiarrhythmic Agents 60 1.979 51 48041 DB01228 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Sodium channel blockers 60 1.877 95 16231 DB00594 Diuretics.Sodium channel blockers 60 1.732 36 4914 DB00721 Anesthetics.Anesthetics, Local.Local Anesthetics 60 1.712 75 4178 DB00379 Anti-Arrhythmia Agents 60 1.62 43 4913 DB01035 Anti-Arrhythmia Agents.Antiarrhythmic Agents 60 1.237 453 125889 DB00230 Analgesics.Anticonvulsants 60 1.088 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 60 0.913 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 60 0.791 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 60 0.791 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 60 0.779 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 60 0.773 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 60 0.772 196 1935 DB00382 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 60 0.734 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 60 0.707 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 60 0.677 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 60 0.67 167 5719 DB00962 Anticonvulsants.Anxiolytics sedatives and hypnotics.Hypnotics and Sedatives 60 0.659 161 122316 DB01367 Monoamine Oxidase Inhibitors.Neuroprotective Agents 60 0.643 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 60 0.622 120 2284 DB00181 GABA Agonists.Muscle Relaxants.Muscle Relaxants, Central.Skeletal Muscle Relaxants 60 0.615 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 60 0.608 149 5394 DB00853 Antineoplastic Agents.Antineoplastic Agents, Alkylating 60 0.593 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 60 0.579 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 60 0.558 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 60 0.55 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 60 0.536 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 60 0.521 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 60 0.516 154 3157 DB00590 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Anticholesteremic Agents.Antihypertensive Agents.Vasodilator Agents 60 0.514 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 60 0.507 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 60 0.506 172 4920 DB00396 Contraceptives.Progestins 60 0.489 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 60 0.435 147 71158 DB00659 Alcohol Deterrents 60 0.433 199 5358 DB00669 Selective Serotonin Agonists.Serotonin Agonists.Vasoconstrictor Agents 60 0.43 99 4889 DB00175 Anticholesteremic Agents.HMG-CoA Reductase Inhibitors.Hydroxymethylglutaryl-CoA Reductase Inhibitors 60 0.422 158 34312 DB00776 Anticonvulsants 60 0.396 154 27661 DB01020 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 60 0.396 84 5978 DB00541 Antineoplastic Agents.Antineoplastic Agents, Phytogenic.Tubulin Modulators 60 0.394 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 60 0.392 105 4659568 DB00494 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Enzyme Inhibitors 60 0.388 84 3016 DB00829 Adjuvants, Anesthesia.Anesthetics, Intravenous.Anti-anxiety Agents.Anticonvulsants.Antiemetics.GABA Modulators.Hypnotics and Sedatives.Muscle Relaxants, Central 60 0.379 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 60 0.373 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 60 0.371 128 3793 DB01167 Antifungal Agents.Antifungals.Antiprotozoal Agents.Antiprotozoals 60 0.368 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 60 0.356 146 3075 DB00343 Antihypertensive Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Cardiovascular Agents.Vasodilator Agents 60 0.355 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 60 0.343 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists 60 0.34 135 5544 DB00620 Adrenergic Agents.Anti-inflammatory Agents.Glucocorticoids 60 0.339 65 2474 DB00297 Anesthetics, Local 60 0.337 185 4594 DB00338 Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 60 0.331 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 60 0.331 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 60 0.326 146 3475 DB01120 Hypoglycemic Agents.Sulfonylureas 60 0.326 188 5040 DB00877 Anti-Bacterial Agents.Antibiotics, Antineoplastic.Antifungal Agents.Antifungals.Immunosuppressive Agents 60 0.325 101 3154 DB00869 Antihypertensive Agents.Carbonic Anhydrase Inhibitors 60 0.319 151 41317 DB00459 Keratolytic Agents 60 0.319 90 2162 DB00381 Antianginals.Antihypertensive Agents.Calcium Channel Blockers.Vasodilator Agents 60 0.319 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 60 0.319 132 3948 DB00978 Anti-Infective Agents.Anti-Infective Agents, Urinary.Antitubercular Agents.Photosensitizing Agents 60 0.313 234 216326 DB00480 Antineoplastic Agents 60 0.305 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 60 0.301 133 2802 DB01068 Anticonvulsants.Benzodiazepines.GABA Modulators 60 0.298 146 4158 DB00422 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Uptake Inhibitors.Sympathomimetics 60 0.298 59 5665 DB01080 Anticonvulsants.Enzyme Inhibitors.GABA Agents 60 0.293 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 60 0.292 161 5212 DB00203 Phosphodiesterase Inhibitors.Vasodilator Agents 60 0.289 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 60 0.284 100 2578 DB00262 Antineoplastic Agents.Antineoplastic Agents, Alkylating 60 0.28 142 3826 DB00465 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 60 0.277 145 3672 DB01050 Analgesics.Analgesics, Non-Narcotic.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 60 0.277 211 93860 DB00188 Antineoplastic Agents.Protease Inhibitors 60 0.274 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 60 0.272 99 5478 DB00373 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents 60 0.267 104 3449 DB00674 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 60 0.264 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 60 0.263 147 5645 DB01586 Cholagogues and Choleretics 60 0.263 236 10631 DB00603 Contraceptives.Contraceptives, Oral, Synthetic.Progestins 60 0.261 211 60953 DB01101 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Prodrugs 60 0.26 157 4659569 DB00323 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Enzyme Inhibitors 60 0.249 264 5372 DB00864 Immunosuppressive Agents 60 0.236 151 60835 DB00476 Adrenergic Uptake Inhibitors.Antidepressive Agents.Dopamine Uptake Inhibitors.Serotonin Uptake Inhibitors 60 0.232 143 4054 DB01043 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agents.Excitatory Amino Acid Antagonists 60 0.231 60 3373 DB01205 Antidotes.GABA Modulators 60 0.221 71 3342 DB00573 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Propionic acid derivatives 60 0.215 137 2462 DB01222 Anti-inflammatory Agents.Bronchodilator Agents.Corticosteroids.Glucocorticoids 60 0.21 61 4192 DB00683 Adjuvants, Anesthesia.Anesthetics, Intravenous.Anti-anxiety Agents.GABA Modulators.Hypnotics and Sedatives #### component 61: positive weight features and high scoring objects #### # positive weight on target proteins 61 0.581 18 SCN5A_HUMAN Sodium channel protein type 5 subunit alpha; 61 0.49 15 KCNH2_HUMAN Potassium voltage-gated channel subfamily H member 2; 61 0.146 17 ACCN3_HUMAN Amiloride-sensitive cation channel 3; 61 0.146 17 SCN4B_HUMAN Sodium channel subunit beta-4; 61 0.146 17 DB124_HUMAN Beta-defensin 124; 61 0.146 17 ACCN4_HUMAN Amiloride-sensitive cation channel 4; 61 0.146 17 SCN4A_HUMAN Sodium channel protein type 4 subunit alpha; 61 0.146 17 SCN3B_HUMAN Sodium channel subunit beta-3; 61 0.146 17 EF1B_HUMAN Elongation factor 1-beta; 61 0.146 17 SCNAA_HUMAN Sodium channel protein type 10 subunit alpha; 61 0.146 17 SCN7A_HUMAN Sodium channel protein type 7 subunit alpha; 61 0.146 17 SCN3A_HUMAN Sodium channel protein type 3 subunit alpha; 61 0.146 17 SCN1B_HUMAN Sodium channel subunit beta-1; 61 0.138 6 DRD4_HUMAN D(4) dopamine receptor; 61 0.108 5 SCN1A_HUMAN Sodium channel protein type 1 subunit alpha; 61 0.089 18 SCNNG_HUMAN Amiloride-sensitive sodium channel subunit gamma; 61 0.089 18 SCNNB_HUMAN Amiloride-sensitive sodium channel subunit beta; 61 0.089 18 SCNND_HUMAN Amiloride-sensitive sodium channel subunit delta; 61 0.082 8 AGTR1_HUMAN Type-1 angiotensin II receptor; 61 0.039 6 ANGT_HUMAN Angiotensinogen; 61 0.02 5 ATP4A_HUMAN Potassium-transporting ATPase alpha chain 1; 61 0.001 9 GABR2_HUMAN Gamma-aminobutyric acid type B receptor subunit 2; # positive weight on side effects 61 0.459 331 pain 61 0.444 274 palpitations 61 0.392 280 chest pain 61 0.323 191 hepatitis 61 0.269 320 fatigue 61 0.247 146 abnormal vision 61 0.207 52 ventricular fibrillation 61 0.203 233 tinnitus 61 0.164 280 myalgia 61 0.144 298 asthenia 61 0.134 87 liver function tests abnormal 61 0.13 355 abdominal pain 61 0.115 143 Stevens Johnson syndrome 61 0.067 41 bundle branch block 61 0.065 43 elevated liver enzymes 61 0.054 19 positive ANA 61 0.051 62 ventricular extrasystoles 61 0.049 326 paresthesia 61 0.041 12 sinus arrest 61 0.033 105 leg cramps 61 0.033 31 lymphoma 61 0.021 29 sinus bradycardia 61 0.012 198 Sinusitis 61 0.001 101 esophagitis 61 0.001 136 renal failure # high scoring drugs for both targets and side effects 61 2.275 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 61 2.181 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 61 1.978 91 3355 DB01195 Anti-Arrhythmia Agents.Antiarrhythmic Agents 61 1.956 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 61 1.949 51 48041 DB01228 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Sodium channel blockers 61 1.856 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 61 1.853 75 4178 DB00379 Anti-Arrhythmia Agents 61 1.784 150 1775 DB00252 Anticonvulsants 61 1.648 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 61 1.567 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 61 1.537 181 4932 DB01182 Anti-Arrhythmia Agents 61 1.5 135 5734 DB00909 Anticonvulsants.Antioxidants 61 1.368 97 1065 DB00908 Adrenergic alpha-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antimalarials.Enzyme Inhibitors.Muscarinic Antagonists 61 1.307 95 16231 DB00594 Diuretics.Sodium channel blockers 61 1.204 61 3114 DB00280 Anti-Arrhythmia Agents.Antiarrhythmic Agents 61 1.002 43 4913 DB01035 Anti-Arrhythmia Agents.Antiarrhythmic Agents 61 0.99 157 3937 DB00722 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents.Cardiotonic Agents 61 0.981 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 61 0.96 135 2585 DB01136 Adrenergic Agents.Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 61 0.94 73 2769 DB00604 Anti-Ulcer Agents.Gastrointestinal Agents.Prokinetic Agents.Serotonin Agonists 61 0.935 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 61 0.93 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 61 0.92 112 71273 DB00296 Anesthetics.Anesthetics, Local.Local Anesthetics 61 0.91 264 5372 DB00864 Immunosuppressive Agents 61 0.908 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 61 0.905 158 34312 DB00776 Anticonvulsants 61 0.899 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 61 0.894 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 61 0.891 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 61 0.887 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 61 0.884 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 61 0.868 152 60184 DB00790 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 61 0.868 74 3676 DB00281 Anesthetics.Anesthetics, Local.Anti-Arrhythmia Agents.Antiarrhythmic Agents 61 0.863 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 61 0.86 453 125889 DB00230 Analgesics.Anticonvulsants 61 0.852 103 2751 DB01340 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 61 0.847 131 3961 DB00678 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents 61 0.842 154 3157 DB00590 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Anticholesteremic Agents.Antihypertensive Agents.Vasodilator Agents 61 0.842 73 34633 DB00680 Anti-Arrhythmia Agents 61 0.829 144 3702 DB00808 Antihypertensive Agents.Diuretics 61 0.825 185 4594 DB00338 Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 61 0.825 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 61 0.815 137 62959 DB00685 Anti-Infective Agents.Anti-Infectives.Fluoroquinolones 61 0.809 90 2162 DB00381 Antianginals.Antihypertensive Agents.Calcium Channel Blockers.Vasodilator Agents 61 0.795 128 2250 DB01076 Anticholesteremic Agents.Hydroxymethylglutaryl-CoA Reductase Inhibitors 61 0.783 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 61 0.774 142 2678 DB00341 Anti-Allergic Agents.Antihistamines.Histamine H1 Antagonists, Non-Sedating 61 0.774 191 450 DB00783 Anti-menopausal Agents.Anticholesteremic Agents.Estrogens 61 0.774 172 4920 DB00396 Contraceptives.Progestins 61 0.77 111 3419 DB00492 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 61 0.766 134 3339 DB01039 Antilipemic Agents.Fribic Acid Derivatives 61 0.759 201 5538 DB00755 Antineoplastic Agents.Cell Stimulants and Proliferants.Keratolytic Agents 61 0.758 146 3475 DB01120 Hypoglycemic Agents.Sulfonylureas 61 0.748 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 61 0.747 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 61 0.734 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 61 0.731 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 61 0.731 76 3108 DB00975 Phosphodiesterase Inhibitors.Platelet Aggregation Inhibitors.Vasodilator Agents 61 0.728 116 5525 DB00519 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 61 0.716 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 61 0.715 68 110635 DB00820 Phosphodiesterase Inhibitors.Vasoconstrictor Agents 61 0.711 104 3449 DB00674 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 61 0.707 141 4819 DB01085 Cholinergic Agents.Miotics.Muscarinic Agonists 61 0.705 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 61 0.701 147 71158 DB00659 Alcohol Deterrents 61 0.699 117 2405 DB00612 Adrenergic Agents.Adrenergic beta-Antagonists.Antihypertensive Agents.Sympatholytics 61 0.697 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 61 0.693 128 3793 DB01167 Antifungal Agents.Antifungals.Antiprotozoal Agents.Antiprotozoals 61 0.685 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 61 0.681 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 61 0.678 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 61 0.675 97 2541 DB00796 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 61 0.671 137 3062316 DB01254 Protein Kinase Inhibitors 61 0.669 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 61 0.661 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 61 0.66 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 61 0.656 199 5358 DB00669 Selective Serotonin Agonists.Serotonin Agonists.Vasoconstrictor Agents 61 0.655 109 60879 DB00876 Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 61 0.655 89 3148 DB00757 Antiemetics.Serotonin Antagonists 61 0.653 127 2156 DB01118 Anti-Arrhythmia Agents.Enzyme Inhibitors.Vasodilator Agents 61 0.653 118 65999 DB00966 Angiotensin II Type 1 Receptor Blockers.Angiotensin-converting Enzyme Inhibitors 61 0.648 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 61 0.647 87 5005 DB00881 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 61 0.646 147 5645 DB01586 Cholagogues and Choleretics 61 0.645 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 61 0.642 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 61 0.64 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 61 0.639 146 3075 DB00343 Antihypertensive Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Cardiovascular Agents.Vasodilator Agents 61 0.635 146 4158 DB00422 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Uptake Inhibitors.Sympathomimetics 61 0.634 72 4893 DB00457 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Antihypertensive Agents 61 0.63 154 27661 DB01020 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 61 0.62 99 4889 DB00175 Anticholesteremic Agents.HMG-CoA Reductase Inhibitors.Hydroxymethylglutaryl-CoA Reductase Inhibitors 61 0.613 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 61 0.61 65 5253 DB00489 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Sympatholytics 61 0.609 131 4428 DB00704 Alcohol Antagonists.Anti-craving Agents.Depressants.Narcotic Antagonists.Opiate Antagonists 61 0.606 123 2806 DB00758 Antiplatelet Agents.Fibrinolytic Agents.Platelet Aggregation Inhibitors 61 0.606 39 37393 DB01218 Antimalarials.Antiprotozoals 61 0.604 132 3948 DB00978 Anti-Infective Agents.Anti-Infective Agents, Urinary.Antitubercular Agents.Photosensitizing Agents 61 0.603 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 61 0.603 76 4170 DB00524 Antihypertensive Agents.Diuretics.Diuretics, Sulfamyl #### component 62: positive weight features and high scoring objects #### # positive weight on target proteins 62 0.669 8 HMDH_HUMAN 3-hydroxy-3-methylglutaryl-coenzyme A reductase; 62 0.399 8 AGTR1_HUMAN Type-1 angiotensin II receptor; 62 0.355 5 PPARA_HUMAN Peroxisome proliferator-activated receptor alpha; 62 0.296 6 ANGT_HUMAN Angiotensinogen; 62 0.189 9 TNFA_HUMAN Tumor necrosis factor; 62 0.159 5 VEGFA_HUMAN Vascular endothelial growth factor A; 62 0.147 26 SC6A4_HUMAN Sodium-dependent serotonin transporter; 62 0.139 6 CRP_HUMAN C-reactive protein; 62 0.079 2 CODA1_HUMAN Collagen alpha-1(XIII) chain; 62 0.079 2 RHOA_HUMAN Transforming protein RhoA; 62 0.074 3 CCL2_HUMAN C-C motif chemokine 2; 62 0.072 10 SO1B1_HUMAN Solute carrier organic anion transporter family member 1B1; 62 0.06 2 RAC1_HUMAN Ras-related C3 botulinum toxin substrate 1; 62 0.059 4 PAI1_HUMAN Plasminogen activator inhibitor 1; 62 0.053 3 PPIA_HUMAN Peptidyl-prolyl cis-trans isomerase A; 62 0.032 6 DRD4_HUMAN D(4) dopamine receptor; 62 0.022 4 PGFRB_HUMAN Beta-type platelet-derived growth factor receptor; 62 0.022 4 KIT_HUMAN Mast/stem cell growth factor receptor; 62 0.019 3 IL8_HUMAN Interleukin-8; 62 0.006 9 GABR2_HUMAN Gamma-aminobutyric acid type B receptor subunit 2; 62 0.005 5 ATP4A_HUMAN Potassium-transporting ATPase alpha chain 1; # positive weight on side effects 62 0.589 56 rhabdomyolysis 62 0.45 222 flatulence 62 0.305 135 muscle cramps 62 0.27 53 myopathy 62 0.27 38 myositis 62 0.198 205 angioedema 62 0.149 144 gastritis 62 0.143 262 anemia 62 0.138 85 peripheral neuropathy 62 0.123 187 photosensitivity 62 0.116 191 hepatitis 62 0.108 304 Dyspepsia 62 0.107 377 constipation 62 0.106 84 muscle weakness 62 0.104 282 arthralgia 62 0.097 377 urticaria 62 0.094 113 eczema 62 0.077 298 asthenia 62 0.071 280 myalgia 62 0.062 270 alopecia 62 0.047 163 pancreatitis 62 0.027 317 thrombocytopenia 62 0.006 139 arthritis # high scoring drugs for both targets and side effects 62 2.405 128 2250 DB01076 Anticholesteremic Agents.Hydroxymethylglutaryl-CoA Reductase Inhibitors 62 2.257 80 54454 DB00641 Anticholesteremic Agents.Antilipemic Agents.Hydroxymethylglutaryl-CoA Reductase Inhibitors 62 1.636 94 3403 DB01095 Anticholesteremic Agents.Antioxidants.Free Radical Scavengers.HMG-CoA Reductase Inhibitors.Hydroxymethylglutaryl-CoA Reductase Inhibitors 62 1.532 87 2676 DB00439 Anticholesteremic Agents.Antilipemic Agents.Hydroxymethylglutaryl-CoA Reductase Inhibitors 62 1.516 99 4889 DB00175 Anticholesteremic Agents.HMG-CoA Reductase Inhibitors.Hydroxymethylglutaryl-CoA Reductase Inhibitors 62 1.476 41 39042 DB01393 Antilipemic Agents 62 1.39 70 4475485 DB01098 Anticholesteremic Agents.HMG-CoA Reductase Inhibitors.Hydroxymethylglutaryl-CoA Reductase Inhibitors 62 1.39 131 3961 DB00678 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents 62 1.326 77 3962 DB00227 Anticholesteremic Agents.Antineoplastic Agents.HMG-CoA Reductase Inhibitors.Hydroxymethylglutaryl-CoA Reductase Inhibitors 62 1.288 82 3749 DB01029 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 62 1.28 171 2909 DB00091 Antifungal Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Immunomodulatory Agents.Immunosuppressive Agents 62 1.263 118 65999 DB00966 Angiotensin II Type 1 Receptor Blockers.Angiotensin-converting Enzyme Inhibitors 62 1.238 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 62 1.224 134 3339 DB01039 Antilipemic Agents.Fribic Acid Derivatives 62 1.176 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 62 1.169 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 62 1.149 62 5650 DB00177 Angiotensin II Receptor Antagonists.Antihypertensive Agents 62 1.09 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 62 1.044 453 125889 DB00230 Analgesics.Anticonvulsants 62 1.041 109 60879 DB00876 Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 62 1.037 144 3702 DB00808 Antihypertensive Agents.Diuretics 62 1.034 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 62 1.03 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 62 0.978 60 3463 DB01241 Antilipemic Agents.Fribic Acid Derivatives 62 0.959 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 62 0.939 215 60787 DB01232 Anti-HIV Agents.HIV Protease Inhibitors 62 0.935 97 2541 DB00796 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 62 0.919 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 62 0.916 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 62 0.915 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 62 0.894 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 62 0.887 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 62 0.864 201 5538 DB00755 Antineoplastic Agents.Cell Stimulants and Proliferants.Keratolytic Agents 62 0.847 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 62 0.843 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 62 0.841 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 62 0.841 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 62 0.828 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 62 0.807 61 5402 DB00857 Allylamines.Antifungal Agents.Antifungals.Enzyme Inhibitors.Trypanocidal Agents 62 0.791 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 62 0.786 151 60835 DB00476 Adrenergic Uptake Inhibitors.Antidepressive Agents.Dopamine Uptake Inhibitors.Serotonin Uptake Inhibitors 62 0.783 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 62 0.78 137 3062316 DB01254 Protein Kinase Inhibitors 62 0.759 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 62 0.757 157 3937 DB00722 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents.Cardiotonic Agents 62 0.755 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 62 0.752 154 5090 DB00533 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase 2 Inhibitors.Cyclooxygenase Inhibitors 62 0.744 172 4920 DB00396 Contraceptives.Progestins 62 0.736 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 62 0.712 264 5372 DB00864 Immunosuppressive Agents 62 0.708 167 170361 DB01273 Nicotinic Agonists 62 0.693 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 62 0.69 144 3899 DB01097 Adjuvants.Anti-inflammatory Agents.Antineoplastic Agents.Antiparasitic Agents.Antirheumatic Agents.Antiviral Agents.Enzyme Inhibitors.Immunosuppressive Agents 62 0.685 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 62 0.678 161 5291 DB00619 Antineoplastic Agents.Protein Kinase Inhibitors 62 0.662 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 62 0.662 123 2806 DB00758 Antiplatelet Agents.Fibrinolytic Agents.Platelet Aggregation Inhibitors 62 0.658 137 62959 DB00685 Anti-Infective Agents.Anti-Infectives.Fluoroquinolones 62 0.654 68 5596 DB00209 Analgesics.Parasympatholytics 62 0.653 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 62 0.639 199 5358 DB00669 Selective Serotonin Agonists.Serotonin Agonists.Vasoconstrictor Agents 62 0.625 90 2162 DB00381 Antianginals.Antihypertensive Agents.Calcium Channel Blockers.Vasodilator Agents 62 0.622 154 27661 DB01020 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 62 0.621 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 62 0.618 145 3672 DB01050 Analgesics.Analgesics, Non-Narcotic.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 62 0.615 146 3075 DB00343 Antihypertensive Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Cardiovascular Agents.Vasodilator Agents 62 0.607 91 937 DB00627 Antilipemic Agents.Vasodilator Agents.Vitamin B Complex.Vitamins (Vitamin B Complex) 62 0.604 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 62 0.602 103 5352 DB00605 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents.Cyclooxygenase Inhibitors 62 0.602 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 62 0.6 127 2156 DB01118 Anti-Arrhythmia Agents.Enzyme Inhibitors.Vasodilator Agents 62 0.591 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 62 0.59 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 62 0.579 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 62 0.575 105 4659568 DB00494 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Enzyme Inhibitors 62 0.569 74 130881 DB00275 Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 62 0.569 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 62 0.569 147 71158 DB00659 Alcohol Deterrents 62 0.539 116 5525 DB00519 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 62 0.537 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 62 0.527 90 5329102 DB01268 Angiogenesis Inhibitors.Antineoplastic Agents 62 0.525 129 5210 DB01105 Anorexigenic Agents.Antidepressants.Antidepressive Agents.Appetite Depressants.Stimulants 62 0.519 133 2802 DB01068 Anticonvulsants.Benzodiazepines.GABA Modulators 62 0.51 181 4932 DB01182 Anti-Arrhythmia Agents 62 0.508 135 2585 DB01136 Adrenergic Agents.Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 62 0.508 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 62 0.502 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 62 0.492 191 450 DB00783 Anti-menopausal Agents.Anticholesteremic Agents.Estrogens 62 0.49 41 5493444 DB01258 Antihypertensive Agents 62 0.488 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 62 0.487 161 5487 DB00697 Adrenergic alpha-Agonists.Analgesics.Anticonvulsants.Muscle Relaxants.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 62 0.481 166 3394 DB00712 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Carbonic Anhydrase Inhibitors.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 62 0.477 167 5719 DB00962 Anticonvulsants.Anxiolytics sedatives and hypnotics.Hypnotics and Sedatives 62 0.475 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 62 0.473 146 4158 DB00422 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Uptake Inhibitors.Sympathomimetics 62 0.471 154 3157 DB00590 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Anticholesteremic Agents.Antihypertensive Agents.Vasodilator Agents 62 0.47 132 3948 DB00978 Anti-Infective Agents.Anti-Infective Agents, Urinary.Antitubercular Agents.Photosensitizing Agents 62 0.464 150 1775 DB00252 Anticonvulsants 62 0.462 112 151165 DB00673 Antiemetics 62 0.46 73 3333 DB01023 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Calcium Channel Blockers.Dihydropyridines.Vasodilator Agents #### component 63: positive weight features and high scoring objects #### # positive weight on target proteins 63 0.527 28 DRD3_HUMAN D(3) dopamine receptor; 63 0.49 35 DRD2_HUMAN D(2) dopamine receptor; 63 0.423 16 TOP2A_HUMAN DNA topoisomerase 2-alpha; 63 0.323 6 DRD4_HUMAN D(4) dopamine receptor; 63 0.267 28 DRD1_HUMAN D(1A) dopamine receptor; 63 0.24 21 DRD5_HUMAN D(1B) dopamine receptor; 63 0.121 3 PPIA_HUMAN Peptidyl-prolyl cis-trans isomerase A; 63 0.064 5 ATP4A_HUMAN Potassium-transporting ATPase alpha chain 1; 63 0.056 13 CAC1A_HUMAN Voltage-dependent P/Q-type calcium channel subunit alpha-1A; 63 0.048 26 SC6A4_HUMAN Sodium-dependent serotonin transporter; 63 0.04 2 PPIE_HUMAN Peptidyl-prolyl cis-trans isomerase E; 63 0.04 2 PPIL3_HUMAN Peptidyl-prolyl cis-trans isomerase-like 3; 63 0.04 2 FKBP5_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP5; 63 0.04 2 FKBP2_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP2; 63 0.04 2 FKB14_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP14; 63 0.04 2 FKB10_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP10; 63 0.04 2 FKB11_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP11; 63 0.04 2 FKBP8_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP8; 63 0.04 2 PPIC_HUMAN Peptidyl-prolyl cis-trans isomerase C; 63 0.04 2 PIN1_HUMAN Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; 63 0.04 2 PPIB_HUMAN Peptidyl-prolyl cis-trans isomerase B; 63 0.04 2 PPID_HUMAN Peptidyl-prolyl cis-trans isomerase D; 63 0.04 2 PPIF_HUMAN Peptidyl-prolyl cis-trans isomerase F, mitochondrial; 63 0.04 2 FKB1B_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP1B; 63 0.04 2 PPIL2_HUMAN Peptidyl-prolyl cis-trans isomerase-like 2; 63 0.04 2 FKBP6_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP6; 63 0.04 2 FKBP3_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP3; 63 0.04 2 PPIG_HUMAN Peptidyl-prolyl cis-trans isomerase G; 63 0.04 2 FKBP9_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP9; 63 0.04 2 PPIL1_HUMAN Peptidyl-prolyl cis-trans isomerase-like 1; 63 0.04 2 PIN4_HUMAN Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4; 63 0.04 2 FKBP7_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP7; 63 0.04 2 FKBP4_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP4; 63 0.013 3 FKB1A_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP1A; 63 0.006 9 GABR2_HUMAN Gamma-aminobutyric acid type B receptor subunit 2; # positive weight on side effects 63 0.5 81 hyperuricemia 63 0.453 67 skin ulcer 63 0.359 87 thrombophlebitis 63 0.28 30 fungal dermatitis 63 0.27 67 gingivitis 63 0.255 35 thrombocythemia 63 0.179 56 hyperlipidemia 63 0.167 102 hyponatremia 63 0.165 29 tooth caries 63 0.153 331 pain 63 0.139 30 hypochromic anemia 63 0.123 85 hiccup 63 0.12 125 dehydration 63 0.114 330 anorexia 63 0.098 90 gout 63 0.088 99 photophobia 63 0.05 75 deafness 63 0.029 30 hypothermia 63 0.019 191 peripheral edema # high scoring drugs for both targets and side effects 63 2.197 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 63 2.046 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 63 1.988 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 63 1.914 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 63 1.848 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 63 1.824 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 63 1.758 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 63 1.696 188 5040 DB00877 Anti-Bacterial Agents.Antibiotics, Antineoplastic.Antifungal Agents.Antifungals.Immunosuppressive Agents 63 1.577 264 5372 DB00864 Immunosuppressive Agents 63 1.536 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 63 1.522 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 63 1.456 453 125889 DB00230 Analgesics.Anticonvulsants 63 1.409 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 63 1.312 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 63 1.229 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 63 1.124 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 63 1.094 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 63 1.057 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 63 0.995 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 63 0.993 137 62959 DB00685 Anti-Infective Agents.Anti-Infectives.Fluoroquinolones 63 0.974 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 63 0.956 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 63 0.915 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 63 0.901 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 63 0.874 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 63 0.862 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 63 0.855 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 63 0.808 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 63 0.787 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 63 0.778 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 63 0.775 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 63 0.764 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 63 0.755 171 2909 DB00091 Antifungal Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Immunomodulatory Agents.Immunosuppressive Agents 63 0.711 125 596 DB02097 Not Available 63 0.708 31 2215 DB00714 Antidyskinetics.Antiparkinson Agents.Dopamine Agonists 63 0.688 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 63 0.649 133 4112 DB00563 Abortifacient Agents.Abortifacient Agents, Nonsteroidal.Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Folic Acid Antagonists.Immunosuppressive Agents.Nucleic Acid Synthesis Inhibitors 63 0.649 161 5212 DB00203 Phosphodiesterase Inhibitors.Vasodilator Agents 63 0.649 90 2477 DB00490 Anti-anxiety Agents.Anxiolytics sedatives and hypnotics.Serotonin Agonists 63 0.63 69 2512 DB00248 Antineoplastic Agents.Antiparkinson Agents.Dopamine Agonists 63 0.624 71 3372 DB00623 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 63 0.615 167 5719 DB00962 Anticonvulsants.Anxiolytics sedatives and hypnotics.Hypnotics and Sedatives 63 0.598 120 82146 DB00307 Anticarcinogenic Agents 63 0.578 132 3948 DB00978 Anti-Infective Agents.Anti-Infective Agents, Urinary.Antitubercular Agents.Photosensitizing Agents 63 0.563 11 3251 DB00696 Adrenergic alpha-Agonists.Analgesics, Non-Narcotic.Sympatholytics.Vasoconstrictor Agents 63 0.551 185 4594 DB00338 Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 63 0.55 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 63 0.543 215 60787 DB01232 Anti-HIV Agents.HIV Protease Inhibitors 63 0.541 57 5454 DB01623 Antipsychotic Agents.Dopamine Antagonists 63 0.538 49 4078 DB00933 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 63 0.538 20 5775 DB00692 Adrenergic alpha-Antagonists.Antihypertensive Agents.Sympatholytics 63 0.535 62 5566 DB00831 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 63 0.533 134 3339 DB01039 Antilipemic Agents.Fribic Acid Derivatives 63 0.533 91 937 DB00627 Antilipemic Agents.Vasodilator Agents.Vitamin B Complex.Vitamins (Vitamin B Complex) 63 0.527 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 63 0.526 110 4212 DB01204 Analgesics.Antineoplastic Agents 63 0.517 106 2958 DB00694 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 63 0.517 35 16362 DB01100 Anti-Dyskinesia Agents.Antipsychotic Agents.Dopamine Antagonists 63 0.514 137 3062316 DB01254 Protein Kinase Inhibitors 63 0.509 143 4054 DB01043 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agents.Excitatory Amino Acid Antagonists 63 0.504 52 5452 DB00679 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 63 0.502 201 5538 DB00755 Antineoplastic Agents.Cell Stimulants and Proliferants.Keratolytic Agents 63 0.495 138 2369 DB00195 Adrenergic beta-Antagonists.Antihypertensive Agents.EENT Drugs.Sympatholytics 63 0.487 33 3340 DB00800 Antihypertensive Agents.Dopamine Agonists.Vasodilator Agents 63 0.485 146 3475 DB01120 Hypoglycemic Agents.Sulfonylureas 63 0.483 46 3685 DB01177 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 63 0.479 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 63 0.465 76 4748 DB00850 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 63 0.459 59 4917 DB00433 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 63 0.458 144 3899 DB01097 Adjuvants.Anti-inflammatory Agents.Antineoplastic Agents.Antiparasitic Agents.Antirheumatic Agents.Antiviral Agents.Enzyme Inhibitors.Immunosuppressive Agents 63 0.458 51 3559 DB00502 Anti-Dyskinesia Agents.Antidyskinetics.Antiemetics.Antipsychotic Agents.Antipsychotics.Butyrophenones.Dopamine Antagonists 63 0.457 141 4819 DB01085 Cholinergic Agents.Miotics.Muscarinic Agonists 63 0.455 70 2179 DB00276 Antineoplastic Agents.Intercalating Agents 63 0.447 64 2726 DB00477 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 63 0.433 97 2541 DB00796 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 63 0.422 72 3440 DB00695 Diuretics.Sodium Potassium Chloride Symporter Inhibitors 63 0.421 211 60953 DB01101 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Prodrugs 63 0.418 66 4053 DB01042 Antineoplastic Agents, Alkylating.Myeloablative Agonists 63 0.409 151 60835 DB00476 Adrenergic Uptake Inhibitors.Antidepressive Agents.Dopamine Uptake Inhibitors.Serotonin Uptake Inhibitors 63 0.405 123 2806 DB00758 Antiplatelet Agents.Fibrinolytic Agents.Platelet Aggregation Inhibitors 63 0.395 135 5734 DB00909 Anticonvulsants.Antioxidants 63 0.39 95 16231 DB00594 Diuretics.Sodium channel blockers 63 0.384 154 3157 DB00590 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Anticholesteremic Agents.Antihypertensive Agents.Vasodilator Agents 63 0.378 151 41317 DB00459 Keratolytic Agents 63 0.369 154 27661 DB01020 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 63 0.354 51 3964 DB00408 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists 63 0.353 161 5487 DB00697 Adrenergic alpha-Agonists.Analgesics.Anticonvulsants.Muscle Relaxants.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 63 0.346 94 4409 DB00461 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents 63 0.344 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 63 0.341 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 63 0.339 116 5525 DB00519 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 63 0.335 50 3657 DB01005 Antineoplastic Agents.Antisickling Agents.Enzyme Inhibitors.Nucleic Acid Synthesis Inhibitors 63 0.33 126 104865 DB00559 Antihypertensive Agents 63 0.328 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 63 0.322 147 71158 DB00659 Alcohol Deterrents 63 0.32 71 3310 DB00773 Antineoplastic Agents, Phytogenic.Nucleic Acid Synthesis Inhibitors 63 0.312 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 63 0.302 161 122316 DB01367 Monoamine Oxidase Inhibitors.Neuroprotective Agents 63 0.294 144 3702 DB00808 Antihypertensive Agents.Diuretics 63 0.29 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists #### component 64: positive weight features and high scoring objects #### # positive weight on target proteins 64 0.497 8 TYSY_HUMAN Thymidylate synthase; 64 0.353 7 TOP2B_HUMAN DNA topoisomerase 2-beta; 64 0.186 5 TBB1_HUMAN Tubulin beta-1 chain; 64 0.123 16 TOP2A_HUMAN DNA topoisomerase 2-alpha; 64 0.118 5 DCK_HUMAN Deoxycytidine kinase; 64 0.109 4 TBA4A_HUMAN Tubulin alpha-4A chain; 64 0.109 4 TBA8_HUMAN Tubulin alpha-8 chain; 64 0.109 4 TBG1_HUMAN Tubulin gamma-1 chain; 64 0.109 4 TBE_HUMAN Tubulin epsilon chain; 64 0.109 4 TBD_HUMAN Tubulin delta chain; 64 0.109 4 TBB4Q_HUMAN Putative tubulin beta-4q chain; 64 0.109 4 TBB4_HUMAN Tubulin beta-4 chain; 64 0.054 6 RIR1_HUMAN Ribonucleoside-diphosphate reductase large subunit; 64 0.043 4 PGFRB_HUMAN Beta-type platelet-derived growth factor receptor; 64 0.043 4 KIT_HUMAN Mast/stem cell growth factor receptor; 64 0.02 4 BCL2_HUMAN Apoptosis regulator Bcl-2; # positive weight on side effects 64 0.513 155 stomatitis 64 0.453 46 constitutional symptoms 64 0.361 109 neuropathy 64 0.285 129 neutropenia 64 0.277 80 tumor 64 0.235 85 peripheral neuropathy 64 0.211 330 anorexia 64 0.182 317 thrombocytopenia 64 0.133 293 cough 64 0.103 101 esophagitis 64 0.09 184 pneumonia 64 0.08 180 seizures 64 0.077 355 abdominal pain 64 0.077 87 thrombophlebitis 64 0.063 86 sepsis 64 0.06 67 amenorrhea 64 0.039 47 cancer 64 0.028 53 proteinuria 64 0.023 84 bone pain 64 0.02 270 alopecia 64 0.019 125 dehydration 64 0.019 61 Pain in limb 64 0.014 35 pulmonary fibrosis 64 0.01 22 enterocolitis 64 0.003 331 pain 64 0.001 262 anemia # high scoring drugs for both targets and side effects 64 2.082 140 3143 DB01248 Antimalarials.Antineoplastic Agents.Antineoplastic Agents, Phytogenic.Radiation-Sensitizing Agents 64 1.723 72 5672 DB00361 Antineoplastic Agents.Antineoplastic Agents, Phytogenic.Radiation-Sensitizing Agents 64 1.452 84 5978 DB00541 Antineoplastic Agents.Antineoplastic Agents, Phytogenic.Tubulin Modulators 64 1.349 81 3461 DB00441 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Antiviral Agents.Enzyme Inhibitors.Immunosuppressive Agents.Radiation-Sensitizing Agents 64 1.312 71 3310 DB00773 Antineoplastic Agents, Phytogenic.Nucleic Acid Synthesis Inhibitors 64 1.298 211 60953 DB01101 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Prodrugs 64 1.24 211 93860 DB00188 Antineoplastic Agents.Protease Inhibitors 64 1.222 110 4212 DB01204 Analgesics.Antineoplastic Agents 64 1.218 85 3385 DB00544 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Immunosuppressive Agents 64 1.139 234 216326 DB00480 Antineoplastic Agents 64 1.121 47 60843 DB00642 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Enzyme Inhibitors.Folic Acid Antagonists 64 1.101 112 3367 DB01073 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Immunosuppressive Agents 64 1.073 60 5515 DB01030 Antineoplastic Agents.Enzyme Inhibitors 64 1.061 106 216239 DB00398 Anticancer Agents.Antineoplastic Agents.Protein Kinase Inhibitors 64 1.032 100 2578 DB00262 Antineoplastic Agents.Antineoplastic Agents, Alkylating 64 1.012 38 30623 DB00380 Antineoplastic Agents.Cardiovascular Agents.Chelating Agents.Immunosuppressive Agents 64 0.987 149 5394 DB00853 Antineoplastic Agents.Antineoplastic Agents, Alkylating 64 0.984 137 3062316 DB01254 Protein Kinase Inhibitors 64 0.982 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 64 0.95 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 64 0.944 215 60787 DB01232 Anti-HIV Agents.HIV Protease Inhibitors 64 0.936 41 104758 DB00293 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Enzyme Inhibitors.Folic Acid Antagonists 64 0.929 39 5396 DB00444 Antineoplastic Agents.Enzyme Inhibitors.Nucleic Acid Synthesis Inhibitors 64 0.923 70 2179 DB00276 Antineoplastic Agents.Intercalating Agents 64 0.916 79 176870 DB00530 Protein Kinase Inhibitors 64 0.912 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 64 0.911 66 4053 DB01042 Antineoplastic Agents, Alkylating.Myeloablative Agonists 64 0.908 88 3750 DB00762 Antineoplastic Agents.Antineoplastic Agents, Phytogenic.Enzyme Inhibitors.Parasympathomimetics.Prodrugs.Radiation-Sensitizing Agents 64 0.906 112 151165 DB00673 Antiemetics 64 0.888 125 596 DB02097 Not Available 64 0.879 90 5329102 DB01268 Angiogenesis Inhibitors.Antineoplastic Agents 64 0.862 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 64 0.84 76 123631 DB00317 Antineoplastic Agents.Protein Kinase Inhibitors 64 0.833 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 64 0.828 23 143 DB00650 Antianemic Agents.Antidote (to folic acid antagonists).Antineoplastic Adjuncts.Vitamin B Complex.Vitamins/minerals 64 0.811 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 64 0.802 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 64 0.801 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 64 0.8 264 5372 DB00864 Immunosuppressive Agents 64 0.795 106 2958 DB00694 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 64 0.787 136 2375 DB01128 Androgen Antagonists.Antineoplastic Agents 64 0.786 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 64 0.784 133 4112 DB00563 Abortifacient Agents.Abortifacient Agents, Nonsteroidal.Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Folic Acid Antagonists.Immunosuppressive Agents.Nucleic Acid Synthesis Inhibitors 64 0.781 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 64 0.766 46 3685 DB01177 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 64 0.748 151 41317 DB00459 Keratolytic Agents 64 0.742 63 3690 DB01181 Antineoplastic Agents.Antineoplastic Agents, Alkylating.Immunosuppressive Agents 64 0.738 185 4594 DB00338 Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 64 0.733 50 3657 DB01005 Antineoplastic Agents.Antisickling Agents.Enzyme Inhibitors.Nucleic Acid Synthesis Inhibitors 64 0.728 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 64 0.708 116 5376 DB00675 Antineoplastic Agents, Hormonal.Bone Density Conservation Agents.Estrogen Antagonists.Selective Estrogen Receptor Modulators 64 0.694 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 64 0.689 171 2909 DB00091 Antifungal Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Immunomodulatory Agents.Immunosuppressive Agents 64 0.685 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 64 0.684 453 125889 DB00230 Analgesics.Anticonvulsants 64 0.678 201 5538 DB00755 Antineoplastic Agents.Cell Stimulants and Proliferants.Keratolytic Agents 64 0.678 188 5040 DB00877 Anti-Bacterial Agents.Antibiotics, Antineoplastic.Antifungal Agents.Antifungals.Immunosuppressive Agents 64 0.675 128 3793 DB01167 Antifungal Agents.Antifungals.Antiprotozoal Agents.Antiprotozoals 64 0.673 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 64 0.671 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 64 0.67 132 4739 DB00552 Antibiotics.Antineoplastic Agents.Enzyme Inhibitors.Immunosuppressive Agents 64 0.657 120 82146 DB00307 Anticarcinogenic Agents 64 0.657 144 3899 DB01097 Adjuvants.Anti-inflammatory Agents.Antineoplastic Agents.Antiparasitic Agents.Antirheumatic Agents.Antiviral Agents.Enzyme Inhibitors.Immunosuppressive Agents 64 0.647 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 64 0.643 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 64 0.641 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 64 0.635 166 54374 DB00104 Anabolic Agents.Antineoplastic Agents, Hormonal.Gastrointestinal Agents.Hormone Replacement Agents 64 0.628 161 5291 DB00619 Antineoplastic Agents.Protein Kinase Inhibitors 64 0.62 81 5353980 DB00795 Anti-Infective Agents.Anti-Inflammatory Agents, Non-Steroidal.Antirheumatic Agents.Gastrointestinal Agents.Sulfonamides 64 0.601 32 5281007 DB00851 Antineoplastic Agents.Antineoplastic Agents, Alkylating 64 0.601 103 5352 DB00605 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents.Cyclooxygenase Inhibitors 64 0.601 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 64 0.595 98 3222 DB00584 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 64 0.591 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 64 0.584 40 13342 DB00570 Antineoplastic Agents, Phytogenic.Tubulin Modulators 64 0.579 110 4666 DB01229 Antineoplastic Agents.Antineoplastic Agents, Phytogenic.Tubulin Modulators 64 0.566 113 4674 DB00282 Anti-inflammatory Agents.Antineoplastic Agents.Bisphosphonates.Bone Density Conservation Agents 64 0.565 91 3902 DB01006 Antineoplastic Agents.Aromatase Inhibitors 64 0.563 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 64 0.553 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 64 0.55 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 64 0.504 166 3394 DB00712 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Carbonic Anhydrase Inhibitors.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 64 0.498 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 64 0.489 41 6918453 DB00995 Antirheumatic Agents, Gold 64 0.487 183 3648 DB00327 Analgesics, Opioid.Narcotics 64 0.481 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 64 0.476 145 3672 DB01050 Analgesics.Analgesics, Non-Narcotic.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 64 0.475 97 4200 DB01017 Anti-Bacterial Agents.Tetracyclines 64 0.472 196 1935 DB00382 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 64 0.466 123 2806 DB00758 Antiplatelet Agents.Fibrinolytic Agents.Platelet Aggregation Inhibitors 64 0.465 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 64 0.464 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 64 0.457 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 64 0.448 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 64 0.446 135 5734 DB00909 Anticonvulsants.Antioxidants 64 0.442 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 64 0.44 106 4539 DB01059 Anti-Bacterial Agents.Anti-Infectives.Enzyme Inhibitors.Nucleic Acid Synthesis Inhibitors.Quinolones 64 0.436 58 1546 DB00242 Antineoplastic Agents.Immunosuppressive Agents 64 0.427 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 64 0.417 119 5064 DB00811 Antimetabolites.Antiviral Agents #### component 65: positive weight features and high scoring objects #### # positive weight on target proteins 65 0.581 35 DRD2_HUMAN D(2) dopamine receptor; 65 0.532 28 DRD3_HUMAN D(3) dopamine receptor; 65 0.361 28 DRD1_HUMAN D(1A) dopamine receptor; 65 0.147 19 CP27B_HUMAN 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; 65 0.127 18 CP2R1_HUMAN Vitamin D 25-hydroxylase; 65 0.125 21 DRD5_HUMAN D(1B) dopamine receptor; 65 0.121 17 CP4F2_HUMAN Leukotriene-B(4) omega-hydroxylase 1; 65 0.121 17 PTGIS_HUMAN Prostacyclin synthase; 65 0.121 17 CP24A_HUMAN 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; 65 0.121 17 CP27A_HUMAN Sterol 26-hydroxylase, mitochondrial; 65 0.121 17 CP4F3_HUMAN Leukotriene-B(4) omega-hydroxylase 2; 65 0.121 17 CP46A_HUMAN Cholesterol 24-hydroxylase; 65 0.121 17 CP8B1_HUMAN 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase; 65 0.121 17 CP7A1_HUMAN Cholesterol 7-alpha-monooxygenase; 65 0.116 16 CP21A_HUMAN Steroid 21-hydroxylase; 65 0.108 16 CP11A_HUMAN Cholesterol side-chain cleavage enzyme, mitochondrial; 65 0.102 18 CP17A_HUMAN Steroid 17-alpha-hydroxylase/17,20 lyase; 65 0.099 16 CP7B1_HUMAN 25-hydroxycholesterol 7-alpha-hydroxylase; 65 0.099 16 CP39A_HUMAN 24-hydroxycholesterol 7-alpha-hydroxylase; 65 0.099 16 COQ6_HUMAN Ubiquinone biosynthesis monooxygenase COQ6; 65 0.089 22 CP51A_HUMAN Lanosterol 14-alpha demethylase; 65 0.05 13 CAH2_HUMAN Carbonic anhydrase 2; 65 0.042 11 CAH4_HUMAN Carbonic anhydrase 4; 65 0.015 38 ADA2A_HUMAN Alpha-2A adrenergic receptor; 65 0.011 13 CAH1_HUMAN Carbonic anhydrase 1; 65 0.001 16 ANDR_HUMAN Androgen receptor; # positive weight on side effects 65 0.252 99 polyuria 65 0.134 45 SIADH 65 0.106 14 hyperprolactinemia # high scoring drugs for both targets and side effects 65 1.278 19 5505 DB01124 Hypoglycemic Agents.Sulfonylureas 65 1.211 7 3562 DB01159 Anesthetics.Anesthetics, Inhalation.General Anesthetics 65 1.211 21 4114 DB00553 Antineoplastic Agents.Cross-Linking Reagents.Photosensitizing Agents.Pigmenting Agents 65 1.157 6 4174 DB01011 Antimetabolites.Enzyme Inhibitors 65 1.153 28 2145 DB00357 Adrenergic Agents.Antineoplastic Agents.Antineoplastic Agents, Hormonal.Aromatase Inhibitors 65 1.136 64 5584 DB00726 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 65 1.124 42 4196 DB00834 Abortifacient Agents, Steroidal.Contraceptives, Oral, Synthetic.Contraceptives, Postcoital, Synthetic.Hormone Antagonists.Luteolytic Agents.Menstruation-Inducing Agents 65 1.124 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 65 1.124 11 2519 DB00201 Anorexigenic Agents.Central Nervous System Stimulants.Phosphodiesterase Inhibitors 65 1.117 14 10100 DB00647 Analgesics.Analgesics, Opioid.Antitussives.Narcotics 65 1.102 28 2583 DB00521 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents.Sympatholytics 65 1.086 41 5516 DB00539 Antineoplastic Agents.Antineoplastic Agents, Hormonal.Bone Density Conservation Agents.Selective Estrogen Receptor Modulators 65 1.049 86 2118 DB00404 Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 65 1.043 50 2973 DB00746 Chelating agent.Iron Chelating Agents.Siderophores 65 1.042 11 3251 DB00696 Adrenergic alpha-Agonists.Analgesics, Non-Narcotic.Sympatholytics.Vasoconstrictor Agents 65 1.017 20 5775 DB00692 Adrenergic alpha-Antagonists.Antihypertensive Agents.Sympatholytics 65 0.998 73 3333 DB01023 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Calcium Channel Blockers.Dihydropyridines.Vasodilator Agents 65 0.916 31 2215 DB00714 Antidyskinetics.Antiparkinson Agents.Dopamine Agonists 65 0.901 35 16362 DB01100 Anti-Dyskinesia Agents.Antipsychotic Agents.Dopamine Antagonists 65 0.844 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 65 0.837 33 3340 DB00800 Antihypertensive Agents.Dopamine Agonists.Vasodilator Agents 65 0.825 69 2512 DB00248 Antineoplastic Agents.Antiparkinson Agents.Dopamine Agonists 65 0.693 49 4078 DB00933 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 65 0.693 52 5452 DB00679 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 65 0.673 26 3151 DB01184 Antiemetics.Dopamine Antagonists 65 0.651 57 5454 DB01623 Antipsychotic Agents.Dopamine Antagonists 65 0.612 55 2130 DB00915 Analgesics, Non-Narcotic.Antiparkinson Agents.Antiviral Agents.Dopamine Agents 65 0.598 49 4168 DB01233 Antiemetics.Dopamine Antagonists.Prokinetic Agents 65 0.589 57 2443 DB01200 Antidyskinetics.Antiparkinson Agents.Dopamine Agonists.Hormone Antagonists 65 0.533 90 2477 DB00490 Anti-anxiety Agents.Anxiolytics sedatives and hypnotics.Serotonin Agonists 65 0.524 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 65 0.5 47 4927 DB01069 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists.Phenothiazine Derivatives 65 0.49 64 2726 DB00477 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 65 0.46 76 4748 DB00850 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 65 0.424 16 3168 DB00450 Adjuvants, Anesthesia.Antiemetics.Antipsychotic Agents.Dopamine Antagonists 65 0.416 71 3372 DB00623 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 65 0.415 15 681 DB00988 Cardiotonic Agents.Dopamine Agents.Sympathomimetic.Sympathomimetics 65 0.412 27 4100 DB00703 Carbonic Anhydrase Inhibitors.Diuretics 65 0.403 19 3249 DB00153 Antihypocalcemic Agents.Antihypoparathyroid Agents.Bone Density Conservation Agents.Essential Vitamin.Vitamins.Vitamins (Vitamin D) 65 0.398 51 3964 DB00408 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists 65 0.387 43 1986 DB00819 Anticonvulsants.Carbonic Anhydrase Inhibitors.Diuretics 65 0.384 17 1206 DB01577 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Agents.Dopamine Uptake Inhibitors.Sympathomimetics 65 0.34 48 2524 DB00136 Antihypocalcemic Agents.Antihypoparathyroid Agents.Bone Density Conservation Agents.Calcium Channel Agonists.Essential Vitamin.Vitamins.Vitamins (Vitamin D) 65 0.319 59 4917 DB00433 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 65 0.319 62 5566 DB00831 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 65 0.315 51 3559 DB00502 Anti-Dyskinesia Agents.Antidyskinetics.Antiemetics.Antipsychotic Agents.Antipsychotics.Butyrophenones.Dopamine Antagonists 65 0.307 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 65 0.301 24 2727 DB00672 Hypoglycemic Agents.Sulfonylureas 65 0.296 77 28112 DB01356 Not Available 65 0.294 24 5503 DB00839 Hypoglycemic Agents 65 0.279 7 5404 DB00251 Antifungal Agents.Antifungals 65 0.273 27 1125 DB00360 Cofactor.Dietary supplement 65 0.259 3 175 DB04184 Indicators and Reagents 65 0.259 15 4189 DB01110 Antifungal Agents 65 0.255 38 3823 DB01026 Antifungal Agents.Antifungals 65 0.253 25 68844 DB01194 Antiglaucomic Agents.Carbonic Anhydrase Inhibitors.Ophthalmics 65 0.243 39 7029 DB00937 Anorexigenic Agents.Appetite Depressants.Stimulants 65 0.242 10 4436 Not Available Not Available 65 0.242 4 4768 DB00925 Adrenergic alpha-Antagonists.Antihypertensive Agents.Vasodilator Agents 65 0.242 8 3105 DB00449 Adrenergic Agonists.Ophthalmologicals.Sympathomimetics 65 0.242 14 951 DB00368 Adrenergic alpha-Agonists.Sympathomimetics.Vasoconstrictor Agents 65 0.235 25 3350 DB01216 Anti-baldness Agents.Antihyperplasia Agents.Enzyme Inhibitors.Skin and Mucous Membrane Agents 65 0.235 4 5878 DB00621 Anabolic Agents.Androgens 65 0.234 16 3382 DB01047 Anti-Allergic Agents.Anti-inflammatory Agents.Glucocorticoids 65 0.234 14 27400 Not Available Not Available 65 0.234 23 4479097 DB00200 Anti-anemic Agents.Hematinics.Nutritional Supplement.Vitamin B Complex 65 0.234 30 2891 DB00115 Antianemic Agents.Essential Vitamin.Vitamins (Vitamin B Complex) 65 0.234 30 156419 DB01012 Calcimimetics 65 0.234 10 3226 DB00228 Anesthetics, Inhalation.General Anesthetics 65 0.234 9 3658 DB00557 Antipruritics.Anxiolytics sedatives and hypnotics.Histamine H1 Antagonists 65 0.234 29 3890 DB00654 Antihypertensive Agents.Neuroprotective Agents 65 0.234 14 2133 DB00288 Corticosteroids, topical 65 0.234 10 5526 DB00302 Antifibrinolytic Agents 65 0.234 17 52421 DB01130 Anti Inflammatory.Anti-inflammatory Agents.Corticosteroid.Glucocorticoids.Steroidal 65 0.234 23 5578 DB00440 Anti-Infective Agents, Urinary.Anti-Infectives.Antimalarials.Folic Acid Antagonists 65 0.234 18 2266 DB00548 Antineoplastic Agents.Dermatologic Agents 65 0.234 18 1046 DB00339 Antitubercular Agents 65 0.234 14 4993 DB00205 Antimalarials.Antiprotozoal Agents.Antiprotozoals.Folic Acid Antagonists 65 0.234 17 48175 DB00596 Anti-inflammatory Agents.Vasoconstrictor Agents 65 0.234 39 564 DB04134 Antifibrinolytic Agents 65 0.234 3 4034 DB00737 Anti-Allergic Agents.Antiemetics.Antihistamines.Histamine H1 Antagonists 65 0.234 17 5403 DB00871 Adrenergic beta-Agonists.Bronchodilator Agents.Sympathomimetic.Sympathomimetics.Tocolytic Agents 65 0.234 16 2905 DB00979 Antimuscarinic eye preparations.Muscarinic Antagonists.Mydriatics.Parasympatholytics 65 0.234 5 10548 DB01057 Cholinesterase Inhibitors.Miotics.Parasympathomimetics 65 0.234 11 3375 DB00223 Anti-inflammatory Agents.Glucocorticoids 65 0.234 3 6256 DB00432 Antimetabolites.Antiviral Agents 65 0.234 13 36339 DB00292 Anesthetics, Intravenous.Hypnotics and Sedatives 65 0.234 10 3392 DB00846 Anti-inflammatory Agents.Glucocorticoids 65 0.234 29 2153 DB00277 Bronchodilator Agents.Phosphodiesterase Inhibitors.Respiratory Smooth Muscle Relaxants.Vasodilator Agents 65 0.234 6 12555 Not Available Not Available 65 0.234 28 3291 DB00593 Anticonvulsants.Succinimides 65 0.234 16 5314 DB00202 Neuromuscular Depolarizing Agents.Skeletal Muscle Relaxants 65 0.234 12 3384 DB00324 Anti-Allergic Agents.Anti-inflammatory Agents.Glucocorticoids 65 0.234 9 3219 DB01084 Anti-Allergic Agents.Histamine H1 Antagonists 65 0.234 6 4908 DB01087 Antimalarial Agents.Antimalarials.Antiprotozoal Agents 65 0.234 9 861 DB00279 Hormone Replacement Agents 65 0.234 3 47641 DB00735 Anti-Inflammatory Agents, Non-Steroidal.Antifungal Agents 65 0.234 17 3000 DB00547 Anti-inflammatory Agents.Glucocorticoids 65 0.234 2 1071 DB00162 Anti-acne Agents.Essential Vitamin.Vitamins.Vitamins (Vitamin A) 65 0.234 3 247 DB04455 Gastrointestinal Agents.Lipotropic Agents #### component 66: positive weight features and high scoring objects #### # positive weight on target proteins 66 0.514 29 GBRA1_HUMAN Gamma-aminobutyric acid receptor subunit alpha-1; 66 0.27 22 GBRA6_HUMAN Gamma-aminobutyric acid receptor subunit alpha-6; 66 0.27 22 GBRA3_HUMAN Gamma-aminobutyric acid receptor subunit alpha-3; 66 0.27 22 GBRA5_HUMAN Gamma-aminobutyric acid receptor subunit alpha-5; 66 0.27 22 GBRA4_HUMAN Gamma-aminobutyric acid receptor subunit alpha-4; 66 0.214 21 GBRR1_HUMAN Gamma-aminobutyric acid receptor subunit rho-1; 66 0.214 21 GBRB2_HUMAN Gamma-aminobutyric acid receptor subunit beta-2; 66 0.214 21 GBRG3_HUMAN Gamma-aminobutyric acid receptor subunit gamma-3; 66 0.214 21 GBRT_HUMAN Gamma-aminobutyric acid receptor subunit theta; 66 0.214 21 GBRB1_HUMAN Gamma-aminobutyric acid receptor subunit beta-1; 66 0.214 21 GBRG2_HUMAN Gamma-aminobutyric acid receptor subunit gamma-2; 66 0.214 21 GBRE_HUMAN Gamma-aminobutyric acid receptor subunit epsilon; 66 0.214 21 GBRD_HUMAN Gamma-aminobutyric acid receptor subunit delta; 66 0.214 21 GBRB3_HUMAN Gamma-aminobutyric acid receptor subunit beta-3; 66 0.178 23 GBRA2_HUMAN Gamma-aminobutyric acid receptor subunit alpha-2; # positive weight on side effects 66 0.516 107 amnesia 66 0.436 64 dysarthria 66 0.312 9 somnambulism 66 0.275 114 lymphadenopathy 66 0.268 44 acidosis 66 0.221 75 amblyopia 66 0.214 6 psychomotor retardation 66 0.207 13 labyrinthitis 66 0.203 70 delirium 66 0.13 20 lymphocytosis 66 0.072 13 strabismus 66 0.056 52 menorrhagia 66 0.049 19 otitis # high scoring drugs for both targets and side effects 66 2.789 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 66 2.774 167 5719 DB00962 Anticonvulsants.Anxiolytics sedatives and hypnotics.Hypnotics and Sedatives 66 2.699 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 66 2.584 84 3016 DB00829 Adjuvants, Anesthesia.Anesthetics, Intravenous.Anti-anxiety Agents.Anticonvulsants.Antiemetics.GABA Modulators.Hypnotics and Sedatives.Muscle Relaxants, Central 66 2.4 73 3958 DB00186 Anti-anxiety Agents.Anticonvulsants.Antiemetics.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 66 2.371 133 2802 DB01068 Anticonvulsants.Benzodiazepines.GABA Modulators 66 2.276 86 2118 DB00404 Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 66 2.218 147 71158 DB00659 Alcohol Deterrents 66 2.169 120 2284 DB00181 GABA Agonists.Muscle Relaxants.Muscle Relaxants, Central.Skeletal Muscle Relaxants 66 1.934 58 5206 DB01236 Anesthetics, Inhalation.Platelet Aggregation Inhibitors 66 1.905 61 4192 DB00683 Adjuvants, Anesthesia.Anesthetics, Intravenous.Anti-anxiety Agents.GABA Modulators.Hypnotics and Sedatives 66 1.896 102 4943 DB00818 Anesthetics, Intravenous.Anticonvulsants.Antiemetics.Free Radical Scavengers.Hypnotics and Sedatives 66 1.873 16 3763 DB00753 Anesthetics.Anesthetics, Inhalation.General Anesthetics 66 1.771 23 4737 DB00312 Adjuvants, Anesthesia.Barbiturates.GABA Modulators.Hypnotics and Sedatives 66 1.771 10 2712 DB00475 Adjuvants, Anesthesia.Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 66 1.771 23 5193 DB00418 Adjuvants.Adjuvants, Anesthesia.Barbiturates.GABA Modulators.Hypnotics and Sedatives 66 1.771 7 3562 DB01159 Anesthetics.Anesthetics, Inhalation.General Anesthetics 66 1.771 38 3393 DB00690 Anti-anxiety Agents.GABA Modulators.Hypnotics and Sedatives 66 1.727 13 36339 DB00292 Anesthetics, Intravenous.Hypnotics and Sedatives 66 1.721 25 9034 DB00474 Anesthetics.Anesthetics, Intravenous.Barbiturates 66 1.62 23 3821 DB01221 Analgesics.Anesthetics, Dissociative.Excitatory Amino Acid Antagonists.General Anesthetics 66 0.867 453 125889 DB00230 Analgesics.Anticonvulsants 66 0.851 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 66 0.841 40 4064 DB00371 Anti-anxiety Agents.Anticonvulsants.Hypnotics and Sedatives.Muscle Relaxants, Central 66 0.777 136 56339 DB01320 Anticonvulsants 66 0.76 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 66 0.738 150 1775 DB00252 Anticonvulsants 66 0.734 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 66 0.711 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 66 0.697 196 1935 DB00382 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 66 0.687 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 66 0.684 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 66 0.673 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 66 0.659 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 66 0.621 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 66 0.612 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 66 0.597 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists 66 0.55 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 66 0.542 132 4739 DB00552 Antibiotics.Antineoplastic Agents.Enzyme Inhibitors.Immunosuppressive Agents 66 0.542 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 66 0.531 264 5372 DB00864 Immunosuppressive Agents 66 0.52 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 66 0.516 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 66 0.511 183 3648 DB00327 Analgesics, Opioid.Narcotics 66 0.509 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 66 0.501 76 3661 DB00572 Adjuvants, Anesthesia.Anti-Arrhythmia Agents.Bronchodilator Agents.Muscarinic Antagonists.Mydriatics.Parasympatholytics 66 0.458 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 66 0.455 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 66 0.443 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 66 0.437 20 4616 DB00842 Anti-anxiety Agents.GABA Modulators.Hypnotics and Sedatives 66 0.432 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 66 0.43 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 66 0.421 161 122316 DB01367 Monoamine Oxidase Inhibitors.Neuroprotective Agents 66 0.415 131 4635 DB00497 Analgesics, Opioid.Antitussives.Narcotics.Opiate Agonists 66 0.396 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 66 0.386 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 66 0.353 158 34312 DB00776 Anticonvulsants 66 0.348 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 66 0.339 102 83786 DB00437 Antimetabolites.Enzyme Inhibitors.Enzyme Inhibitors Antimetabolites.Free Radical Scavengers.Gout Suppressants 66 0.339 167 170361 DB01273 Nicotinic Agonists 66 0.335 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 66 0.335 111 5281104 DB00910 Not Available 66 0.33 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 66 0.33 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 66 0.325 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 66 0.32 128 2250 DB01076 Anticholesteremic Agents.Hydroxymethylglutaryl-CoA Reductase Inhibitors 66 0.307 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 66 0.307 135 5734 DB00909 Anticonvulsants.Antioxidants 66 0.306 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 66 0.303 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 66 0.293 147 5645 DB01586 Cholagogues and Choleretics 66 0.285 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 66 0.276 117 2182 DB00261 Antithrombotic Agents.Fibrinolytic Agents.Platelet Aggregation Inhibitors 66 0.262 106 2958 DB00694 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 66 0.26 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 66 0.258 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 66 0.241 129 5210 DB01105 Anorexigenic Agents.Antidepressants.Antidepressive Agents.Appetite Depressants.Stimulants 66 0.239 128 4253 DB00295 Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 66 0.231 73 2769 DB00604 Anti-Ulcer Agents.Gastrointestinal Agents.Prokinetic Agents.Serotonin Agonists 66 0.225 31 2441 DB01558 Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 66 0.221 118 4236 DB00745 Anorexigenic Agents.Central Nervous System Agents.Central Nervous System Stimulants.Neuroprotective Agents.Stimulants 66 0.22 166 3394 DB00712 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Carbonic Anhydrase Inhibitors.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 66 0.213 137 2462 DB01222 Anti-inflammatory Agents.Bronchodilator Agents.Corticosteroids.Glucocorticoids 66 0.209 215 60787 DB01232 Anti-HIV Agents.HIV Protease Inhibitors 66 0.204 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 66 0.202 60 3373 DB01205 Antidotes.GABA Modulators 66 0.201 138 2369 DB00195 Adrenergic beta-Antagonists.Antihypertensive Agents.EENT Drugs.Sympatholytics 66 0.194 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 66 0.191 172 4920 DB00396 Contraceptives.Progestins 66 0.179 30 42113 DB01189 Anesthetics, Inhalation.Neuroprotective Agents 66 0.179 12 4909 DB00794 Anticonvulsants.Barbiturates 66 0.179 26 4506 DB01595 Anti-anxiety Agents.Anticonvulsants.GABA Modulators.Hypnotics and Sedatives 66 0.178 146 3075 DB00343 Antihypertensive Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Cardiovascular Agents.Vasodilator Agents 66 0.174 154 3157 DB00590 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Anticholesteremic Agents.Antihypertensive Agents.Vasodilator Agents 66 0.173 157 4659569 DB00323 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Enzyme Inhibitors 66 0.171 154 27661 DB01020 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 66 0.162 196 3911 DB00007 Anti-Estrogen Agents.Antineoplastic Agents 66 0.161 68 5596 DB00209 Analgesics.Parasympatholytics 66 0.155 236 10631 DB00603 Contraceptives.Contraceptives, Oral, Synthetic.Progestins 66 0.15 166 54374 DB00104 Anabolic Agents.Antineoplastic Agents, Hormonal.Gastrointestinal Agents.Hormone Replacement Agents #### component 67: positive weight features and high scoring objects #### # positive weight on target proteins 67 0.689 29 PGH2_HUMAN Prostaglandin G/H synthase 2; 67 0.488 26 SC6A4_HUMAN Sodium-dependent serotonin transporter; 67 0.287 28 SC6A2_HUMAN Sodium-dependent noradrenaline transporter; 67 0.201 5 ATP4A_HUMAN Potassium-transporting ATPase alpha chain 1; 67 0.168 3 PPIA_HUMAN Peptidyl-prolyl cis-trans isomerase A; 67 0.075 2 PPIL3_HUMAN Peptidyl-prolyl cis-trans isomerase-like 3; 67 0.075 2 FKB11_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP11; 67 0.075 2 FKBP2_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP2; 67 0.075 2 FKBP8_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP8; 67 0.075 2 FKBP7_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP7; 67 0.075 2 FKB14_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP14; 67 0.075 2 FKB10_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP10; 67 0.075 2 FKBP5_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP5; 67 0.075 2 PPIE_HUMAN Peptidyl-prolyl cis-trans isomerase E; 67 0.075 2 PPIC_HUMAN Peptidyl-prolyl cis-trans isomerase C; 67 0.075 2 PIN1_HUMAN Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; 67 0.075 2 FKBP6_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP6; 67 0.075 2 PPIB_HUMAN Peptidyl-prolyl cis-trans isomerase B; 67 0.075 2 PIN4_HUMAN Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4; 67 0.075 2 PPIF_HUMAN Peptidyl-prolyl cis-trans isomerase F, mitochondrial; 67 0.075 2 FKBP4_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP4; 67 0.075 2 PPIL2_HUMAN Peptidyl-prolyl cis-trans isomerase-like 2; 67 0.075 2 FKBP3_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP3; 67 0.075 2 FKB1B_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP1B; 67 0.075 2 PPIG_HUMAN Peptidyl-prolyl cis-trans isomerase G; 67 0.075 2 FKBP9_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP9; 67 0.075 2 PPIL1_HUMAN Peptidyl-prolyl cis-trans isomerase-like 1; 67 0.075 2 PPID_HUMAN Peptidyl-prolyl cis-trans isomerase D; 67 0.059 6 DRD4_HUMAN D(4) dopamine receptor; 67 0.059 3 FKB1A_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP1A; # positive weight on side effects 67 0.542 67 albuminuria 67 0.344 185 impotence 67 0.336 210 agitation 67 0.328 155 stomatitis 67 0.294 60 cellulitis 67 0.239 175 urinary tract infection 67 0.206 247 tremor 67 0.19 35 carcinoma 67 0.188 64 mouth ulceration 67 0.178 28 pyuria 67 0.136 84 herpes simplex 67 0.131 54 gastroesophageal reflux 67 0.125 38 peripheral vascular disorder 67 0.109 62 SGOT increased 67 0.075 42 hernia 67 0.07 373 fever 67 0.037 59 herpes zoster 67 0.035 59 cyst 67 0.034 115 hypokalemia 67 0.016 262 anemia 67 0.015 124 migraine 67 0.012 127 dry skin 67 0.009 162 urinary frequency 67 0.006 41 nail disorder 67 0.002 20 duodenitis # high scoring drugs for both targets and side effects 67 2.345 188 5040 DB00877 Anti-Bacterial Agents.Antibiotics, Antineoplastic.Antifungal Agents.Antifungals.Immunosuppressive Agents 67 2.271 264 5372 DB00864 Immunosuppressive Agents 67 1.683 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 67 1.572 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 67 1.446 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 67 1.439 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 67 1.417 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 67 1.36 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 67 1.345 453 125889 DB00230 Analgesics.Anticonvulsants 67 1.341 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 67 1.257 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 67 1.197 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 67 1.176 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 67 1.139 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 67 1.091 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 67 1.079 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 67 1.071 234 216326 DB00480 Antineoplastic Agents 67 1.064 185 4594 DB00338 Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 67 1.047 166 3394 DB00712 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Carbonic Anhydrase Inhibitors.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 67 1.039 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 67 1.015 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 67 0.989 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 67 0.989 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 67 0.978 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 67 0.963 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 67 0.925 146 4158 DB00422 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Uptake Inhibitors.Sympathomimetics 67 0.92 94 4409 DB00461 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents 67 0.911 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 67 0.887 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 67 0.86 196 1935 DB00382 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 67 0.842 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 67 0.834 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 67 0.829 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 67 0.809 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 67 0.807 119 4052 DB00814 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Antiemetics.Antineoplastic Agents.Cyclooxygenase Inhibitors.Growth Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 67 0.805 215 60787 DB01232 Anti-HIV Agents.HIV Protease Inhibitors 67 0.804 129 5210 DB01105 Anorexigenic Agents.Antidepressants.Antidepressive Agents.Appetite Depressants.Stimulants 67 0.801 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 67 0.799 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 67 0.797 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 67 0.797 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 67 0.793 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 67 0.783 118 4236 DB00745 Anorexigenic Agents.Central Nervous System Agents.Central Nervous System Stimulants.Neuroprotective Agents.Stimulants 67 0.782 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 67 0.759 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 67 0.725 167 5719 DB00962 Anticonvulsants.Anxiolytics sedatives and hypnotics.Hypnotics and Sedatives 67 0.715 157 4659569 DB00323 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Enzyme Inhibitors 67 0.699 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 67 0.697 161 122316 DB01367 Monoamine Oxidase Inhibitors.Neuroprotective Agents 67 0.683 135 5734 DB00909 Anticonvulsants.Antioxidants 67 0.679 161 5212 DB00203 Phosphodiesterase Inhibitors.Vasodilator Agents 67 0.671 64 5584 DB00726 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 67 0.671 72 2160 DB00321 Adrenergic Uptake Inhibitors.Analgesics, Non-Narcotic.Antidepressive Agents, Tricyclic 67 0.671 69 3696 DB00458 Adrenergic Uptake Inhibitors.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 67 0.671 67 4976 DB00344 Adrenergic Uptake Inhibitors.Antidepressive Agents.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 67 0.671 65 4543 DB00540 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 67 0.669 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 67 0.669 171 2909 DB00091 Antifungal Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Immunomodulatory Agents.Immunosuppressive Agents 67 0.66 84 2995 DB01151 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Enzyme Inhibitors.Norepinephrine-Reuptake Inhibitors 67 0.652 183 3648 DB00327 Analgesics, Opioid.Narcotics 67 0.65 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 67 0.64 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 67 0.622 62 3007 DB00182 Adrenergic Agents.Adrenergic Uptake Inhibitors.Amphetamines.Central Nervous System Stimulants.Dopamine Agents.Dopamine Uptake Inhibitors.Sympathomimetics 67 0.598 154 27661 DB01020 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 67 0.596 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 67 0.586 161 5487 DB00697 Adrenergic alpha-Agonists.Analgesics.Anticonvulsants.Muscle Relaxants.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 67 0.576 149 5394 DB00853 Antineoplastic Agents.Antineoplastic Agents, Alkylating 67 0.573 146 3075 DB00343 Antihypertensive Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Cardiovascular Agents.Vasodilator Agents 67 0.56 97 159 DB01240 Antihypertensive Agents.Platelet Aggregation Inhibitors 67 0.557 128 3793 DB01167 Antifungal Agents.Antifungals.Antiprotozoal Agents.Antiprotozoals 67 0.551 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 67 0.547 83 5487301 DB01079 Gastrointestinal Agents.Serotonin Agonists 67 0.547 154 5090 DB00533 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase 2 Inhibitors.Cyclooxygenase Inhibitors 67 0.546 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists 67 0.518 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 67 0.508 144 3899 DB01097 Adjuvants.Anti-inflammatory Agents.Antineoplastic Agents.Antiparasitic Agents.Antirheumatic Agents.Antiviral Agents.Enzyme Inhibitors.Immunosuppressive Agents 67 0.503 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 67 0.503 112 71273 DB00296 Anesthetics.Anesthetics, Local.Local Anesthetics 67 0.503 69 2170 DB00543 Adrenergic Uptake Inhibitors.Antidepressive Agents, Second-Generation.Dopamine Antagonists.Neurotransmitter Uptake Inhibitors.Serotonin Uptake Inhibitors 67 0.494 120 2284 DB00181 GABA Agonists.Muscle Relaxants.Muscle Relaxants, Central.Skeletal Muscle Relaxants 67 0.492 154 3157 DB00590 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Anticholesteremic Agents.Antihypertensive Agents.Vasodilator Agents 67 0.489 131 4635 DB00497 Analgesics, Opioid.Antitussives.Narcotics.Opiate Agonists 67 0.472 106 4539 DB01059 Anti-Bacterial Agents.Anti-Infectives.Enzyme Inhibitors.Nucleic Acid Synthesis Inhibitors.Quinolones 67 0.47 133 2802 DB01068 Anticonvulsants.Benzodiazepines.GABA Modulators 67 0.469 144 3702 DB00808 Antihypertensive Agents.Diuretics 67 0.467 12 4771 DB00191 Adrenergic Agents.Anorexigenic Agents.Appetite Depressants.Central Nervous System Agents.Central Nervous System Stimulants.Stimulants.Sympathomimetics 67 0.467 17 1206 DB01577 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Agents.Dopamine Uptake Inhibitors.Sympathomimetics 67 0.464 201 5538 DB00755 Antineoplastic Agents.Cell Stimulants and Proliferants.Keratolytic Agents 67 0.45 146 3475 DB01120 Hypoglycemic Agents.Sulfonylureas 67 0.447 120 82146 DB00307 Anticarcinogenic Agents 67 0.447 147 71158 DB00659 Alcohol Deterrents 67 0.442 145 3672 DB01050 Analgesics.Analgesics, Non-Narcotic.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 67 0.427 66 4011 DB00934 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Second-Generation 67 0.427 89 59708 DB01202 Anticonvulsants.Nootropic Agents 67 0.421 143 4054 DB01043 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agents.Excitatory Amino Acid Antagonists 67 0.419 141 4819 DB01085 Cholinergic Agents.Miotics.Muscarinic Agonists 67 0.419 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 67 0.411 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 67 0.408 131 3961 DB00678 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents 67 0.407 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives #### component 68: positive weight features and high scoring objects #### # positive weight on target proteins 68 0.49 9 GABR2_HUMAN Gamma-aminobutyric acid type B receptor subunit 2; 68 0.38 8 TSPOA_HUMAN Translocator protein; 68 0.38 8 GBRR2_HUMAN Gamma-aminobutyric acid receptor subunit rho-2; 68 0.214 5 ATP4A_HUMAN Potassium-transporting ATPase alpha chain 1; 68 0.208 9 CHLE_HUMAN Cholinesterase; 68 0.173 6 DRD4_HUMAN D(4) dopamine receptor; 68 0.151 11 ACES_HUMAN Acetylcholinesterase; 68 0.112 3 PPIA_HUMAN Peptidyl-prolyl cis-trans isomerase A; 68 0.103 5 SCN1A_HUMAN Sodium channel protein type 1 subunit alpha; 68 0.028 5 GABT_HUMAN 4-aminobutyrate aminotransferase, mitochondrial; 68 0.002 2 PPIE_HUMAN Peptidyl-prolyl cis-trans isomerase E; 68 0.002 2 FKBP2_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP2; 68 0.002 3 FKB1A_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP1A; 68 0.002 2 FKB11_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP11; 68 0.002 2 FKB14_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP14; 68 0.002 2 FKB10_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP10; 68 0.002 2 PIN1_HUMAN Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; 68 0.002 2 FKBP8_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP8; 68 0.002 2 PPIC_HUMAN Peptidyl-prolyl cis-trans isomerase C; 68 0.002 2 PPIB_HUMAN Peptidyl-prolyl cis-trans isomerase B; 68 0.002 2 PPID_HUMAN Peptidyl-prolyl cis-trans isomerase D; 68 0.002 2 PPIF_HUMAN Peptidyl-prolyl cis-trans isomerase F, mitochondrial; 68 0.002 2 FKBP4_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP4; 68 0.002 2 PPIL2_HUMAN Peptidyl-prolyl cis-trans isomerase-like 2; 68 0.002 2 FKBP6_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP6; 68 0.002 2 FKBP3_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP3; 68 0.002 2 FKB1B_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP1B; 68 0.002 2 PPIG_HUMAN Peptidyl-prolyl cis-trans isomerase G; 68 0.002 2 FKBP9_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP9; 68 0.002 2 PPIL1_HUMAN Peptidyl-prolyl cis-trans isomerase-like 1; 68 0.002 2 PIN4_HUMAN Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4; 68 0.002 2 FKBP7_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP7; 68 0.002 2 PPIL3_HUMAN Peptidyl-prolyl cis-trans isomerase-like 3; 68 0.002 2 FKBP5_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP5; # positive weight on side effects 68 0.522 184 pneumonia 68 0.521 155 dysphagia 68 0.419 152 weight loss 68 0.26 262 anemia 68 0.209 162 dysuria 68 0.151 151 asthma 68 0.132 86 vaginitis 68 0.131 125 dehydration 68 0.121 146 abnormal vision 68 0.117 85 pulmonary embolism 68 0.108 233 tinnitus 68 0.106 175 urinary tract infection 68 0.1 232 hemorrhage 68 0.097 107 amnesia 68 0.095 119 gastroenteritis 68 0.078 284 syncope 68 0.078 90 gout 68 0.059 191 peripheral edema 68 0.058 75 amblyopia 68 0.052 124 migraine 68 0.052 109 neuropathy 68 0.052 190 epistaxis 68 0.052 87 phlebitis 68 0.031 75 deafness 68 0.027 60 bilirubinemia 68 0.021 113 ear pain 68 0.01 210 agitation # high scoring drugs for both targets and side effects 68 1.842 167 5719 DB00962 Anticonvulsants.Anxiolytics sedatives and hypnotics.Hypnotics and Sedatives 68 1.808 147 71158 DB00659 Alcohol Deterrents 68 1.789 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 68 1.625 120 2284 DB00181 GABA Agonists.Muscle Relaxants.Muscle Relaxants, Central.Skeletal Muscle Relaxants 68 1.569 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 68 1.451 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 68 1.43 196 1935 DB00382 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 68 1.413 264 5372 DB00864 Immunosuppressive Agents 68 1.404 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 68 1.39 453 125889 DB00230 Analgesics.Anticonvulsants 68 1.381 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 68 1.377 211 60953 DB01101 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Prodrugs 68 1.371 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 68 1.359 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 68 1.356 133 2802 DB01068 Anticonvulsants.Benzodiazepines.GABA Modulators 68 1.347 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 68 1.341 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 68 1.335 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 68 1.321 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 68 1.311 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 68 1.3 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 68 1.296 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 68 1.29 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 68 1.285 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 68 1.284 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 68 1.276 188 5040 DB00877 Anti-Bacterial Agents.Antibiotics, Antineoplastic.Antifungal Agents.Antifungals.Immunosuppressive Agents 68 1.271 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 68 1.263 84 3016 DB00829 Adjuvants, Anesthesia.Anesthetics, Intravenous.Anti-anxiety Agents.Anticonvulsants.Antiemetics.GABA Modulators.Hypnotics and Sedatives.Muscle Relaxants, Central 68 1.253 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 68 1.237 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 68 1.229 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 68 1.218 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 68 1.216 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 68 1.206 157 4659569 DB00323 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Enzyme Inhibitors 68 1.192 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 68 1.191 196 3911 DB00007 Anti-Estrogen Agents.Antineoplastic Agents 68 1.184 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 68 1.142 183 3648 DB00327 Analgesics, Opioid.Narcotics 68 1.142 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 68 1.135 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 68 1.122 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 68 1.116 149 5394 DB00853 Antineoplastic Agents.Antineoplastic Agents, Alkylating 68 1.111 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 68 1.097 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 68 1.096 172 4920 DB00396 Contraceptives.Progestins 68 1.082 117 2182 DB00261 Antithrombotic Agents.Fibrinolytic Agents.Platelet Aggregation Inhibitors 68 1.062 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 68 1.06 201 5538 DB00755 Antineoplastic Agents.Cell Stimulants and Proliferants.Keratolytic Agents 68 1.051 131 4635 DB00497 Analgesics, Opioid.Antitussives.Narcotics.Opiate Agonists 68 1.034 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 68 1.03 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 68 1.023 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 68 1.014 234 216326 DB00480 Antineoplastic Agents 68 0.998 171 2909 DB00091 Antifungal Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Immunomodulatory Agents.Immunosuppressive Agents 68 0.99 136 2375 DB01128 Androgen Antagonists.Antineoplastic Agents 68 0.988 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 68 0.974 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists 68 0.973 144 3702 DB00808 Antihypertensive Agents.Diuretics 68 0.972 111 5281104 DB00910 Not Available 68 0.971 104 3449 DB00674 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 68 0.97 185 4594 DB00338 Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 68 0.954 147 5645 DB01586 Cholagogues and Choleretics 68 0.949 161 5487 DB00697 Adrenergic alpha-Agonists.Analgesics.Anticonvulsants.Muscle Relaxants.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 68 0.944 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 68 0.936 150 1775 DB00252 Anticonvulsants 68 0.925 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 68 0.917 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 68 0.909 158 34312 DB00776 Anticonvulsants 68 0.895 138 2369 DB00195 Adrenergic beta-Antagonists.Antihypertensive Agents.EENT Drugs.Sympatholytics 68 0.887 215 60787 DB01232 Anti-HIV Agents.HIV Protease Inhibitors 68 0.885 136 56339 DB01320 Anticonvulsants 68 0.877 211 93860 DB00188 Antineoplastic Agents.Protease Inhibitors 68 0.874 128 2250 DB01076 Anticholesteremic Agents.Hydroxymethylglutaryl-CoA Reductase Inhibitors 68 0.872 112 151165 DB00673 Antiemetics 68 0.868 143 4054 DB01043 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agents.Excitatory Amino Acid Antagonists 68 0.835 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 68 0.821 236 10631 DB00603 Contraceptives.Contraceptives, Oral, Synthetic.Progestins 68 0.81 154 27661 DB01020 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 68 0.806 137 62959 DB00685 Anti-Infective Agents.Anti-Infectives.Fluoroquinolones 68 0.799 199 5358 DB00669 Selective Serotonin Agonists.Serotonin Agonists.Vasoconstrictor Agents 68 0.79 72 4183806 DB00929 Abortifacient Agents.Abortifacient Agents, Nonsteroidal.Anti-Ulcer Agents.Oxytocics.Prostaglandins 68 0.781 140 3143 DB01248 Antimalarials.Antineoplastic Agents.Antineoplastic Agents, Phytogenic.Radiation-Sensitizing Agents 68 0.778 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 68 0.775 166 54374 DB00104 Anabolic Agents.Antineoplastic Agents, Hormonal.Gastrointestinal Agents.Hormone Replacement Agents 68 0.767 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 68 0.766 157 3937 DB00722 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents.Cardiotonic Agents 68 0.758 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 68 0.722 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 68 0.716 161 122316 DB01367 Monoamine Oxidase Inhibitors.Neuroprotective Agents 68 0.714 137 3062316 DB01254 Protein Kinase Inhibitors 68 0.711 141 4819 DB01085 Cholinergic Agents.Miotics.Muscarinic Agonists 68 0.695 132 4739 DB00552 Antibiotics.Antineoplastic Agents.Enzyme Inhibitors.Immunosuppressive Agents 68 0.686 135 5734 DB00909 Anticonvulsants.Antioxidants 68 0.681 102 4943 DB00818 Anesthetics, Intravenous.Anticonvulsants.Antiemetics.Free Radical Scavengers.Hypnotics and Sedatives 68 0.681 97 5245 DB00884 Antihypocalcemic Agents.Antiresorptives.Bisphosphonates.Bone Density Conservation Agents.Calcium Channel Blockers 68 0.68 128 3793 DB01167 Antifungal Agents.Antifungals.Antiprotozoal Agents.Antiprotozoals 68 0.658 128 4253 DB00295 Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 68 0.654 166 3394 DB00712 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Carbonic Anhydrase Inhibitors.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 68 0.65 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 68 0.635 132 4542 DB00367 Contraceptive Agents, Female.Contraceptives.Contraceptives, Oral, Synthetic #### component 69: positive weight features and high scoring objects #### # positive weight on target proteins 69 0.6 11 ACES_HUMAN Acetylcholinesterase; 69 0.522 9 CHLE_HUMAN Cholinesterase; 69 0.207 13 CAC1A_HUMAN Voltage-dependent P/Q-type calcium channel subunit alpha-1A; 69 0.199 16 CAC1G_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1G; 69 0.139 17 SCN1B_HUMAN Sodium channel subunit beta-1; 69 0.139 17 SCN4A_HUMAN Sodium channel protein type 4 subunit alpha; 69 0.139 17 DB124_HUMAN Beta-defensin 124; 69 0.139 17 ACCN3_HUMAN Amiloride-sensitive cation channel 3; 69 0.139 17 EF1B_HUMAN Elongation factor 1-beta; 69 0.139 17 SCNAA_HUMAN Sodium channel protein type 10 subunit alpha; 69 0.139 17 ACCN4_HUMAN Amiloride-sensitive cation channel 4; 69 0.139 17 SCN4B_HUMAN Sodium channel subunit beta-4; 69 0.139 17 SCN3A_HUMAN Sodium channel protein type 3 subunit alpha; 69 0.139 17 SCN3B_HUMAN Sodium channel subunit beta-3; 69 0.139 17 SCN7A_HUMAN Sodium channel protein type 7 subunit alpha; 69 0.128 15 CAC1I_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1I; 69 0.128 15 CAC1H_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1H; 69 0.113 18 SCNNB_HUMAN Amiloride-sensitive sodium channel subunit beta; 69 0.113 18 SCNNG_HUMAN Amiloride-sensitive sodium channel subunit gamma; 69 0.113 18 SCNND_HUMAN Amiloride-sensitive sodium channel subunit delta; 69 0.053 5 SCN1A_HUMAN Sodium channel protein type 1 subunit alpha; # positive weight on side effects 69 0.446 49 urinary urgency 69 0.435 117 atrial fibrillation 69 0.36 39 aphasia 69 0.292 113 ear pain 69 0.253 101 esophagitis 69 0.237 40 fecal incontinence 69 0.229 179 hematuria 69 0.215 31 neurosis 69 0.2 105 leg cramps 69 0.191 282 vertigo 69 0.188 107 melena 69 0.158 125 dehydration 69 0.132 59 herpes zoster 69 0.129 159 increased sweating 69 0.052 101 coma 69 0.046 67 gingivitis 69 0.039 169 bronchitis 69 0.032 104 pulmonary edema 69 0.014 191 peripheral edema 69 0.006 136 renal failure 69 0.002 56 kidney calculus 69 0.002 71 glaucoma 69 0.002 11 subdural hematoma 69 0.001 249 blurred vision 69 0.001 75 deafness # high scoring drugs for both targets and side effects 69 2.743 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 69 2.491 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 69 2.071 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 69 2.066 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 69 2.064 135 5734 DB00909 Anticonvulsants.Antioxidants 69 1.92 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 69 1.876 196 1935 DB00382 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 69 1.761 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 69 1.726 150 1775 DB00252 Anticonvulsants 69 1.548 453 125889 DB00230 Analgesics.Anticonvulsants 69 1.406 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 69 1.388 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 69 1.329 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 69 1.3 211 60953 DB01101 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Prodrugs 69 1.291 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 69 1.288 183 3648 DB00327 Analgesics, Opioid.Narcotics 69 1.283 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 69 1.255 112 71273 DB00296 Anesthetics.Anesthetics, Local.Local Anesthetics 69 1.227 95 16231 DB00594 Diuretics.Sodium channel blockers 69 1.204 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 69 1.175 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 69 1.173 36 4914 DB00721 Anesthetics.Anesthetics, Local.Local Anesthetics 69 1.152 104 3449 DB00674 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 69 1.126 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 69 1.092 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 69 1.088 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 69 1.032 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 69 1.029 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 69 0.958 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 69 0.946 154 3157 DB00590 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Anticholesteremic Agents.Antihypertensive Agents.Vasodilator Agents 69 0.945 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 69 0.941 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 69 0.932 91 3355 DB01195 Anti-Arrhythmia Agents.Antiarrhythmic Agents 69 0.894 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 69 0.889 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 69 0.873 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 69 0.85 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 69 0.846 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 69 0.845 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 69 0.837 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 69 0.836 196 3911 DB00007 Anti-Estrogen Agents.Antineoplastic Agents 69 0.789 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 69 0.788 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 69 0.783 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 69 0.779 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 69 0.772 61 3114 DB00280 Anti-Arrhythmia Agents.Antiarrhythmic Agents 69 0.769 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 69 0.75 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 69 0.746 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists 69 0.716 234 216326 DB00480 Antineoplastic Agents 69 0.715 141 4819 DB01085 Cholinergic Agents.Miotics.Muscarinic Agonists 69 0.702 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 69 0.699 74 3676 DB00281 Anesthetics.Anesthetics, Local.Anti-Arrhythmia Agents.Antiarrhythmic Agents 69 0.696 264 5372 DB00864 Immunosuppressive Agents 69 0.679 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 69 0.676 75 4178 DB00379 Anti-Arrhythmia Agents 69 0.643 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 69 0.641 161 122316 DB01367 Monoamine Oxidase Inhibitors.Neuroprotective Agents 69 0.637 143 4054 DB01043 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agents.Excitatory Amino Acid Antagonists 69 0.634 157 4659569 DB00323 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Enzyme Inhibitors 69 0.631 151 60835 DB00476 Adrenergic Uptake Inhibitors.Antidepressive Agents.Dopamine Uptake Inhibitors.Serotonin Uptake Inhibitors 69 0.618 51 48041 DB01228 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Sodium channel blockers 69 0.614 215 60787 DB01232 Anti-HIV Agents.HIV Protease Inhibitors 69 0.611 43 4913 DB01035 Anti-Arrhythmia Agents.Antiarrhythmic Agents 69 0.601 136 2375 DB01128 Androgen Antagonists.Antineoplastic Agents 69 0.595 188 5040 DB00877 Anti-Bacterial Agents.Antibiotics, Antineoplastic.Antifungal Agents.Antifungals.Immunosuppressive Agents 69 0.568 147 71158 DB00659 Alcohol Deterrents 69 0.56 11 2131 DB01122 Antiarrhythmic Agents.Antimyasthenics 69 0.559 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 69 0.557 199 5358 DB00669 Selective Serotonin Agonists.Serotonin Agonists.Vasoconstrictor Agents 69 0.542 171 2909 DB00091 Antifungal Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Immunomodulatory Agents.Immunosuppressive Agents 69 0.538 118 65999 DB00966 Angiotensin II Type 1 Receptor Blockers.Angiotensin-converting Enzyme Inhibitors 69 0.536 147 5645 DB01586 Cholagogues and Choleretics 69 0.531 167 5719 DB00962 Anticonvulsants.Anxiolytics sedatives and hypnotics.Hypnotics and Sedatives 69 0.521 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 69 0.521 158 34312 DB00776 Anticonvulsants 69 0.518 185 4594 DB00338 Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 69 0.516 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 69 0.516 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 69 0.491 135 2585 DB01136 Adrenergic Agents.Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 69 0.477 146 4158 DB00422 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Uptake Inhibitors.Sympathomimetics 69 0.461 134 3339 DB01039 Antilipemic Agents.Fribic Acid Derivatives 69 0.46 161 5487 DB00697 Adrenergic alpha-Agonists.Analgesics.Anticonvulsants.Muscle Relaxants.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 69 0.457 149 5394 DB00853 Antineoplastic Agents.Antineoplastic Agents, Alkylating 69 0.456 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 69 0.452 109 60879 DB00876 Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 69 0.452 117 2405 DB00612 Adrenergic Agents.Adrenergic beta-Antagonists.Antihypertensive Agents.Sympatholytics 69 0.442 201 5538 DB00755 Antineoplastic Agents.Cell Stimulants and Proliferants.Keratolytic Agents 69 0.44 154 27661 DB01020 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 69 0.437 136 56339 DB01320 Anticonvulsants 69 0.434 106 2083 DB01001 Adrenergic beta-Agonists.Bronchodilator Agents.Tocolytic Agents 69 0.432 91 937 DB00627 Antilipemic Agents.Vasodilator Agents.Vitamin B Complex.Vitamins (Vitamin B Complex) 69 0.415 76 3661 DB00572 Adjuvants, Anesthesia.Anti-Arrhythmia Agents.Bronchodilator Agents.Muscarinic Antagonists.Mydriatics.Parasympatholytics 69 0.401 142 2678 DB00341 Anti-Allergic Agents.Antihistamines.Histamine H1 Antagonists, Non-Sedating 69 0.4 211 93860 DB00188 Antineoplastic Agents.Protease Inhibitors 69 0.39 181 4932 DB01182 Anti-Arrhythmia Agents 69 0.39 144 3899 DB01097 Adjuvants.Anti-inflammatory Agents.Antineoplastic Agents.Antiparasitic Agents.Antirheumatic Agents.Antiviral Agents.Enzyme Inhibitors.Immunosuppressive Agents 69 0.38 129 5210 DB01105 Anorexigenic Agents.Antidepressants.Antidepressive Agents.Appetite Depressants.Stimulants 69 0.366 128 2250 DB01076 Anticholesteremic Agents.Hydroxymethylglutaryl-CoA Reductase Inhibitors 69 0.364 146 3075 DB00343 Antihypertensive Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Cardiovascular Agents.Vasodilator Agents #### component 70: positive weight features and high scoring objects #### # positive weight on target proteins 70 0.532 18 ESR1_HUMAN Estrogen receptor; 70 0.295 26 SC6A4_HUMAN Sodium-dependent serotonin transporter; 70 0.157 8 PRGR_HUMAN Progesterone receptor; 70 0.13 10 ESR2_HUMAN Estrogen receptor beta; 70 0.124 19 OPRM_HUMAN Mu-type opioid receptor; 70 0.067 16 TOP2A_HUMAN DNA topoisomerase 2-alpha; 70 0.051 4 PGFRB_HUMAN Beta-type platelet-derived growth factor receptor; 70 0.051 4 KIT_HUMAN Mast/stem cell growth factor receptor; 70 0.037 17 OPRD_HUMAN Delta-type opioid receptor; 70 0.025 28 SC6A2_HUMAN Sodium-dependent noradrenaline transporter; 70 0.018 16 OPRK_HUMAN Kappa-type opioid receptor; 70 0.018 4 DPOLA_HUMAN DNA polymerase alpha catalytic subunit; 70 0.013 6 DRD4_HUMAN D(4) dopamine receptor; 70 0.003 5 DCK_HUMAN Deoxycytidine kinase; 70 0.002 16 ANDR_HUMAN Androgen receptor; # positive weight on side effects 70 0.502 59 cyst 70 0.342 38 hypercalcemia 70 0.331 67 connective tissue disorders 70 0.307 91 Mediastinal Disorders 70 0.281 92 heart disease 70 0.256 84 bone pain 70 0.228 55 breast disorders 70 0.129 253 back pain 70 0.114 169 bronchitis 70 0.096 17 vaginal discharge 70 0.086 27 erythema nodosum 70 0.069 52 hypocalcemia 70 0.065 45 musculoskeletal pain 70 0.051 62 abdominal distention 70 0.041 29 breast neoplasm 70 0.035 80 tumor 70 0.018 191 peripheral edema 70 0.012 175 urinary tract infection # high scoring drugs for both targets and side effects 70 1.567 191 450 DB00783 Anti-menopausal Agents.Anticholesteremic Agents.Estrogens 70 1.539 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 70 1.536 172 4920 DB00396 Contraceptives.Progestins 70 1.428 236 10631 DB00603 Contraceptives.Contraceptives, Oral, Synthetic.Progestins 70 1.342 132 4542 DB00367 Contraceptive Agents, Female.Contraceptives.Contraceptives, Oral, Synthetic 70 1.227 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 70 1.218 91 3902 DB01006 Antineoplastic Agents.Aromatase Inhibitors 70 1.079 215 60787 DB01232 Anti-HIV Agents.HIV Protease Inhibitors 70 1.028 131 4635 DB00497 Analgesics, Opioid.Antitussives.Narcotics.Opiate Agonists 70 1.021 116 5376 DB00675 Antineoplastic Agents, Hormonal.Bone Density Conservation Agents.Estrogen Antagonists.Selective Estrogen Receptor Modulators 70 1.006 83 5487301 DB01079 Gastrointestinal Agents.Serotonin Agonists 70 0.949 136 2375 DB01128 Androgen Antagonists.Antineoplastic Agents 70 0.893 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 70 0.891 453 125889 DB00230 Analgesics.Anticonvulsants 70 0.881 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 70 0.875 125 596 DB02097 Not Available 70 0.871 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 70 0.871 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 70 0.857 112 151165 DB00673 Antiemetics 70 0.837 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 70 0.835 211 93860 DB00188 Antineoplastic Agents.Protease Inhibitors 70 0.817 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 70 0.81 116 5525 DB00519 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 70 0.794 144 3899 DB01097 Adjuvants.Anti-inflammatory Agents.Antineoplastic Agents.Antiparasitic Agents.Antirheumatic Agents.Antiviral Agents.Enzyme Inhibitors.Immunosuppressive Agents 70 0.793 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 70 0.792 147 5645 DB01586 Cholagogues and Choleretics 70 0.762 146 4158 DB00422 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Uptake Inhibitors.Sympathomimetics 70 0.752 121 5408 DB00624 Androgens 70 0.736 88 365716 Not Available Not Available 70 0.702 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 70 0.701 167 170361 DB01273 Nicotinic Agonists 70 0.696 125 3285 DB00977 Estrogens 70 0.695 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 70 0.689 137 3062316 DB01254 Protein Kinase Inhibitors 70 0.682 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 70 0.67 149 5394 DB00853 Antineoplastic Agents.Antineoplastic Agents, Alkylating 70 0.656 128 3793 DB01167 Antifungal Agents.Antifungals.Antiprotozoal Agents.Antiprotozoals 70 0.654 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 70 0.635 152 60184 DB00790 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 70 0.633 234 216326 DB00480 Antineoplastic Agents 70 0.633 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 70 0.616 90 4634 DB01062 Anticholinergic Agents.Antispasmodics.Genitourinary Smooth Muscle Relaxants.Muscarinic Antagonists.Parasympatholytics 70 0.613 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 70 0.601 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 70 0.594 151 60835 DB00476 Adrenergic Uptake Inhibitors.Antidepressive Agents.Dopamine Uptake Inhibitors.Serotonin Uptake Inhibitors 70 0.591 68 5596 DB00209 Analgesics.Parasympatholytics 70 0.582 112 3367 DB01073 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Immunosuppressive Agents 70 0.577 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 70 0.563 106 216239 DB00398 Anticancer Agents.Antineoplastic Agents.Protein Kinase Inhibitors 70 0.561 90 5329102 DB01268 Angiogenesis Inhibitors.Antineoplastic Agents 70 0.553 33 4425 DB01183 Antinarcotic Agents.Depressants.Narcotic Antagonists.Opiate Antagonists 70 0.541 196 3911 DB00007 Anti-Estrogen Agents.Antineoplastic Agents 70 0.536 101 2800 DB00822 Alcohol Deterrents.Enzyme Inhibitors 70 0.535 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 70 0.528 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 70 0.526 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 70 0.523 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 70 0.516 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 70 0.515 61 40976 DB00294 Contraceptive Agents, Female.Contraceptives 70 0.496 161 5212 DB00203 Phosphodiesterase Inhibitors.Vasodilator Agents 70 0.471 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 70 0.47 124 62924 DB00588 Adrenergic Agents.Anti-Allergic Agents.Anti-inflammatory Agents.Bronchodilator Agents.Dermatologic Agents 70 0.462 111 5281104 DB00910 Not Available 70 0.458 185 4594 DB00338 Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 70 0.452 41 5516 DB00539 Antineoplastic Agents.Antineoplastic Agents, Hormonal.Bone Density Conservation Agents.Selective Estrogen Receptor Modulators 70 0.45 86 115237 DB01267 Antipsychotic Agents 70 0.446 53 5035 DB00481 Antihypocalcemic Agents.Bone Density Conservation Agents.Estrogen Antagonists.Osteoporosis Prophylactic.Selective Estrogen Receptor Modulators 70 0.443 64 19090 DB00351 Antineoplastic Agents, Hormonal.Contraceptives, Oral, Synthetic 70 0.44 39 104741 DB00947 Antineoplastic Agents.Antineoplastic Agents, Hormonal.Estrogen Antagonists 70 0.44 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 70 0.433 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 70 0.432 131 4428 DB00704 Alcohol Antagonists.Anti-craving Agents.Depressants.Narcotic Antagonists.Opiate Antagonists 70 0.428 264 5372 DB00864 Immunosuppressive Agents 70 0.419 84 57469 DB00724 Adjuvants, Immunologic.Antineoplastic Agents.Antiviral Agents.Interferon Inducers 70 0.415 69 5311297 DB00471 Anti-Asthmatic Agents.Antiarrhythmic Agents.Leukotriene Antagonists 70 0.414 72 60831 DB01409 Anticholinergic Agents.Bronchodilator Agents.Cholinergic Antagonists.Muscarinic Antagonists.Parasympatholytics 70 0.414 40 18140 DB01196 Antineoplastic Agents.Antineoplastic Agents, Alkylating.Antineoplastic Agents, Hormonal.Radiation-Protective Agents 70 0.411 161 5291 DB00619 Antineoplastic Agents.Protein Kinase Inhibitors 70 0.411 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 70 0.408 188 5040 DB00877 Anti-Bacterial Agents.Antibiotics, Antineoplastic.Antifungal Agents.Antifungals.Immunosuppressive Agents 70 0.406 199 5358 DB00669 Selective Serotonin Agonists.Serotonin Agonists.Vasoconstrictor Agents 70 0.405 118 68740 DB00399 Antihypocalcemic Agents.Antiresorptives.Bisphosphonates.Bone Density Conservation Agents 70 0.398 114 5379 DB01044 Anti-Infective Agents.Antibiotics 70 0.397 83 54841 DB00289 Adrenergic Uptake Inhibitors.Antidepressants.Central Nervous System Agents 70 0.392 86 2118 DB00404 Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 70 0.391 81 3461 DB00441 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Antiviral Agents.Enzyme Inhibitors.Immunosuppressive Agents.Radiation-Sensitizing Agents 70 0.385 53 2092 DB00346 Adrenergic alpha-Antagonists.Antihypertensive Agents 70 0.38 70 4091 DB00331 Hypoglycemic Agents 70 0.372 70 2179 DB00276 Antineoplastic Agents.Intercalating Agents 70 0.366 38 125017 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 70 0.362 151 41317 DB00459 Keratolytic Agents 70 0.362 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 70 0.359 50 2973 DB00746 Chelating agent.Iron Chelating Agents.Siderophores 70 0.358 54 4159 DB00959 Adrenergic Agents.Anti-inflammatory Agents.Antiemetics.Glucocorticoids.Neuroprotective Agents 70 0.35 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 70 0.348 38 30623 DB00380 Antineoplastic Agents.Cardiovascular Agents.Chelating Agents.Immunosuppressive Agents 70 0.343 58 60147 DB00706 Adrenergic alpha-Antagonists.Antineoplastic Agents 70 0.332 141 4819 DB01085 Cholinergic Agents.Miotics.Muscarinic Agonists 70 0.326 201 5538 DB00755 Antineoplastic Agents.Cell Stimulants and Proliferants.Keratolytic Agents 70 0.323 97 159 DB01240 Antihypertensive Agents.Platelet Aggregation Inhibitors #### component 71: positive weight features and high scoring objects #### # positive weight on target proteins 71 0.582 14 A1AG1_HUMAN Alpha-1-acid glycoprotein 1; 71 0.574 11 A1AG2_HUMAN Alpha-1-acid glycoprotein 2; 71 0.288 14 TTHY_HUMAN Transthyretin; 71 0.231 9 NMD3A_HUMAN Glutamate [NMDA] receptor subunit 3A; 71 0.132 12 SC6A3_HUMAN Sodium-dependent dopamine transporter; 71 0.119 23 PGH1_HUMAN Prostaglandin G/H synthase 1; 71 0.101 18 SCN5A_HUMAN Sodium channel protein type 5 subunit alpha; 71 0.094 9 OPRX_HUMAN Nociceptin receptor; 71 0.085 8 LX12B_HUMAN Arachidonate 12-lipoxygenase, 12R-type; 71 0.085 8 LOXE3_HUMAN Epidermis-type lipoxygenase 3; 71 0.085 8 LOX12_HUMAN Arachidonate 12-lipoxygenase, 12S-type; 71 0.051 8 OGFR_HUMAN Opioid growth factor receptor; 71 0.042 12 AOFB_HUMAN Amine oxidase [flavin-containing] B; 71 0.037 8 TSPOA_HUMAN Translocator protein; 71 0.037 8 GBRR2_HUMAN Gamma-aminobutyric acid receptor subunit rho-2; 71 0.025 17 OPRD_HUMAN Delta-type opioid receptor; 71 0.024 16 OPRK_HUMAN Kappa-type opioid receptor; 71 0.024 14 LOX5_HUMAN Arachidonate 5-lipoxygenase; 71 0.016 17 EF1B_HUMAN Elongation factor 1-beta; 71 0.016 17 SCNAA_HUMAN Sodium channel protein type 10 subunit alpha; 71 0.016 17 SCN1B_HUMAN Sodium channel subunit beta-1; 71 0.016 17 ACCN3_HUMAN Amiloride-sensitive cation channel 3; 71 0.016 17 SCN3A_HUMAN Sodium channel protein type 3 subunit alpha; 71 0.016 17 SCN7A_HUMAN Sodium channel protein type 7 subunit alpha; 71 0.016 5 GLRA2_HUMAN Glycine receptor subunit alpha-2; 71 0.016 17 SCN4A_HUMAN Sodium channel protein type 4 subunit alpha; 71 0.016 17 ACCN4_HUMAN Amiloride-sensitive cation channel 4; 71 0.016 17 DB124_HUMAN Beta-defensin 124; 71 0.016 17 SCN4B_HUMAN Sodium channel subunit beta-4; 71 0.016 5 GLRB_HUMAN Glycine receptor subunit beta; 71 0.016 17 SCN3B_HUMAN Sodium channel subunit beta-3; 71 0.01 8 CALL3_HUMAN Calmodulin-like protein 3; 71 0.004 7 LX15B_HUMAN Arachidonate 15-lipoxygenase B; 71 0.003 12 ACE_HUMAN Angiotensin-converting enzyme; # positive weight on side effects 71 0.529 377 urticaria 71 0.457 118 shock 71 0.336 284 syncope 71 0.296 322 hypotension 71 0.247 322 tachycardia 71 0.199 474 dizziness 71 0.179 373 fever 71 0.156 63 lupus 71 0.143 189 hallucinations 71 0.137 152 urinary retention 71 0.101 368 somnolence 71 0.1 342 insomnia 71 0.055 101 coma 71 0.054 32 bloating 71 0.053 249 blurred vision 71 0.042 205 bradycardia 71 0.038 280 anxiety 71 0.029 79 lightheadedness 71 0.023 28 meningitis 71 0.008 210 agitation 71 0.005 38 loss of consciousness 71 0.003 180 agranulocytosis # high scoring drugs for both targets and side effects 71 1.539 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 71 1.503 59 4095 DB00333 Analgesics.Analgesics, Opioid.Antitussive Agents.Antitussives.Narcotics.Opiate Agonists 71 1.485 74 3676 DB00281 Anesthetics.Anesthetics, Local.Anti-Arrhythmia Agents.Antiarrhythmic Agents 71 1.467 61 3114 DB00280 Anti-Arrhythmia Agents.Antiarrhythmic Agents 71 1.359 64 2726 DB00477 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 71 1.295 72 2160 DB00321 Adrenergic Uptake Inhibitors.Analgesics, Non-Narcotic.Antidepressive Agents, Tricyclic 71 1.276 69 3696 DB00458 Adrenergic Uptake Inhibitors.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 71 1.205 45 6691 DB00682 Anticoagulants.Coumarin and Indandione Derivatives.Rodenticides 71 1.132 120 3715 DB00328 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cardiovascular Agents.Cyclooxygenase Inhibitors.Gout Suppressants.Nonsteroidal Antiinflammatory Agents (NSAIDs).Tocolytic Agents 71 0.984 42 4196 DB00834 Abortifacient Agents, Steroidal.Contraceptives, Oral, Synthetic.Contraceptives, Postcoital, Synthetic.Hormone Antagonists.Luteolytic Agents.Menstruation-Inducing Agents 71 0.945 150 1775 DB00252 Anticonvulsants 71 0.919 61 4946 DB00571 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Anti-anxiety Agents.Antiarrhythmic Agents.Antihypertensive Agents.Vasodilator Agents 71 0.919 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 71 0.867 84 3016 DB00829 Adjuvants, Anesthesia.Anesthetics, Intravenous.Anti-anxiety Agents.Anticonvulsants.Antiemetics.GABA Modulators.Hypnotics and Sedatives.Muscle Relaxants, Central 71 0.866 119 3308 DB00749 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 71 0.858 62 3007 DB00182 Adrenergic Agents.Adrenergic Uptake Inhibitors.Amphetamines.Central Nervous System Stimulants.Dopamine Agents.Dopamine Uptake Inhibitors.Sympathomimetics 71 0.851 28 4058 DB00454 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 71 0.839 23 51263 DB00802 Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 71 0.837 91 60815 DB00899 Analgesics, Opioid.Anesthetics, Intravenous.Hypnotics and Sedatives 71 0.83 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 71 0.812 102 4943 DB00818 Anesthetics, Intravenous.Anticonvulsants.Antiemetics.Free Radical Scavengers.Hypnotics and Sedatives 71 0.806 76 4748 DB00850 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 71 0.803 145 3672 DB01050 Analgesics.Analgesics, Non-Narcotic.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 71 0.794 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 71 0.79 112 71273 DB00296 Anesthetics.Anesthetics, Local.Local Anesthetics 71 0.776 453 125889 DB00230 Analgesics.Anticonvulsants 71 0.768 47 4419 DB00844 Analgesics, Opioid.Narcotic Antagonists.Narcotics 71 0.767 65 2474 DB00297 Anesthetics, Local 71 0.756 128 4253 DB00295 Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 71 0.727 183 3648 DB00327 Analgesics, Opioid.Narcotics 71 0.695 147 71158 DB00659 Alcohol Deterrents 71 0.691 120 2284 DB00181 GABA Agonists.Muscle Relaxants.Muscle Relaxants, Central.Skeletal Muscle Relaxants 71 0.681 166 3394 DB00712 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Carbonic Anhydrase Inhibitors.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 71 0.68 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 71 0.677 97 1065 DB00908 Adrenergic alpha-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antimalarials.Enzyme Inhibitors.Muscarinic Antagonists 71 0.666 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 71 0.66 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 71 0.659 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 71 0.658 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 71 0.653 142 3826 DB00465 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 71 0.65 131 4635 DB00497 Analgesics, Opioid.Antitussives.Narcotics.Opiate Agonists 71 0.646 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 71 0.637 108 4856 DB00554 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 71 0.637 89 4044 DB00784 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 71 0.631 92 3825 DB01009 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 71 0.625 36 4914 DB00721 Anesthetics.Anesthetics, Local.Local Anesthetics 71 0.618 84 2995 DB01151 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Enzyme Inhibitors.Norepinephrine-Reuptake Inhibitors 71 0.615 201 5538 DB00755 Antineoplastic Agents.Cell Stimulants and Proliferants.Keratolytic Agents 71 0.615 161 5487 DB00697 Adrenergic alpha-Agonists.Analgesics.Anticonvulsants.Muscle Relaxants.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 71 0.609 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 71 0.608 181 4932 DB01182 Anti-Arrhythmia Agents 71 0.606 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 71 0.604 119 4052 DB00814 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Antiemetics.Antineoplastic Agents.Cyclooxygenase Inhibitors.Growth Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 71 0.602 196 3911 DB00007 Anti-Estrogen Agents.Antineoplastic Agents 71 0.588 69 2170 DB00543 Adrenergic Uptake Inhibitors.Antidepressive Agents, Second-Generation.Dopamine Antagonists.Neurotransmitter Uptake Inhibitors.Serotonin Uptake Inhibitors 71 0.585 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 71 0.585 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 71 0.584 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 71 0.581 106 2083 DB01001 Adrenergic beta-Agonists.Bronchodilator Agents.Tocolytic Agents 71 0.563 71 2487 DB00611 Analgesics, Opioid.Antitussive Agents.Narcotic Antagonists.Narcotics 71 0.56 117 2405 DB00612 Adrenergic Agents.Adrenergic beta-Antagonists.Antihypertensive Agents.Sympatholytics 71 0.558 211 93860 DB00188 Antineoplastic Agents.Protease Inhibitors 71 0.546 104 4614 DB00991 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Nonsteroidal Antiinflammatory Agents (NSAIDs) 71 0.542 71 4740 DB00806 Free Radical Scavengers.Hematologic Agents.Hemorrheologic Agents.Phosphodiesterase Inhibitors.Platelet Aggregation Inhibitors.Radiation-Protective Agents.Vasodilator Agents 71 0.536 30 8612 DB01161 Anesthetics, Local 71 0.534 108 3015 DB04839 Androgen Antagonists 71 0.525 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 71 0.522 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 71 0.519 59 2476 DB00921 Analgesics, Opioid.Narcotic Antagonists.Narcotics 71 0.517 91 937 DB00627 Antilipemic Agents.Vasodilator Agents.Vitamin B Complex.Vitamins (Vitamin B Complex) 71 0.516 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 71 0.514 89 3148 DB00757 Antiemetics.Serotonin Antagonists 71 0.513 199 5358 DB00669 Selective Serotonin Agonists.Serotonin Agonists.Vasoconstrictor Agents 71 0.499 95 16231 DB00594 Diuretics.Sodium channel blockers 71 0.493 73 34633 DB00680 Anti-Arrhythmia Agents 71 0.492 97 159 DB01240 Antihypertensive Agents.Platelet Aggregation Inhibitors 71 0.491 172 4920 DB00396 Contraceptives.Progestins 71 0.489 166 54374 DB00104 Anabolic Agents.Antineoplastic Agents, Hormonal.Gastrointestinal Agents.Hormone Replacement Agents 71 0.488 234 216326 DB00480 Antineoplastic Agents 71 0.487 58 5206 DB01236 Anesthetics, Inhalation.Platelet Aggregation Inhibitors 71 0.486 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 71 0.486 91 3355 DB01195 Anti-Arrhythmia Agents.Antiarrhythmic Agents 71 0.485 143 4054 DB01043 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agents.Excitatory Amino Acid Antagonists 71 0.484 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 71 0.48 103 2751 DB01340 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 71 0.475 94 4171 DB00264 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Sympatholytics 71 0.465 161 5212 DB00203 Phosphodiesterase Inhibitors.Vasodilator Agents 71 0.464 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 71 0.457 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 71 0.457 76 2803 DB00575 Adrenergic alpha-Agonists.Analgesics.Antihypertensive Agents.Central Alpha-Agonists.Sympatholytics 71 0.452 60 3059 DB00861 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 71 0.45 78 2249 DB00335 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Sympatholytics 71 0.446 72 3440 DB00695 Diuretics.Sodium Potassium Chloride Symporter Inhibitors 71 0.443 67 4976 DB00344 Adrenergic Uptake Inhibitors.Antidepressive Agents.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 71 0.443 64 5584 DB00726 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 71 0.44 58 60147 DB00706 Adrenergic alpha-Antagonists.Antineoplastic Agents 71 0.438 111 3419 DB00492 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 71 0.436 118 68740 DB00399 Antihypocalcemic Agents.Antiresorptives.Bisphosphonates.Bone Density Conservation Agents 71 0.432 114 5379 DB01044 Anti-Infective Agents.Antibiotics 71 0.431 264 5372 DB00864 Immunosuppressive Agents #### component 72: positive weight features and high scoring objects #### # positive weight on target proteins 72 0.603 35 HRH1_HUMAN Histamine H1 receptor; 72 0.359 9 HRH4_HUMAN Histamine H4 receptor; 72 0.34 8 HRH3_HUMAN Histamine H3 receptor; 72 0.196 12 AOFB_HUMAN Amine oxidase [flavin-containing] B; 72 0.138 13 CAH2_HUMAN Carbonic anhydrase 2; 72 0.128 9 OPRX_HUMAN Nociceptin receptor; 72 0.127 11 CAH4_HUMAN Carbonic anhydrase 4; 72 0.125 5 AOFA_HUMAN Amine oxidase [flavin-containing] A; 72 0.123 12 KCMA1_HUMAN Calcium-activated potassium channel subunit alpha-1; 72 0.094 18 SCN5A_HUMAN Sodium channel protein type 5 subunit alpha; 72 0.08 8 OGFR_HUMAN Opioid growth factor receptor; 72 0.067 28 SC6A2_HUMAN Sodium-dependent noradrenaline transporter; 72 0.064 6 S12A3_HUMAN Solute carrier family 12 member 3; 72 0.047 10 AT1A1_HUMAN Sodium/potassium-transporting ATPase subunit alpha-1; 72 0.044 23 PGH1_HUMAN Prostaglandin G/H synthase 1; 72 0.044 9 S12A1_HUMAN Solute carrier family 12 member 1; 72 0.04 8 CALL3_HUMAN Calmodulin-like protein 3; 72 0.014 18 GCR_HUMAN Glucocorticoid receptor; 72 0.014 6 NMD3B_HUMAN Glutamate [NMDA] receptor subunit 3B; 72 0.011 17 OPRD_HUMAN Delta-type opioid receptor; 72 0.009 8 SHBG_HUMAN Sex hormone-binding globulin; 72 0.006 8 GLRA1_HUMAN Glycine receptor subunit alpha-1; # positive weight on side effects 72 0.297 137 convulsions 72 0.254 301 dry mouth 72 0.128 368 somnolence 72 0.08 210 agitation 72 0.039 180 agranulocytosis 72 0.015 187 photosensitivity # high scoring drugs for both targets and side effects 72 1.453 66 4011 DB00934 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Second-Generation 72 1.414 47 4927 DB01069 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists.Phenothiazine Derivatives 72 1.369 9 3658 DB00557 Antipruritics.Anxiolytics sedatives and hypnotics.Histamine H1 Antagonists 72 1.358 37 3100 DB01075 Anesthetics.Anesthetics, Local.Anti-Allergic Agents.Antidyskinetics.Antiemetics.Antiparkinson Agents.Antipruritics.Antitussives.Ethanolamine Derivatives.Histamine H1 Antagonists.Hypnotics and Sedatives 72 1.143 9 2366 Not Available Not Available 72 1.127 80 3325 DB00927 Anti-Ulcer Agents.Histamine H2 Antagonists 72 1.013 84 2995 DB01151 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Enzyme Inhibitors.Norepinephrine-Reuptake Inhibitors 72 1.008 32 2725 DB01114 Anti-Allergic Agents.Antihistamines.Antipruritics.Histamine H1 Antagonists 72 1.008 37 2781 DB00283 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists 72 1.008 36 2564 DB00748 Antihistamines 72 1.008 44 2913 DB00434 Anti-Allergic Agents.Antihistamine derivatives.Antipruritics.Gastrointestinal Agents.Histamine H1 Antagonists.Serotonin Antagonists 72 0.974 33 60865 DB00768 Anti-Allergic Agents.Anti-Inflammatory Agents, Non-Steroidal.Antihistamines.Histamine H1 Antagonists.Histamine H1 Antagonists, Non-Sedating 72 0.967 42 3675 DB00780 Antidepressants.Antidepressive Agents.Monoamine Oxidase Inhibitors 72 0.92 3 4034 DB00737 Anti-Allergic Agents.Antiemetics.Antihistamines.Histamine H1 Antagonists 72 0.879 69 3696 DB00458 Adrenergic Uptake Inhibitors.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 72 0.873 50 3158 DB01142 Anti-anxiety Agents.Antidepressants.Antidepressive Agents, Tricyclic.Antipruritics.Histamine Antagonists.Norepinephrine-Reuptake Inhibitors 72 0.862 55 3019 DB01119 Antihypertensive Agents.Diuretics, Thiazide.Vasodilator Agents 72 0.852 28 4058 DB00454 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 72 0.84 20 4601 DB01173 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 72 0.819 20 5775 DB00692 Adrenergic alpha-Antagonists.Antihypertensive Agents.Sympatholytics 72 0.799 27 4100 DB00703 Carbonic Anhydrase Inhibitors.Diuretics 72 0.799 43 1986 DB00819 Anticonvulsants.Carbonic Anhydrase Inhibitors.Diuretics 72 0.786 29 3759 DB01247 Antidepressants.Antidepressive Agents.Monoamine Oxidase Inhibitors 72 0.766 12 3915 DB01106 Histamine H1 Antagonists.Histamine H1 Antagonists, Non-Sedating 72 0.733 27 3647 DB00774 Antihypertensive Agents.Diuretics.Diuretics, Thiazide.Sodium Chloride Symporter Inhibitors 72 0.733 38 4121 DB00232 Diuretics.Diuretics, Thiazide.Sodium Chloride Symporter Inhibitors 72 0.72 43 2720 DB00880 Antihypertensive Agents.Diuretics.Diuretics, Thiazide.Sodium Chloride Symporter Inhibitors 72 0.72 41 2315 DB00436 Antihypertensive Agents.Diuretics.Diuretics, Thiazide.Sodium Chloride Symporter Inhibitors 72 0.711 67 4976 DB00344 Adrenergic Uptake Inhibitors.Antidepressive Agents.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 72 0.711 65 4543 DB00540 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 72 0.711 64 5584 DB00726 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 72 0.674 59 4917 DB00433 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 72 0.665 18 3957 DB00455 Anti-Allergic Agents.Antihistamines.Antipruritics.Histamine H1 Antagonists, Non-Sedating 72 0.663 35 16362 DB01100 Anti-Dyskinesia Agents.Antipsychotic Agents.Dopamine Antagonists 72 0.661 12 4771 DB00191 Adrenergic Agents.Anorexigenic Agents.Appetite Depressants.Central Nervous System Agents.Central Nervous System Stimulants.Stimulants.Sympathomimetics 72 0.658 8 2381 DB00810 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists.Parasympatholytics 72 0.651 34 3827 DB00920 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists 72 0.646 9 3219 DB01084 Anti-Allergic Agents.Histamine H1 Antagonists 72 0.643 41 5530 DB00752 Anti-anxiety Agents.Antidepressants.Antidepressive Agents.Monoamine Oxidase Inhibitors 72 0.64 32 3278 DB00903 Diuretics.Enzyme Inhibitors 72 0.63 36 4914 DB00721 Anesthetics.Anesthetics, Local.Local Anesthetics 72 0.628 49 4078 DB00933 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 72 0.628 72 2160 DB00321 Adrenergic Uptake Inhibitors.Analgesics, Non-Narcotic.Antidepressive Agents, Tricyclic 72 0.618 14 3354 DB01148 Parasympatholytics 72 0.618 21 4057 DB04843 Anticholinergic Agents.Parasympatholytics 72 0.618 9 1148 DB00150 Antidepressive Agents, Second-Generation.Dietary supplement.Essential Amino Acids.Micronutrient 72 0.615 30 8612 DB01161 Anesthetics, Local 72 0.611 54 3639 DB00999 Antihypertensive Agents.Diuretics.Sodium Chloride Symporter Inhibitors 72 0.609 31 2441 DB01558 Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 72 0.602 27 23897 DB01618 Antipsychotic Agents 72 0.595 25 3767 DB00951 Antitubercular Agents.Fatty Acid Synthesis Inhibitors 72 0.594 14 10100 DB00647 Analgesics.Analgesics, Opioid.Antitussives.Narcotics 72 0.591 23 51263 DB00802 Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 72 0.575 19 4032 DB00657 Antihypertensive Agents.Ganglionic Blockers.Nicotinic Antagonists 72 0.575 16 5771 DB00107 Anti-tocolytic Agents.Labor Induction Agents.Oxytocics 72 0.569 37 3494 DB00986 Adjuvants, Anesthesia.Anti-cholinergic Agents.Muscarinic Antagonists 72 0.568 38 125017 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 72 0.566 65 2474 DB00297 Anesthetics, Local 72 0.561 21 5546 DB00384 Diuretics.Potassium-sparing Diuretics 72 0.557 22 60164 DB00210 Anti-Inflammatory Agents, Non-Steroidal.Dermatologic Agents 72 0.553 9 2733 DB00356 Muscle Relaxants, Central 72 0.552 73 3958 DB00186 Anti-anxiety Agents.Anticonvulsants.Antiemetics.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 72 0.547 76 4748 DB00850 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 72 0.544 23 3821 DB01221 Analgesics.Anesthetics, Dissociative.Excitatory Amino Acid Antagonists.General Anesthetics 72 0.539 44 4060 DB00532 Anticonvulsants 72 0.536 27 750 DB00145 Dietary supplement.Glycine Agents.Micronutrient.Non-Essential Amino Acids 72 0.534 4 4768 DB00925 Adrenergic alpha-Antagonists.Antihypertensive Agents.Vasodilator Agents 72 0.531 51 3964 DB00408 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists 72 0.531 23 5193 DB00418 Adjuvants.Adjuvants, Anesthesia.Barbiturates.GABA Modulators.Hypnotics and Sedatives 72 0.531 23 4737 DB00312 Adjuvants, Anesthesia.Barbiturates.GABA Modulators.Hypnotics and Sedatives 72 0.531 25 5572 DB00376 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists 72 0.526 28 4870 DB01324 Antihypertensive Agents.Diuretics.Sodium Chloride Symporter Inhibitors 72 0.518 31 4900 DB00635 Adrenergic Agents.Anti-inflammatory Agents.Antineoplastic Agents.Antineoplastic Agents, Hormonal.Glucocorticoids 72 0.516 30 2732 DB00310 Antihypertensive Agents.Diuretics.Sodium Chloride Symporter Inhibitors 72 0.513 16 2905 DB00979 Antimuscarinic eye preparations.Muscarinic Antagonists.Mydriatics.Parasympatholytics 72 0.511 20 4616 DB00842 Anti-anxiety Agents.GABA Modulators.Hypnotics and Sedatives 72 0.511 12 4909 DB00794 Anticonvulsants.Barbiturates 72 0.505 19 2344 DB00245 Antidyskinetics.Antiparkinson Agents.Dopamine Uptake Inhibitors.Muscarinic Antagonists.Parasympatholytics 72 0.505 11 4919 DB00387 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists 72 0.498 10 2712 DB00475 Adjuvants, Anesthesia.Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 72 0.498 35 3397 DB00499 Androgen Antagonists.Antineoplastic Agents, Hormonal 72 0.496 3 175 DB04184 Indicators and Reagents 72 0.496 16 4211 DB00648 Antineoplastic Agents.Antineoplastic Agents, Hormonal 72 0.492 62 5566 DB00831 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 72 0.492 21 6398525 DB00364 Anti-Ulcer Agents 72 0.492 10 3226 DB00228 Anesthetics, Inhalation.General Anesthetics 72 0.491 6 12555 Not Available Not Available 72 0.491 11 40704 Not Available Not Available 72 0.491 11 3117 DB00822 Alcohol Deterrents.Enzyme Inhibitors 72 0.49 69 2170 DB00543 Adrenergic Uptake Inhibitors.Antidepressive Agents, Second-Generation.Dopamine Antagonists.Neurotransmitter Uptake Inhibitors.Serotonin Uptake Inhibitors 72 0.476 61 4192 DB00683 Adjuvants, Anesthesia.Anesthetics, Intravenous.Anti-anxiety Agents.GABA Modulators.Hypnotics and Sedatives 72 0.476 49 3467 DB00798 Anti-Bacterial Agents.Protein Synthesis Inhibitors 72 0.473 83 3640 DB00741 Anti-inflammatory Agents 72 0.47 8 3241 DB00751 Antihistamines.Histamine H1 Antagonists.Ophthalmics 72 0.469 86 3003 DB01234 Adrenergic Agents.Anti-inflammatory Agents.Antiemetics.Antineoplastic Agents, Hormonal.Glucocorticoids 72 0.469 74 4894 DB00860 Adrenergic Agents.Anti-inflammatory Agents.Antineoplastic Agents.Antineoplastic Agents, Hormonal.Glucocorticoids 72 0.467 15 3739 DB04711 Contrast Media 72 0.464 17 5403 DB00871 Adrenergic beta-Agonists.Bronchodilator Agents.Sympathomimetic.Sympathomimetics.Tocolytic Agents 72 0.462 43 31378 DB00687 Adrenergic Agents.Anti-inflammatory Agents 72 0.46 20 838 DB00668 Adrenergic Agonists.Adrenergic alpha-Agonists.Adrenergic beta-Agonists.Bronchodilator Agents.Mydriatics.Sympathomimetics.Vasoconstrictor Agents #### component 73: positive weight features and high scoring objects #### # positive weight on target proteins 73 0.634 18 SCN5A_HUMAN Sodium channel protein type 5 subunit alpha; 73 0.341 38 ADA2A_HUMAN Alpha-2A adrenergic receptor; 73 0.305 33 ADA2B_HUMAN Alpha-2B adrenergic receptor; 73 0.228 18 SCNNB_HUMAN Amiloride-sensitive sodium channel subunit beta; 73 0.228 18 SCNNG_HUMAN Amiloride-sensitive sodium channel subunit gamma; 73 0.228 18 SCNND_HUMAN Amiloride-sensitive sodium channel subunit delta; 73 0.137 17 SCN1B_HUMAN Sodium channel subunit beta-1; 73 0.137 17 EF1B_HUMAN Elongation factor 1-beta; 73 0.137 17 SCNAA_HUMAN Sodium channel protein type 10 subunit alpha; 73 0.137 17 DB124_HUMAN Beta-defensin 124; 73 0.137 17 ACCN3_HUMAN Amiloride-sensitive cation channel 3; 73 0.137 17 SCN4A_HUMAN Sodium channel protein type 4 subunit alpha; 73 0.137 17 SCN4B_HUMAN Sodium channel subunit beta-4; 73 0.137 17 SCN7A_HUMAN Sodium channel protein type 7 subunit alpha; 73 0.137 17 ACCN4_HUMAN Amiloride-sensitive cation channel 4; 73 0.137 17 SCN3B_HUMAN Sodium channel subunit beta-3; 73 0.137 17 SCN3A_HUMAN Sodium channel protein type 3 subunit alpha; 73 0.115 34 ADA1B_HUMAN Alpha-1B adrenergic receptor; # positive weight on side effects 73 0.311 83 leukocytosis 73 0.303 129 neutropenia 73 0.282 101 coma 73 0.173 57 elevated blood pressure 73 0.151 71 numbness 73 0.13 209 jaundice 73 0.119 19 positive ANA 73 0.103 249 blurred vision 73 0.097 62 ventricular extrasystoles 73 0.089 368 somnolence 73 0.088 16 choreoathetosis 73 0.076 70 petechiae 73 0.068 77 breast pain 73 0.068 7 Diabetic ketoacidosis 73 0.064 5 diabetes insipidus 73 0.046 118 exfoliative dermatitis 73 0.045 35 pericarditis 73 0.038 11 subdural hematoma 73 0.037 75 deafness 73 0.029 29 sinus bradycardia 73 0.027 75 amblyopia 73 0.027 14 megaloblastic anemia 73 0.026 159 increased sweating 73 0.015 9 phobia 73 0.004 4 breast abscess 73 0.004 179 myocardial infarction # high scoring drugs for both targets and side effects 73 2.03 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 73 1.633 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 73 1.63 150 1775 DB00252 Anticonvulsants 73 1.501 95 16231 DB00594 Diuretics.Sodium channel blockers 73 1.434 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 73 1.408 112 71273 DB00296 Anesthetics.Anesthetics, Local.Local Anesthetics 73 1.403 74 3676 DB00281 Anesthetics.Anesthetics, Local.Anti-Arrhythmia Agents.Antiarrhythmic Agents 73 1.398 43 4913 DB01035 Anti-Arrhythmia Agents.Antiarrhythmic Agents 73 1.383 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 73 1.239 91 3355 DB01195 Anti-Arrhythmia Agents.Antiarrhythmic Agents 73 1.222 75 4178 DB00379 Anti-Arrhythmia Agents 73 1.189 51 48041 DB01228 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Sodium channel blockers 73 1.165 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 73 1.131 61 3114 DB00280 Anti-Arrhythmia Agents.Antiarrhythmic Agents 73 1.032 36 4914 DB00721 Anesthetics.Anesthetics, Local.Local Anesthetics 73 1.002 135 5734 DB00909 Anticonvulsants.Antioxidants 73 0.886 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 73 0.845 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 73 0.784 76 3661 DB00572 Adjuvants, Anesthesia.Anti-Arrhythmia Agents.Bronchodilator Agents.Muscarinic Antagonists.Mydriatics.Parasympatholytics 73 0.639 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 73 0.618 161 5487 DB00697 Adrenergic alpha-Agonists.Analgesics.Anticonvulsants.Muscle Relaxants.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 73 0.608 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 73 0.58 51 3559 DB00502 Anti-Dyskinesia Agents.Antidyskinetics.Antiemetics.Antipsychotic Agents.Antipsychotics.Butyrophenones.Dopamine Antagonists 73 0.556 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists 73 0.542 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 73 0.535 44 4060 DB00532 Anticonvulsants 73 0.518 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 73 0.503 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 73 0.496 111 3419 DB00492 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 73 0.484 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 73 0.483 84 2995 DB01151 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Enzyme Inhibitors.Norepinephrine-Reuptake Inhibitors 73 0.469 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 73 0.453 103 5352 DB00605 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents.Cyclooxygenase Inhibitors 73 0.443 264 5372 DB00864 Immunosuppressive Agents 73 0.411 87 5533 DB00656 Anti-anxiety Agents.Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 73 0.406 72 2160 DB00321 Adrenergic Uptake Inhibitors.Analgesics, Non-Narcotic.Antidepressive Agents, Tricyclic 73 0.404 72 4893 DB00457 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Antihypertensive Agents 73 0.404 152 60184 DB00790 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 73 0.402 166 3394 DB00712 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Carbonic Anhydrase Inhibitors.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 73 0.398 201 5538 DB00755 Antineoplastic Agents.Cell Stimulants and Proliferants.Keratolytic Agents 73 0.388 108 3015 DB04839 Androgen Antagonists 73 0.382 101 14888 DB01169 Antineoplastic Agents.Homeopathic Agents 73 0.38 62 3007 DB00182 Adrenergic Agents.Adrenergic Uptake Inhibitors.Amphetamines.Central Nervous System Stimulants.Dopamine Agents.Dopamine Uptake Inhibitors.Sympathomimetics 73 0.372 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 73 0.362 136 56339 DB01320 Anticonvulsants 73 0.351 181 4932 DB01182 Anti-Arrhythmia Agents 73 0.348 16 3168 DB00450 Adjuvants, Anesthesia.Antiemetics.Antipsychotic Agents.Dopamine Antagonists 73 0.339 85 3385 DB00544 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Immunosuppressive Agents 73 0.338 60 3519 DB01018 Adrenergic alpha-Agonists.Antihypertensive Agents.Sympatholytics 73 0.337 98 3222 DB00584 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 73 0.329 145 3672 DB01050 Analgesics.Analgesics, Non-Narcotic.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 73 0.325 52 5452 DB00679 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 73 0.318 33 3340 DB00800 Antihypertensive Agents.Dopamine Agonists.Vasodilator Agents 73 0.313 71 3372 DB00623 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 73 0.309 100 2578 DB00262 Antineoplastic Agents.Antineoplastic Agents, Alkylating 73 0.305 119 3308 DB00749 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 73 0.304 14 951 DB00368 Adrenergic alpha-Agonists.Sympathomimetics.Vasoconstrictor Agents 73 0.304 20 5775 DB00692 Adrenergic alpha-Antagonists.Antihypertensive Agents.Sympatholytics 73 0.303 185 4594 DB00338 Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 73 0.3 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 73 0.295 144 3702 DB00808 Antihypertensive Agents.Diuretics 73 0.295 77 3066 DB00320 Analgesics.Analgesics, Non-Narcotic.Anti-migraine Agents.Dopamine Agonists.Sympatholytics.Vasoconstrictor Agents 73 0.294 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 73 0.293 64 2726 DB00477 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 73 0.288 81 2022 DB00787 Antiviral Agents.Nucleosides and Nucleotides 73 0.283 120 2284 DB00181 GABA Agonists.Muscle Relaxants.Muscle Relaxants, Central.Skeletal Muscle Relaxants 73 0.28 100 5038 DB00178 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 73 0.269 34 3518 DB01170 Adrenergic Agents.Antihypertensive Agents.Sympatholytics 73 0.262 4 4768 DB00925 Adrenergic alpha-Antagonists.Antihypertensive Agents.Vasodilator Agents 73 0.262 34 4195 DB00211 Adrenergic alpha-Agonists.Sympathomimetics.Vasoconstrictor Agents 73 0.262 133 4112 DB00563 Abortifacient Agents.Abortifacient Agents, Nonsteroidal.Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Folic Acid Antagonists.Immunosuppressive Agents.Nucleic Acid Synthesis Inhibitors 73 0.262 10 4436 Not Available Not Available 73 0.261 77 28112 DB01356 Not Available 73 0.258 21 5546 DB00384 Diuretics.Potassium-sparing Diuretics 73 0.257 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 73 0.256 61 2435 DB00484 Adrenergic alpha-Agonists.Antihypertensive Agents.EENT Drugs 73 0.254 55 2130 DB00915 Analgesics, Non-Narcotic.Antiparkinson Agents.Antiviral Agents.Dopamine Agents 73 0.25 125 596 DB02097 Not Available 73 0.238 211 60953 DB01101 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Prodrugs 73 0.237 102 83786 DB00437 Antimetabolites.Enzyme Inhibitors.Enzyme Inhibitors Antimetabolites.Free Radical Scavengers.Gout Suppressants 73 0.237 55 3019 DB01119 Antihypertensive Agents.Diuretics, Thiazide.Vasodilator Agents 73 0.232 108 4856 DB00554 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 73 0.218 11 3251 DB00696 Adrenergic alpha-Agonists.Analgesics, Non-Narcotic.Sympatholytics.Vasoconstrictor Agents 73 0.218 16 5504 DB00797 Adrenergic alpha-Antagonists.Antihypertensive Agents.Vasodilator Agents 73 0.209 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 73 0.209 97 1065 DB00908 Adrenergic alpha-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antimalarials.Enzyme Inhibitors.Muscarinic Antagonists 73 0.204 166 54374 DB00104 Anabolic Agents.Antineoplastic Agents, Hormonal.Gastrointestinal Agents.Hormone Replacement Agents 73 0.2 8 3241 DB00751 Antihistamines.Histamine H1 Antagonists.Ophthalmics 73 0.197 63 3690 DB01181 Antineoplastic Agents.Antineoplastic Agents, Alkylating.Immunosuppressive Agents 73 0.195 97 4200 DB01017 Anti-Bacterial Agents.Tetracyclines 73 0.193 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 73 0.19 57 5454 DB01623 Antipsychotic Agents.Dopamine Antagonists 73 0.184 161 5291 DB00619 Antineoplastic Agents.Protein Kinase Inhibitors 73 0.184 158 34312 DB00776 Anticonvulsants 73 0.183 236 10631 DB00603 Contraceptives.Contraceptives, Oral, Synthetic.Progestins 73 0.183 188 5040 DB00877 Anti-Bacterial Agents.Antibiotics, Antineoplastic.Antifungal Agents.Antifungals.Immunosuppressive Agents 73 0.18 183 3648 DB00327 Analgesics, Opioid.Narcotics 73 0.179 45 2216 DB00964 Adrenergic alpha-Agonists.Antiglaucomic Agents.EENT Drugs.Ophthalmics 73 0.175 82 3749 DB01029 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 73 0.174 112 3367 DB01073 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Immunosuppressive Agents #### component 74: positive weight features and high scoring objects #### # positive weight on target proteins 74 0.653 17 ANXA1_HUMAN Annexin A1; 74 0.639 18 GCR_HUMAN Glucocorticoid receptor; 74 0.221 17 CBG_HUMAN Corticosteroid-binding globulin; 74 0.131 8 SHBG_HUMAN Sex hormone-binding globulin; 74 0.094 18 ESR1_HUMAN Estrogen receptor; 74 0.073 2 COLI_HUMAN Pro-opiomelanocortin; 74 0.071 14 LOX5_HUMAN Arachidonate 5-lipoxygenase; 74 0.07 7 MCR_HUMAN Mineralocorticoid receptor; 74 0.06 1 SDF1_HUMAN Stromal cell-derived factor 1; 74 0.051 8 PRGR_HUMAN Progesterone receptor; 74 0.049 2 NFKB1_HUMAN Nuclear factor NF-kappa-B p105 subunit; 74 0.029 12 AOFB_HUMAN Amine oxidase [flavin-containing] B; 74 0.023 4 RXRG_HUMAN Retinoic acid receptor RXR-gamma; 74 0.021 8 PA24A_HUMAN Cytosolic phospholipase A2; 74 0.021 9 OPRX_HUMAN Nociceptin receptor; 74 0.016 3 RARA_HUMAN Retinoic acid receptor alpha; 74 0.016 3 RXRA_HUMAN Retinoic acid receptor RXR-alpha; 74 0.016 3 RARB_HUMAN Retinoic acid receptor beta; 74 0.015 5 RXRB_HUMAN Retinoic acid receptor RXR-beta; 74 0.013 17 OPRD_HUMAN Delta-type opioid receptor; 74 0.013 5 ACHD_HUMAN Acetylcholine receptor subunit delta; 74 0.013 5 ACHB_HUMAN Acetylcholine receptor subunit beta; 74 0.013 5 MUSK_HUMAN Muscle, skeletal receptor tyrosine-protein kinase; 74 0.013 5 ACHA_HUMAN Acetylcholine receptor subunit alpha; 74 0.013 19 OPRM_HUMAN Mu-type opioid receptor; 74 0.01 8 OGFR_HUMAN Opioid growth factor receptor; 74 0.008 16 OPRK_HUMAN Kappa-type opioid receptor; 74 0.005 7 ACHA7_HUMAN Neuronal acetylcholine receptor subunit alpha-7; # positive weight on side effects 74 0.323 20 pseudotumor cerebri 74 0.25 14 telangiectasia 74 0.245 15 latent diabetes 74 0.237 21 papilledema 74 0.232 8 Aseptic necrosis 74 0.221 14 alkalosis 74 0.208 28 hypernatremia 74 0.197 29 pathological fracture 74 0.161 62 abdominal distention 74 0.137 8 nasal septum perforation 74 0.128 14 exophthalmos 74 0.095 53 myopathy 74 0.091 34 hyperpigmentation 74 0.084 16 ocular infection 74 0.047 31 hypertrichosis 74 0.034 60 peptic ulcer 74 0.033 342 insomnia 74 0.031 4 fat embolism 74 0.009 7 paraplegia 74 0.009 6 paraparesis 74 0.004 68 glycosuria 74 0.002 70 petechiae # high scoring drugs for both targets and side effects 74 2.187 83 3640 DB00741 Anti-inflammatory Agents 74 2.156 86 3003 DB01234 Adrenergic Agents.Anti-inflammatory Agents.Antiemetics.Antineoplastic Agents, Hormonal.Glucocorticoids 74 2.059 135 5544 DB00620 Adrenergic Agents.Anti-inflammatory Agents.Glucocorticoids 74 1.959 31 4900 DB00635 Adrenergic Agents.Anti-inflammatory Agents.Antineoplastic Agents.Antineoplastic Agents, Hormonal.Glucocorticoids 74 1.903 54 4159 DB00959 Adrenergic Agents.Anti-inflammatory Agents.Antiemetics.Glucocorticoids.Neuroprotective Agents 74 1.715 74 4894 DB00860 Adrenergic Agents.Anti-inflammatory Agents.Antineoplastic Agents.Antineoplastic Agents, Hormonal.Glucocorticoids 74 1.302 43 31378 DB00687 Adrenergic Agents.Anti-inflammatory Agents 74 0.959 66 123620 DB00764 Anti-Allergic Agents.Anti-inflammatory Agents 74 0.928 14 2133 DB00288 Corticosteroids, topical 74 0.719 17 48175 DB00596 Anti-inflammatory Agents.Vasoconstrictor Agents 74 0.69 29 2308 DB00394 Anti-Asthmatic Agents.Anti-inflammatory Agents.Antiarrhythmic Agents.Corticosteroids.Glucocorticoids 74 0.688 137 2462 DB01222 Anti-inflammatory Agents.Bronchodilator Agents.Corticosteroids.Glucocorticoids 74 0.659 54 444033 DB01410 Anti-Allergic Agents.Glucocorticoids 74 0.657 41 32797 DB01013 Anti-inflammatory Agents.Corticosteroids, topical.Glucocorticoids 74 0.649 191 450 DB00783 Anti-menopausal Agents.Anticholesteremic Agents.Estrogens 74 0.647 77 3379 DB00180 Anti-Asthmatic Agents.Anti-inflammatory Agents 74 0.616 63 3381 DB00591 Anti-inflammatory Agents.Antipruritics.Glucocorticoids 74 0.613 15 39507 DB00896 Anti-inflammatory Agents.Corticosteroids 74 0.611 17 3000 DB00547 Anti-inflammatory Agents.Glucocorticoids 74 0.609 26 12536 DB01260 Anti-inflammatory Agents 74 0.609 17 52421 DB01130 Anti Inflammatory.Anti-inflammatory Agents.Corticosteroid.Glucocorticoids.Steroidal 74 0.571 10 4630253 DB00240 Anti-inflammatory Agents.Antipruritic Agents.Corticosteroids.Glucocorticoids 74 0.547 61 40976 DB00294 Contraceptive Agents, Female.Contraceptives 74 0.525 53 5035 DB00481 Antihypocalcemic Agents.Bone Density Conservation Agents.Estrogen Antagonists.Osteoporosis Prophylactic.Selective Estrogen Receptor Modulators 74 0.489 21 5267 DB00421 Aldosterone Antagonists.Diuretics 74 0.484 11 3375 DB00223 Anti-inflammatory Agents.Glucocorticoids 74 0.479 62 5566 DB00831 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 74 0.464 42 4196 DB00834 Abortifacient Agents, Steroidal.Contraceptives, Oral, Synthetic.Contraceptives, Postcoital, Synthetic.Hormone Antagonists.Luteolytic Agents.Menstruation-Inducing Agents 74 0.458 151 41317 DB00459 Keratolytic Agents 74 0.432 124 62924 DB00588 Adrenergic Agents.Anti-Allergic Agents.Anti-inflammatory Agents.Bronchodilator Agents.Dermatologic Agents 74 0.426 77 28112 DB01356 Not Available 74 0.387 37 6058 DB00847 Nephropathic cystinosis therapy.Radiation-Protective Agents 74 0.343 120 3715 DB00328 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cardiovascular Agents.Cyclooxygenase Inhibitors.Gout Suppressants.Nonsteroidal Antiinflammatory Agents (NSAIDs).Tocolytic Agents 74 0.341 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 74 0.324 11 4043 DB00253 Topical anti-inflammatory Agent 74 0.324 12 3384 DB00324 Anti-Allergic Agents.Anti-inflammatory Agents.Glucocorticoids 74 0.291 64 19090 DB00351 Antineoplastic Agents, Hormonal.Contraceptives, Oral, Synthetic 74 0.284 121 5408 DB00624 Androgens 74 0.283 16 4211 DB00648 Antineoplastic Agents.Antineoplastic Agents, Hormonal 74 0.281 16 3382 DB01047 Anti-Allergic Agents.Anti-inflammatory Agents.Glucocorticoids 74 0.281 161 5212 DB00203 Phosphodiesterase Inhibitors.Vasodilator Agents 74 0.278 10 3392 DB00846 Anti-inflammatory Agents.Glucocorticoids 74 0.275 236 10631 DB00603 Contraceptives.Contraceptives, Oral, Synthetic.Progestins 74 0.274 19 3387 DB01185 Anabolic Agents.Antineoplastic Agents, Hormonal 74 0.273 132 4542 DB00367 Contraceptive Agents, Female.Contraceptives.Contraceptives, Oral, Synthetic 74 0.271 453 125889 DB00230 Analgesics.Anticonvulsants 74 0.269 42 3675 DB00780 Antidepressants.Antidepressive Agents.Monoamine Oxidase Inhibitors 74 0.266 125 3285 DB00977 Estrogens 74 0.263 172 4920 DB00396 Contraceptives.Progestins 74 0.261 22 60164 DB00210 Anti-Inflammatory Agents, Non-Steroidal.Dermatologic Agents 74 0.26 29 3954 DB00836 Antidiarrheals 74 0.255 136 56339 DB01320 Anticonvulsants 74 0.249 11 5381 DB00799 Dermatologic Agents.Keratolytic Agents.Prodrugs.Teratogens 74 0.247 29 3759 DB01247 Antidepressants.Antidepressive Agents.Monoamine Oxidase Inhibitors 74 0.241 34 4536 DB00717 Contraceptives, Oral, Synthetic.Progestins 74 0.23 14 10100 DB00647 Analgesics.Analgesics, Opioid.Antitussives.Narcotics 74 0.226 16 4160 DB00624 Androgens 74 0.225 68 27686 DB01003 Anti-Asthmatic Agents 74 0.224 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 74 0.22 171 2909 DB00091 Antifungal Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Immunomodulatory Agents.Immunosuppressive Agents 74 0.216 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 74 0.215 16 3405 DB00158 Dietary supplement.Hematinics.Micronutrient.Vitamin B Complex 74 0.215 166 54374 DB00104 Anabolic Agents.Antineoplastic Agents, Hormonal.Gastrointestinal Agents.Hormone Replacement Agents 74 0.212 196 3911 DB00007 Anti-Estrogen Agents.Antineoplastic Agents 74 0.212 131 4635 DB00497 Analgesics, Opioid.Antitussives.Narcotics.Opiate Agonists 74 0.206 91 937 DB00627 Antilipemic Agents.Vasodilator Agents.Vitamin B Complex.Vitamins (Vitamin B Complex) 74 0.196 4 6503 DB03754 Buffers.Excipients 74 0.196 16 2905 DB00979 Antimuscarinic eye preparations.Muscarinic Antagonists.Mydriatics.Parasympatholytics 74 0.196 36 5636 Not Available Not Available 74 0.195 49 60937 DB01133 Antihypocalcemic Agents.Bone Density Conservation Agents.Osteoporosis Prophylactic 74 0.194 57 2949 DB01406 Estrogen Antagonists 74 0.184 71 2487 DB00611 Analgesics, Opioid.Antitussive Agents.Narcotic Antagonists.Narcotics 74 0.184 84 57469 DB00724 Adjuvants, Immunologic.Antineoplastic Agents.Antiviral Agents.Interferon Inducers 74 0.183 64 2726 DB00477 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 74 0.18 13 137 DB00855 Photosensitizing Agents 74 0.18 11 2522 DB02300 Antipsoriatic Agents.Dermatologic Agents.Vitamin D3 Receptor inhibitor 74 0.18 54 4599 DB01083 Anti-Obesity Agents.Enzyme Inhibitors 74 0.177 21 4057 DB04843 Anticholinergic Agents.Parasympatholytics 74 0.175 27 23897 DB01618 Antipsychotic Agents 74 0.173 55 3019 DB01119 Antihypertensive Agents.Diuretics, Thiazide.Vasodilator Agents 74 0.168 78 6447131 DB00337 Anti-Inflammatory Agents, Non-Steroidal.Dermatologic Agents.Enzyme Inhibitors.Immunosuppressive Agents 74 0.168 33 4425 DB01183 Antinarcotic Agents.Depressants.Narcotic Antagonists.Opiate Antagonists 74 0.167 28 4058 DB00454 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 74 0.167 23 51263 DB00802 Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 74 0.163 23 3821 DB01221 Analgesics.Anesthetics, Dissociative.Excitatory Amino Acid Antagonists.General Anesthetics 74 0.162 9 2733 DB00356 Muscle Relaxants, Central 74 0.161 16 5771 DB00107 Anti-tocolytic Agents.Labor Induction Agents.Oxytocics 74 0.161 9 861 DB00279 Hormone Replacement Agents 74 0.161 9 232 DB00125 Conditionally Essential Amino Acids.Dietary supplement.Micronutrient 74 0.161 2 1071 DB00162 Anti-acne Agents.Essential Vitamin.Vitamins.Vitamins (Vitamin A) 74 0.161 12 4812 DB01022 Antifibrinolytic Agents.Vitamins.Vitamins (Vitamin K) 74 0.161 5 2283 DB00626 Anti-Bacterial Agents.Anti-Infective Agents, Local 74 0.161 24 145068 DB00435 Bronchodilator Agents.Endothelium-Dependent Relaxing Factors.Free Radical Scavengers 74 0.161 14 27400 Not Available Not Available 74 0.161 19 3249 DB00153 Antihypocalcemic Agents.Antihypoparathyroid Agents.Bone Density Conservation Agents.Essential Vitamin.Vitamins.Vitamins (Vitamin D) 74 0.161 9 1148 DB00150 Antidepressive Agents, Second-Generation.Dietary supplement.Essential Amino Acids.Micronutrient 74 0.161 6 12555 Not Available Not Available 74 0.161 4 5878 DB00621 Anabolic Agents.Androgens 74 0.161 3 6256 DB00432 Antimetabolites.Antiviral Agents 74 0.161 6 4908 DB01087 Antimalarial Agents.Antimalarials.Antiprotozoal Agents #### component 75: positive weight features and high scoring objects #### # positive weight on target proteins 75 0.698 26 SC6A4_HUMAN Sodium-dependent serotonin transporter; 75 0.595 28 SC6A2_HUMAN Sodium-dependent noradrenaline transporter; 75 0.175 12 SC6A3_HUMAN Sodium-dependent dopamine transporter; 75 0.127 16 TOP2A_HUMAN DNA topoisomerase 2-alpha; 75 0.107 5 ATP4A_HUMAN Potassium-transporting ATPase alpha chain 1; 75 0.098 13 CAC1A_HUMAN Voltage-dependent P/Q-type calcium channel subunit alpha-1A; 75 0.096 5 GABT_HUMAN 4-aminobutyrate aminotransferase, mitochondrial; 75 0.081 6 DRD4_HUMAN D(4) dopamine receptor; 75 0.065 5 SCN1A_HUMAN Sodium channel protein type 1 subunit alpha; 75 0.06 16 OPRK_HUMAN Kappa-type opioid receptor; 75 0.051 19 OPRM_HUMAN Mu-type opioid receptor; 75 0.05 9 GABR2_HUMAN Gamma-aminobutyric acid type B receptor subunit 2; 75 0.041 13 CAC1B_HUMAN Voltage-dependent N-type calcium channel subunit alpha-1B; 75 0.039 12 CACB4_HUMAN Voltage-dependent L-type calcium channel subunit beta-4; 75 0.039 12 CACB3_HUMAN Voltage-dependent L-type calcium channel subunit beta-3; 75 0.039 12 CAC1S_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1S; 75 0.039 12 TRPA1_HUMAN Transient receptor potential cation channel subfamily A member 1; 75 0.039 12 CCG4_HUMAN Voltage-dependent calcium channel gamma-4 subunit; 75 0.039 12 PKD2_HUMAN Polycystin-2; 75 0.039 12 PKD1_HUMAN Polycystin-1; 75 0.039 12 CA2D1_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-1; 75 0.039 12 ITPR1_HUMAN Inositol 1,4,5-trisphosphate receptor type 1; 75 0.039 12 CCG2_HUMAN Voltage-dependent calcium channel gamma-2 subunit; 75 0.039 12 ITPR3_HUMAN Inositol 1,4,5-trisphosphate receptor type 3; 75 0.039 12 TRPV6_HUMAN Transient receptor potential cation channel subfamily V member 6; 75 0.039 12 CAC1E_HUMAN Voltage-dependent R-type calcium channel subunit alpha-1E; 75 0.039 16 CAC1G_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1G; 75 0.039 12 CCG7_HUMAN Voltage-dependent calcium channel gamma-7 subunit; 75 0.036 15 RYR3_HUMAN Ryanodine receptor 3; 75 0.036 15 RYR2_HUMAN Ryanodine receptor 2; 75 0.028 15 CAC1I_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1I; 75 0.028 13 CACB1_HUMAN Voltage-dependent L-type calcium channel subunit beta-1; 75 0.028 15 CAC1H_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1H; 75 0.024 21 GBRB3_HUMAN Gamma-aminobutyric acid receptor subunit beta-3; 75 0.024 21 GBRE_HUMAN Gamma-aminobutyric acid receptor subunit epsilon; 75 0.024 21 GBRR1_HUMAN Gamma-aminobutyric acid receptor subunit rho-1; 75 0.024 21 GBRB2_HUMAN Gamma-aminobutyric acid receptor subunit beta-2; 75 0.024 21 GBRG3_HUMAN Gamma-aminobutyric acid receptor subunit gamma-3; 75 0.024 21 GBRD_HUMAN Gamma-aminobutyric acid receptor subunit delta; 75 0.024 21 GBRG2_HUMAN Gamma-aminobutyric acid receptor subunit gamma-2; 75 0.024 21 GBRT_HUMAN Gamma-aminobutyric acid receptor subunit theta; 75 0.024 21 GBRB1_HUMAN Gamma-aminobutyric acid receptor subunit beta-1; 75 0.017 14 RYR1_HUMAN Ryanodine receptor 1; 75 0.004 8 TSPOA_HUMAN Translocator protein; 75 0.004 8 GBRR2_HUMAN Gamma-aminobutyric acid receptor subunit rho-2; 75 0.003 22 GBRA5_HUMAN Gamma-aminobutyric acid receptor subunit alpha-5; 75 0.003 22 GBRA3_HUMAN Gamma-aminobutyric acid receptor subunit alpha-3; 75 0.003 22 GBRA6_HUMAN Gamma-aminobutyric acid receptor subunit alpha-6; 75 0.003 22 GBRA4_HUMAN Gamma-aminobutyric acid receptor subunit alpha-4; # positive weight on side effects 75 0.466 254 nervousness 75 0.343 66 sleep disorder 75 0.342 111 swelling 75 0.323 25 halitosis 75 0.302 55 menstrual disorder 75 0.243 172 chills 75 0.23 52 heart block 75 0.227 30 sexual dysfunction 75 0.204 113 ear pain 75 0.186 124 migraine 75 0.173 9 adenitis 75 0.171 342 insomnia 75 0.148 27 abuse 75 0.133 46 breast enlargement 75 0.101 12 bruxism 75 0.065 12 serotonin syndrome 75 0.003 90 colitis # high scoring drugs for both targets and side effects 75 1.806 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 75 1.667 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 75 1.561 151 60835 DB00476 Adrenergic Uptake Inhibitors.Antidepressive Agents.Dopamine Uptake Inhibitors.Serotonin Uptake Inhibitors 75 1.516 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 75 1.45 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 75 1.441 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 75 1.38 146 4158 DB00422 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Uptake Inhibitors.Sympathomimetics 75 1.35 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 75 1.315 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 75 1.244 69 3696 DB00458 Adrenergic Uptake Inhibitors.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 75 1.228 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 75 1.195 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 75 1.171 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 75 1.133 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 75 1.093 453 125889 DB00230 Analgesics.Anticonvulsants 75 1.072 69 2170 DB00543 Adrenergic Uptake Inhibitors.Antidepressive Agents, Second-Generation.Dopamine Antagonists.Neurotransmitter Uptake Inhibitors.Serotonin Uptake Inhibitors 75 1.054 129 5210 DB01105 Anorexigenic Agents.Antidepressants.Antidepressive Agents.Appetite Depressants.Stimulants 75 0.934 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 75 0.919 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors 75 0.903 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 75 0.893 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 75 0.865 196 3911 DB00007 Anti-Estrogen Agents.Antineoplastic Agents 75 0.848 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 75 0.842 62 3007 DB00182 Adrenergic Agents.Adrenergic Uptake Inhibitors.Amphetamines.Central Nervous System Stimulants.Dopamine Agents.Dopamine Uptake Inhibitors.Sympathomimetics 75 0.842 83 54841 DB00289 Adrenergic Uptake Inhibitors.Antidepressants.Central Nervous System Agents 75 0.839 67 4976 DB00344 Adrenergic Uptake Inhibitors.Antidepressive Agents.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 75 0.839 65 4543 DB00540 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 75 0.839 84 2995 DB01151 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Enzyme Inhibitors.Norepinephrine-Reuptake Inhibitors 75 0.839 64 5584 DB00726 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 75 0.825 146 3075 DB00343 Antihypertensive Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Cardiovascular Agents.Vasodilator Agents 75 0.822 87 5533 DB00656 Anti-anxiety Agents.Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 75 0.816 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 75 0.809 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 75 0.807 186 3883 DB00448 Anti-Infective Agents.Anti-Infectives.Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 75 0.801 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 75 0.786 72 2160 DB00321 Adrenergic Uptake Inhibitors.Analgesics, Non-Narcotic.Antidepressive Agents, Tricyclic 75 0.785 150 1775 DB00252 Anticonvulsants 75 0.783 38 125017 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 75 0.767 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 75 0.742 172 4920 DB00396 Contraceptives.Progestins 75 0.716 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 75 0.711 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 75 0.702 183 3648 DB00327 Analgesics, Opioid.Narcotics 75 0.691 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 75 0.691 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 75 0.675 131 4428 DB00704 Alcohol Antagonists.Anti-craving Agents.Depressants.Narcotic Antagonists.Opiate Antagonists 75 0.673 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 75 0.67 50 3158 DB01142 Anti-anxiety Agents.Antidepressants.Antidepressive Agents, Tricyclic.Antipruritics.Histamine Antagonists.Norepinephrine-Reuptake Inhibitors 75 0.664 133 2802 DB01068 Anticonvulsants.Benzodiazepines.GABA Modulators 75 0.656 161 5212 DB00203 Phosphodiesterase Inhibitors.Vasodilator Agents 75 0.654 152 60184 DB00790 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 75 0.613 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 75 0.581 167 5719 DB00962 Anticonvulsants.Anxiolytics sedatives and hypnotics.Hypnotics and Sedatives 75 0.579 137 62959 DB00685 Anti-Infective Agents.Anti-Infectives.Fluoroquinolones 75 0.579 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 75 0.575 167 170361 DB01273 Nicotinic Agonists 75 0.562 17 1206 DB01577 Adrenergic Agents.Adrenergic Uptake Inhibitors.Central Nervous System Stimulants.Dopamine Agents.Dopamine Uptake Inhibitors.Sympathomimetics 75 0.558 185 4594 DB00338 Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 75 0.557 57 2951 DB01219 Muscle Relaxants, Central 75 0.553 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 75 0.552 66 4011 DB00934 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Second-Generation 75 0.551 95 16231 DB00594 Diuretics.Sodium channel blockers 75 0.549 73 3333 DB01023 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Calcium Channel Blockers.Dihydropyridines.Vasodilator Agents 75 0.53 114 5379 DB01044 Anti-Infective Agents.Antibiotics 75 0.525 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 75 0.516 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 75 0.506 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 75 0.504 142 2678 DB00341 Anti-Allergic Agents.Antihistamines.Histamine H1 Antagonists, Non-Sedating 75 0.504 137 2462 DB01222 Anti-inflammatory Agents.Bronchodilator Agents.Corticosteroids.Glucocorticoids 75 0.491 82 47725 DB00014 Antineoplastic Agents.Antineoplastic Agents, Hormonal 75 0.488 12 4771 DB00191 Adrenergic Agents.Anorexigenic Agents.Appetite Depressants.Central Nervous System Agents.Central Nervous System Stimulants.Stimulants.Sympathomimetics 75 0.481 166 54374 DB00104 Anabolic Agents.Antineoplastic Agents, Hormonal.Gastrointestinal Agents.Hormone Replacement Agents 75 0.476 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 75 0.474 125 3285 DB00977 Estrogens 75 0.465 86 2118 DB00404 Anti-anxiety Agents.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 75 0.457 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 75 0.428 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 75 0.425 132 3948 DB00978 Anti-Infective Agents.Anti-Infective Agents, Urinary.Antitubercular Agents.Photosensitizing Agents 75 0.422 131 3961 DB00678 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents 75 0.42 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 75 0.409 82 3749 DB01029 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 75 0.391 118 4236 DB00745 Anorexigenic Agents.Central Nervous System Agents.Central Nervous System Stimulants.Neuroprotective Agents.Stimulants 75 0.391 157 4659569 DB00323 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Enzyme Inhibitors 75 0.391 61 4192 DB00683 Adjuvants, Anesthesia.Anesthetics, Intravenous.Anti-anxiety Agents.GABA Modulators.Hypnotics and Sedatives 75 0.383 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 75 0.372 236 10631 DB00603 Contraceptives.Contraceptives, Oral, Synthetic.Progestins 75 0.372 39 7029 DB00937 Anorexigenic Agents.Appetite Depressants.Stimulants 75 0.367 83 5487301 DB01079 Gastrointestinal Agents.Serotonin Agonists 75 0.359 71 2487 DB00611 Analgesics, Opioid.Antitussive Agents.Narcotic Antagonists.Narcotics 75 0.355 138 2369 DB00195 Adrenergic beta-Antagonists.Antihypertensive Agents.EENT Drugs.Sympatholytics 75 0.353 90 5152 DB00938 Adrenergic beta-Agonists.Bronchodilator Agents.Sympathomimetic 75 0.343 106 4539 DB01059 Anti-Bacterial Agents.Anti-Infectives.Enzyme Inhibitors.Nucleic Acid Synthesis Inhibitors.Quinolones 75 0.343 147 71158 DB00659 Alcohol Deterrents 75 0.335 73 3958 DB00186 Anti-anxiety Agents.Anticonvulsants.Antiemetics.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 75 0.335 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 75 0.334 68 942 DB00184 Anti-craving Agents.Autonomic drugs.Central Nervous System Agents.Ganglionic Stimulants.Nicotinic Agonists 75 0.329 90 4634 DB01062 Anticholinergic Agents.Antispasmodics.Genitourinary Smooth Muscle Relaxants.Muscarinic Antagonists.Parasympatholytics 75 0.327 191 450 DB00783 Anti-menopausal Agents.Anticholesteremic Agents.Estrogens 75 0.325 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 75 0.321 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents #### component 76: positive weight features and high scoring objects #### # positive weight on target proteins 76 0.55 38 ADRB1_HUMAN Beta-1 adrenergic receptor; 76 0.482 23 PGH1_HUMAN Prostaglandin G/H synthase 1; 76 0.159 34 ADRB2_HUMAN Beta-2 adrenergic receptor; 76 0.002 24 ADRB3_HUMAN Beta-3 adrenergic receptor; # positive weight on side effects 76 0.287 189 hallucinations 76 0.112 111 hypoglycemia 76 0.098 244 arrhythmia # high scoring drugs for both targets and side effects 76 0.796 76 3661 DB00572 Adjuvants, Anesthesia.Anti-Arrhythmia Agents.Bronchodilator Agents.Muscarinic Antagonists.Mydriatics.Parasympatholytics 76 0.725 20 5775 DB00692 Adrenergic alpha-Antagonists.Antihypertensive Agents.Sympatholytics 76 0.725 19 3779 DB01064 Adrenergic beta-Agonists.Bronchodilator Agents.Cardiotonic Agents.Sympathomimetic.Sympathomimetics 76 0.725 14 951 DB00368 Adrenergic alpha-Agonists.Sympathomimetics.Vasoconstrictor Agents 76 0.724 20 838 DB00668 Adrenergic Agonists.Adrenergic alpha-Agonists.Adrenergic beta-Agonists.Bronchodilator Agents.Mydriatics.Sympathomimetics.Vasoconstrictor Agents 76 0.692 38 3914 DB01210 Adrenergic beta-Antagonists.EENT Drugs.Sympatholytics 76 0.678 84 2995 DB01151 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Enzyme Inhibitors.Norepinephrine-Reuptake Inhibitors 76 0.676 17 5403 DB00871 Adrenergic beta-Agonists.Bronchodilator Agents.Sympathomimetic.Sympathomimetics.Tocolytic Agents 76 0.676 14 36811 DB00841 Adrenergic beta-Agonists.Cardiotonic Agents.Sympathomimetic.Sympathomimetics 76 0.676 30 31477 DB01214 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents.Sympatholytics 76 0.663 10 4436 Not Available Not Available 76 0.644 15 681 DB00988 Cardiotonic Agents.Dopamine Agents.Sympathomimetic.Sympathomimetics 76 0.63 42 4411 DB01203 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents.Sympatholytics 76 0.592 61 4828 DB00960 Adrenergic beta-Antagonists.Antihypertensive Agents.Serotonin Antagonists.Vasodilator Agents 76 0.579 24 2431 DB01158 Adrenergic Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents 76 0.561 14 2749 DB01188 Antifungal Agents 76 0.561 7 5359 DB00870 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 76 0.553 28 2583 DB00521 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents.Sympatholytics 76 0.546 51 3559 DB00502 Anti-Dyskinesia Agents.Antidyskinetics.Antiemetics.Antipsychotic Agents.Antipsychotics.Butyrophenones.Dopamine Antagonists 76 0.539 61 4946 DB00571 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Anti-anxiety Agents.Antiarrhythmic Agents.Antihypertensive Agents.Vasodilator Agents 76 0.513 31 3062 DB00390 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Cardiotonic Agents.Enzyme Inhibitors 76 0.504 60 3373 DB01205 Antidotes.GABA Modulators 76 0.5 16 3763 DB00753 Anesthetics.Anesthetics, Inhalation.General Anesthetics 76 0.499 62 59768 DB00187 Adrenergic beta-Antagonists 76 0.485 25 4724 DB01359 Adrenergic beta-Antagonists.Antihypertensive Agents 76 0.467 23 3821 DB01221 Analgesics.Anesthetics, Dissociative.Excitatory Amino Acid Antagonists.General Anesthetics 76 0.464 33 4425 DB01183 Antinarcotic Agents.Depressants.Narcotic Antagonists.Opiate Antagonists 76 0.464 25 5572 DB00376 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists 76 0.464 50 3657 DB01005 Antineoplastic Agents.Antisickling Agents.Enzyme Inhibitors.Nucleic Acid Synthesis Inhibitors 76 0.464 14 10100 DB00647 Analgesics.Analgesics, Opioid.Antitussives.Narcotics 76 0.464 16 2905 DB00979 Antimuscarinic eye preparations.Muscarinic Antagonists.Mydriatics.Parasympatholytics 76 0.464 9 3658 DB00557 Antipruritics.Anxiolytics sedatives and hypnotics.Histamine H1 Antagonists 76 0.462 19 2344 DB00245 Antidyskinetics.Antiparkinson Agents.Dopamine Uptake Inhibitors.Muscarinic Antagonists.Parasympatholytics 76 0.437 20 4601 DB01173 Antidyskinetics.Antiparkinson Agents.Muscarinic Antagonists.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 76 0.428 24 4140 DB00353 Oxytocics 76 0.428 78 2249 DB00335 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Sympatholytics 76 0.425 76 2803 DB00575 Adrenergic alpha-Agonists.Analgesics.Antihypertensive Agents.Central Alpha-Agonists.Sympatholytics 76 0.425 59 4095 DB00333 Analgesics.Analgesics, Opioid.Antitussive Agents.Antitussives.Narcotics.Opiate Agonists 76 0.418 61 4192 DB00683 Adjuvants, Anesthesia.Anesthetics, Intravenous.Anti-anxiety Agents.GABA Modulators.Hypnotics and Sedatives 76 0.415 43 4913 DB01035 Anti-Arrhythmia Agents.Antiarrhythmic Agents 76 0.398 34 71301 DB04861 Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 76 0.388 39 2756 DB00501 Adjuvants.Analgesics.Anti-Ulcer Agents.Enzyme Inhibitors.Histamine Antagonists.Histamine H2 Antagonists 76 0.388 40 4845 DB01291 Adrenergic beta-Agonists.Bronchodilator Agents.Cardiotonic Agents 76 0.386 52 32170 DB00668 Adrenergic Agonists.Adrenergic alpha-Agonists.Adrenergic beta-Agonists.Bronchodilator Agents.Mydriatics.Sympathomimetics.Vasoconstrictor Agents 76 0.376 26 4506 DB01595 Anti-anxiety Agents.Anticonvulsants.GABA Modulators.Hypnotics and Sedatives 76 0.376 23 5193 DB00418 Adjuvants.Adjuvants, Anesthesia.Barbiturates.GABA Modulators.Hypnotics and Sedatives 76 0.376 90 2477 DB00490 Anti-anxiety Agents.Anxiolytics sedatives and hypnotics.Serotonin Agonists 76 0.376 38 3393 DB00690 Anti-anxiety Agents.GABA Modulators.Hypnotics and Sedatives 76 0.376 28 4058 DB00454 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 76 0.376 23 4737 DB00312 Adjuvants, Anesthesia.Barbiturates.GABA Modulators.Hypnotics and Sedatives 76 0.369 8 3105 DB00449 Adrenergic Agonists.Ophthalmologicals.Sympathomimetics 76 0.369 41 104758 DB00293 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Enzyme Inhibitors.Folic Acid Antagonists 76 0.369 13 36339 DB00292 Anesthetics, Intravenous.Hypnotics and Sedatives 76 0.369 21 4114 DB00553 Antineoplastic Agents.Cross-Linking Reagents.Photosensitizing Agents.Pigmenting Agents 76 0.369 41 5516 DB00539 Antineoplastic Agents.Antineoplastic Agents, Hormonal.Bone Density Conservation Agents.Selective Estrogen Receptor Modulators 76 0.369 9 861 DB00279 Hormone Replacement Agents 76 0.369 10 3226 DB00228 Anesthetics, Inhalation.General Anesthetics 76 0.369 30 42113 DB01189 Anesthetics, Inhalation.Neuroprotective Agents 76 0.369 16 5504 DB00797 Adrenergic alpha-Antagonists.Antihypertensive Agents.Vasodilator Agents 76 0.368 94 4171 DB00264 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Sympatholytics 76 0.368 73 3958 DB00186 Anti-anxiety Agents.Anticonvulsants.Antiemetics.Benzodiazepines.GABA Modulators.Hypnotics and Sedatives 76 0.368 47 4419 DB00844 Analgesics, Opioid.Narcotic Antagonists.Narcotics 76 0.36 54 4159 DB00959 Adrenergic Agents.Anti-inflammatory Agents.Antiemetics.Glucocorticoids.Neuroprotective Agents 76 0.36 39 7029 DB00937 Anorexigenic Agents.Appetite Depressants.Stimulants 76 0.357 61 60612 DB00633 Adrenergic alpha-Agonists.Analgesics.Analgesics, Non-Narcotic.Hypnotics and Sedatives 76 0.356 29 2153 DB00277 Bronchodilator Agents.Phosphodiesterase Inhibitors.Respiratory Smooth Muscle Relaxants.Vasodilator Agents 76 0.356 29 9433 DB01223 Bronchodilator Agents.Cardiotonic Agents.Phosphodiesterase Inhibitors.Respiratory Smooth Muscle Relaxants 76 0.349 61 4046 DB00358 Antimalarials 76 0.348 75 4178 DB00379 Anti-Arrhythmia Agents 76 0.344 24 2244 DB00945 Anti-Inflammatory Agents, Non-Steroidal.Anticoagulants.Cyclooxygenase Inhibitors.Fibrinolytic Agents.Platelet Aggregation Inhibitors.Salicylates 76 0.342 75 1978 DB01193 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents 76 0.342 16 5314 DB00202 Neuromuscular Depolarizing Agents.Skeletal Muscle Relaxants 76 0.342 16 5771 DB00107 Anti-tocolytic Agents.Labor Induction Agents.Oxytocics 76 0.342 48 2524 DB00136 Antihypocalcemic Agents.Antihypoparathyroid Agents.Bone Density Conservation Agents.Calcium Channel Agonists.Essential Vitamin.Vitamins.Vitamins (Vitamin D) 76 0.342 21 60696 DB00728 Neuromuscular Nondepolarizing Agents.Skeletal Muscle Relaxants 76 0.342 23 51263 DB00802 Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 76 0.342 14 104803 DB01226 Neuromuscular Nondepolarizing Agents 76 0.342 32 5281007 DB00851 Antineoplastic Agents.Antineoplastic Agents, Alkylating 76 0.328 24 2727 DB00672 Hypoglycemic Agents.Sulfonylureas 76 0.328 19 5505 DB01124 Hypoglycemic Agents.Sulfonylureas 76 0.328 24 5503 DB00839 Hypoglycemic Agents 76 0.328 44 2913 DB00434 Anti-Allergic Agents.Antihistamine derivatives.Antipruritics.Gastrointestinal Agents.Histamine H1 Antagonists.Serotonin Antagonists 76 0.323 67 4976 DB00344 Adrenergic Uptake Inhibitors.Antidepressive Agents.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 76 0.323 33 2978 DB00470 Analgesics.Analgesics, Non-Narcotic.Antiemetics.Hallucinogens.Psychotropic Drugs 76 0.323 64 5584 DB00726 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Norepinephrine-Reuptake Inhibitors 76 0.32 4 6503 DB03754 Buffers.Excipients 76 0.32 11 3375 DB00223 Anti-inflammatory Agents.Glucocorticoids 76 0.32 12 60169 DB01334 Neuromuscular Nondepolarizing Agents 76 0.32 9 232 DB00125 Conditionally Essential Amino Acids.Dietary supplement.Micronutrient 76 0.32 138 2369 DB00195 Adrenergic beta-Antagonists.Antihypertensive Agents.EENT Drugs.Sympatholytics 76 0.32 40 18140 DB01196 Antineoplastic Agents.Antineoplastic Agents, Alkylating.Antineoplastic Agents, Hormonal.Radiation-Protective Agents 76 0.32 18 1046 DB00339 Antitubercular Agents 76 0.32 18 4873 DB00761 Not Available 76 0.32 3 4034 DB00737 Anti-Allergic Agents.Antiemetics.Antihistamines.Histamine H1 Antagonists 76 0.32 15 4189 DB01110 Antifungal Agents 76 0.32 39 5396 DB00444 Antineoplastic Agents.Enzyme Inhibitors.Nucleic Acid Synthesis Inhibitors 76 0.32 5 10548 DB01057 Cholinesterase Inhibitors.Miotics.Parasympathomimetics 76 0.32 20 667490 DB01033 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Immunosuppressive Agents.Nucleic Acid Synthesis Inhibitors.Purine analogues 76 0.32 14 3354 DB01148 Parasympatholytics 76 0.32 18 2266 DB00548 Antineoplastic Agents.Dermatologic Agents #### component 77: positive weight features and high scoring objects #### # positive weight on target proteins 77 0.383 18 GCR_HUMAN Glucocorticoid receptor; # positive weight on side effects 77 0.453 317 thrombocytopenia 77 0.036 158 dermatitis # high scoring drugs for both targets and side effects 77 0.473 124 62924 DB00588 Adrenergic Agents.Anti-Allergic Agents.Anti-inflammatory Agents.Bronchodilator Agents.Dermatologic Agents 77 0.469 116 5376 DB00675 Antineoplastic Agents, Hormonal.Bone Density Conservation Agents.Estrogen Antagonists.Selective Estrogen Receptor Modulators 77 0.405 38 3823 DB01026 Antifungal Agents.Antifungals 77 0.405 23 143 DB00650 Antianemic Agents.Antidote (to folic acid antagonists).Antineoplastic Adjuncts.Vitamin B Complex.Vitamins/minerals 77 0.405 52 5452 DB00679 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 77 0.405 47 4927 DB01069 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists.Phenothiazine Derivatives 77 0.405 50 3657 DB01005 Antineoplastic Agents.Antisickling Agents.Enzyme Inhibitors.Nucleic Acid Synthesis Inhibitors 77 0.405 63 3690 DB01181 Antineoplastic Agents.Antineoplastic Agents, Alkylating.Immunosuppressive Agents 77 0.387 25 5486 DB00775 Fibrinolytic Agents.Platelet Aggregation Inhibitors 77 0.387 24 5503 DB00839 Hypoglycemic Agents 77 0.387 21 5546 DB00384 Diuretics.Potassium-sparing Diuretics 77 0.387 41 104758 DB00293 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Enzyme Inhibitors.Folic Acid Antagonists 77 0.387 16 5504 DB00797 Adrenergic alpha-Antagonists.Antihypertensive Agents.Vasodilator Agents 77 0.387 51 27991 DB00035 Antidiuretic Agents.Hemostatics.Renal Agents 77 0.387 32 5281007 DB00851 Antineoplastic Agents.Antineoplastic Agents, Alkylating 77 0.387 19 5505 DB01124 Hypoglycemic Agents.Sulfonylureas 77 0.387 60 3059 DB00861 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 77 0.387 32 2265 DB00993 Antimetabolites.Antimetabolites, Antineoplastic.Antirheumatic Agents.Immunosuppressive Agents 77 0.387 23 5578 DB00440 Anti-Infective Agents, Urinary.Anti-Infectives.Antimalarials.Folic Acid Antagonists 77 0.387 43 5508 DB00500 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 77 0.387 32 5361912 DB00615 Anti-Bacterial Agents.Antibiotics, Antitubercular 77 0.387 37 5746 DB00305 Alkylating Agents.Antibiotics, Antineoplastic.Cross-Linking Reagents.Nucleic Acid Synthesis Inhibitors 77 0.387 49 4078 DB00933 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 77 0.387 40 4547 DB00912 Hypoglycemic Agents.Meglitinides 77 0.387 28 2719 DB00608 Amebicides.Antimalarials.Antirheumatic Agents 77 0.387 49 3467 DB00798 Anti-Bacterial Agents.Protein Synthesis Inhibitors 77 0.387 65 5253 DB00489 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Sympatholytics 77 0.387 34 71301 DB04861 Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 77 0.387 50 5472 DB00208 Fibrinolytic Agents.Platelet Aggregation Inhibitors 77 0.387 41 39042 DB01393 Antilipemic Agents 77 0.387 71 3342 DB00573 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Propionic acid derivatives 77 0.387 40 2617 DB01327 Anti-Bacterial Agents.Cephalosporins 77 0.387 24 2244 DB00945 Anti-Inflammatory Agents, Non-Steroidal.Anticoagulants.Cyclooxygenase Inhibitors.Fibrinolytic Agents.Platelet Aggregation Inhibitors.Salicylates 77 0.387 15 5582 DB01157 Antibiotics.Antifungal Agents.Antimetabolites, Antineoplastic.Antiprotozoals.Folic Acid Antagonists 77 0.387 31 3062 DB00390 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Cardiotonic Agents.Enzyme Inhibitors 77 0.387 47 4163 DB00247 Serotonin Antagonists.Sympatholytics.Vasoconstrictor Agents 77 0.387 33 657298 DB00550 Antimetabolites.Antithyroid Agents 77 0.387 39 5396 DB00444 Antineoplastic Agents.Enzyme Inhibitors.Nucleic Acid Synthesis Inhibitors 77 0.387 20 667490 DB01033 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Immunosuppressive Agents.Nucleic Acid Synthesis Inhibitors.Purine analogues 77 0.387 61 5402 DB00857 Allylamines.Antifungal Agents.Antifungals.Enzyme Inhibitors.Trypanocidal Agents 77 0.387 62 5650 DB00177 Angiotensin II Receptor Antagonists.Antihypertensive Agents 77 0.387 24 2727 DB00672 Hypoglycemic Agents.Sulfonylureas 77 0.387 14 4993 DB00205 Antimalarials.Antiprotozoal Agents.Antiprotozoals.Folic Acid Antagonists 77 0.387 24 1349907 DB00763 Antithyroid Agents 77 0.387 50 2973 DB00746 Chelating agent.Iron Chelating Agents.Siderophores 77 0.387 29 3125 DB00765 Enzyme Inhibitors 77 0.387 52 598 DB01181 Antineoplastic Agents.Antineoplastic Agents, Alkylating.Immunosuppressive Agents 77 0.387 14 36811 DB00841 Adrenergic beta-Agonists.Cardiotonic Agents.Sympathomimetic.Sympathomimetics 77 0.387 49 3365 DB00196 Antifungal Agents.Antifungals 77 0.387 46 3366 DB01099 Antifungal Agents.Antifungals.Antimetabolites 77 0.387 38 150311 DB00973 Anticholesteremic Agents.Cholesterol Absorption Inhibitors 77 0.387 18 3698 DB01427 Calcium Channel Blockers.Cardiotonic Agents.Phosphodiesterase Inhibitors.Vasodilator Agents 77 0.387 34 3827 DB00920 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists 77 0.375 89 59708 DB01202 Anticonvulsants.Nootropic Agents 77 0.373 31 4497 DB00393 Antihypertensive Agents.Calcium Channel Blockers.Vasodilator Agents 77 0.373 40 2610 DB01140 Anti-Bacterial Agents.Cephalosporins 77 0.371 63 3381 DB00591 Anti-inflammatory Agents.Antipruritics.Glucocorticoids 77 0.371 66 123620 DB00764 Anti-Allergic Agents.Anti-inflammatory Agents 77 0.371 14 2133 DB00288 Corticosteroids, topical 77 0.361 60 5515 DB01030 Antineoplastic Agents.Enzyme Inhibitors 77 0.353 77 3379 DB00180 Anti-Asthmatic Agents.Anti-inflammatory Agents 77 0.353 21 5267 DB00421 Aldosterone Antagonists.Diuretics 77 0.353 31 4900 DB00635 Adrenergic Agents.Anti-inflammatory Agents.Antineoplastic Agents.Antineoplastic Agents, Hormonal.Glucocorticoids 77 0.353 54 444033 DB01410 Anti-Allergic Agents.Glucocorticoids 77 0.353 42 4196 DB00834 Abortifacient Agents, Steroidal.Contraceptives, Oral, Synthetic.Contraceptives, Postcoital, Synthetic.Hormone Antagonists.Luteolytic Agents.Menstruation-Inducing Agents 77 0.351 49 51634 DB00419 Anti-HIV Agents.Enzyme Inhibitors 77 0.35 53 5035 DB00481 Antihypocalcemic Agents.Bone Density Conservation Agents.Estrogen Antagonists.Osteoporosis Prophylactic.Selective Estrogen Receptor Modulators 77 0.346 34 3518 DB01170 Adrenergic Agents.Antihypertensive Agents.Sympatholytics 77 0.343 21 5473385 DB00352 Antimetabolites, Antineoplastic 77 0.341 71 3310 DB00773 Antineoplastic Agents, Phytogenic.Nucleic Acid Synthesis Inhibitors 77 0.341 72 5672 DB00361 Antineoplastic Agents.Antineoplastic Agents, Phytogenic.Radiation-Sensitizing Agents 77 0.341 76 3108 DB00975 Phosphodiesterase Inhibitors.Platelet Aggregation Inhibitors.Vasodilator Agents 77 0.335 46 4201 DB00350 Antihypertensive Agents.Vasodilator Agents 77 0.333 27 298 DB00446 Anti-Bacterial Agents.Protein Synthesis Inhibitors 77 0.323 38 30623 DB00380 Antineoplastic Agents.Cardiovascular Agents.Chelating Agents.Immunosuppressive Agents 77 0.323 79 176870 DB00530 Protein Kinase Inhibitors 77 0.323 47 60843 DB00642 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Enzyme Inhibitors.Folic Acid Antagonists 77 0.323 39 5412 DB00759 Anti-Bacterial Agents.Antiprotozoals.Protein Synthesis Inhibitors.Tetracyclines 77 0.321 36 2564 DB00748 Antihistamines 77 0.321 37 2781 DB00283 Anti-Allergic Agents.Antipruritics.Histamine H1 Antagonists 77 0.321 46 163742 DB00569 Anticoagulants.Antithrombotics 77 0.321 41 5530 DB00752 Anti-anxiety Agents.Antidepressants.Antidepressive Agents.Monoamine Oxidase Inhibitors 77 0.321 32 2725 DB01114 Anti-Allergic Agents.Antihistamines.Antipruritics.Histamine H1 Antagonists 77 0.321 39 2756 DB00501 Adjuvants.Analgesics.Anti-Ulcer Agents.Enzyme Inhibitors.Histamine Antagonists.Histamine H2 Antagonists 77 0.321 44 2913 DB00434 Anti-Allergic Agents.Antihistamine derivatives.Antipruritics.Gastrointestinal Agents.Histamine H1 Antagonists.Serotonin Antagonists 77 0.321 37 3100 DB01075 Anesthetics.Anesthetics, Local.Anti-Allergic Agents.Antidyskinetics.Antiemetics.Antiparkinson Agents.Antipruritics.Antitussives.Ethanolamine Derivatives.Histamine H1 Antagonists.Hypnotics and Sedatives 77 0.321 50 3158 DB01142 Anti-anxiety Agents.Antidepressants.Antidepressive Agents, Tricyclic.Antipruritics.Histamine Antagonists.Norepinephrine-Reuptake Inhibitors 77 0.315 71 4740 DB00806 Free Radical Scavengers.Hematologic Agents.Hemorrheologic Agents.Phosphodiesterase Inhibitors.Platelet Aggregation Inhibitors.Radiation-Protective Agents.Vasodilator Agents 77 0.315 38 3488 DB01016 Antiarrhythmic Agents.Hypoglycemic Agents.Sulfonylureas 77 0.315 59 772 DB01109 Anticoagulants.Fibrinolytic Agents.Heparins 77 0.315 21 5311082 DB00063 Anticoagulants.Antiplatelet Agents.Platelet Aggregation Inhibitors 77 0.315 46 3685 DB01177 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 77 0.315 14 4197 DB00235 Cardiotonic Agents.Phosphodiesterase Inhibitors.Platelet Aggregation Inhibitors.Vasodilator Agents 77 0.315 43 4913 DB01035 Anti-Arrhythmia Agents.Antiarrhythmic Agents 77 0.31 76 123631 DB00317 Antineoplastic Agents.Protein Kinase Inhibitors 77 0.309 70 2179 DB00276 Antineoplastic Agents.Intercalating Agents 77 0.305 61 119182 DB00631 Antimetabolites.Antineoplastic Agents.Purine analogues 77 0.302 9 5342 DB01138 Uricosuric Agents 77 0.298 135 5544 DB00620 Adrenergic Agents.Anti-inflammatory Agents.Glucocorticoids 77 0.292 88 3750 DB00762 Antineoplastic Agents.Antineoplastic Agents, Phytogenic.Enzyme Inhibitors.Parasympathomimetics.Prodrugs.Radiation-Sensitizing Agents #### component 78: positive weight features and high scoring objects #### # positive weight on target proteins 78 0.585 38 ADRB1_HUMAN Beta-1 adrenergic receptor; 78 0.339 26 SC6A4_HUMAN Sodium-dependent serotonin transporter; 78 0.315 34 ADRB2_HUMAN Beta-2 adrenergic receptor; 78 0.286 24 ADRB3_HUMAN Beta-3 adrenergic receptor; 78 0.278 38 ADA2A_HUMAN Alpha-2A adrenergic receptor; 78 0.221 42 ADA1A_HUMAN Alpha-1A adrenergic receptor; 78 0.221 34 ADA1B_HUMAN Alpha-1B adrenergic receptor; 78 0.211 33 ADA2B_HUMAN Alpha-2B adrenergic receptor; 78 0.207 30 ADA1D_HUMAN Alpha-1D adrenergic receptor; 78 0.188 28 DRD3_HUMAN D(3) dopamine receptor; 78 0.116 28 SC6A2_HUMAN Sodium-dependent noradrenaline transporter; 78 0.107 35 DRD2_HUMAN D(2) dopamine receptor; 78 0.104 16 TOP2A_HUMAN DNA topoisomerase 2-alpha; 78 0.056 11 ACES_HUMAN Acetylcholinesterase; 78 0.036 9 CHLE_HUMAN Cholinesterase; 78 0.029 7 GRIA1_HUMAN Glutamate receptor 1; 78 0.024 6 DRD4_HUMAN D(4) dopamine receptor; 78 0.023 28 DRD1_HUMAN D(1A) dopamine receptor; 78 0.018 4 BCL2_HUMAN Apoptosis regulator Bcl-2; 78 0.016 12 ACE_HUMAN Angiotensin-converting enzyme; 78 0.01 8 PDE5A_HUMAN cGMP-specific 3',5'-cyclic phosphodiesterase; # positive weight on side effects 78 0.416 152 postural hypotension 78 0.383 50 blepharitis 78 0.382 48 psoriasis 78 0.341 24 stridor 78 0.289 170 angina pectoris 78 0.217 244 arrhythmia 78 0.189 117 atrial fibrillation 78 0.163 26 chest pain substernal 78 0.078 130 cardiac arrest 78 0.069 99 photophobia 78 0.044 41 shortness of breath # high scoring drugs for both targets and side effects 78 1.7 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 78 1.575 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 78 1.572 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 78 1.518 76 3661 DB00572 Adjuvants, Anesthesia.Anti-Arrhythmia Agents.Bronchodilator Agents.Muscarinic Antagonists.Mydriatics.Parasympatholytics 78 1.466 20 5775 DB00692 Adrenergic alpha-Antagonists.Antihypertensive Agents.Sympatholytics 78 1.381 135 2585 DB01136 Adrenergic Agents.Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 78 1.313 69 3869 DB00598 Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Sympatholytics 78 1.245 72 4893 DB00457 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Antihypertensive Agents 78 1.191 14 951 DB00368 Adrenergic alpha-Agonists.Sympathomimetics.Vasoconstrictor Agents 78 1.19 61 4828 DB00960 Adrenergic beta-Antagonists.Antihypertensive Agents.Serotonin Antagonists.Vasodilator Agents 78 1.149 87 5533 DB00656 Anti-anxiety Agents.Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 78 0.994 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 78 0.992 99 5478 DB00373 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents 78 0.923 78 2249 DB00335 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Sympatholytics 78 0.915 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 78 0.909 10 4436 Not Available Not Available 78 0.902 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 78 0.878 154 3157 DB00590 Adrenergic alpha-Antagonists.Alpha-adrenergic Blocking Agents.Anticholesteremic Agents.Antihypertensive Agents.Vasodilator Agents 78 0.843 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 78 0.83 30 31477 DB01214 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents.Sympatholytics 78 0.799 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 78 0.759 84 2995 DB01151 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Enzyme Inhibitors.Norepinephrine-Reuptake Inhibitors 78 0.708 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 78 0.706 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 78 0.704 52 5452 DB00679 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 78 0.689 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 78 0.689 117 2405 DB00612 Adrenergic Agents.Adrenergic beta-Antagonists.Antihypertensive Agents.Sympatholytics 78 0.668 61 4946 DB00571 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Anti-anxiety Agents.Antiarrhythmic Agents.Antihypertensive Agents.Vasodilator Agents 78 0.665 51 3559 DB00502 Anti-Dyskinesia Agents.Antidyskinetics.Antiemetics.Antipsychotic Agents.Antipsychotics.Butyrophenones.Dopamine Antagonists 78 0.653 138 2369 DB00195 Adrenergic beta-Antagonists.Antihypertensive Agents.EENT Drugs.Sympatholytics 78 0.635 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 78 0.615 11 3251 DB00696 Adrenergic alpha-Agonists.Analgesics, Non-Narcotic.Sympatholytics.Vasoconstrictor Agents 78 0.615 53 2092 DB00346 Adrenergic alpha-Antagonists.Antihypertensive Agents 78 0.612 34 71301 DB04861 Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 78 0.606 4 4768 DB00925 Adrenergic alpha-Antagonists.Antihypertensive Agents.Vasodilator Agents 78 0.601 34 3518 DB01170 Adrenergic Agents.Antihypertensive Agents.Sympatholytics 78 0.586 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 78 0.584 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 78 0.577 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 78 0.576 76 2803 DB00575 Adrenergic alpha-Agonists.Analgesics.Antihypertensive Agents.Central Alpha-Agonists.Sympatholytics 78 0.57 84 5401 DB01162 Adrenergic alpha-Antagonists.Antineoplastic Agents.Platelet Aggregation Inhibitors 78 0.55 94 4171 DB00264 Adrenergic Agents.Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Sympatholytics 78 0.549 127 2156 DB01118 Anti-Arrhythmia Agents.Enzyme Inhibitors.Vasodilator Agents 78 0.547 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 78 0.536 19 3779 DB01064 Adrenergic beta-Agonists.Bronchodilator Agents.Cardiotonic Agents.Sympathomimetic.Sympathomimetics 78 0.531 14 36811 DB00841 Adrenergic beta-Agonists.Cardiotonic Agents.Sympathomimetic.Sympathomimetics 78 0.526 62 3007 DB00182 Adrenergic Agents.Adrenergic Uptake Inhibitors.Amphetamines.Central Nervous System Stimulants.Dopamine Agents.Dopamine Uptake Inhibitors.Sympathomimetics 78 0.518 453 125889 DB00230 Analgesics.Anticonvulsants 78 0.517 106 2083 DB01001 Adrenergic beta-Agonists.Bronchodilator Agents.Tocolytic Agents 78 0.515 171 4205 DB00370 Adrenergic alpha-Antagonists.Antidepressive Agents, Tricyclic.Histamine H1 Antagonists 78 0.513 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 78 0.512 75 1978 DB01193 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents 78 0.51 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 78 0.508 24 2431 DB01158 Adrenergic Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents 78 0.508 28 2583 DB00521 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents.Sympatholytics 78 0.507 16 5504 DB00797 Adrenergic alpha-Antagonists.Antihypertensive Agents.Vasodilator Agents 78 0.504 20 838 DB00668 Adrenergic Agonists.Adrenergic alpha-Agonists.Adrenergic beta-Agonists.Bronchodilator Agents.Mydriatics.Sympathomimetics.Vasoconstrictor Agents 78 0.479 64 2726 DB00477 Antiemetics.Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Phenothiazines 78 0.471 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 78 0.467 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 78 0.459 157 3937 DB00722 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents.Cardiotonic Agents 78 0.453 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 78 0.451 211 60953 DB01101 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Prodrugs 78 0.447 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 78 0.446 33 3340 DB00800 Antihypertensive Agents.Dopamine Agonists.Vasodilator Agents 78 0.441 253 1690 DB00997 Antibiotics.Antibiotics, Antineoplastic.Antineoplastic Agents 78 0.439 77 3066 DB00320 Analgesics.Analgesics, Non-Narcotic.Anti-migraine Agents.Dopamine Agonists.Sympatholytics.Vasoconstrictor Agents 78 0.433 16 3168 DB00450 Adjuvants, Anesthesia.Antiemetics.Antipsychotic Agents.Dopamine Antagonists 78 0.424 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 78 0.413 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 78 0.411 167 5719 DB00962 Anticonvulsants.Anxiolytics sedatives and hypnotics.Hypnotics and Sedatives 78 0.401 126 104865 DB00559 Antihypertensive Agents 78 0.399 101 3154 DB00869 Antihypertensive Agents.Carbonic Anhydrase Inhibitors 78 0.398 34 4195 DB00211 Adrenergic alpha-Agonists.Sympathomimetics.Vasoconstrictor Agents 78 0.398 8 3241 DB00751 Antihistamines.Histamine H1 Antagonists.Ophthalmics 78 0.394 143 4054 DB01043 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agents.Excitatory Amino Acid Antagonists 78 0.39 100 5038 DB00178 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 78 0.379 161 5487 DB00697 Adrenergic alpha-Agonists.Analgesics.Anticonvulsants.Muscle Relaxants.Muscle Relaxants, Central.Parasympatholytics.Skeletal Muscle Relaxants 78 0.375 140 3143 DB01248 Antimalarials.Antineoplastic Agents.Antineoplastic Agents, Phytogenic.Radiation-Sensitizing Agents 78 0.373 72 2160 DB00321 Adrenergic Uptake Inhibitors.Analgesics, Non-Narcotic.Antidepressive Agents, Tricyclic 78 0.371 76 3108 DB00975 Phosphodiesterase Inhibitors.Platelet Aggregation Inhibitors.Vasodilator Agents 78 0.369 38 3914 DB01210 Adrenergic beta-Antagonists.EENT Drugs.Sympatholytics 78 0.364 211 93860 DB00188 Antineoplastic Agents.Protease Inhibitors 78 0.364 40 4845 DB01291 Adrenergic beta-Agonists.Bronchodilator Agents.Cardiotonic Agents 78 0.353 118 4236 DB00745 Anorexigenic Agents.Central Nervous System Agents.Central Nervous System Stimulants.Neuroprotective Agents.Stimulants 78 0.352 31 2215 DB00714 Antidyskinetics.Antiparkinson Agents.Dopamine Agonists 78 0.351 61 2435 DB00484 Adrenergic alpha-Agonists.Antihypertensive Agents.EENT Drugs 78 0.347 85 3385 DB00544 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Immunosuppressive Agents 78 0.346 147 5645 DB01586 Cholagogues and Choleretics 78 0.339 42 4411 DB01203 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents.Sympatholytics 78 0.335 60 3519 DB01018 Adrenergic alpha-Agonists.Antihypertensive Agents.Sympatholytics 78 0.332 52 32170 DB00668 Adrenergic Agonists.Adrenergic alpha-Agonists.Adrenergic beta-Agonists.Bronchodilator Agents.Mydriatics.Sympathomimetics.Vasoconstrictor Agents 78 0.332 161 122316 DB01367 Monoamine Oxidase Inhibitors.Neuroprotective Agents 78 0.33 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 78 0.329 103 2751 DB01340 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 78 0.329 15 681 DB00988 Cardiotonic Agents.Dopamine Agents.Sympathomimetic.Sympathomimetics 78 0.327 118 65999 DB00966 Angiotensin II Type 1 Receptor Blockers.Angiotensin-converting Enzyme Inhibitors 78 0.324 90 5152 DB00938 Adrenergic beta-Agonists.Bronchodilator Agents.Sympathomimetic 78 0.314 57 2443 DB01200 Antidyskinetics.Antiparkinson Agents.Dopamine Agonists.Hormone Antagonists 78 0.308 152 60184 DB00790 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents #### component 79: positive weight features and high scoring objects #### # positive weight on target proteins 79 0.863 12 ACE_HUMAN Angiotensin-converting enzyme; 79 0.182 13 CAC1B_HUMAN Voltage-dependent N-type calcium channel subunit alpha-1B; 79 0.149 16 CAC1F_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1F; 79 0.149 16 CAC1D_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1D; 79 0.149 16 CACB2_HUMAN Voltage-dependent L-type calcium channel subunit beta-2; 79 0.128 18 SCNNG_HUMAN Amiloride-sensitive sodium channel subunit gamma; 79 0.128 18 SCNND_HUMAN Amiloride-sensitive sodium channel subunit delta; 79 0.128 18 SCNNB_HUMAN Amiloride-sensitive sodium channel subunit beta; 79 0.098 17 CCG1_HUMAN Voltage-dependent calcium channel gamma-1 subunit; 79 0.081 18 CAC1C_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1C; 79 0.07 17 EF1B_HUMAN Elongation factor 1-beta; 79 0.07 17 SCN4A_HUMAN Sodium channel protein type 4 subunit alpha; 79 0.07 17 DB124_HUMAN Beta-defensin 124; 79 0.07 17 ACCN3_HUMAN Amiloride-sensitive cation channel 3; 79 0.07 17 SCN4B_HUMAN Sodium channel subunit beta-4; 79 0.07 17 SCN3B_HUMAN Sodium channel subunit beta-3; 79 0.07 17 ACCN4_HUMAN Amiloride-sensitive cation channel 4; 79 0.07 17 SCN7A_HUMAN Sodium channel protein type 7 subunit alpha; 79 0.07 17 SCN1B_HUMAN Sodium channel subunit beta-1; 79 0.07 17 SCNAA_HUMAN Sodium channel protein type 10 subunit alpha; 79 0.07 17 SCN3A_HUMAN Sodium channel protein type 3 subunit alpha; 79 0.056 15 CAC1I_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1I; 79 0.056 15 CAC1H_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1H; 79 0.053 14 LOX5_HUMAN Arachidonate 5-lipoxygenase; 79 0.03 12 CACB4_HUMAN Voltage-dependent L-type calcium channel subunit beta-4; 79 0.03 12 PKD1_HUMAN Polycystin-1; 79 0.03 12 TRPV6_HUMAN Transient receptor potential cation channel subfamily V member 6; 79 0.03 12 CA2D1_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-1; 79 0.03 12 ITPR3_HUMAN Inositol 1,4,5-trisphosphate receptor type 3; 79 0.03 12 CCG4_HUMAN Voltage-dependent calcium channel gamma-4 subunit; 79 0.03 12 CACB3_HUMAN Voltage-dependent L-type calcium channel subunit beta-3; 79 0.03 12 CAC1S_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1S; 79 0.03 12 PKD2_HUMAN Polycystin-2; 79 0.03 12 CAC1E_HUMAN Voltage-dependent R-type calcium channel subunit alpha-1E; 79 0.03 12 TRPA1_HUMAN Transient receptor potential cation channel subfamily A member 1; 79 0.03 12 ITPR1_HUMAN Inositol 1,4,5-trisphosphate receptor type 1; 79 0.03 12 CCG2_HUMAN Voltage-dependent calcium channel gamma-2 subunit; 79 0.03 12 CCG7_HUMAN Voltage-dependent calcium channel gamma-7 subunit; 79 0.024 13 CACB1_HUMAN Voltage-dependent L-type calcium channel subunit beta-1; 79 0.014 5 ATP4A_HUMAN Potassium-transporting ATPase alpha chain 1; 79 0.011 15 RYR3_HUMAN Ryanodine receptor 3; 79 0.011 15 RYR2_HUMAN Ryanodine receptor 2; 79 0.001 14 RYR1_HUMAN Ryanodine receptor 1; # positive weight on side effects 79 0.647 205 angioedema 79 0.313 133 bronchospasm 79 0.293 129 eosinophilia 79 0.262 284 syncope 79 0.253 134 cerebrovascular accident 79 0.242 293 cough 79 0.235 159 increased sweating 79 0.197 229 Pharyngitis 79 0.141 301 dry mouth 79 0.135 252 malaise 79 0.117 249 blurred vision 79 0.116 282 vertigo 79 0.099 218 rhinitis 79 0.09 191 peripheral edema 79 0.075 439 pruritus 79 0.068 118 exfoliative dermatitis 79 0.064 112 hemolytic anemia 79 0.056 476 rash 79 0.047 104 vasculitis 79 0.047 13 pemphigus 79 0.045 19 positive ANA 79 0.043 346 dyspnea 79 0.037 94 arthrosis 79 0.036 254 nervousness # high scoring drugs for both targets and side effects 79 2.291 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 79 2.201 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 79 1.988 83 2520 DB00661 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Vasodilator Agents 79 1.712 140 4485 DB01115 Calcium Channel Blockers.Dihydropyridines.Tocolytic Agents.Vasodilator Agents 79 1.502 150 1775 DB00252 Anticonvulsants 79 1.472 95 16231 DB00594 Diuretics.Sodium channel blockers 79 1.432 146 3075 DB00343 Antihypertensive Agents.Calcium Channel Blockers.Calcium-channel blocking agents.Cardiovascular Agents.Vasodilator Agents 79 1.271 157 3937 DB00722 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents.Cardiotonic Agents 79 1.254 151 2554 DB00564 Analgesics.Analgesics, Non-Narcotic.Anticonvulsants.Antimanic Agents 79 1.211 239 5514 DB00273 Anti-Obesity Agents.Anticonvulsants.Neuroprotective Agents 79 1.194 112 71273 DB00296 Anesthetics.Anesthetics, Local.Local Anesthetics 79 1.168 55 91270 DB00691 Angiotensin-converting Enzyme Inhibitors 79 1.129 152 60184 DB00790 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 79 1.116 111 3419 DB00492 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 79 1.112 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 79 1.045 98 3222 DB00584 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 79 1.029 75 2550 DB01197 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 79 1.024 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 79 1.013 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 79 0.998 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 79 0.989 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 79 0.985 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 79 0.976 103 2751 DB01340 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 79 0.973 73 3333 DB01023 Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents.Calcium Channel Blockers.Dihydropyridines.Vasodilator Agents 79 0.969 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 79 0.966 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 79 0.949 135 2585 DB01136 Adrenergic Agents.Adrenergic alpha-Antagonists.Adrenergic beta-Antagonists.Antihypertensive Agents.Vasodilator Agents 79 0.949 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 79 0.941 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 79 0.938 100 5038 DB00178 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 79 0.923 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 79 0.921 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 79 0.921 90 2162 DB00381 Antianginals.Antihypertensive Agents.Calcium Channel Blockers.Vasodilator Agents 79 0.921 132 3948 DB00978 Anti-Infective Agents.Anti-Infective Agents, Urinary.Antitubercular Agents.Photosensitizing Agents 79 0.898 87 5005 DB00881 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 79 0.895 118 65999 DB00966 Angiotensin II Type 1 Receptor Blockers.Angiotensin-converting Enzyme Inhibitors 79 0.894 145 3672 DB01050 Analgesics.Analgesics, Non-Narcotic.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 79 0.892 61 3114 DB00280 Anti-Arrhythmia Agents.Antiarrhythmic Agents 79 0.881 91 3355 DB01195 Anti-Arrhythmia Agents.Antiarrhythmic Agents 79 0.873 135 5734 DB00909 Anticonvulsants.Antioxidants 79 0.863 453 125889 DB00230 Analgesics.Anticonvulsants 79 0.846 185 4594 DB00338 Anti-Ulcer Agents.Enzyme Inhibitors.Proton-pump Inhibitors 79 0.821 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 79 0.816 116 5525 DB00519 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 79 0.812 76 3108 DB00975 Phosphodiesterase Inhibitors.Platelet Aggregation Inhibitors.Vasodilator Agents 79 0.806 241 3404 DB00176 Anti-anxiety Agents.Antidepressive Agents.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 79 0.797 137 62959 DB00685 Anti-Infective Agents.Anti-Infectives.Fluoroquinolones 79 0.797 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 79 0.796 119 4052 DB00814 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Antiemetics.Antineoplastic Agents.Cyclooxygenase Inhibitors.Growth Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 79 0.792 166 3394 DB00712 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Carbonic Anhydrase Inhibitors.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 79 0.787 74 3676 DB00281 Anesthetics.Anesthetics, Local.Anti-Arrhythmia Agents.Antiarrhythmic Agents 79 0.781 244 5426 DB01041 Angiogenesis Inhibitors.Immunosuppressive Agents.Leprostatic Agents.Teratogens 79 0.772 97 4200 DB01017 Anti-Bacterial Agents.Tetracyclines 79 0.772 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 79 0.769 117 2405 DB00612 Adrenergic Agents.Adrenergic beta-Antagonists.Antihypertensive Agents.Sympatholytics 79 0.762 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 79 0.757 128 3793 DB01167 Antifungal Agents.Antifungals.Antiprotozoal Agents.Antiprotozoals 79 0.755 79 2311 DB00542 Angiotensin-converting Enzyme Inhibitors.Antihypertensive Agents 79 0.748 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 79 0.747 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 79 0.743 142 2678 DB00341 Anti-Allergic Agents.Antihistamines.Histamine H1 Antagonists, Non-Sedating 79 0.731 205 4075 DB00244 Anti-Inflammatory Agents, Non-Steroidal 79 0.726 142 3826 DB00465 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 79 0.72 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 79 0.716 144 3702 DB00808 Antihypertensive Agents.Diuretics 79 0.711 119 3308 DB00749 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 79 0.709 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 79 0.697 144 3899 DB01097 Adjuvants.Anti-inflammatory Agents.Antineoplastic Agents.Antiparasitic Agents.Antirheumatic Agents.Antiviral Agents.Enzyme Inhibitors.Immunosuppressive Agents 79 0.686 154 5090 DB00533 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase 2 Inhibitors.Cyclooxygenase Inhibitors 79 0.681 126 104865 DB00559 Antihypertensive Agents 79 0.675 158 34312 DB00776 Anticonvulsants 79 0.647 236 10631 DB00603 Contraceptives.Contraceptives, Oral, Synthetic.Progestins 79 0.64 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 79 0.635 101 3154 DB00869 Antihypertensive Agents.Carbonic Anhydrase Inhibitors 79 0.635 264 5372 DB00864 Immunosuppressive Agents 79 0.634 53 3784 DB00270 Antihypertensive Agents.Calcium Channel Blockers.Vasodilator Agents 79 0.633 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 79 0.632 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 79 0.628 75 4178 DB00379 Anti-Arrhythmia Agents 79 0.623 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 79 0.619 191 450 DB00783 Anti-menopausal Agents.Anticholesteremic Agents.Estrogens 79 0.618 43 4913 DB01035 Anti-Arrhythmia Agents.Antiarrhythmic Agents 79 0.616 103 5352 DB00605 Anti-Inflammatory Agents, Non-Steroidal.Antineoplastic Agents.Cyclooxygenase Inhibitors 79 0.61 183 3648 DB00327 Analgesics, Opioid.Narcotics 79 0.61 99 4889 DB00175 Anticholesteremic Agents.HMG-CoA Reductase Inhibitors.Hydroxymethylglutaryl-CoA Reductase Inhibitors 79 0.61 166 54374 DB00104 Anabolic Agents.Antineoplastic Agents, Hormonal.Gastrointestinal Agents.Hormone Replacement Agents 79 0.61 154 27661 DB01020 Nitrates and Nitrites.Nitric Oxide Donors.Vasodilator Agents 79 0.605 171 2909 DB00091 Antifungal Agents.Antirheumatic Agents.Dermatologic Agents.Enzyme Inhibitors.Immunomodulatory Agents.Immunosuppressive Agents 79 0.601 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 79 0.594 151 60835 DB00476 Adrenergic Uptake Inhibitors.Antidepressive Agents.Dopamine Uptake Inhibitors.Serotonin Uptake Inhibitors 79 0.592 109 60879 DB00876 Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents 79 0.587 137 2462 DB01222 Anti-inflammatory Agents.Bronchodilator Agents.Corticosteroids.Glucocorticoids 79 0.584 131 3961 DB00678 Angiotensin II Receptor Antagonists.Angiotensin II Type 1 Receptor Blockers.Anti-Arrhythmia Agents.Antiarrhythmic Agents.Antihypertensive Agents 79 0.583 199 5358 DB00669 Selective Serotonin Agonists.Serotonin Agonists.Vasoconstrictor Agents 79 0.582 99 5478 DB00373 Adrenergic beta-Antagonists.Anti-Arrhythmia Agents.Antihypertensive Agents 79 0.578 136 2375 DB01128 Androgen Antagonists.Antineoplastic Agents 79 0.565 172 4920 DB00396 Contraceptives.Progestins 79 0.564 89 3148 DB00757 Antiemetics.Serotonin Antagonists 79 0.554 104 4614 DB00991 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Nonsteroidal Antiinflammatory Agents (NSAIDs) 79 0.554 118 4236 DB00745 Anorexigenic Agents.Central Nervous System Agents.Central Nervous System Stimulants.Neuroprotective Agents.Stimulants #### component 80: positive weight features and high scoring objects #### # positive weight on target proteins 80 0.491 36 ACM1_HUMAN Muscarinic acetylcholine receptor M1; 80 0.448 34 ACM2_HUMAN Muscarinic acetylcholine receptor M2; 80 0.186 16 TOP2A_HUMAN DNA topoisomerase 2-alpha; 80 0.09 35 HRH1_HUMAN Histamine H1 receptor; 80 0.016 7 TOP2B_HUMAN DNA topoisomerase 2-beta; 80 0.006 4 KIT_HUMAN Mast/stem cell growth factor receptor; 80 0.006 4 PGFRB_HUMAN Beta-type platelet-derived growth factor receptor; # positive weight on side effects 80 0.57 322 tachycardia 80 0.435 232 hemorrhage 80 0.329 355 abdominal pain 80 0.313 262 anemia 80 0.277 189 hallucinations 80 0.189 301 confusion 80 0.181 301 dry mouth 80 0.175 279 infection 80 0.112 152 urinary retention 80 0.111 87 dry eyes 80 0.088 439 pruritus 80 0.081 280 hypertension 80 0.081 100 hepatic failure 80 0.055 86 sepsis 80 0.049 155 stomatitis 80 0.039 391 edema 80 0.038 85 acute renal failure 80 0.03 52 ventricular fibrillation 80 0.023 179 myocardial infarction 80 0.005 368 somnolence 80 0.003 280 myalgia 80 0.002 254 nervousness # high scoring drugs for both targets and side effects 80 1.26 227 4585 DB00334 Antiemetics.Antipsychotic Agents.Antipsychotics.Serotonin Uptake Inhibitors 80 1.177 196 1935 DB00382 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 80 0.991 141 4819 DB01085 Cholinergic Agents.Miotics.Muscarinic Agonists 80 0.976 219 3152 DB00843 Cholinesterase Inhibitors.Nootropic Agents.Parasympathomimetics 80 0.937 200 4259 DB00218 Anti-Bacterial Agents.Anti-Infective Agents.Quinolones 80 0.923 151 2818 DB00363 Antipsychotic Agents.Antipsychotics.GABA Antagonists.Serotonin Antagonists 80 0.912 183 3648 DB00327 Analgesics, Opioid.Narcotics 80 0.898 73 2769 DB00604 Anti-Ulcer Agents.Gastrointestinal Agents.Prokinetic Agents.Serotonin Agonists 80 0.88 37 5512 DB01036 Anti-Incontinence Agents.Antispasmodics.Genitourinary Smooth Muscle Relaxants.Muscarinic Antagonists 80 0.852 293 3386 DB00472 Antidepressants, Second-Generation.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 80 0.844 248 5195 DB01037 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopaminergics.Monoamine Oxidase Inhibitors.Neuroprotective Agents 80 0.842 294 3446 DB00996 Analgesics.Anti-anxiety Agents.Anticonvulsants.Antimanic Agents.Antiparkinson Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 80 0.832 64 3746 DB00332 Antimuscarinics.Antispasmodics.Bronchodilator Agents.Cholinergic Antagonists 80 0.826 206 3878 DB00555 Analgesics.Anticonvulsants.Antidepressants.Antimanic Agents.Calcium Channel Blockers.Excitatory Amino Acid Antagonists 80 0.825 272 60795 DB01238 Antipsychotic Agents.Antipsychotics 80 0.824 224 508230 DB01024 Antibiotics, Antineoplastic.Enzyme Inhibitors 80 0.816 240 2764 DB00537 Anti-Infective Agents.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 80 0.802 183 3121 DB00313 Anticonvulsants.Antimanic Agents.Enzyme Inhibitors.GABA Agents 80 0.799 137 62959 DB00685 Anti-Infective Agents.Anti-Infectives.Fluoroquinolones 80 0.797 264 5372 DB00864 Immunosuppressive Agents 80 0.796 196 5466 DB00906 Anticonvulsants.GABA Agonists.Neuroprotective Agents.Neurotransmitter Uptake Inhibitors 80 0.787 262 4583 DB01165 Anti-Bacterial Agents.Anti-Infective Agents, Urinary.Anti-Infectives.Nucleic Acid Synthesis Inhibitors.Quinolones 80 0.785 253 5073 DB00734 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 80 0.781 220 3345 DB00813 Adjuvants.Adjuvants, Anesthesia.Analgesics.Analgesics, Opioid.Anesthetics.Anesthetics, Intravenous.Narcotics.Opiate Agonists 80 0.778 142 3826 DB00465 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 80 0.769 201 5538 DB00755 Antineoplastic Agents.Cell Stimulants and Proliferants.Keratolytic Agents 80 0.768 172 4449 DB01149 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Agents 80 0.764 157 4659569 DB00323 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Enzyme Inhibitors 80 0.764 319 5656 DB00285 Analgesics.Antidepressants.Antidepressive Agents, Second-Generation.Serotonin Uptake Inhibitors 80 0.762 214 4679 DB00213 Anti-Ulcer Agents.Proton-pump Inhibitors 80 0.762 453 125889 DB00230 Analgesics.Anticonvulsants 80 0.761 409 5095 DB00268 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists 80 0.76 259 444 DB01156 Antidepressive Agents.Antidepressive Agents, Second-Generation.Dopamine Uptake Inhibitors 80 0.755 267 5070 DB00740 Anesthetics.Anticonvulsants.Excitatory Amino Acid Antagonists.Neuroprotective Agents 80 0.748 225 1302 DB00788 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Gout Suppressants 80 0.746 288 5523 DB00193 Analgesics.Analgesics, Opioid.Narcotics 80 0.745 112 151165 DB00673 Antiemetics 80 0.744 131 4635 DB00497 Analgesics, Opioid.Antitussives.Narcotics.Opiate Agonists 80 0.733 189 5203 DB01104 Antidepressants.Antidepressive Agents.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 80 0.722 282 5077 DB00989 Cholinergic Agents.Cholinesterase Inhibitors.Neuroprotective Agents.Nootropic Agents.Parasympathomimetics 80 0.709 176 5732 DB00425 GABA Agonists.Hypnotics and Sedatives 80 0.709 108 4856 DB00554 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 80 0.709 104 4614 DB00991 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Nonsteroidal Antiinflammatory Agents (NSAIDs) 80 0.707 147 71158 DB00659 Alcohol Deterrents 80 0.705 61 60612 DB00633 Adrenergic alpha-Agonists.Analgesics.Analgesics, Non-Narcotic.Hypnotics and Sedatives 80 0.705 210 3032 DB00586 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 80 0.692 166 3394 DB00712 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Carbonic Anhydrase Inhibitors.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 80 0.69 89 4044 DB00784 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 80 0.69 119 3308 DB00749 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 80 0.671 167 5719 DB00962 Anticonvulsants.Anxiolytics sedatives and hypnotics.Hypnotics and Sedatives 80 0.664 151 60835 DB00476 Adrenergic Uptake Inhibitors.Antidepressive Agents.Dopamine Uptake Inhibitors.Serotonin Uptake Inhibitors 80 0.659 120 82146 DB00307 Anticarcinogenic Agents 80 0.655 137 3062316 DB01254 Protein Kinase Inhibitors 80 0.651 168 60854 DB00246 Antipsychotic Agents.Antipsychotics.Dopamine Antagonists.Serotonin Antagonists 80 0.651 39 5396 DB00444 Antineoplastic Agents.Enzyme Inhibitors.Nucleic Acid Synthesis Inhibitors 80 0.651 249 4745 DB01186 Antidyskinetics.Antiparkinson Agents.Central Nervous System Agents.Dopamine Agonists.Neuroprotective Agents 80 0.65 389 4885 DB00413 Antidyskinetics.Antioxidants.Antiparkinson Agents.Dopamine Agonists.Free Radical Scavengers 80 0.648 72 60831 DB01409 Anticholinergic Agents.Bronchodilator Agents.Cholinergic Antagonists.Muscarinic Antagonists.Parasympatholytics 80 0.647 68 5596 DB00209 Analgesics.Parasympatholytics 80 0.644 140 3143 DB01248 Antimalarials.Antineoplastic Agents.Antineoplastic Agents, Phytogenic.Radiation-Sensitizing Agents 80 0.643 195 5002 DB01224 Antipsychotic Agents.Antipsychotics 80 0.643 211 93860 DB00188 Antineoplastic Agents.Protease Inhibitors 80 0.641 101 14888 DB01169 Antineoplastic Agents.Homeopathic Agents 80 0.64 211 60953 DB01101 Antimetabolites.Antimetabolites, Antineoplastic.Antineoplastic Agents.Prodrugs 80 0.624 35 3042 DB00804 Anticholinergic Agents.Antimuscarinics.Antispasmodics.Muscarinic Antagonists.Parasympatholytics 80 0.624 291 2771 DB00215 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 80 0.621 227 119607 DB00580 Anti-Inflammatory Agents, Non-Steroidal.Anti-inflammatory Agents.Cyclooxygenase Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 80 0.62 188 5040 DB00877 Anti-Bacterial Agents.Antibiotics, Antineoplastic.Antifungal Agents.Antifungals.Immunosuppressive Agents 80 0.619 113 4674 DB00282 Anti-inflammatory Agents.Antineoplastic Agents.Bisphosphonates.Bone Density Conservation Agents 80 0.615 112 71273 DB00296 Anesthetics.Anesthetics, Local.Local Anesthetics 80 0.614 100 2578 DB00262 Antineoplastic Agents.Antineoplastic Agents, Alkylating 80 0.607 110 4212 DB01204 Analgesics.Antineoplastic Agents 80 0.604 127 2156 DB01118 Anti-Arrhythmia Agents.Enzyme Inhibitors.Vasodilator Agents 80 0.6 224 2801 DB01242 Antidepressive Agents, Tricyclic.Serotonin Uptake Inhibitors 80 0.597 97 159 DB01240 Antihypertensive Agents.Platelet Aggregation Inhibitors 80 0.592 129 5210 DB01105 Anorexigenic Agents.Antidepressants.Antidepressive Agents.Appetite Depressants.Stimulants 80 0.591 77 39860 DB00486 Anti-anxiety Agents.Antiemetics 80 0.588 119 4052 DB00814 Analgesics.Anti-Inflammatory Agents, Non-Steroidal.Antiemetics.Antineoplastic Agents.Cyclooxygenase Inhibitors.Growth Inhibitors.Nonsteroidal Antiinflammatory Agents (NSAIDs) 80 0.588 167 170361 DB01273 Nicotinic Agonists 80 0.582 119 5064 DB00811 Antimetabolites.Antiviral Agents 80 0.582 192 2662 DB00482 Anti-Inflammatory Agents, Non-Steroidal.Cyclooxygenase Inhibitors 80 0.58 234 216326 DB00480 Antineoplastic Agents 80 0.577 199 5358 DB00669 Selective Serotonin Agonists.Serotonin Agonists.Vasoconstrictor Agents 80 0.574 131 4428 DB00704 Alcohol Antagonists.Anti-craving Agents.Depressants.Narcotic Antagonists.Opiate Antagonists 80 0.57 125 596 DB02097 Not Available 80 0.57 147 5645 DB01586 Cholagogues and Choleretics 80 0.57 91 60815 DB00899 Analgesics, Opioid.Anesthetics, Intravenous.Hypnotics and Sedatives 80 0.57 117 2182 DB00261 Antithrombotic Agents.Fibrinolytic Agents.Platelet Aggregation Inhibitors 80 0.57 146 3475 DB01120 Hypoglycemic Agents.Sulfonylureas 80 0.567 84 2995 DB01151 Adrenergic Uptake Inhibitors.Antidepressants.Antidepressive Agents, Tricyclic.Enzyme Inhibitors.Norepinephrine-Reuptake Inhibitors 80 0.564 89 3086258 DB00707 Antineoplastic Agents.Antiviral Agents.Dermatologic Agents.Photosensitizing Agents 80 0.564 81 214 DB00770 Fibrinolytic Agents.Platelet Aggregation Inhibitors.Vasodilator Agents 80 0.561 128 4253 DB00295 Analgesics.Analgesics, Opioid.Narcotics.Opiate Agonists 80 0.558 132 4739 DB00552 Antibiotics.Antineoplastic Agents.Enzyme Inhibitors.Immunosuppressive Agents 80 0.556 319 4691 DB00715 Antidepressants.Antidepressive Agents, Second-Generation.Selective Serotonin Reuptake Inhibitors (SSRIs).Serotonin Uptake Inhibitors 80 0.555 181 4932 DB01182 Anti-Arrhythmia Agents 80 0.554 102 4943 DB00818 Anesthetics, Intravenous.Anticonvulsants.Antiemetics.Free Radical Scavengers.Hypnotics and Sedatives 80 0.553 106 216239 DB00398 Anticancer Agents.Antineoplastic Agents.Protein Kinase Inhibitors 80 0.551 19 2344 DB00245 Antidyskinetics.Antiparkinson Agents.Dopamine Uptake Inhibitors.Muscarinic Antagonists.Parasympatholytics 80 0.548 227 5029 DB01129 Anti-Ulcer Agents.Enzyme Inhibitors